Karyopharm Therapeutics Inc.
KPTI- Exchange
- Nasdaq
- Industry
- Pharmaceutical Preparations
- SEC CIK
- 0001503802
In the last 90 days, Karyopharm Therapeutics Inc. insiders filed 0 open-market purchases and 2 sales; 96 institutions reported holding it in 13F filings for Q2 2026, worth $206.8M in total; no superinvestor holds it.
13F holders, Q1 2022
Institutional positions in Karyopharm Therapeutics Inc. as of Mar 31, 2022. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 139
- −2 vs. Q4 2021
- Shares held
- 68.3M
- +14.3M (+26.4%) vs. Q4 2021
- Total value
- $501.8M
- +$155.2M (+44.8%) vs. Q4 2021
- New holders
- 26
- 43 more added
- Sold out
- 28
- 46 more reduced
2 institutions that held it in Q4 2021 haven't filed for Q1 2022 yet. Not filing isn't selling, so they aren't counted as sold out or in the changes above.
Compare with Q4 2021: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting KPTI on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 96 | $206.8M |
| Q1 2026 | 77 | $98.4M |
| Q4 2025 | 68 | $69.6M |
| Q3 2025 | 52 | $19.5M |
| Q2 2025 | 50 | $19.0M |
| Q1 2025 | 50 | $13.7M |
| Q4 2024 | 87 | $41.2M |
| Q3 2024 | 91 | $49.2M |
| Q2 2024 | 114 | $58.6M |
| Q1 2024 | 114 | $113.0M |
| Q4 2023 | 120 | $63.5M |
| Q3 2023 | 120 | $102.8M |
| Q2 2023 | 138 | $145.0M |
| Q1 2023 | 132 | $340.1M |
| Q4 2022 | 155 | $334.4M |
| Q3 2022 | 147 | $364.1M |
| Q2 2022 | 150 | $302.8M |
| Q1 2022 | 139 | $501.8M |
| Q4 2021 | 143 | $347.5M |
| Q3 2021 | 134 | $334.4M |
| Q2 2021 | 154 | $608.7M |
| Q1 2021 | 171 | $637.1M |
Institutions, Q1 2022
Shares, value and share of portfolio for each institution holding Karyopharm Therapeutics Inc.; share changes are against Q4 2021.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| Parametric Portfolio Associates LLC | 256,291 | $1.89M | 0.00% | −21,228−7.6% | Reduced |
| Birchview Capital, LP | 269,332 | $1.99M | 1.43% | +23,332+9.5% | Added |
| Susquehanna International Group, LLP | 281,129 | $2.07M | 0.00% | −321,697−53.4% | Reduced |
| Bank of New York Mellon Corp | 296,900 | $2.19M | 0.00% | −641−0.2% | Reduced |
| Balyasny Asset Management LLC | 342,484 | $2.52M | 0.01% | +342,484 | New |
| Macquarie Group Ltd | 382,041 | $2.82M | 0.00% | 00.0% | Unchanged |
| Hennion & Walsh Asset Management, Inc. | 385,837 | $2.84M | 0.15% | −7,855−2.0% | Reduced |
| Jane Street Group, LLC | 416,843 | $3.07M | 0.01% | +209,700+101.2% | Added |
| Acadian Asset Management LLC | 498,922 | $3.67M | 0.02% | +498,922 | New |
| UBS Group AG | 518,460 | $3.82M | 0.00% | +251,465+94.2% | Added |
| Deutsche Bank AG | 599,436 | $4.42M | 0.00% | +551,470+1,149.7% | Added |
| Altium Capital Management LP | 645,000 | $4.75M | 1.66% | +645,000 | New |
| Jacobs Levy Equity Management, Inc | 663,512 | $4.89M | 0.03% | +663,512 | New |
| Voloridge Investment Management, LLC | 676,834 | $4.99M | 0.03% | +479,443+242.9% | Added |
| JPMorgan Chase & Co | 718,640 | $5.30M | 0.00% | −24,760−3.3% | Reduced |
| Northern Trust Corp | 764,335 | $5.63M | 0.00% | −11,216−1.4% | Reduced |
| Two Sigma Advisers, LP | 775,300 | $5.71M | 0.02% | +347,700+81.3% | Added |
| Lombard Odier Asset Management (Switzerland) SA | 776,053 | $5.72M | 0.45% | −881,994−53.2% | Reduced |
| Rafferty Asset Management, LLC | 808,939 | $5.96M | 0.04% | +428,371+112.6% | Added |
| Citadel Advisors LLC | 854,517 | $6.30M | 0.01% | +625,634+273.3% | Added |
| Goldman Sachs Group Inc | 898,906 | $6.63M | 0.00% | −129,976−12.6% | Reduced |
| Bank of America Corp | 1,116,230 | $8.23M | 0.00% | +861,362+338.0% | Added |
| Two Sigma Investments, LP | 1,117,925 | $8.24M | 0.02% | +128,894+13.0% | Added |
| Millennium Management LLC | 1,252,873 | $9.23M | 0.01% | −267,351−17.6% | Reduced |
| Frontier Capital Management Co LLC | 1,279,295 | $9.43M | 0.09% | −406,110−24.1% | Reduced |
| Candriam Luxembourg S.C.A. | 1,335,026 | $9.84M | 0.07% | +457,358+52.1% | Added |
| Geode Capital Management, LLC | 1,337,888 | $9.86M | 0.00% | −104,843−7.3% | Reduced |
| Rice Hall James & Associates, LLC | 1,344,929 | $9.91M | 0.39% | +68,295+5.3% | Added |
| C WorldWide Group Holding A/S | 1,500,000 | $11.1M | 0.12% | 00.0% | Unchanged |
| Nuveen Asset Management, LLC | 1,819,048 | $11.9M | 0.00% | +634,738+53.6% | Added |
| Iron Triangle Partners LP | 2,000,000 | $14.7M | 1.75% | +2,000,000 | New |
| Morgan Stanley | 2,812,563 | $20.7M | 0.00% | +1,746,944+163.9% | Added |
| Commodore Capital LP | 3,561,052 | $26.2M | 5.86% | +3,561,052 | New |
| Rubric Capital Management LP | 3,607,443 | $26.6M | 1.24% | +825,000+29.7% | Added |
| Vanguard Group Inc | 3,960,708 | $29.2M | 0.00% | +601,901+17.9% | Added |
| Palo Alto Investors LP | 5,621,533 | $41.4M | 3.20% | +151,081+2.8% | Added |
| BlackRock Inc. | 7,927,618 | $58.4M | 0.00% | −990,588−11.1% | Reduced |
| State Street Corp | 10,966,701 | $80.8M | 0.00% | +5,453,021+98.9% | Added |
| Aaron Wealth Advisors | 2,837 | – | – | +2,837 | New |
| Alkeon Capital Management LLC | 0 | $0 | 0.00% | −1,961,588−100.0% | Sold out |
| J. Goldman & Co LP | 0 | $0 | 0.00% | −274,243−100.0% | Sold out |
| Jennison Associates LLC | 0 | $0 | 0.00% | −270,757−100.0% | Sold out |
| HRT Financial LP | 0 | $0 | 0.00% | −248,332−100.0% | Sold out |
| Tudor Investment Corp Et Al | 0 | $0 | 0.00% | −208,526−100.0% | Sold out |
| Gsa Capital Partners LLP | 0 | $0 | 0.00% | −191,976−100.0% | Sold out |
| Squarepoint Ops LLC | 0 | $0 | 0.00% | −124,274−100.0% | Sold out |
| Group One Trading, L.P. | 0 | $0 | 0.00% | −120,114−100.0% | Sold out |
| Jump Financial, LLC | 0 | $0 | 0.00% | −85,615−100.0% | Sold out |
| Algert Global LLC | 0 | $0 | 0.00% | −78,239−100.0% | Sold out |
| Dynamic Technology Lab Private Ltd | 0 | $0 | 0.00% | −61,045−100.0% | Sold out |
| Simplex Trading, LLC | 0 | $0 | 0.00% | −58,733−100.0% | Sold out |
| Virginia Retirement Systems Et Al | 0 | $0 | 0.00% | −43,100−100.0% | Sold out |
| Patriot Financial Group Insurance Agency, LLC | 0 | $0 | 0.00% | −38,750−100.0% | Sold out |
| Spearhead Capital Advisors, LLC | 0 | $0 | 0.00% | −34,459−100.0% | Sold out |
| Engineers Gate Manager LP | 0 | $0 | 0.00% | −28,200−100.0% | Sold out |
| Bridgefront Capital, LLC | 0 | $0 | 0.00% | −24,396−100.0% | Sold out |
| SG Americas Securities, LLC | 0 | $0 | 0.00% | −23,716−100.0% | Sold out |
| Prelude Capital Management, LLC | 0 | $0 | 0.00% | −21,000−100.0% | Sold out |
| North Star Investment Management Corp. | 0 | $0 | 0.00% | −20,000−100.0% | Sold out |
| Assenagon Asset Management S.A. | 0 | $0 | 0.00% | −19,366−100.0% | Sold out |
| Fox Run Management, L.L.C. | 0 | $0 | 0.00% | −15,443−100.0% | Sold out |
| Graham Capital Management, L.P. | 0 | $0 | 0.00% | −12,618−100.0% | Sold out |
| Marshall Wace, LLP | 0 | $0 | 0.00% | −9,006−100.0% | Sold out |
| Belvedere Trading LLC | 0 | $0 | 0.00% | −5,371−100.0% | Sold out |
| Parallel Advisors, LLC | 0 | $0 | 0.00% | −324−100.0% | Sold out |
| Glassman Wealth Services | 0 | $0 | 0.00% | −45−100.0% | Sold out |
| Dark Forest Capital Management LP | 0 | $0 | 0.00% | −22−100.0% | Sold out |
| AlphaCentric Advisors LLC | – | – | – | – | Not filed |
| Harbour Investments, Inc. | – | – | – | – | Not filed |