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Ionis Pharmaceuticals Inc

IONS
Exchange
Nasdaq
Industry
Pharmaceutical Preparations
SEC CIK
0000874015

In the last 90 days, Ionis Pharmaceuticals Inc insiders filed 1 open-market purchase and 3 sales; 515 institutions reported holding it in 13F filings for Q2 2026, worth $14.3B in total; ARK Invest is the only superinvestor holding it.

13F holders, Q3 2026

Institutional positions in Ionis Pharmaceuticals Inc as of Sep 30, 2026. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works

Q3 2026 data is still coming in (13F filing deadline: Nov 16, 2026), so these numbers are incomplete.

Institutional holders
3
0 vs. Q2 2026
Shares held
2.06K
+387 (+23.2%) vs. Q2 2026
Total value
$91.8K
−$40.6K (−30.6%) vs. Q2 2026
New holders
0
2 more added
Sold out
0
1 more reduced

512 institutions that held it in Q2 2026 haven't filed for Q3 2026 yet. Not filing isn't selling, so they aren't counted as sold out or in the changes above.

Compare with Q2 2026: new holders, sold out and not filed yet

Holders and value by quarter

Institutions reporting IONS on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.

Institutional holders
Q1 2021: 365 institutionsQ2 2021: 338 institutionsQ3 2021: 326 institutionsQ4 2021: 341 institutionsQ1 2022: 333 institutionsQ2 2022: 351 institutionsQ3 2022: 350 institutionsQ4 2022: 339 institutionsQ1 2023: 315 institutionsQ2 2023: 305 institutionsQ3 2023: 312 institutionsQ4 2023: 365 institutionsQ1 2024: 361 institutionsQ2 2024: 357 institutionsQ3 2024: 354 institutionsQ4 2024: 356 institutionsQ1 2025: 344 institutionsQ2 2025: 363 institutionsQ3 2025: 437 institutionsQ4 2025: 494 institutionsQ1 2026: 497 institutionsQ2 2026: 515 institutions
Value held
Q1 2021: $5.55BQ2 2021: $4.96BQ3 2021: $4.08BQ4 2021: $3.75BQ1 2022: $4.63BQ2 2022: $4.61BQ3 2022: $5.59BQ4 2022: $4.93BQ1 2023: $4.69BQ2 2023: $5.60BQ3 2023: $6.35BQ4 2023: $7.21BQ1 2024: $6.17BQ2 2024: $6.83BQ3 2024: $6.31BQ4 2024: $5.61BQ1 2025: $5.03BQ2 2025: $6.67BQ3 2025: $11.0BQ4 2025: $13.5BQ1 2026: $13.0BQ2 2026: $14.3B
Institutions holding IONS and their total value by quarter
QuarterHoldersValue
Q2 2026515$14.3B
Q1 2026497$13.0B
Q4 2025494$13.5B
Q3 2025437$11.0B
Q2 2025363$6.67B
Q1 2025344$5.03B
Q4 2024356$5.61B
Q3 2024354$6.31B
Q2 2024357$6.83B
Q1 2024361$6.17B
Q4 2023365$7.21B
Q3 2023312$6.35B
Q2 2023305$5.60B
Q1 2023315$4.69B
Q4 2022339$4.93B
Q3 2022350$5.59B
Q2 2022351$4.61B
Q1 2022333$4.63B
Q4 2021341$3.75B
Q3 2021326$4.08B
Q2 2021338$4.96B
Q1 2021365$5.55B

Institutions, Q3 2026

Shares, value and share of portfolio for each institution holding Ionis Pharmaceuticals Inc; share changes are against Q2 2026.

Institutions holding IONS in Q3 2026
InstitutionSharesValue% of portfolioChange in sharesAction
Ethic Inc.––––Not filed
Blair William & Co––––Not filed
Trexquant Investment LP––––Not filed
Mutual of America Capital Management LLC––––Not filed
LMR Partners LLP––––Not filed
PEAK6 LLC––––Not filed
Calamos Advisors LLC––––Not filed
Kornitzer Capital Management Inc––––Not filed
BLB&B Advisors, LLC––––Not filed
LPL Financial LLC––––Not filed
Xponance, Inc.––––Not filed
Intech Investment Management LLC––––Not filed
Jupiter Asset Management Ltd––––Not filed
Bank of Montreal––––Not filed
BI Asset Management Fondsmaeglerselskab A/S––––Not filed
Brinker Capital Investments, LLC––––Not filed
Great West Life Assurance Co––––Not filed
Inceptionr LLC––––Not filed
Dana Investment Advisors, Inc.––––Not filed
Wolverine Asset Management LLC––––Not filed
AQR Capital Management LLC––––Not filed
Teachers Retirement System of the State of Kentucky––––Not filed
Cetera Investment Advisers––––Not filed
Nicollet Investment Management, Inc.––––Not filed
Amundi––––Not filed
Profund Advisors LLC––––Not filed
DnB Asset Management AS––––Not filed
Gsa Capital Partners LLP––––Not filed
Allstate Corp––––Not filed
Graham Capital Management, L.P.––––Not filed
North Star Asset Management Inc––––Not filed
BIT Capital GmbH––––Not filed
Allianz Asset Management GmbH––––Not filed
Virtus Investment Advisers, Inc.––––Not filed
Brown Advisory Inc––––Not filed
Davy Global Fund Management Ltd––––Not filed
Dark Forest Capital Management LP––––Not filed
AlphaCentric Advisors LLC––––Not filed
Engineers Gate Manager LP––––Not filed
Advisor Group Holdings, Inc.––––Not filed
Bleakley Financial Group, LLC––––Not filed
The PNC Financial Services Group, Inc.––––Not filed
Truist Financial Corp––––Not filed
Bamco Inc––––Not filed
Summit Trail Advisors, LLC––––Not filed
FORA Capital, LLC––––Not filed
Oppenheimer Asset Management Inc.––––Not filed
Dynasty Wealth Management, LLC––––Not filed
Mitsubishi UFJ Trust & Banking Corp––––Not filed
Virginia Retirement Systems Et Al––––Not filed
Westmount Partners, LLC––––Not filed
SBI Okasan Asset Management Co.Ltd.––––Not filed
Annis Gardner Whiting Capital Advisors, LLC––––Not filed
Man Group plc––––Not filed
Arrowpoint Investment Partners (Singapore) Pte. Ltd.––––Not filed
Federation des caisses Desjardins du Quebec––––Not filed
JustInvest LLC––––Not filed
Boothbay Fund Management, LLC––––Not filed
Commerce Bank––––Not filed
Amalgamated Bank––––Not filed
Militia Capital Management LLC––––Not filed
Northwestern Mutual Wealth Management Co––––Not filed
Horizon Kinetics Asset Management LLC––––Not filed
Suvretta Capital Management, LLC––––Not filed
Evolve Private Wealth, LLC––––Not filed
Axq Capital, LP––––Not filed
Swiss Life Asset Management Ltd––––Not filed
Marex Group plc––––Not filed
Vident Advisory, LLC––––Not filed
Wiley Bros.-Aintree Capital, LLC––––Not filed
Fifth Third Bancorp––––Not filed
Assetmark, Inc––––Not filed
Mackenzie Financial Corp––––Not filed
Ensign Peak Advisors, Inc––––Not filed
NewEdge Wealth, LLC––––Not filed
MetLife Investment Management––––Not filed
iA Global Asset Management Inc.––––Not filed
Utah Retirement Systems––––Not filed
Marshall Wace, LLP––––Not filed
denkapparat Operations GmbH––––Not filed
Maryland State Retirement & Pension System––––Not filed
Commonwealth Equity Services, LLC––––Not filed
CWM Advisors, LLC––––Not filed
Plancorp, LLC––––Not filed
Mirae Asset Global Investments Co., Ltd.––––Not filed
Stratos Wealth Partners, LTD.––––Not filed
Meeder Advisory Services, Inc.––––Not filed
M&T Bank Corp––––Not filed
Savant Capital, LLC––––Not filed
Fiduciary Trust Co––––Not filed
Sectoral Asset Management Inc––––Not filed
O'Shaughnessy Asset Management, LLC––––Not filed
Callan Family Office, LLC––––Not filed
Silvercrest Asset Management Group LLC––––Not filed
Mercer Global Advisors Inc––––Not filed
PSP Research LLC––––Not filed
J. Safra Sarasin Holding AG––––Not filed
Significant Wealth Partners LLC––––Not filed
Group One Trading, L.P.––––Not filed
US Bancorp––––Not filed