Karyopharm Therapeutics Inc.
KPTI- Exchange
- Nasdaq
- Industry
- Pharmaceutical Preparations
- SEC CIK
- 0001503802
In the last 90 days, Karyopharm Therapeutics Inc. insiders filed 0 open-market purchases and 2 sales; 96 institutions reported holding it in 13F filings for Q2 2026, worth $206.8M in total; no superinvestor holds it.
13F holders, Q3 2021
Institutional positions in Karyopharm Therapeutics Inc. as of Sep 30, 2021. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 134
- −20 vs. Q2 2021
- Shares held
- 57.4M
- −1.58M (−2.7%) vs. Q2 2021
- Total value
- $334.4M
- −$274.3M (−45.1%) vs. Q2 2021
- New holders
- 14
- 58 more added
- Sold out
- 34
- 34 more reduced
Compare with Q2 2021: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting KPTI on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 96 | $206.8M |
| Q1 2026 | 77 | $98.4M |
| Q4 2025 | 68 | $69.6M |
| Q3 2025 | 52 | $19.5M |
| Q2 2025 | 50 | $19.0M |
| Q1 2025 | 50 | $13.7M |
| Q4 2024 | 87 | $41.2M |
| Q3 2024 | 91 | $49.2M |
| Q2 2024 | 114 | $58.6M |
| Q1 2024 | 114 | $113.0M |
| Q4 2023 | 120 | $63.5M |
| Q3 2023 | 120 | $102.8M |
| Q2 2023 | 138 | $145.0M |
| Q1 2023 | 132 | $340.1M |
| Q4 2022 | 155 | $334.4M |
| Q3 2022 | 147 | $364.1M |
| Q2 2022 | 150 | $302.8M |
| Q1 2022 | 139 | $501.8M |
| Q4 2021 | 143 | $347.5M |
| Q3 2021 | 134 | $334.4M |
| Q2 2021 | 154 | $608.7M |
| Q1 2021 | 171 | $637.1M |
Institutions, Q3 2021
Shares, value and share of portfolio for each institution holding Karyopharm Therapeutics Inc.; share changes are against Q2 2021.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| Deutsche Bank AG | 224,636 | $1.31M | 0.00% | −2,107−0.9% | Reduced |
| Bank of America Corp | 235,915 | $1.37M | 0.00% | +487+0.2% | Added |
| Citigroup Inc | 243,248 | $1.42M | 0.00% | −145,778−37.5% | Reduced |
| Birchview Capital, LP | 246,000 | $1.43M | 0.97% | +16,000+7.0% | Added |
| Jennison Associates LLC | 270,092 | $1.57M | 0.00% | +135,862+101.2% | Added |
| Parametric Portfolio Associates LLC | 293,130 | $1.71M | 0.00% | +120,656+70.0% | Added |
| Bank of New York Mellon Corp | 302,501 | $1.76M | 0.00% | +13,445+4.7% | Added |
| Rafferty Asset Management, LLC | 370,983 | $2.16M | 0.01% | +118,219+46.8% | Added |
| Macquarie Group Ltd | 382,041 | $2.22M | 0.00% | 00.0% | Unchanged |
| Hennion & Walsh Asset Management, Inc. | 407,474 | $2.37M | 0.12% | +31,676+8.4% | Added |
| JPMorgan Chase & Co | 464,921 | $2.71M | 0.00% | −18,301−3.8% | Reduced |
| BNP Paribas Arbitrage, SA | 468,241 | $2.73M | 0.01% | +75,509+19.2% | Added |
| Renaissance Technologies LLC | 495,400 | $2.88M | 0.00% | +476,928+2,581.9% | Added |
| Susquehanna International Group, LLP | 540,393 | $3.15M | 0.00% | +217,288+67.2% | Added |
| UBS Group AG | 608,485 | $3.54M | 0.00% | +314,950+107.3% | Added |
| Candriam Luxembourg S.C.A. | 717,668 | $4.18M | 0.03% | 00.0% | Unchanged |
| Northern Trust Corp | 767,060 | $4.46M | 0.00% | −18,222−2.3% | Reduced |
| Goldman Sachs Group Inc | 985,382 | $5.74M | 0.00% | −20,339−2.0% | Reduced |
| Two Sigma Advisers, LP | 1,082,000 | $6.30M | 0.02% | +99,600+10.1% | Added |
| Two Sigma Investments, LP | 1,096,683 | $6.38M | 0.02% | +250,565+29.6% | Added |
| Frontier Capital Management Co LLC | 1,102,427 | $6.42M | 0.05% | −386,512−26.0% | Reduced |
| Nuveen Asset Management, LLC | 1,119,008 | $6.79M | 0.00% | −16,908−1.5% | Reduced |
| C WorldWide Group Holding A/S | 1,200,000 | $6.98M | 0.07% | 00.0% | Unchanged |
| Rice Hall James & Associates, LLC | 1,401,861 | $8.16M | 0.30% | −7,536−0.5% | Reduced |
| Geode Capital Management, LLC | 1,407,157 | $8.19M | 0.00% | +211,879+17.7% | Added |
| Lombard Odier Asset Management (Switzerland) SA | 1,517,804 | $8.83M | 0.55% | +141,432+10.3% | Added |
| Morgan Stanley | 1,892,933 | $11.0M | 0.00% | +250,252+15.2% | Added |
| Alkeon Capital Management LLC | 1,961,588 | $11.4M | 0.04% | −701,589−26.3% | Reduced |
| Delphi Management Partners VIII, L.L.C. | 2,263,006 | $13.2M | 9.51% | 00.0% | Unchanged |
| Rubric Capital Management LP | 3,375,758 | $19.6M | 1.13% | −877,454−20.6% | Reduced |
| Vanguard Group Inc | 3,642,699 | $21.2M | 0.00% | +29,363+0.8% | Added |
| Palo Alto Investors LP | 5,383,052 | $31.3M | 1.89% | 00.0% | Unchanged |
| State Street Corp | 8,019,999 | $46.7M | 0.00% | +2,203,450+37.9% | Added |
| BlackRock Inc. | 8,790,318 | $51.2M | 0.00% | +9,070+0.1% | Added |
| Hood River Capital Management LLC | 0 | $0 | 0.00% | −802,246−100.0% | Sold out |
| Granahan Investment Management Inc | 0 | $0 | 0.00% | −731,558−100.0% | Sold out |
| Wellington Management Group LLP | 0 | $0 | 0.00% | −596,000−100.0% | Sold out |
| Ami Asset Management Corp | 0 | $0 | 0.00% | −514,101−100.0% | Sold out |
| Mutual of America Capital Management LLC | 0 | $0 | 0.00% | −218,516−100.0% | Sold out |
| Integral Health Asset Management, LLC | 0 | $0 | 0.00% | −150,000−100.0% | Sold out |
| Millennium Management LLC | 0 | $0 | 0.00% | −115,013−100.0% | Sold out |
| Jacobs Levy Equity Management, Inc | 0 | $0 | 0.00% | −81,257−100.0% | Sold out |
| Jump Financial, LLC | 0 | $0 | 0.00% | −70,285−100.0% | Sold out |
| Laurion Capital Management LP | 0 | $0 | 0.00% | −60,786−100.0% | Sold out |
| M&G Investment Management Ltd | 0 | $0 | 0.00% | −62,183−100.0% | Sold out |
| Squarepoint Ops LLC | 0 | $0 | 0.00% | −34,409−100.0% | Sold out |
| SEI Investments Co | 0 | $0 | 0.00% | −30,807−100.0% | Sold out |
| Symons Capital Management Inc | 0 | $0 | 0.00% | −21,766−100.0% | Sold out |
| Centiva Capital, LP | 0 | $0 | 0.00% | −20,405−100.0% | Sold out |
| Virtu Financial LLC | 0 | $0 | 0.00% | −18,229−100.0% | Sold out |
| Parametrica Management Ltd | 0 | $0 | 0.00% | −13,466−100.0% | Sold out |
| Altfest L J & Co Inc | 0 | $0 | 0.00% | −12,374−100.0% | Sold out |
| Silvant Capital Management LLC | 0 | $0 | 0.00% | −11,386−100.0% | Sold out |
| LPL Financial LLC | 0 | $0 | 0.00% | −10,558−100.0% | Sold out |
| Altshuler Shaham Ltd | 0 | $0 | 0.00% | −9,739−100.0% | Sold out |
| Lazard Asset Management LLC | 0 | $0 | 0.00% | −5,726−100.0% | Sold out |
| Tortoise Investment Management, LLC | 0 | $0 | 0.00% | −2,200−100.0% | Sold out |
| Thomas J. Herzfeld Advisors, Inc. | 0 | $0 | 0.00% | −1,500−100.0% | Sold out |
| Advisory Services Network, LLC | 0 | $0 | 0.00% | −900−100.0% | Sold out |
| Bank of Montreal | 0 | $0 | 0.00% | −536−100.0% | Sold out |
| Sargent Bickham Lagudis LLC | 0 | $0 | 0.00% | −606−100.0% | Sold out |
| Lindbrook Capital, LLC | 0 | $0 | 0.00% | −575−100.0% | Sold out |
| Trust Co of Vermont | 0 | $0 | 0.00% | −400−100.0% | Sold out |
| TCI Wealth Advisors, Inc. | 0 | $0 | 0.00% | −298−100.0% | Sold out |
| Simplex Trading, LLC | 0 | $0 | 0.00% | −284−100.0% | Sold out |
| Gemmer Asset Management LLC | 0 | $0 | 0.00% | −140−100.0% | Sold out |
| Cypress Capital Management LLC (WY) | 0 | $0 | 0.00% | −50−100.0% | Sold out |
| FMR LLC | 0 | $0 | 0.00% | −2−100.0% | Sold out |