Karyopharm Therapeutics Inc.
KPTI- Exchange
- Nasdaq
- Industry
- Pharmaceutical Preparations
- SEC CIK
- 0001503802
In the last 90 days, Karyopharm Therapeutics Inc. insiders filed 0 open-market purchases and 2 sales; 96 institutions reported holding it in 13F filings for Q2 2026, worth $206.8M in total; no superinvestor holds it.
13F holders, Q4 2021
Institutional positions in Karyopharm Therapeutics Inc. as of Dec 31, 2021. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 143
- +12 vs. Q3 2021
- Shares held
- 54.2M
- −955.4K (−1.7%) vs. Q3 2021
- Total value
- $347.5M
- +$26.3M (+8.2%) vs. Q3 2021
- New holders
- 29
- 51 more added
- Sold out
- 17
- 46 more reduced
3 institutions that held it in Q3 2021 haven't filed for Q4 2021 yet. Not filing isn't selling, so they aren't counted as sold out or in the changes above.
Compare with Q3 2021: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting KPTI on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 96 | $206.8M |
| Q1 2026 | 77 | $98.4M |
| Q4 2025 | 68 | $69.6M |
| Q3 2025 | 52 | $19.5M |
| Q2 2025 | 50 | $19.0M |
| Q1 2025 | 50 | $13.7M |
| Q4 2024 | 87 | $41.2M |
| Q3 2024 | 91 | $49.2M |
| Q2 2024 | 114 | $58.6M |
| Q1 2024 | 114 | $113.0M |
| Q4 2023 | 120 | $63.5M |
| Q3 2023 | 120 | $102.8M |
| Q2 2023 | 138 | $145.0M |
| Q1 2023 | 132 | $340.1M |
| Q4 2022 | 155 | $334.4M |
| Q3 2022 | 147 | $364.1M |
| Q2 2022 | 150 | $302.8M |
| Q1 2022 | 139 | $501.8M |
| Q4 2021 | 143 | $347.5M |
| Q3 2021 | 134 | $334.4M |
| Q2 2021 | 154 | $608.7M |
| Q1 2021 | 171 | $637.1M |
Institutions, Q4 2021
Shares, value and share of portfolio for each institution holding Karyopharm Therapeutics Inc.; share changes are against Q3 2021.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| Charles Schwab Investment Management Inc | 188,149 | $1.21M | 0.00% | 00.0% | Unchanged |
| Allianz Asset Management GmbH | 187,101 | $1.21M | 0.00% | +54,153+40.7% | Added |
| Gsa Capital Partners LLP | 191,976 | $1.23M | 0.16% | +14,980+8.5% | Added |
| Voloridge Investment Management, LLC | 197,391 | $1.27M | 0.01% | +197,391 | New |
| Wellington Management Group LLP | 201,550 | $1.30M | 0.00% | +201,550 | New |
| Jane Street Group, LLC | 207,143 | $1.33M | 0.00% | +178,815+631.2% | Added |
| Tudor Investment Corp Et Al | 208,526 | $1.34M | 0.03% | +15,595+8.1% | Added |
| Trexquant Investment LP | 220,875 | $1.42M | 0.09% | +184,674+510.1% | Added |
| Citadel Advisors LLC | 228,883 | $1.47M | 0.00% | +8,106+3.7% | Added |
| Birchview Capital, LP | 246,000 | $1.58M | 1.02% | 00.0% | Unchanged |
| HRT Financial LP | 248,332 | $1.60M | 0.01% | +248,332 | New |
| Bank of America Corp | 254,868 | $1.64M | 0.00% | +18,953+8.0% | Added |
| UBS Group AG | 266,995 | $1.72M | 0.00% | −341,490−56.1% | Reduced |
| Jennison Associates LLC | 270,757 | $1.74M | 0.00% | +665+0.2% | Added |
| J. Goldman & Co LP | 274,243 | $1.76M | 0.16% | +216,517+375.1% | Added |
| Parametric Portfolio Associates LLC | 277,519 | $1.78M | 0.00% | −15,611−5.3% | Reduced |
| Bank of New York Mellon Corp | 297,541 | $1.91M | 0.00% | −4,960−1.6% | Reduced |
| Citigroup Inc | 304,098 | $1.96M | 0.00% | +60,850+25.0% | Added |
| Rafferty Asset Management, LLC | 380,568 | $2.45M | 0.01% | +9,585+2.6% | Added |
| Macquarie Group Ltd | 382,041 | $2.46M | 0.00% | 00.0% | Unchanged |
| Hennion & Walsh Asset Management, Inc. | 393,692 | $2.53M | 0.12% | −13,782−3.4% | Reduced |
| Two Sigma Advisers, LP | 427,600 | $2.75M | 0.01% | −654,400−60.5% | Reduced |
| Cubist Systematic Strategies, LLC | 563,530 | $3.62M | 0.03% | +467,536+487.0% | Added |
| Susquehanna International Group, LLP | 602,826 | $3.88M | 0.01% | +62,433+11.6% | Added |
| JPMorgan Chase & Co | 743,400 | $4.78M | 0.00% | +278,479+59.9% | Added |
| Northern Trust Corp | 775,551 | $4.99M | 0.00% | +8,491+1.1% | Added |
| Candriam Luxembourg S.C.A. | 877,668 | $5.64M | 0.04% | +160,000+22.3% | Added |
| Two Sigma Investments, LP | 989,031 | $6.36M | 0.02% | −107,652−9.8% | Reduced |
| Goldman Sachs Group Inc | 1,028,882 | $6.62M | 0.00% | +43,500+4.4% | Added |
| Nuveen Asset Management, LLC | 1,184,310 | $6.71M | 0.00% | +65,302+5.8% | Added |
| Morgan Stanley | 1,065,619 | $6.85M | 0.00% | −827,314−43.7% | Reduced |
| Rice Hall James & Associates, LLC | 1,276,634 | $8.21M | 0.29% | −125,227−8.9% | Reduced |
| Geode Capital Management, LLC | 1,442,731 | $9.28M | 0.00% | +35,574+2.5% | Added |
| C WorldWide Group Holding A/S | 1,500,000 | $9.64M | 0.09% | +300,000+25.0% | Added |
| Millennium Management LLC | 1,520,224 | $9.78M | 0.01% | +1,520,224 | New |
| Lombard Odier Asset Management (Switzerland) SA | 1,658,047 | $10.7M | 0.68% | +140,243+9.2% | Added |
| Frontier Capital Management Co LLC | 1,685,405 | $10.8M | 0.09% | +582,978+52.9% | Added |
| Alkeon Capital Management LLC | 1,961,588 | $12.6M | 0.04% | 00.0% | Unchanged |
| Rubric Capital Management LP | 2,782,443 | $17.9M | 0.85% | −593,315−17.6% | Reduced |
| Vanguard Group Inc | 3,358,807 | $21.6M | 0.00% | −283,892−7.8% | Reduced |
| Palo Alto Investors LP | 5,470,452 | $35.2M | 2.25% | +87,400+1.6% | Added |
| State Street Corp | 5,513,680 | $35.5M | 0.00% | −2,506,319−31.3% | Reduced |
| BlackRock Inc. | 8,918,206 | $57.3M | 0.00% | +127,888+1.5% | Added |
| Balyasny Asset Management LLC | 0 | $0 | 0.00% | −200,412−100.0% | Sold out |
| Banque Cantonale Vaudoise | 0 | $0 | 0.00% | −50,000−100.0% | Sold out |
| Virtus ETF Advisers LLC | 0 | $0 | 0.00% | −44,364−100.0% | Sold out |
| Boothbay Fund Management, LLC | 0 | $0 | 0.00% | −39,622−100.0% | Sold out |
| DekaBank Deutsche Girozentrale | 0 | $0 | 0.00% | −36,200−100.0% | Sold out |
| Vontobel Holding Ltd. | 0 | $0 | 0.00% | −30,000−100.0% | Sold out |
| SG3 Management, LLC | 0 | $0 | 0.00% | −25,000−100.0% | Sold out |
| Schonfeld Strategic Advisors LLC | 0 | $0 | 0.00% | −17,613−100.0% | Sold out |
| ACT Capital Management, LLC | 0 | $0 | 0.00% | −14,000−100.0% | Sold out |
| Handelsbanken Fonder AB | 0 | $0 | 0.00% | −10,400−100.0% | Sold out |
| Cambridge Investment Research Advisors, Inc. | 0 | $0 | 0.00% | −10,431−100.0% | Sold out |
| Atlas Private Wealth Advisors | 0 | $0 | 0.00% | −3,500−100.0% | Sold out |
| Tarbox Family Office, Inc. | 0 | $0 | 0.00% | −3,000−100.0% | Sold out |
| Penserra Capital Management LLC | 0 | $0 | 0.00% | −1,725−100.0% | Sold out |
| Private Capital Group, LLC | 0 | $0 | 0.00% | −1,000−100.0% | Sold out |
| O'Shaughnessy Asset Management, LLC | 0 | $0 | 0.00% | −753−100.0% | Sold out |
| Glen Eagle Advisors, LLC | 0 | $0 | 0.00% | −600−100.0% | Sold out |
| Delphi Management Partners VIII, L.L.C. | – | – | – | – | Not filed |
| First Mercantile Trust Co | – | – | – | – | Not filed |
| Berman Capital Advisors, LLC | – | – | – | – | Not filed |