Karyopharm Therapeutics Inc.
KPTI- Exchange
- Nasdaq
- Industry
- Pharmaceutical Preparations
- SEC CIK
- 0001503802
In the last 90 days, Karyopharm Therapeutics Inc. insiders filed 0 open-market purchases and 2 sales; 96 institutions reported holding it in 13F filings for Q2 2026, worth $206.8M in total; no superinvestor holds it.
13F holders, Q1 2023
Institutional positions in Karyopharm Therapeutics Inc. as of Mar 31, 2023. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 132
- −23 vs. Q4 2022
- Shares held
- 87.5M
- −10.9M (−11.1%) vs. Q4 2022
- Total value
- $340.1M
- +$5.77M (+1.7%) vs. Q4 2022
- New holders
- 20
- 53 more added
- Sold out
- 43
- 30 more reduced
Compare with Q4 2022: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting KPTI on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 96 | $206.8M |
| Q1 2026 | 77 | $98.4M |
| Q4 2025 | 68 | $69.6M |
| Q3 2025 | 52 | $19.5M |
| Q2 2025 | 50 | $19.0M |
| Q1 2025 | 50 | $13.7M |
| Q4 2024 | 87 | $41.2M |
| Q3 2024 | 91 | $49.2M |
| Q2 2024 | 114 | $58.6M |
| Q1 2024 | 114 | $113.0M |
| Q4 2023 | 120 | $63.5M |
| Q3 2023 | 120 | $102.8M |
| Q2 2023 | 138 | $145.0M |
| Q1 2023 | 132 | $340.1M |
| Q4 2022 | 155 | $334.4M |
| Q3 2022 | 147 | $364.1M |
| Q2 2022 | 150 | $302.8M |
| Q1 2022 | 139 | $501.8M |
| Q4 2021 | 143 | $347.5M |
| Q3 2021 | 134 | $334.4M |
| Q2 2021 | 154 | $608.7M |
| Q1 2021 | 171 | $637.1M |
Institutions, Q1 2023
Shares, value and share of portfolio for each institution holding Karyopharm Therapeutics Inc.; share changes are against Q4 2022.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| Two Sigma Advisers, LP | 401,500 | $1.56M | 0.00% | −301,700−42.9% | Reduced |
| Bank of New York Mellon Corp | 454,466 | $1.77M | 0.00% | +21,585+5.0% | Added |
| Affinity Asset Advisors, LLC | 460,979 | $1.79M | 0.69% | −200,285−30.3% | Reduced |
| Alyeska Investment Group, L.P. | 481,696 | $1.87M | 0.02% | 00.0% | Unchanged |
| Tejara Capital Ltd | 501,562 | $1.95M | 1.00% | 00.0% | Unchanged |
| Altium Capital Management LP | 505,781 | $1.97M | 1.18% | +505,781 | New |
| D. E. Shaw & Co., Inc. | 549,607 | $2.14M | 0.00% | +241,648+78.5% | Added |
| UBS Oconnor LLC | 593,805 | $2.31M | 0.06% | +593,805 | New |
| Morgan Stanley | 726,690 | $2.83M | 0.00% | −562,747−43.6% | Reduced |
| Citigroup Inc | 730,027 | $2.84M | 0.00% | +221,434+43.5% | Added |
| Renaissance Technologies LLC | 735,700 | $2.86M | 0.00% | +546,400+288.6% | Added |
| Northern Trust Corp | 824,749 | $3.21M | 0.00% | +79,016+10.6% | Added |
| Rafferty Asset Management, LLC | 913,301 | $3.55M | 0.02% | +216,635+31.1% | Added |
| Jacobs Levy Equity Management, Inc | 1,075,074 | $4.18M | 0.03% | −1,174,325−52.2% | Reduced |
| Candriam Luxembourg S.C.A. | 1,535,026 | $5.50M | 0.04% | 00.0% | Unchanged |
| Goldman Sachs Group Inc | 1,469,147 | $5.71M | 0.00% | +412,514+39.0% | Added |
| C WorldWide Group Holding A/S | 1,500,000 | $5.83M | 0.08% | 00.0% | Unchanged |
| Silverarc Capital Management, LLC | 1,541,426 | $6.00M | 2.69% | +1,541,426 | New |
| Deutsche Bank AG | 1,644,934 | $6.40M | 0.00% | +1,050,608+176.8% | Added |
| Geode Capital Management, LLC | 1,771,733 | $6.89M | 0.00% | +394,605+28.7% | Added |
| Nuveen Asset Management, LLC | 1,778,532 | $6.92M | 0.00% | +184,822+11.6% | Added |
| Marshall Wace, LLP | 1,984,906 | $7.72M | 0.02% | −225,317−10.2% | Reduced |
| Bank of America Corp | 2,157,781 | $8.39M | 0.00% | +646,615+42.8% | Added |
| Opaleye Management Inc. | 2,810,800 | $10.9M | 3.27% | +1,603,959+132.9% | Added |
| Barclays PLC | 2,847,389 | $11.1M | 0.01% | +1,800,677+172.0% | Added |
| Citadel Advisors LLC | 3,602,460 | $14.0M | 0.02% | −110,693−3.0% | Reduced |
| Rubric Capital Management LP | 4,441,056 | $17.3M | 0.69% | −3,853,565−46.5% | Reduced |
| Palo Alto Investors LP | 5,675,876 | $22.1M | 1.83% | +20,200+0.4% | Added |
| Vanguard Group Inc | 7,503,836 | $29.2M | 0.00% | +2,306,334+44.4% | Added |
| BlackRock Inc. | 9,072,188 | $35.3M | 0.00% | +563,951+6.6% | Added |
| Avidity Partners Management LP | 9,633,911 | $37.5M | 1.24% | 00.0% | Unchanged |
| State Street Corp | 10,175,989 | $39.6M | 0.00% | +1,888,953+22.8% | Added |
| Armistice Capital, LLC | 0 | $0 | 0.00% | −3,853,565−100.0% | Sold out |
| Point72 Asset Management, L.P. | 0 | $0 | 0.00% | −1,991,613−100.0% | Sold out |
| Commodore Capital LP | 0 | $0 | 0.00% | −1,935,609−100.0% | Sold out |
| Iron Triangle Partners LP | 0 | $0 | 0.00% | −1,926,782−100.0% | Sold out |
| Woodline Partners LP | 0 | $0 | 0.00% | −1,324,884−100.0% | Sold out |
| CVI Holdings, LLC | 0 | $0 | 0.00% | −1,252,408−100.0% | Sold out |
| ExodusPoint Capital Management, LP | 0 | $0 | 0.00% | −1,106,132−100.0% | Sold out |
| Ally Bridge Group (NY) LLC | 0 | $0 | 0.00% | −896,618−100.0% | Sold out |
| Acadian Asset Management LLC | 0 | $0 | 0.00% | −845,744−100.0% | Sold out |
| Adage Capital Partners GP, L.L.C. | 0 | $0 | 0.00% | −770,713−100.0% | Sold out |
| Qube Research & Technologies Ltd | 0 | $0 | 0.00% | −523,788−100.0% | Sold out |
| Cubist Systematic Strategies, LLC | 0 | $0 | 0.00% | −490,010−100.0% | Sold out |
| Monashee Investment Management LLC | 0 | $0 | 0.00% | −481,696−100.0% | Sold out |
| Two Sigma Investments, LP | 0 | $0 | 0.00% | −265,308−100.0% | Sold out |
| XTX Topco Ltd | 0 | $0 | 0.00% | −130,817−100.0% | Sold out |
| Jane Street Group, LLC | 0 | $0 | 0.00% | −97,336−100.0% | Sold out |
| Gsa Capital Partners LLP | 0 | $0 | 0.00% | −82,162−100.0% | Sold out |
| New York Life Investment Management LLC | 0 | $0 | 0.00% | −76,968−100.0% | Sold out |
| Jump Financial, LLC | 0 | $0 | 0.00% | −58,472−100.0% | Sold out |
| Engineers Gate Manager LP | 0 | $0 | 0.00% | −49,552−100.0% | Sold out |
| Point72 Middle East FZE | 0 | $0 | 0.00% | −47,257−100.0% | Sold out |
| Martingale Asset Management L P | 0 | $0 | 0.00% | −45,315−100.0% | Sold out |
| Federated Hermes, Inc. | 0 | $0 | 0.00% | −38,605−100.0% | Sold out |
| Occudo Quantitative Strategies LP | 0 | $0 | 0.00% | −29,817−100.0% | Sold out |
| Fox Run Management, L.L.C. | 0 | $0 | 0.00% | −28,823−100.0% | Sold out |
| Aquatic Capital Management LLC | 0 | $0 | 0.00% | −25,400−100.0% | Sold out |
| DuPont Capital Management Corp | 0 | $0 | 0.00% | −22,957−100.0% | Sold out |
| Franklin Resources Inc | 0 | $0 | 0.00% | −20,647−100.0% | Sold out |
| Simplex Trading, LLC | 0 | $0 | 0.00% | −17,405−100.0% | Sold out |
| State of Wyoming | 0 | $0 | 0.00% | −17,082−100.0% | Sold out |
| Alpine Global Management, LLC | 0 | $0 | 0.00% | −17,081−100.0% | Sold out |
| Mackenzie Financial Corp | 0 | $0 | 0.00% | −15,817−100.0% | Sold out |
| Y-Intercept (Hong Kong) Ltd | 0 | $0 | 0.00% | −15,087−100.0% | Sold out |
| Prudential Financial Inc | 0 | $0 | 0.00% | −13,800−100.0% | Sold out |
| Ergoteles LLC | 0 | $0 | 0.00% | −13,321−100.0% | Sold out |
| Mercer Global Advisors Inc | 0 | $0 | 0.00% | −12,221−100.0% | Sold out |
| Balyasny Asset Management LLC | 0 | $0 | 0.00% | −12,249−100.0% | Sold out |
| Running Point Capital Advisors, LLC | 0 | $0 | 0.00% | −10,000−100.0% | Sold out |
| Cutler Group LP | 0 | $0 | 0.00% | −4,819−100.0% | Sold out |
| DT Investment Partners, LLC | 0 | $0 | 0.00% | −1,000−100.0% | Sold out |
| Money Concepts Capital Corp | 0 | $0 | 0.00% | −800−100.0% | Sold out |
| CWM, LLC | 0 | $0 | 0.00% | −177−100.0% | Sold out |
| Key Financial Inc | 0 | $0 | 0.00% | −150−100.0% | Sold out |