Ionis Pharmaceuticals Inc
IONS- Exchange
- Nasdaq
- Industry
- Pharmaceutical Preparations
- SEC CIK
- 0000874015
In the last 90 days, Ionis Pharmaceuticals Inc insiders filed 1 open-market purchase and 4 sales; 515 institutions reported holding it in 13F filings for Q2 2026, worth $14.3B in total; ARK Invest is the only superinvestor holding it.
13F holders, Q2 2026
Institutional positions in Ionis Pharmaceuticals Inc as of Jun 30, 2026. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 515
- +21 vs. Q1 2026
- Shares held
- 179.7M
- +7.19M (+4.2%) vs. Q1 2026
- Total value
- $14.3B
- +$1.30B (+10.0%) vs. Q1 2026
- New holders
- 67
- 199 more added
- Sold out
- 46
- 162 more reduced
3 institutions that held it in Q1 2026 haven't filed for Q2 2026 yet. Not filing isn't selling, so they aren't counted as sold out or in the changes above.
Compare with Q1 2026: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting IONS on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 515 | $14.3B |
| Q1 2026 | 497 | $13.0B |
| Q4 2025 | 494 | $13.5B |
| Q3 2025 | 437 | $11.0B |
| Q2 2025 | 363 | $6.67B |
| Q1 2025 | 344 | $5.03B |
| Q4 2024 | 356 | $5.61B |
| Q3 2024 | 354 | $6.31B |
| Q2 2024 | 357 | $6.83B |
| Q1 2024 | 361 | $6.17B |
| Q4 2023 | 365 | $7.21B |
| Q3 2023 | 312 | $6.35B |
| Q2 2023 | 305 | $5.60B |
| Q1 2023 | 315 | $4.69B |
| Q4 2022 | 339 | $4.93B |
| Q3 2022 | 350 | $5.59B |
| Q2 2022 | 351 | $4.61B |
| Q1 2022 | 333 | $4.63B |
| Q4 2021 | 341 | $3.75B |
| Q3 2021 | 326 | $4.08B |
| Q2 2021 | 338 | $4.96B |
| Q1 2021 | 365 | $5.55B |
Institutions, Q2 2026
Shares, value and share of portfolio for each institution holding Ionis Pharmaceuticals Inc; share changes are against Q1 2026.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| SEI Investments Co | 127,868 | $10.1M | 0.01% | −29,354−18.7% | Reduced |
| State Board of Administration of Florida Retirement System | 131,818 | $10.5M | 0.02% | −4,060−3.0% | Reduced |
| Lazard Asset Management LLC | 132,480 | $10.5M | 0.02% | +107,070+421.4% | Added |
| HealthInvest Partners AB | 137,131 | $10.9M | 2.93% | +109,258+392.0% | Added |
| Fisher Asset Management, LLC | 137,184 | $10.9M | 0.00% | −4,360−3.1% | Reduced |
| Artia Global Partners LP | 144,376 | $11.4M | 2.18% | 00.0% | Unchanged |
| Hudson Bay Capital Management LP | 145,000 | $11.5M | 0.05% | −150,100−50.9% | Reduced |
| Colony Group, LLC | 147,917 | $11.7M | 0.01% | −17,627−10.6% | Reduced |
| Adage Capital Partners GP, L.L.C. | 150,000 | $11.9M | 0.02% | +100,000+200.0% | Added |
| DZ BANK AG Deutsche Zentral Genossenschafts Bank, Frankfurt am Main | 151,301 | $12.0M | 0.01% | −16,356−9.8% | Reduced |
| CSS LLC | 152,289 | $12.1M | 0.54% | +73,196+92.5% | Added |
| Vanguard Asset Management, Ltd | 155,088 | $12.3M | 0.01% | +17,581+12.8% | Added |
| HRT Financial LP | 156,798 | $12.4M | 0.02% | −95,452−37.8% | Reduced |
| Sicart Associates LLC | 160,694 | $12.7M | 3.12% | +1,282+0.8% | Added |
| Rhumbline Advisers | 164,911 | $13.1M | 0.01% | −8,529−4.9% | Reduced |
| ADAR1 Capital Management, LLC | 166,286 | $13.2M | 0.62% | +5,948+3.7% | Added |
| Deutsche Bank AG | 169,614 | $13.4M | 0.00% | +9,723+6.1% | Added |
| Polymer Capital Management (HK) LTD | 177,897 | $14.1M | 1.43% | +116,697+190.7% | Added |
| California State Teachers Retirement System | 180,949 | $14.3M | 0.01% | +4,464+2.5% | Added |
| Sector Gamma AS | 189,468 | $15.0M | 3.26% | +20,000+11.8% | Added |
| HSBC Holdings PLC | 188,402 | $15.0M | 0.01% | +2,435+1.3% | Added |
| Eagle Health Investments LP | 194,577 | $15.4M | 2.56% | +194,577 | New |
| CI Private Wealth, LLC | 196,661 | $15.6M | 0.02% | +620.0% | Added |
| Stifel Financial Corp | 202,983 | $16.1M | 0.01% | +6,280+3.2% | Added |
| Algert Global LLC | 206,853 | $16.4M | 0.19% | +90,290+77.5% | Added |
| Life Cycle Investment Partners Ltd | 219,896 | $17.4M | 0.08% | +219,896 | New |
| Orion Investment Co | 220,335 | $17.5M | 5.12% | −4,680−2.1% | Reduced |
| Empowered Funds, LLC | 223,142 | $17.7M | 0.09% | +120,001+116.3% | Added |
| Wells Fargo & Company | 226,213 | $17.9M | 0.00% | +36,360+19.2% | Added |
| Universal- Beteiligungs- und Servicegesellschaft mbH | 233,499 | $18.5M | 0.03% | +13,847+6.3% | Added |
| Citadel Advisors LLC | 236,284 | $18.7M | 0.01% | −706,250−74.9% | Reduced |
| Raymond James Financial Inc | 237,348 | $18.8M | 0.01% | +2,227+0.9% | Added |
| Tocqueville Asset Management L.P. | 251,215 | $19.9M | 0.26% | +31,995+14.6% | Added |
| California Public Employees Retirement System | 270,843 | $21.5M | 0.01% | +15,358+6.0% | Added |
| Standard Life Aberdeen plc | 277,400 | $22.0M | 0.03% | +163,557+143.7% | Added |
| Davenport & Co LLC | 283,960 | $22.5M | 0.11% | +45,722+19.2% | Added |
| Millennium Management LLC | 288,872 | $22.9M | 0.02% | −762,634−72.5% | Reduced |
| D. E. Shaw & Co., Inc. | 297,041 | $23.6M | 0.01% | −132,558−30.9% | Reduced |
| Legal & General Group Plc | 299,184 | $23.7M | 0.00% | +4,505+1.5% | Added |
| ARK Investment Management LLCSuperinvestorARK Invest | 300,770 | $23.8M | 0.15% | +12,054+4.2% | Added |
| Jump Financial, LLC | 306,330 | $24.3M | 0.22% | +99,655+48.2% | Added |
| Swiss National Bank | 315,000 | $25.0M | 0.01% | +10,500+3.4% | Added |
| Privium Fund Management B.V. | 319,924 | $25.4M | 4.66% | +29,900+10.3% | Added |
| Carmignac Gestion | 321,000 | $25.5M | 0.33% | +268,000+505.7% | Added |
| Alliancebernstein L.P. | 340,450 | $25.6M | 0.01% | −60,219−15.0% | Reduced |
| Capital Fund Management S.A. | 329,554 | $26.1M | 0.19% | +187,353+131.8% | Added |
| Capital Research Global Investors | 331,936 | $26.3M | 0.00% | +8,921+2.8% | Added |
| Qube Research & Technologies Ltd | 333,952 | $26.5M | 0.03% | +291,096+679.2% | Added |
| Freestone Grove Partners LP | 339,967 | $27.0M | 0.18% | +339,967 | New |
| TD Asset Management Inc | 340,548 | $27.0M | 0.02% | −189,406−35.7% | Reduced |
| C WorldWide Group Holding A/S | 366,000 | $29.0M | 0.70% | 00.0% | Unchanged |
| Handelsbanken Fonder AB | 383,211 | $30.4M | 0.09% | +169,300+79.1% | Added |
| Nomura Holdings Inc | 402,192 | $31.9M | 0.13% | +288,112+252.6% | Added |
| Pinnacle Associates Ltd | 419,752 | $33.3M | 0.36% | −16,705−3.8% | Reduced |
| First Trust Advisors LP | 427,197 | $33.9M | 0.02% | −41,166−8.8% | Reduced |
| Candriam Luxembourg S.C.A. | 445,019 | $35.3M | 0.16% | −39,034−8.1% | Reduced |
| BNP Paribas Arbitrage, SA | 454,649 | $36.0M | 0.02% | −24,811−5.2% | Reduced |
| New York State Common Retirement Fund | 500,050 | $39.6M | 0.05% | +149,636+42.7% | Added |
| Jane Street Group, LLC | 503,647 | $39.9M | 0.03% | +311,829+162.6% | Added |
| Boone Capital Management LLC | 519,977 | $41.2M | 9.64% | +19,455+3.9% | Added |
| Teacher Retirement System of Texas | 522,317 | $41.4M | 0.11% | −1,615−0.3% | Reduced |
| Bank of New York Mellon Corp | 542,454 | $43.0M | 0.01% | +27,837+5.4% | Added |
| Renaissance Technologies LLC | 559,414 | $44.4M | 0.06% | +253,865+83.1% | Added |
| Perceptive Advisors LLC | 566,000 | $44.9M | 0.70% | +62,000+12.3% | Added |
| Eventide Asset Management, LLC | 575,000 | $45.6M | 0.61% | 00.0% | Unchanged |
| TimesSquare Capital Management, LLC | 614,070 | $48.7M | 0.72% | +338,396+122.8% | Added |
| UBS Group AG | 624,874 | $49.5M | 0.01% | −183,569−22.7% | Reduced |
| Arrowstreet Capital, Limited Partnership | 632,028 | $50.1M | 0.02% | −105,831−14.3% | Reduced |
| Neuberger Berman Group LLC | 633,533 | $50.2M | 0.03% | +190,261+42.9% | Added |
| Massachusetts Financial Services Co | 651,816 | $51.7M | 0.02% | −14,300−2.1% | Reduced |
| Voloridge Investment Management, LLC | 655,454 | $52.0M | 0.22% | −17,404−2.6% | Reduced |
| Eversept Partners, LP | 664,684 | $52.7M | 2.87% | +32,584+5.2% | Added |
| Connor, Clark & Lunn Investment Management Ltd. | 684,236 | $54.3M | 0.10% | −189,853−21.7% | Reduced |
| Nuveen, LLC | 726,282 | $57.6M | 0.01% | +77,786+12.0% | Added |
| BNP PARIBAS ASSET MANAGEMENT Holding S.A. | 734,219 | $58.2M | 0.06% | −173,314−19.1% | Reduced |
| GW&K Investment Management, LLC | 746,966 | $59.2M | 0.46% | −32,383−4.2% | Reduced |
| Summit Partners Public Asset Management, LLC | 787,263 | $62.4M | 1.62% | −616,770−43.9% | Reduced |
| Bank of America Corp | 790,990 | $62.7M | 0.00% | −49,608−5.9% | Reduced |
| Davern Capital Partners, LP | 798,709 | $63.3M | 10.80% | +411,806+106.4% | Added |
| Capital International Investors | 823,764 | $65.3M | 0.01% | +823,764 | New |
| Northern Trust Corp | 913,610 | $72.4M | 0.01% | +45,431+5.2% | Added |
| Groupama Asset Managment | 937,083 | $75.2M | 0.95% | +112,543+13.6% | Added |
| Bellevue Group AG | 972,258 | $77.1M | 1.62% | −846,407−46.5% | Reduced |
| Vanguard Fiduciary Trust Co | 1,060,845 | $84.1M | 0.02% | +36,468+3.6% | Added |
| Invesco Ltd. | 1,120,707 | $88.9M | 0.01% | −156,651−12.3% | Reduced |
| Morgan Stanley | 1,281,444 | $101.6M | 0.01% | +254,935+24.8% | Added |
| Nomura Asset Management International Inc. | 1,300,392 | $103.1M | 0.15% | +515,111+65.6% | Added |
| Alyeska Investment Group, L.P. | 1,417,916 | $112.4M | 0.29% | +944,766+199.7% | Added |
| Polar Capital Holdings Plc | 1,454,021 | $115.3M | 0.33% | +624,510+75.3% | Added |
| UBS Asset Management Americas Inc | 1,454,672 | $115.3M | 0.02% | −20,960−1.4% | Reduced |
| Pictet Asset Management Holding SA | 1,596,998 | $127.0M | 0.12% | +162,003+11.3% | Added |
| Barclays PLC | 1,603,136 | $127.1M | 0.04% | +1,313,262+453.0% | Added |
| Charles Schwab Investment Management Inc | 1,605,054 | $127.3M | 0.02% | +21,788+1.4% | Added |
| Franklin Resources Inc | 1,623,377 | $128.7M | 0.03% | +48,354+3.1% | Added |
| American Century Companies Inc | 1,947,076 | $154.4M | 0.07% | +283,273+17.0% | Added |
| Deerfield Management Company, L.P. (Series C) | 1,979,669 | $157.0M | 1.64% | 00.0% | Unchanged |
| Baker Bros. Advisors LP | 2,047,727 | $162.4M | 0.81% | 00.0% | Unchanged |
| Goldman Sachs Group Inc | 2,109,945 | $167.3M | 0.02% | +410,098+24.1% | Added |
| Deep Track Capital, LP | 2,200,000 | $174.4M | 2.57% | +250,000+12.8% | Added |
| Tweedy, Browne Co LLC | 2,280,311 | $180.8M | 13.70% | +4,686+0.2% | Added |