Karyopharm Therapeutics Inc.
KPTI- Exchange
- Nasdaq
- Industry
- Pharmaceutical Preparations
- SEC CIK
- 0001503802
In the last 90 days, Karyopharm Therapeutics Inc. insiders filed 0 open-market purchases and 2 sales; 96 institutions reported holding it in 13F filings for Q2 2026, worth $206.8M in total; no superinvestor holds it.
13F holders, Q4 2023
Institutional positions in Karyopharm Therapeutics Inc. as of Dec 31, 2023. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 120
- 0 vs. Q3 2023
- Shares held
- 73.5M
- −3.74M (−4.8%) vs. Q3 2023
- Total value
- $63.5M
- −$39.3M (−38.2%) vs. Q3 2023
- New holders
- 23
- 24 more added
- Sold out
- 23
- 42 more reduced
Compare with Q3 2023: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting KPTI on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 96 | $206.8M |
| Q1 2026 | 77 | $98.4M |
| Q4 2025 | 68 | $69.6M |
| Q3 2025 | 52 | $19.5M |
| Q2 2025 | 50 | $19.0M |
| Q1 2025 | 50 | $13.7M |
| Q4 2024 | 87 | $41.2M |
| Q3 2024 | 91 | $49.2M |
| Q2 2024 | 114 | $58.6M |
| Q1 2024 | 114 | $113.0M |
| Q4 2023 | 120 | $63.5M |
| Q3 2023 | 120 | $102.8M |
| Q2 2023 | 138 | $145.0M |
| Q1 2023 | 132 | $340.1M |
| Q4 2022 | 155 | $334.4M |
| Q3 2022 | 147 | $364.1M |
| Q2 2022 | 150 | $302.8M |
| Q1 2022 | 139 | $501.8M |
| Q4 2021 | 143 | $347.5M |
| Q3 2021 | 134 | $334.4M |
| Q2 2021 | 154 | $608.7M |
| Q1 2021 | 171 | $637.1M |
Institutions, Q4 2023
Shares, value and share of portfolio for each institution holding Karyopharm Therapeutics Inc.; share changes are against Q3 2023.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| Northern Trust Corp | 996,147 | $861.7K | 0.00% | +10,415+1.1% | Added |
| Tejara Capital Ltd | 1,031,348 | $892.1K | 0.37% | −46,040−4.3% | Reduced |
| AlphaCentric Advisors LLC | 1,125,000 | $973.1K | 0.65% | 00.0% | Unchanged |
| JPMorgan Chase & Co | 1,181,120 | $1.02M | 0.00% | +39,994+3.5% | Added |
| Goldman Sachs Group Inc | 1,296,593 | $1.12M | 0.00% | −618,454−32.3% | Reduced |
| Deutsche Bank AG | 1,327,008 | $1.15M | 0.00% | +1,268,777+2,178.9% | Added |
| C WorldWide Group Holding A/S | 1,500,000 | $1.30M | 0.02% | 00.0% | Unchanged |
| Millennium Management LLC | 1,534,264 | $1.33M | 0.00% | +416,356+37.2% | Added |
| Adage Capital Partners GP, L.L.C. | 1,663,300 | $1.44M | 0.00% | +1,663,300 | New |
| BNP Paribas Arbitrage, SA | 1,769,184 | $1.53M | 0.00% | +108,286+6.5% | Added |
| Marshall Wace, LLP | 1,926,782 | $1.66M | 0.00% | −256,419−11.7% | Reduced |
| Renaissance Technologies LLC | 1,964,377 | $1.70M | 0.00% | +1,233,977+168.9% | Added |
| State Street Corp | 2,053,773 | $1.78M | 0.00% | +10,768+0.5% | Added |
| Gsa Capital Partners LLP | 2,337,985 | $2.02M | 0.17% | +1,769,687+311.4% | Added |
| Geode Capital Management, LLC | 2,382,428 | $2.06M | 0.00% | +95,282+4.2% | Added |
| Citadel Advisors LLC | 3,101,399 | $2.68M | 0.00% | −2,489−0.1% | Reduced |
| Palo Alto Investors LP | 5,102,193 | $4.41M | 0.40% | −573,683−10.1% | Reduced |
| Avidity Partners Management LP | 8,298,570 | $7.18M | 0.27% | 00.0% | Unchanged |
| Vanguard Group Inc | 8,710,158 | $7.53M | 0.00% | −109,771−1.2% | Reduced |
| BlackRock Inc. | 10,071,677 | $8.71M | 0.00% | −1,014,856−9.2% | Reduced |
| AIGH Capital Management LLC | 0 | $0 | 0.00% | −1,773,474−100.0% | Sold out |
| ExodusPoint Capital Management, LP | 0 | $0 | 0.00% | −1,397,543−100.0% | Sold out |
| Parkwood LLC | 0 | $0 | 0.00% | −1,000,000−100.0% | Sold out |
| Worth Venture Partners, LLC | 0 | $0 | 0.00% | −445,981−100.0% | Sold out |
| J. Goldman & Co LP | 0 | $0 | 0.00% | −120,000−100.0% | Sold out |
| Alps Advisors Inc | 0 | $0 | 0.00% | −84,432−100.0% | Sold out |
| Graham Capital Management, L.P. | 0 | $0 | 0.00% | −82,309−100.0% | Sold out |
| MetLife Investment Management | 0 | $0 | 0.00% | −60,235−100.0% | Sold out |
| Manufacturers Life Insurance Company, The | 0 | $0 | 0.00% | −47,088−100.0% | Sold out |
| Centiva Capital, LP | 0 | $0 | 0.00% | −45,790−100.0% | Sold out |
| Squarepoint Ops LLC | 0 | $0 | 0.00% | −34,154−100.0% | Sold out |
| Brevan Howard Capital Management LP | 0 | $0 | 0.00% | −22,824−100.0% | Sold out |
| Quantbot Technologies LP | 0 | $0 | 0.00% | −21,699−100.0% | Sold out |
| Nomura Holdings Inc | 0 | $0 | 0.00% | −19,433−100.0% | Sold out |
| Allspring Global Investments Holdings, LLC | 0 | $0 | 0.00% | −14,964−100.0% | Sold out |
| Headlands Technologies LLC | 0 | $0 | 0.00% | −13,817−100.0% | Sold out |
| Victory Capital Management Inc | 0 | $0 | 0.00% | −11,436−100.0% | Sold out |
| Metropolitan Life Insurance Co | 0 | $0 | 0.00% | −6,242−100.0% | Sold out |
| PEAK6 Investments LLC | 0 | $0 | 0.00% | −4,552−100.0% | Sold out |
| China Universal Asset Management Co., Ltd. | 0 | $0 | 0.00% | −2,929−100.0% | Sold out |
| Nisa Investment Advisors, LLC | 0 | $0 | 0.00% | −800−100.0% | Sold out |
| Point72 Asset Management, L.P. | 0 | $0 | 0.00% | −272−100.0% | Sold out |
| Daiwa Securities Group Inc. | 0 | $0 | 0.00% | −138−100.0% | Sold out |