Ionis Pharmaceuticals Inc
IONS- Exchange
- Nasdaq
- Industry
- Pharmaceutical Preparations
- SEC CIK
- 0000874015
In the last 90 days, Ionis Pharmaceuticals Inc insiders filed 1 open-market purchase and 4 sales; 515 institutions reported holding it in 13F filings for Q2 2026, worth $14.3B in total; ARK Invest is the only superinvestor holding it.
13F holders, Q2 2026
Institutional positions in Ionis Pharmaceuticals Inc as of Jun 30, 2026. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 515
- +21 vs. Q1 2026
- Shares held
- 179.7M
- +7.19M (+4.2%) vs. Q1 2026
- Total value
- $14.3B
- +$1.30B (+10.0%) vs. Q1 2026
- New holders
- 67
- 199 more added
- Sold out
- 46
- 162 more reduced
3 institutions that held it in Q1 2026 haven't filed for Q2 2026 yet. Not filing isn't selling, so they aren't counted as sold out or in the changes above.
Compare with Q1 2026: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting IONS on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 515 | $14.3B |
| Q1 2026 | 497 | $13.0B |
| Q4 2025 | 494 | $13.5B |
| Q3 2025 | 437 | $11.0B |
| Q2 2025 | 363 | $6.67B |
| Q1 2025 | 344 | $5.03B |
| Q4 2024 | 356 | $5.61B |
| Q3 2024 | 354 | $6.31B |
| Q2 2024 | 357 | $6.83B |
| Q1 2024 | 361 | $6.17B |
| Q4 2023 | 365 | $7.21B |
| Q3 2023 | 312 | $6.35B |
| Q2 2023 | 305 | $5.60B |
| Q1 2023 | 315 | $4.69B |
| Q4 2022 | 339 | $4.93B |
| Q3 2022 | 350 | $5.59B |
| Q2 2022 | 351 | $4.61B |
| Q1 2022 | 333 | $4.63B |
| Q4 2021 | 341 | $3.75B |
| Q3 2021 | 326 | $4.08B |
| Q2 2021 | 338 | $4.96B |
| Q1 2021 | 365 | $5.55B |
Institutions, Q2 2026
Shares, value and share of portfolio for each institution holding Ionis Pharmaceuticals Inc; share changes are against Q1 2026.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| Mutual of America Capital Management LLC | 31,299 | $2.48M | 0.02% | +3,173+11.3% | Added |
| LMR Partners LLP | 30,800 | $2.44M | 0.02% | +15,800+105.3% | Added |
| PEAK6 LLC | 29,460 | $2.34M | 0.06% | −4,959−14.4% | Reduced |
| Calamos Advisors LLC | 29,358 | $2.33M | 0.01% | +9,577+48.4% | Added |
| Kornitzer Capital Management Inc | 29,105 | $2.31M | 0.05% | 00.0% | Unchanged |
| BLB&B Advisors, LLC | 28,570 | $2.27M | 0.08% | −6,600−18.8% | Reduced |
| LPL Financial LLC | 27,868 | $2.21M | 0.00% | −4,064−12.7% | Reduced |
| Xponance, Inc. | 26,687 | $2.12M | 0.01% | +303+1.1% | Added |
| Intech Investment Management LLC | 26,041 | $2.06M | 0.02% | −12,474−32.4% | Reduced |
| Jupiter Asset Management Ltd | 25,949 | $2.06M | 0.01% | +25,949 | New |
| Bank of Montreal | 25,782 | $2.04M | 0.00% | −803−3.0% | Reduced |
| BI Asset Management Fondsmaeglerselskab A/S | 25,727 | $2.04M | 0.02% | +25,727 | New |
| Brinker Capital Investments, LLC | 24,870 | $1.97M | 0.02% | −36,474−59.5% | Reduced |
| Great West Life Assurance Co | 24,515 | $1.94M | 0.00% | +2,380+10.8% | Added |
| Inceptionr LLC | 24,251 | $1.92M | 0.47% | +7,430+44.2% | Added |
| Dana Investment Advisors, Inc. | 23,272 | $1.85M | 0.05% | +4,785+25.9% | Added |
| Wolverine Asset Management LLC | 22,340 | $1.77M | 0.02% | −475−2.1% | Reduced |
| AQR Capital Management LLC | 22,059 | $1.75M | 0.00% | −6,724−23.4% | Reduced |
| Teachers Retirement System of the State of Kentucky | 21,945 | $1.74M | 0.01% | −2,138−8.9% | Reduced |
| Cetera Investment Advisers | 21,808 | $1.73M | 0.00% | +10,528+93.3% | Added |
| Nicollet Investment Management, Inc. | 20,240 | $1.60M | 0.50% | +594+3.0% | Added |
| Amundi | 20,190 | $1.60M | 0.00% | −3,768−15.7% | Reduced |
| Profund Advisors LLC | 18,321 | $1.45M | 0.04% | −7,966−30.3% | Reduced |
| DnB Asset Management AS | 17,986 | $1.43M | 0.00% | −1,074−5.6% | Reduced |
| Gsa Capital Partners LLP | 17,306 | $1.37M | 0.09% | +14,134+445.6% | Added |
| Allstate Corp | 16,943 | $1.34M | 0.01% | −3,622−17.6% | Reduced |
| Graham Capital Management, L.P. | 16,717 | $1.33M | 0.04% | +16,717 | New |
| North Star Asset Management Inc | 16,560 | $1.31M | 0.05% | −50−0.3% | Reduced |
| BIT Capital GmbH | 16,300 | $1.29M | 0.04% | +16,300 | New |
| Allianz Asset Management GmbH | 16,129 | $1.28M | 0.00% | +3,528+28.0% | Added |
| Virtus Investment Advisers, Inc. | 15,870 | $1.26M | 0.29% | +5,425+51.9% | Added |
| Brown Advisory Inc | 15,846 | $1.26M | 0.00% | +741+4.9% | Added |
| Davy Global Fund Management Ltd | 15,819 | $1.25M | 0.08% | +1,430+9.9% | Added |
| Dark Forest Capital Management LP | 15,511 | $1.23M | 0.08% | +15,511 | New |
| AlphaCentric Advisors LLC | 15,430 | $1.22M | 1.04% | −4,157−21.2% | Reduced |
| Engineers Gate Manager LP | 14,840 | $1.18M | 0.02% | −118,987−88.9% | Reduced |
| Advisor Group Holdings, Inc. | 14,800 | $1.17M | 0.00% | +6,090+69.9% | Added |
| Bleakley Financial Group, LLC | 14,793 | $1.17M | 0.01% | +477+3.3% | Added |
| The PNC Financial Services Group, Inc. | 14,185 | $1.12M | 0.00% | +640+4.7% | Added |
| Truist Financial Corp | 14,068 | $1.12M | 0.00% | +1,222+9.5% | Added |
| Bamco Inc | 14,000 | $1.11M | 0.00% | −31,000−68.9% | Reduced |
| Summit Trail Advisors, LLC | 13,931 | $1.10M | 0.01% | +2,382+20.6% | Added |
| FORA Capital, LLC | 13,833 | $1.10M | 0.08% | −5,860−29.8% | Reduced |
| Oppenheimer Asset Management Inc. | 13,752 | $1.09M | 0.01% | +1,899+16.0% | Added |
| Dynasty Wealth Management, LLC | 13,661 | $1.08M | 0.01% | −419−3.0% | Reduced |
| Mitsubishi UFJ Trust & Banking Corp | 13,446 | $1.07M | 0.00% | +13,446 | New |
| Virginia Retirement Systems Et Al | 13,400 | $1.06M | 0.01% | +3,100+30.1% | Added |
| Westmount Partners, LLC | 12,961 | $1.03M | 0.23% | 00.0% | Unchanged |
| SBI Okasan Asset Management Co.Ltd. | 12,600 | $1.02M | 0.03% | 00.0% | Unchanged |
| Annis Gardner Whiting Capital Advisors, LLC | 12,801 | $1.01M | 0.15% | 00.0% | Unchanged |
| Man Group plc | 12,361 | $980.1K | 0.00% | −11,652−48.5% | Reduced |
| Arrowpoint Investment Partners (Singapore) Pte. Ltd. | 12,338 | $978.3K | 0.29% | −26,650−68.4% | Reduced |
| Federation des caisses Desjardins du Quebec | 12,017 | $952.8K | 0.00% | +2,012+20.1% | Added |
| JustInvest LLC | 11,933 | $946.2K | 0.01% | +519+4.5% | Added |
| Boothbay Fund Management, LLC | 11,808 | $936.3K | 0.02% | −64,763−84.6% | Reduced |
| Commerce Bank | 11,681 | $926.2K | 0.00% | +3,516+43.1% | Added |
| Amalgamated Bank | 11,519 | $913.0K | 0.01% | −535−4.4% | Reduced |
| Militia Capital Management LLC | 11,400 | $903.9K | 0.16% | +11,400 | New |
| Northwestern Mutual Wealth Management Co | 10,925 | $866.2K | 0.00% | −198−1.8% | Reduced |
| Horizon Kinetics Asset Management LLC | 10,904 | $864.6K | 0.01% | −524−4.6% | Reduced |
| Suvretta Capital Management, LLC | 10,800 | $856.3K | 0.02% | 00.0% | Unchanged |
| Evolve Private Wealth, LLC | 10,653 | $844.7K | 0.05% | +10,653 | New |
| Axq Capital, LP | 10,423 | $826.4K | 0.09% | +6,577+171.0% | Added |
| Swiss Life Asset Management Ltd | 10,275 | $814.7K | 0.00% | +1,100+12.0% | Added |
| Marex Group plc | 10,189 | $807.9K | 0.01% | +6,579+182.2% | Added |
| Vident Advisory, LLC | 10,187 | $807.7K | 0.01% | +698+7.4% | Added |
| Wiley Bros.-Aintree Capital, LLC | 10,184 | $807.5K | 0.00% | −725−6.6% | Reduced |
| Fifth Third Bancorp | 10,061 | $797.7K | 0.00% | −950−8.6% | Reduced |
| Assetmark, Inc | 9,939 | $788.1K | 0.00% | +365+3.8% | Added |
| Mackenzie Financial Corp | 9,289 | $736.5K | 0.00% | +5,494+144.8% | Added |
| Ensign Peak Advisors, Inc | 9,120 | $723.1K | 0.00% | −36,884−80.2% | Reduced |
| NewEdge Wealth, LLC | 8,977 | $711.8K | 0.01% | +8,977 | New |
| MetLife Investment Management | 8,776 | $695.8K | 0.00% | −448−4.9% | Reduced |
| iA Global Asset Management Inc. | 8,658 | $686.0K | 0.01% | +8,658 | New |
| Utah Retirement Systems | 8,577 | $680.1K | 0.01% | +277+3.3% | Added |
| Marshall Wace, LLP | 8,501 | $674.0K | 0.00% | −87,453−91.1% | Reduced |
| denkapparat Operations GmbH | 8,364 | $663.2K | 0.22% | 00.0% | Unchanged |
| Maryland State Retirement & Pension System | 8,343 | $661.5K | 0.01% | +963+13.0% | Added |
| Commonwealth Equity Services, LLC | 8,153 | $646.5K | 0.00% | +324+4.1% | Added |
| CWM Advisors, LLC | 8,127 | $644.4K | 0.03% | +8,127 | New |
| Plancorp, LLC | 11,128 | $631.5K | 0.02% | −80−0.7% | Reduced |
| Mirae Asset Global Investments Co., Ltd. | 7,867 | $623.8K | 0.00% | −1,162−12.9% | Reduced |
| Stratos Wealth Partners, LTD. | 7,801 | $618.5K | 0.01% | +86+1.1% | Added |
| Meeder Advisory Services, Inc. | 7,660 | $607.4K | 0.02% | +421+5.8% | Added |
| M&T Bank Corp | 7,510 | $595.4K | 0.00% | −161−2.1% | Reduced |
| Savant Capital, LLC | 7,476 | $587.6K | 0.00% | −985−11.6% | Reduced |
| Fiduciary Trust Co | 7,399 | $586.7K | 0.01% | 00.0% | Unchanged |
| Sectoral Asset Management Inc | 7,200 | $570.9K | 0.40% | 00.0% | Unchanged |
| O'Shaughnessy Asset Management, LLC | 7,166 | $568.2K | 0.00% | −521−6.8% | Reduced |
| Callan Family Office, LLC | 7,143 | $566.4K | 0.01% | +61+0.9% | Added |
| Silvercrest Asset Management Group LLC | 7,055 | $559.4K | 0.00% | +20.0% | Added |
| Mercer Global Advisors Inc | 6,918 | $548.4K | 0.00% | +622+9.9% | Added |
| PSP Research LLC | 6,800 | $539.2K | 0.29% | 00.0% | Unchanged |
| J. Safra Sarasin Holding AG | 6,751 | $535.3K | 0.01% | +320+5.0% | Added |
| Significant Wealth Partners LLC | 6,613 | $524.3K | 0.57% | −51−0.8% | Reduced |
| Group One Trading, L.P. | 6,493 | $514.8K | 0.01% | +4,601+243.2% | Added |
| US Bancorp | 6,366 | $504.8K | 0.00% | +1,319+26.1% | Added |
| Everence Capital Management Inc | 6,232 | $494.0K | 0.03% | 00.0% | Unchanged |
| Nykredit A/S | 6,154 | $488.0K | 0.00% | +6,154 | New |
| Janney Montgomery Scott LLC | 6,138 | $487.0K | 0.00% | +6,138 | New |