Ionis Pharmaceuticals Inc
IONS- Exchange
- Nasdaq
- Industry
- Pharmaceutical Preparations
- SEC CIK
- 0000874015
In the last 90 days, Ionis Pharmaceuticals Inc insiders filed 1 open-market purchase and 4 sales; 515 institutions reported holding it in 13F filings for Q2 2026, worth $14.3B in total; ARK Invest is the only superinvestor holding it.
13F holders, Q2 2026
Institutional positions in Ionis Pharmaceuticals Inc as of Jun 30, 2026. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 515
- +21 vs. Q1 2026
- Shares held
- 179.7M
- +7.19M (+4.2%) vs. Q1 2026
- Total value
- $14.3B
- +$1.30B (+10.0%) vs. Q1 2026
- New holders
- 67
- 199 more added
- Sold out
- 46
- 162 more reduced
3 institutions that held it in Q1 2026 haven't filed for Q2 2026 yet. Not filing isn't selling, so they aren't counted as sold out or in the changes above.
Compare with Q1 2026: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting IONS on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 515 | $14.3B |
| Q1 2026 | 497 | $13.0B |
| Q4 2025 | 494 | $13.5B |
| Q3 2025 | 437 | $11.0B |
| Q2 2025 | 363 | $6.67B |
| Q1 2025 | 344 | $5.03B |
| Q4 2024 | 356 | $5.61B |
| Q3 2024 | 354 | $6.31B |
| Q2 2024 | 357 | $6.83B |
| Q1 2024 | 361 | $6.17B |
| Q4 2023 | 365 | $7.21B |
| Q3 2023 | 312 | $6.35B |
| Q2 2023 | 305 | $5.60B |
| Q1 2023 | 315 | $4.69B |
| Q4 2022 | 339 | $4.93B |
| Q3 2022 | 350 | $5.59B |
| Q2 2022 | 351 | $4.61B |
| Q1 2022 | 333 | $4.63B |
| Q4 2021 | 341 | $3.75B |
| Q3 2021 | 326 | $4.08B |
| Q2 2021 | 338 | $4.96B |
| Q1 2021 | 365 | $5.55B |
Institutions, Q2 2026
Shares, value and share of portfolio for each institution holding Ionis Pharmaceuticals Inc; share changes are against Q1 2026.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| Captrust Financial Advisors | 5,030 | $398.8K | 0.00% | +30+0.6% | Added |
| R Squared Ltd | 5,313 | $421.3K | 0.22% | +954+21.9% | Added |
| Resources Investment Advisors, LLC. | 5,345 | $423.8K | 0.00% | −45−0.8% | Reduced |
| Coldstream Capital Management Inc | 5,352 | $424.4K | 0.01% | −301−5.3% | Reduced |
| VARCOV Co. | 5,390 | $427.4K | 0.16% | +5,390 | New |
| ProShare Advisors LLC | 5,417 | $429.5K | 0.00% | −1,973−26.7% | Reduced |
| Tema ETFs LLC | 5,525 | $438.1K | 0.01% | −148−2.6% | Reduced |
| E Fund Management Co., Ltd. | 5,569 | $441.6K | 0.01% | −41,119−88.1% | Reduced |
| Robeco Institutional Asset Management B.V. | 5,578 | $442.3K | 0.00% | −82−1.4% | Reduced |
| Regions Financial Corp | 5,604 | $444.3K | 0.00% | −518−8.5% | Reduced |
| Frank, Rimerman Advisors LLC | 5,807 | $460.4K | 0.03% | +26+0.4% | Added |
| Cerity Partners LLC | 5,989 | $474.9K | 0.00% | −1,607−21.2% | Reduced |
| Cypress Capital, LLC | 6,000 | $475.7K | 0.13% | 00.0% | Unchanged |
| MCF Advisors LLC | 6,136 | $486.5K | 0.02% | +6,086+12,172.0% | Added |
| Janney Montgomery Scott LLC | 6,138 | $487.0K | 0.00% | +6,138 | New |
| Nykredit A/S | 6,154 | $488.0K | 0.00% | +6,154 | New |
| Everence Capital Management Inc | 6,232 | $494.0K | 0.03% | 00.0% | Unchanged |
| US Bancorp | 6,366 | $504.8K | 0.00% | +1,319+26.1% | Added |
| Group One Trading, L.P. | 6,493 | $514.8K | 0.01% | +4,601+243.2% | Added |
| Significant Wealth Partners LLC | 6,613 | $524.3K | 0.57% | −51−0.8% | Reduced |
| J. Safra Sarasin Holding AG | 6,751 | $535.3K | 0.01% | +320+5.0% | Added |
| PSP Research LLC | 6,800 | $539.2K | 0.29% | 00.0% | Unchanged |
| Mercer Global Advisors Inc | 6,918 | $548.4K | 0.00% | +622+9.9% | Added |
| Silvercrest Asset Management Group LLC | 7,055 | $559.4K | 0.00% | +20.0% | Added |
| Callan Family Office, LLC | 7,143 | $566.4K | 0.01% | +61+0.9% | Added |
| O'Shaughnessy Asset Management, LLC | 7,166 | $568.2K | 0.00% | −521−6.8% | Reduced |
| Sectoral Asset Management Inc | 7,200 | $570.9K | 0.40% | 00.0% | Unchanged |
| Fiduciary Trust Co | 7,399 | $586.7K | 0.01% | 00.0% | Unchanged |
| Savant Capital, LLC | 7,476 | $587.6K | 0.00% | −985−11.6% | Reduced |
| M&T Bank Corp | 7,510 | $595.4K | 0.00% | −161−2.1% | Reduced |
| Meeder Advisory Services, Inc. | 7,660 | $607.4K | 0.02% | +421+5.8% | Added |
| Stratos Wealth Partners, LTD. | 7,801 | $618.5K | 0.01% | +86+1.1% | Added |
| Mirae Asset Global Investments Co., Ltd. | 7,867 | $623.8K | 0.00% | −1,162−12.9% | Reduced |
| Plancorp, LLC | 11,128 | $631.5K | 0.02% | −80−0.7% | Reduced |
| CWM Advisors, LLC | 8,127 | $644.4K | 0.03% | +8,127 | New |
| Commonwealth Equity Services, LLC | 8,153 | $646.5K | 0.00% | +324+4.1% | Added |
| Maryland State Retirement & Pension System | 8,343 | $661.5K | 0.01% | +963+13.0% | Added |
| denkapparat Operations GmbH | 8,364 | $663.2K | 0.22% | 00.0% | Unchanged |
| Marshall Wace, LLP | 8,501 | $674.0K | 0.00% | −87,453−91.1% | Reduced |
| Utah Retirement Systems | 8,577 | $680.1K | 0.01% | +277+3.3% | Added |
| iA Global Asset Management Inc. | 8,658 | $686.0K | 0.01% | +8,658 | New |
| MetLife Investment Management | 8,776 | $695.8K | 0.00% | −448−4.9% | Reduced |
| NewEdge Wealth, LLC | 8,977 | $711.8K | 0.01% | +8,977 | New |
| Ensign Peak Advisors, Inc | 9,120 | $723.1K | 0.00% | −36,884−80.2% | Reduced |
| Mackenzie Financial Corp | 9,289 | $736.5K | 0.00% | +5,494+144.8% | Added |
| Assetmark, Inc | 9,939 | $788.1K | 0.00% | +365+3.8% | Added |
| Fifth Third Bancorp | 10,061 | $797.7K | 0.00% | −950−8.6% | Reduced |
| Wiley Bros.-Aintree Capital, LLC | 10,184 | $807.5K | 0.00% | −725−6.6% | Reduced |
| Vident Advisory, LLC | 10,187 | $807.7K | 0.01% | +698+7.4% | Added |
| Marex Group plc | 10,189 | $807.9K | 0.01% | +6,579+182.2% | Added |
| Swiss Life Asset Management Ltd | 10,275 | $814.7K | 0.00% | +1,100+12.0% | Added |
| Axq Capital, LP | 10,423 | $826.4K | 0.09% | +6,577+171.0% | Added |
| Evolve Private Wealth, LLC | 10,653 | $844.7K | 0.05% | +10,653 | New |
| Suvretta Capital Management, LLC | 10,800 | $856.3K | 0.02% | 00.0% | Unchanged |
| Horizon Kinetics Asset Management LLC | 10,904 | $864.6K | 0.01% | −524−4.6% | Reduced |
| Northwestern Mutual Wealth Management Co | 10,925 | $866.2K | 0.00% | −198−1.8% | Reduced |
| Militia Capital Management LLC | 11,400 | $903.9K | 0.16% | +11,400 | New |
| Amalgamated Bank | 11,519 | $913.0K | 0.01% | −535−4.4% | Reduced |
| Commerce Bank | 11,681 | $926.2K | 0.00% | +3,516+43.1% | Added |
| Boothbay Fund Management, LLC | 11,808 | $936.3K | 0.02% | −64,763−84.6% | Reduced |
| JustInvest LLC | 11,933 | $946.2K | 0.01% | +519+4.5% | Added |
| Federation des caisses Desjardins du Quebec | 12,017 | $952.8K | 0.00% | +2,012+20.1% | Added |
| Arrowpoint Investment Partners (Singapore) Pte. Ltd. | 12,338 | $978.3K | 0.29% | −26,650−68.4% | Reduced |
| Man Group plc | 12,361 | $980.1K | 0.00% | −11,652−48.5% | Reduced |
| Annis Gardner Whiting Capital Advisors, LLC | 12,801 | $1.01M | 0.15% | 00.0% | Unchanged |
| SBI Okasan Asset Management Co.Ltd. | 12,600 | $1.02M | 0.03% | 00.0% | Unchanged |
| Westmount Partners, LLC | 12,961 | $1.03M | 0.23% | 00.0% | Unchanged |
| Virginia Retirement Systems Et Al | 13,400 | $1.06M | 0.01% | +3,100+30.1% | Added |
| Mitsubishi UFJ Trust & Banking Corp | 13,446 | $1.07M | 0.00% | +13,446 | New |
| Dynasty Wealth Management, LLC | 13,661 | $1.08M | 0.01% | −419−3.0% | Reduced |
| Oppenheimer Asset Management Inc. | 13,752 | $1.09M | 0.01% | +1,899+16.0% | Added |
| FORA Capital, LLC | 13,833 | $1.10M | 0.08% | −5,860−29.8% | Reduced |
| Summit Trail Advisors, LLC | 13,931 | $1.10M | 0.01% | +2,382+20.6% | Added |
| Bamco Inc | 14,000 | $1.11M | 0.00% | −31,000−68.9% | Reduced |
| Truist Financial Corp | 14,068 | $1.12M | 0.00% | +1,222+9.5% | Added |
| The PNC Financial Services Group, Inc. | 14,185 | $1.12M | 0.00% | +640+4.7% | Added |
| Bleakley Financial Group, LLC | 14,793 | $1.17M | 0.01% | +477+3.3% | Added |
| Advisor Group Holdings, Inc. | 14,800 | $1.17M | 0.00% | +6,090+69.9% | Added |
| Engineers Gate Manager LP | 14,840 | $1.18M | 0.02% | −118,987−88.9% | Reduced |
| AlphaCentric Advisors LLC | 15,430 | $1.22M | 1.04% | −4,157−21.2% | Reduced |
| Dark Forest Capital Management LP | 15,511 | $1.23M | 0.08% | +15,511 | New |
| Davy Global Fund Management Ltd | 15,819 | $1.25M | 0.08% | +1,430+9.9% | Added |
| Brown Advisory Inc | 15,846 | $1.26M | 0.00% | +741+4.9% | Added |
| Virtus Investment Advisers, Inc. | 15,870 | $1.26M | 0.29% | +5,425+51.9% | Added |
| Allianz Asset Management GmbH | 16,129 | $1.28M | 0.00% | +3,528+28.0% | Added |
| BIT Capital GmbH | 16,300 | $1.29M | 0.04% | +16,300 | New |
| North Star Asset Management Inc | 16,560 | $1.31M | 0.05% | −50−0.3% | Reduced |
| Graham Capital Management, L.P. | 16,717 | $1.33M | 0.04% | +16,717 | New |
| Allstate Corp | 16,943 | $1.34M | 0.01% | −3,622−17.6% | Reduced |
| Gsa Capital Partners LLP | 17,306 | $1.37M | 0.09% | +14,134+445.6% | Added |
| DnB Asset Management AS | 17,986 | $1.43M | 0.00% | −1,074−5.6% | Reduced |
| Profund Advisors LLC | 18,321 | $1.45M | 0.04% | −7,966−30.3% | Reduced |
| Amundi | 20,190 | $1.60M | 0.00% | −3,768−15.7% | Reduced |
| Nicollet Investment Management, Inc. | 20,240 | $1.60M | 0.50% | +594+3.0% | Added |
| Cetera Investment Advisers | 21,808 | $1.73M | 0.00% | +10,528+93.3% | Added |
| Teachers Retirement System of the State of Kentucky | 21,945 | $1.74M | 0.01% | −2,138−8.9% | Reduced |
| AQR Capital Management LLC | 22,059 | $1.75M | 0.00% | −6,724−23.4% | Reduced |
| Wolverine Asset Management LLC | 22,340 | $1.77M | 0.02% | −475−2.1% | Reduced |
| Dana Investment Advisors, Inc. | 23,272 | $1.85M | 0.05% | +4,785+25.9% | Added |
| Inceptionr LLC | 24,251 | $1.92M | 0.47% | +7,430+44.2% | Added |