Karyopharm Therapeutics Inc.
KPTI- Exchange
- Nasdaq
- Industry
- Pharmaceutical Preparations
- SEC CIK
- 0001503802
In the last 90 days, Karyopharm Therapeutics Inc. insiders filed 0 open-market purchases and 2 sales; 96 institutions reported holding it in 13F filings for Q2 2026, worth $206.8M in total; no superinvestor holds it.
13F holders, Q1 2024
Institutional positions in Karyopharm Therapeutics Inc. as of Mar 31, 2024. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 114
- −4 vs. Q4 2023
- Shares held
- 74.8M
- +1.38M (+1.9%) vs. Q4 2023
- Total value
- $113.0M
- +$49.6M (+78.2%) vs. Q4 2023
- New holders
- 18
- 38 more added
- Sold out
- 22
- 31 more reduced
2 institutions that held it in Q4 2023 haven't filed for Q1 2024 yet. Not filing isn't selling, so they aren't counted as sold out or in the changes above.
Compare with Q4 2023: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting KPTI on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 96 | $206.8M |
| Q1 2026 | 77 | $98.4M |
| Q4 2025 | 68 | $69.6M |
| Q3 2025 | 52 | $19.5M |
| Q2 2025 | 50 | $19.0M |
| Q1 2025 | 50 | $13.7M |
| Q4 2024 | 87 | $41.2M |
| Q3 2024 | 91 | $49.2M |
| Q2 2024 | 114 | $58.6M |
| Q1 2024 | 114 | $113.0M |
| Q4 2023 | 120 | $63.5M |
| Q3 2023 | 120 | $102.8M |
| Q2 2023 | 138 | $145.0M |
| Q1 2023 | 132 | $340.1M |
| Q4 2022 | 155 | $334.4M |
| Q3 2022 | 147 | $364.1M |
| Q2 2022 | 150 | $302.8M |
| Q1 2022 | 139 | $501.8M |
| Q4 2021 | 143 | $347.5M |
| Q3 2021 | 134 | $334.4M |
| Q2 2021 | 154 | $608.7M |
| Q1 2021 | 171 | $637.1M |
Institutions, Q1 2024
Shares, value and share of portfolio for each institution holding Karyopharm Therapeutics Inc.; share changes are against Q4 2023.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| JPMorgan Chase & Co | 1,377,584 | $2.08M | 0.00% | +196,464+16.6% | Added |
| C WorldWide Group Holding A/S | 1,500,000 | $2.27M | 0.03% | 00.0% | Unchanged |
| Goldman Sachs Group Inc | 1,508,262 | $2.28M | 0.00% | +211,669+16.3% | Added |
| BNP Paribas Arbitrage, SA | 1,773,758 | $2.68M | 0.00% | +4,574+0.3% | Added |
| State Street Corp | 2,285,788 | $3.45M | 0.00% | +232,015+11.3% | Added |
| Geode Capital Management, LLC | 2,520,105 | $3.81M | 0.00% | +137,677+5.8% | Added |
| Marshall Wace, LLP | 2,595,599 | $3.92M | 0.01% | +668,817+34.7% | Added |
| Citadel Advisors LLC | 3,105,069 | $4.69M | 0.00% | +3,670+0.1% | Added |
| Adage Capital Partners GP, L.L.C. | 3,500,000 | $5.29M | 0.01% | +1,836,700+110.4% | Added |
| Eversept Partners, LP | 5,016,320 | $7.57M | 0.57% | +5,016,320 | New |
| Palo Alto Investors LP | 5,102,193 | $7.70M | 0.87% | 00.0% | Unchanged |
| Avidity Partners Management LP | 8,298,570 | $12.5M | 0.45% | 00.0% | Unchanged |
| Vanguard Group Inc | 8,338,401 | $12.6M | 0.00% | −371,757−4.3% | Reduced |
| BlackRock Inc. | 9,447,678 | $14.3M | 0.00% | −623,999−6.2% | Reduced |
| Tejara Capital Ltd | 0 | $0 | 0.00% | −1,031,348−100.0% | Sold out |
| Candriam Luxembourg S.C.A. | 0 | $0 | 0.00% | −530,694−100.0% | Sold out |
| Ameriprise Financial Inc | 0 | $0 | 0.00% | −309,967−100.0% | Sold out |
| Jacobs Levy Equity Management, Inc | 0 | $0 | 0.00% | −284,457−100.0% | Sold out |
| Acadian Asset Management LLC | 0 | $0 | 0.00% | −275,059−100.0% | Sold out |
| SG Americas Securities, LLC | 0 | $0 | 0.00% | −73,430−100.0% | Sold out |
| Two Sigma Advisers, LP | 0 | $0 | 0.00% | −63,200−100.0% | Sold out |
| Monashee Investment Management LLC | 0 | $0 | 0.00% | −132,435−100.0% | Sold out |
| Redwood Wealth Management Group, LLC | 0 | $0 | 0.00% | −29,730−100.0% | Sold out |
| Wexford Capital LP | 0 | $0 | 0.00% | −27,280−100.0% | Sold out |
| Weiss Multi-Strategy Advisers LLC | 0 | $0 | 0.00% | −27,043−100.0% | Sold out |
| Point72 Middle East FZE | 0 | $0 | 0.00% | −22,028−100.0% | Sold out |
| Neuberger Berman Group LLC | 0 | $0 | 0.00% | −13,317−100.0% | Sold out |
| Brinker Capital Investments, LLC | 0 | $0 | 0.00% | −10,965−100.0% | Sold out |
| Orion Portfolio Solutions, LLC | 0 | $0 | 0.00% | −10,965−100.0% | Sold out |
| Creative Planning | 0 | $0 | 0.00% | −11,600−100.0% | Sold out |
| Bayesian Capital Management, LP | 0 | $0 | 0.00% | −11,100−100.0% | Sold out |
| Virtu Financial LLC | 0 | $0 | 0.00% | −10,007−100.0% | Sold out |
| Russell Investments Group, Ltd. | 0 | $0 | 0.00% | −6,519−100.0% | Sold out |
| Cubist Systematic Strategies, LLC | 0 | $0 | 0.00% | −4,684−100.0% | Sold out |
| TD Waterhouse Canada Inc. | 0 | $0 | 0.00% | −2,060−100.0% | Sold out |
| Advisory Services Network, LLC | 0 | $0 | 0.00% | −500−100.0% | Sold out |
| Wade G W & Inc | – | – | – | – | Not filed |
| Sawtooth Solutions, LLC | – | – | – | – | Not filed |