Karyopharm Therapeutics Inc.
KPTI- Exchange
- Nasdaq
- Industry
- Pharmaceutical Preparations
- SEC CIK
- 0001503802
In the last 90 days, Karyopharm Therapeutics Inc. insiders filed 0 open-market purchases and 2 sales; 96 institutions reported holding it in 13F filings for Q2 2026, worth $206.8M in total; no superinvestor holds it.
13F holders, Q2 2023
Institutional positions in Karyopharm Therapeutics Inc. as of Jun 30, 2023. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 138
- +6 vs. Q1 2023
- Shares held
- 81.5M
- −5.97M (−6.8%) vs. Q1 2023
- Total value
- $145.0M
- −$195.1M (−57.4%) vs. Q1 2023
- New holders
- 30
- 43 more added
- Sold out
- 24
- 42 more reduced
Compare with Q1 2023: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting KPTI on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 96 | $206.8M |
| Q1 2026 | 77 | $98.4M |
| Q4 2025 | 68 | $69.6M |
| Q3 2025 | 52 | $19.5M |
| Q2 2025 | 50 | $19.0M |
| Q1 2025 | 50 | $13.7M |
| Q4 2024 | 87 | $41.2M |
| Q3 2024 | 91 | $49.2M |
| Q2 2024 | 114 | $58.6M |
| Q1 2024 | 114 | $113.0M |
| Q4 2023 | 120 | $63.5M |
| Q3 2023 | 120 | $102.8M |
| Q2 2023 | 138 | $145.0M |
| Q1 2023 | 132 | $340.1M |
| Q4 2022 | 155 | $334.4M |
| Q3 2022 | 147 | $364.1M |
| Q2 2022 | 150 | $302.8M |
| Q1 2022 | 139 | $501.8M |
| Q4 2021 | 143 | $347.5M |
| Q3 2021 | 134 | $334.4M |
| Q2 2021 | 154 | $608.7M |
| Q1 2021 | 171 | $637.1M |
Institutions, Q2 2023
Shares, value and share of portfolio for each institution holding Karyopharm Therapeutics Inc.; share changes are against Q1 2023.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| Worth Venture Partners, LLC | 445,981 | $798.3K | 0.44% | +445,981 | New |
| BNP Paribas Arbitrage, SA | 461,096 | $825.4K | 0.00% | +91,491+24.8% | Added |
| Nuveen Asset Management, LLC | 463,534 | $829.7K | 0.00% | −1,314,998−73.9% | Reduced |
| Alyeska Investment Group, L.P. | 481,696 | $862.2K | 0.01% | 00.0% | Unchanged |
| Platinum Investment Management Ltd | 500,000 | $895.0K | 0.03% | +500,000 | New |
| Silverarc Capital Management, LLC | 518,985 | $929.0K | 0.31% | −1,022,441−66.3% | Reduced |
| J. Goldman & Co LP | 539,742 | $966.1K | 0.06% | +539,742 | New |
| Wellington Management Group LLP | 561,799 | $1.01M | 0.00% | +327,750+140.0% | Added |
| D. E. Shaw & Co., Inc. | 597,759 | $1.07M | 0.00% | +48,152+8.8% | Added |
| UBS Oconnor LLC | 606,710 | $1.09M | 0.02% | +12,905+2.2% | Added |
| Bank of New York Mellon Corp | 660,616 | $1.18M | 0.00% | +206,150+45.4% | Added |
| Jane Street Group, LLC | 662,363 | $1.19M | 0.00% | +662,363 | New |
| Renaissance Technologies LLC | 667,400 | $1.20M | 0.00% | −68,300−9.3% | Reduced |
| Jacobs Levy Equity Management, Inc | 676,855 | $1.21M | 0.01% | −398,219−37.0% | Reduced |
| Qube Research & Technologies Ltd | 703,062 | $1.26M | 0.00% | +703,062 | New |
| Altium Capital Management LP | 740,000 | $1.32M | 1.04% | +234,219+46.3% | Added |
| AlphaCentric Advisors LLC | 810,000 | $1.45M | 0.81% | +570,000+237.5% | Added |
| Rubric Capital Management LP | 919,196 | $1.65M | 0.07% | −3,521,860−79.3% | Reduced |
| Northern Trust Corp | 1,069,094 | $1.91M | 0.00% | +244,345+29.6% | Added |
| Barclays PLC | 1,106,361 | $1.98M | 0.00% | −1,741,028−61.1% | Reduced |
| Tejara Capital Ltd | 1,143,991 | $2.05M | 1.01% | +642,429+128.1% | Added |
| Millennium Management LLC | 1,151,241 | $2.06M | 0.00% | +1,137,478+8,264.8% | Added |
| Candriam Luxembourg S.C.A. | 1,435,694 | $2.57M | 0.02% | −99,332−6.5% | Reduced |
| C WorldWide Group Holding A/S | 1,500,000 | $2.69M | 0.03% | 00.0% | Unchanged |
| Deutsche Bank AG | 1,593,184 | $2.85M | 0.00% | −51,750−3.1% | Reduced |
| Goldman Sachs Group Inc | 1,621,019 | $2.90M | 0.00% | +151,872+10.3% | Added |
| AIGH Capital Management LLC | 1,773,474 | $3.17M | 1.30% | +1,773,474 | New |
| Opaleye Management Inc. | 1,785,000 | $3.20M | 0.76% | −1,025,800−36.5% | Reduced |
| Geode Capital Management, LLC | 2,137,094 | $3.83M | 0.00% | +365,361+20.6% | Added |
| State Street Corp | 2,212,367 | $3.96M | 0.00% | −7,963,622−78.3% | Reduced |
| ExodusPoint Capital Management, LP | 2,382,451 | $4.26M | 0.05% | +2,382,451 | New |
| Marshall Wace, LLP | 2,443,997 | $4.37M | 0.01% | +459,091+23.1% | Added |
| Citadel Advisors LLC | 3,149,682 | $5.64M | 0.01% | −452,778−12.6% | Reduced |
| Palo Alto Investors LP | 5,675,876 | $10.2M | 0.82% | 00.0% | Unchanged |
| Avidity Partners Management LP | 8,370,100 | $15.0M | 0.52% | −1,263,811−13.1% | Reduced |
| Vanguard Group Inc | 8,684,128 | $15.5M | 0.00% | +1,180,292+15.7% | Added |
| BlackRock Inc. | 11,537,281 | $20.7M | 0.00% | +2,465,093+27.2% | Added |
| Sofos Investments, Inc. | 2 | – | – | −2−50.0% | Reduced |
| Proequities, Inc. | 0 | $0 | 0.00% | −1−100.0% | Sold out |
| Rafferty Asset Management, LLC | 0 | $0 | 0.00% | −913,301−100.0% | Sold out |
| Affinity Asset Advisors, LLC | 0 | $0 | 0.00% | −460,979−100.0% | Sold out |
| Caxton Associates LP | 0 | $0 | 0.00% | −235,626−100.0% | Sold out |
| State of Wisconsin Investment Board | 0 | $0 | 0.00% | −197,433−100.0% | Sold out |
| Profund Advisors LLC | 0 | $0 | 0.00% | −167,517−100.0% | Sold out |
| Tudor Investment Corp Et Al | 0 | $0 | 0.00% | −151,235−100.0% | Sold out |
| Hennion & Walsh Asset Management, Inc. | 0 | $0 | 0.00% | −139,574−100.0% | Sold out |
| Los Angeles Capital Management LLC | 0 | $0 | 0.00% | −113,724−100.0% | Sold out |
| Algert Global LLC | 0 | $0 | 0.00% | −86,813−100.0% | Sold out |
| Fred Alger Management, LLC | 0 | $0 | 0.00% | −69,420−100.0% | Sold out |
| Walleye Capital LLC | 0 | $0 | 0.00% | −56,700−100.0% | Sold out |
| E Fund Management Co., Ltd. | 0 | $0 | 0.00% | −51,849−100.0% | Sold out |
| Man Group plc | 0 | $0 | 0.00% | – | Sold out |
| Mirae Asset Global Investments Co., Ltd. | 0 | $0 | 0.00% | −37,398−100.0% | Sold out |
| Allspring Global Investments Holdings, LLC | 0 | $0 | 0.00% | −24,593−100.0% | Sold out |
| Ashton Thomas Private Wealth, LLC | 0 | $0 | 0.00% | −16,000−100.0% | Sold out |
| Squarepoint Ops LLC | 0 | $0 | 0.00% | −12,553−100.0% | Sold out |
| Moors & Cabot, Inc. | 0 | $0 | 0.00% | −12,200−100.0% | Sold out |
| Bayesian Capital Management, LP | 0 | $0 | 0.00% | −11,880−100.0% | Sold out |
| Belpointe Asset Management LLC | 0 | $0 | 0.00% | −1,000−100.0% | Sold out |
| Advisory Services Network, LLC | 0 | $0 | 0.00% | −600−100.0% | Sold out |
| Lindbrook Capital, LLC | 0 | $0 | 0.00% | −399−100.0% | Sold out |
| Quent Capital, LLC | 0 | $0 | 0.00% | −386−100.0% | Sold out |