Ionis Pharmaceuticals Inc
IONS- Exchange
- Nasdaq
- Industry
- Pharmaceutical Preparations
- SEC CIK
- 0000874015
In the last 90 days, Ionis Pharmaceuticals Inc insiders filed 1 open-market purchase and 4 sales; 515 institutions reported holding it in 13F filings for Q2 2026, worth $14.3B in total; ARK Invest is the only superinvestor holding it.
13F holders, Q1 2026
Institutional positions in Ionis Pharmaceuticals Inc as of Mar 31, 2026. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 497
- +8 vs. Q4 2025
- Shares held
- 172.6M
- +19.1M (+12.5%) vs. Q4 2025
- Total value
- $13.0B
- +$828.1M (+6.8%) vs. Q4 2025
- New holders
- 73
- 179 more added
- Sold out
- 65
- 158 more reduced
5 institutions that held it in Q4 2025 haven't filed for Q1 2026 yet. Not filing isn't selling, so they aren't counted as sold out or in the changes above.
Compare with Q4 2025: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting IONS on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 515 | $14.3B |
| Q1 2026 | 497 | $13.0B |
| Q4 2025 | 494 | $13.5B |
| Q3 2025 | 437 | $11.0B |
| Q2 2025 | 363 | $6.67B |
| Q1 2025 | 344 | $5.03B |
| Q4 2024 | 356 | $5.61B |
| Q3 2024 | 354 | $6.31B |
| Q2 2024 | 357 | $6.83B |
| Q1 2024 | 361 | $6.17B |
| Q4 2023 | 365 | $7.21B |
| Q3 2023 | 312 | $6.35B |
| Q2 2023 | 305 | $5.60B |
| Q1 2023 | 315 | $4.69B |
| Q4 2022 | 339 | $4.93B |
| Q3 2022 | 350 | $5.59B |
| Q2 2022 | 351 | $4.61B |
| Q1 2022 | 333 | $4.63B |
| Q4 2021 | 341 | $3.75B |
| Q3 2021 | 326 | $4.08B |
| Q2 2021 | 338 | $4.96B |
| Q1 2021 | 365 | $5.55B |
Institutions, Q1 2026
Shares, value and share of portfolio for each institution holding Ionis Pharmaceuticals Inc; share changes are against Q4 2025.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| Colony Group, LLC | 165,544 | $12.4M | 0.01% | −16,273−9.0% | Reduced |
| DZ BANK AG Deutsche Zentral Genossenschafts Bank, Frankfurt am Main | 167,657 | $12.6M | 0.01% | 00.0% | Unchanged |
| Sector Gamma AS | 169,468 | $12.7M | 3.00% | −15,509−8.4% | Reduced |
| Rhumbline Advisers | 173,440 | $13.0M | 0.01% | −1,947−1.1% | Reduced |
| California State Teachers Retirement System | 176,485 | $13.3M | 0.01% | +32,312+22.4% | Added |
| HSBC Holdings PLC | 185,967 | $14.0M | 0.01% | +159,026+590.3% | Added |
| Wells Fargo & Company | 189,853 | $14.3M | 0.00% | −90,192−32.2% | Reduced |
| Jane Street Group, LLC | 191,818 | $14.4M | 0.02% | +161,347+529.5% | Added |
| CI Private Wealth, LLC | 196,599 | $14.8M | 0.02% | −19,839−9.2% | Reduced |
| Stifel Financial Corp | 196,703 | $14.8M | 0.01% | −2,160−1.1% | Reduced |
| Jump Financial, LLC | 206,675 | $15.5M | 0.23% | +206,675 | New |
| Trexquant Investment LP | 213,645 | $16.0M | 0.12% | +81,404+61.6% | Added |
| Handelsbanken Fonder AB | 213,911 | $16.1M | 0.05% | +166,000+346.5% | Added |
| Tocqueville Asset Management L.P. | 219,220 | $16.5M | 0.24% | +15,490+7.6% | Added |
| Universal- Beteiligungs- und Servicegesellschaft mbH | 219,652 | $16.5M | 0.03% | +780.0% | Added |
| Orion Investment Co | 225,015 | $16.9M | 5.38% | −146−0.1% | Reduced |
| ExodusPoint Capital Management, LP | 227,084 | $17.1M | 0.17% | +143,209+170.7% | Added |
| Raymond James Financial Inc | 235,121 | $17.7M | 0.01% | −22,089−8.6% | Reduced |
| J. Goldman & Co LP | 235,260 | $17.7M | 0.82% | +167,621+247.8% | Added |
| Davenport & Co LLC | 238,238 | $17.9M | 0.10% | +20,341+9.3% | Added |
| Zurich Insurance Group Ltd | 239,645 | $18.0M | 0.14% | −22,175−8.5% | Reduced |
| HRT Financial LP | 252,250 | $18.9M | 0.05% | +229,322+1,000.2% | Added |
| California Public Employees Retirement System | 255,485 | $19.2M | 0.01% | +42,117+19.7% | Added |
| Dimensional Fund Advisors LP | 267,215 | $20.1M | 0.00% | +91,180+51.8% | Added |
| TimesSquare Capital Management, LLC | 275,674 | $20.7M | 0.35% | +275,674 | New |
| ARK Investment Management LLCSuperinvestorARK Invest | 288,716 | $21.7M | 0.17% | −134,252−31.7% | Reduced |
| Barclays PLC | 289,874 | $21.8M | 0.01% | −552,997−65.6% | Reduced |
| Privium Fund Management B.V. | 290,024 | $21.8M | 4.53% | +49,200+20.4% | Added |
| Legal & General Group Plc | 294,679 | $22.1M | 0.01% | −30,469−9.4% | Reduced |
| Hudson Bay Capital Management LP | 295,100 | $22.2M | 0.13% | −179,900−37.9% | Reduced |
| Swiss National Bank | 304,500 | $22.9M | 0.01% | +6,000+2.0% | Added |
| Renaissance Technologies LLC | 305,549 | $22.9M | 0.04% | +81,942+36.6% | Added |
| Capital Research Global Investors | 323,015 | $24.3M | 0.00% | +323,015 | New |
| New York State Common Retirement Fund | 350,414 | $26.3M | 0.04% | +108,561+44.9% | Added |
| C WorldWide Group Holding A/S | 366,000 | $27.5M | 0.59% | 00.0% | Unchanged |
| Davern Capital Partners, LP | 386,903 | $29.1M | 7.97% | +148,426+62.2% | Added |
| Alliancebernstein L.P. | 400,669 | $31.7M | 0.01% | +58,820+17.2% | Added |
| D. E. Shaw & Co., Inc. | 429,599 | $32.3M | 0.03% | +96,796+29.1% | Added |
| Pinnacle Associates Ltd | 436,457 | $32.8M | 0.42% | −25,511−5.5% | Reduced |
| Neuberger Berman Group LLC | 443,272 | $33.3M | 0.03% | +335,228+310.3% | Added |
| First Trust Advisors LP | 468,363 | $35.2M | 0.03% | −56,876−10.8% | Reduced |
| Alyeska Investment Group, L.P. | 473,150 | $35.5M | 0.10% | −8,561−1.8% | Reduced |
| BNP Paribas Arbitrage, SA | 479,460 | $36.0M | 0.02% | +144,852+43.3% | Added |
| Candriam Luxembourg S.C.A. | 484,053 | $36.3M | 0.19% | −193,576−28.6% | Reduced |
| Boone Capital Management LLC | 500,522 | $37.6M | 11.51% | +82,689+19.8% | Added |
| Perceptive Advisors LLC | 504,000 | $37.8M | 0.75% | +504,000 | New |
| Bank of New York Mellon Corp | 514,617 | $38.6M | 0.01% | −23,269−4.3% | Reduced |
| Teacher Retirement System of Texas | 523,932 | $39.3M | 0.16% | +101,033+23.9% | Added |
| TD Asset Management Inc | 529,954 | $39.8M | 0.03% | −243,230−31.5% | Reduced |
| Eventide Asset Management, LLC | 575,000 | $43.2M | 0.71% | 00.0% | Unchanged |
| Eversept Partners, LP | 632,100 | $47.5M | 3.13% | +93,882+17.4% | Added |
| Nuveen, LLC | 648,496 | $48.7M | 0.01% | −12,273−1.9% | Reduced |
| Ameriprise Financial Inc | 660,144 | $49.6M | 0.01% | +61,396+10.3% | Added |
| Massachusetts Financial Services Co | 666,116 | $50.0M | 0.02% | −146,631−18.0% | Reduced |
| Voloridge Investment Management, LLC | 672,858 | $50.5M | 0.20% | +87,888+15.0% | Added |
| Squarepoint Ops LLC | 695,276 | $52.2M | 0.11% | +258,997+59.4% | Added |
| Arrowstreet Capital, Limited Partnership | 737,859 | $55.4M | 0.03% | −325,468−30.6% | Reduced |
| GW&K Investment Management, LLC | 779,349 | $58.5M | 0.52% | −7,319−0.9% | Reduced |
| Nomura Asset Management International Inc. | 785,281 | $59.0M | 0.10% | −79,611−9.2% | Reduced |
| UBS Group AG | 808,443 | $60.7M | 0.01% | −236,598−22.6% | Reduced |
| Groupama Asset Managment | 824,540 | $61.9M | 0.90% | +57,651+7.5% | Added |
| Polar Capital Holdings Plc | 829,511 | $62.3M | 0.27% | −503,913−37.8% | Reduced |
| Bank of America Corp | 840,598 | $63.1M | 0.00% | +57,019+7.3% | Added |
| Northern Trust Corp | 868,179 | $65.2M | 0.01% | +21,461+2.5% | Added |
| Connor, Clark & Lunn Investment Management Ltd. | 874,089 | $65.6M | 0.15% | −202,281−18.8% | Reduced |
| BNP PARIBAS ASSET MANAGEMENT Holding S.A. | 907,533 | $68.1M | 0.08% | −445,304−32.9% | Reduced |
| Citadel Advisors LLC | 942,534 | $70.8M | 0.05% | −1,192,102−55.8% | Reduced |
| Vanguard Fiduciary Trust Co | 1,024,377 | $76.9M | 0.02% | +1,024,377 | New |
| Morgan Stanley | 1,026,509 | $77.1M | 0.00% | +6,603+0.6% | Added |
| Millennium Management LLC | 1,051,506 | $79.0M | 0.06% | +958,244+1,027.5% | Added |
| Invesco Ltd. | 1,277,358 | $95.9M | 0.01% | +8,068+0.6% | Added |
| Summit Partners Public Asset Management, LLC | 1,404,033 | $105.4M | 4.88% | −58,673−4.0% | Reduced |
| Pictet Asset Management Holding SA | 1,434,995 | $107.1M | 0.11% | +16,504+1.2% | Added |
| UBS Asset Management Americas Inc | 1,475,632 | $110.8M | 0.02% | +87,065+6.3% | Added |
| Franklin Resources Inc | 1,575,023 | $118.3M | 0.03% | +253,678+19.2% | Added |
| Charles Schwab Investment Management Inc | 1,583,266 | $118.9M | 0.02% | +41,425+2.7% | Added |
| American Century Companies Inc | 1,663,803 | $124.9M | 0.06% | +46,697+2.9% | Added |
| Goldman Sachs Group Inc | 1,699,847 | $127.6M | 0.02% | +843,881+98.6% | Added |
| Bellevue Group AG | 1,818,665 | $136.6M | 3.25% | −2,983,534−62.1% | Reduced |
| Deep Track Capital, LP | 1,950,000 | $146.4M | 3.02% | +250,000+14.7% | Added |
| Deerfield Management Company, L.P. (Series C) | 1,979,669 | $148.7M | 1.75% | 00.0% | Unchanged |
| Baker Bros. Advisors LP | 2,047,727 | $153.8M | 0.88% | +255,886+14.3% | Added |
| Artisan Partners Limited Partnership | 2,058,308 | $154.6M | 0.25% | +876,892+74.2% | Added |
| Tweedy, Browne Co LLC | 2,275,625 | $170.9M | 13.57% | −189,305−7.7% | Reduced |
| JPMorgan Chase & Co | 2,363,567 | $171.4M | 0.01% | +58,775+2.6% | Added |
| Price T Rowe Associates Inc | 3,025,251 | $227.2M | 0.03% | +37,411+1.3% | Added |
| Royal Bank of Canada | 3,801,815 | $285.5M | 0.05% | +2,683,018+239.8% | Added |
| State Street Corp | 3,995,564 | $300.0M | 0.01% | +20,699+0.5% | Added |
| Geode Capital Management, LLC | 3,984,332 | $305.2M | 0.02% | +835,483+26.5% | Added |
| Two Sigma Investments, LP | 5,857,629 | $439.8M | 0.37% | +3,198,983+120.3% | Added |
| T. Rowe Price Investment Management, Inc. | 6,159,027 | $462.5M | 0.32% | −2,948,992−32.4% | Reduced |
| Wellington Management Group LLP | 6,391,816 | $480.0M | 0.09% | +131,491+2.1% | Added |
| Vanguard Capital Management LLC | 7,118,330 | $534.5M | 0.01% | +7,118,330 | New |
| Vanguard Portfolio Management LLC | 7,808,902 | $586.4M | 0.03% | +7,808,902 | New |
| BlackRock, Inc. | 10,442,476 | $784.1M | 0.01% | −205,387−1.9% | Reduced |
| Capital World Investors | 21,186,369 | $1.59B | 0.22% | +3,225,070+18.0% | Added |
| FMR LLC | 24,556,637 | $1.84B | 0.10% | +484,536+2.0% | Added |
| Two Sigma Advisers, LP | 0 | $0 | 0.00% | −3,052,111−100.0% | Sold out |
| Tri Locum Partners LP | 0 | $0 | 0.00% | −557,174−100.0% | Sold out |
| Balyasny Asset Management LLC | 0 | $0 | 0.00% | −120,577−100.0% | Sold out |