Ionis Pharmaceuticals Inc
IONS- Exchange
- Nasdaq
- Industry
- Pharmaceutical Preparations
- SEC CIK
- 0000874015
In the last 90 days, Ionis Pharmaceuticals Inc insiders filed 1 open-market purchase and 4 sales; 515 institutions reported holding it in 13F filings for Q2 2026, worth $14.3B in total; ARK Invest is the only superinvestor holding it.
13F holders, Q1 2026
Institutional positions in Ionis Pharmaceuticals Inc as of Mar 31, 2026. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 497
- +8 vs. Q4 2025
- Shares held
- 172.6M
- +19.1M (+12.5%) vs. Q4 2025
- Total value
- $13.0B
- +$828.1M (+6.8%) vs. Q4 2025
- New holders
- 73
- 179 more added
- Sold out
- 65
- 158 more reduced
5 institutions that held it in Q4 2025 haven't filed for Q1 2026 yet. Not filing isn't selling, so they aren't counted as sold out or in the changes above.
Compare with Q4 2025: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting IONS on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 515 | $14.3B |
| Q1 2026 | 497 | $13.0B |
| Q4 2025 | 494 | $13.5B |
| Q3 2025 | 437 | $11.0B |
| Q2 2025 | 363 | $6.67B |
| Q1 2025 | 344 | $5.03B |
| Q4 2024 | 356 | $5.61B |
| Q3 2024 | 354 | $6.31B |
| Q2 2024 | 357 | $6.83B |
| Q1 2024 | 361 | $6.17B |
| Q4 2023 | 365 | $7.21B |
| Q3 2023 | 312 | $6.35B |
| Q2 2023 | 305 | $5.60B |
| Q1 2023 | 315 | $4.69B |
| Q4 2022 | 339 | $4.93B |
| Q3 2022 | 350 | $5.59B |
| Q2 2022 | 351 | $4.61B |
| Q1 2022 | 333 | $4.63B |
| Q4 2021 | 341 | $3.75B |
| Q3 2021 | 326 | $4.08B |
| Q2 2021 | 338 | $4.96B |
| Q1 2021 | 365 | $5.55B |
Institutions, Q1 2026
Shares, value and share of portfolio for each institution holding Ionis Pharmaceuticals Inc; share changes are against Q4 2025.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| Wedmont Private Capital | 6,564 | $492.2K | 0.02% | +1,028+18.6% | Added |
| Significant Wealth Partners LLC | 6,664 | $500.4K | 0.62% | −100−1.5% | Reduced |
| PSP Research LLC | 6,800 | $510.6K | 0.36% | 00.0% | Unchanged |
| Principal Financial Group Inc | 7,019 | $527.1K | 0.00% | +3,680+110.2% | Added |
| Silvercrest Asset Management Group LLC | 7,053 | $529.6K | 0.00% | −189−2.6% | Reduced |
| Callan Family Office, LLC | 7,082 | $531.8K | 0.01% | −22−0.3% | Reduced |
| Meeder Advisory Services, Inc. | 7,239 | $543.6K | 0.02% | +83+1.2% | Added |
| Ground Swell Capital, LLC | 7,285 | $547.0K | 1.08% | +7,285 | New |
| Maryland State Retirement & Pension System | 7,380 | $554.2K | 0.01% | −904−10.9% | Reduced |
| ProShare Advisors LLC | 7,390 | $554.9K | 0.00% | +236+3.3% | Added |
| Fiduciary Trust Co | 7,399 | $555.6K | 0.01% | 00.0% | Unchanged |
| Cerity Partners LLC | 7,596 | $570.4K | 0.00% | −16,331−68.3% | Reduced |
| M&T Bank Corp | 7,671 | $575.5K | 0.00% | −479−5.9% | Reduced |
| O'Shaughnessy Asset Management, LLC | 7,687 | $577.2K | 0.00% | +655+9.3% | Added |
| Stratos Wealth Partners, LTD. | 7,715 | $579.3K | 0.01% | −25−0.3% | Reduced |
| Commonwealth Equity Services, LLC | 7,829 | $587.9K | 0.00% | −3,977−33.7% | Reduced |
| Commerce Bank | 8,165 | $613.1K | 0.00% | +54+0.7% | Added |
| Sectoral Asset Management Inc | 7,200 | $617.2K | 0.51% | −1,165−13.9% | Reduced |
| Utah Retirement Systems | 8,300 | $623.2K | 0.01% | 00.0% | Unchanged |
| denkapparat Operations GmbH | 8,364 | $628.1K | 0.26% | 00.0% | Unchanged |
| Savant Capital, LLC | 8,461 | $635.3K | 0.00% | +1,272+17.7% | Added |
| Advisor Group Holdings, Inc. | 8,710 | $654.0K | 0.00% | −2,936−25.2% | Reduced |
| Aigen Investment Management, LP | 8,790 | $660.0K | 0.17% | −71−0.8% | Reduced |
| Mirae Asset Global Investments Co., Ltd. | 9,029 | $678.0K | 0.00% | +763+9.2% | Added |
| Swiss Life Asset Management Ltd | 9,175 | $689.0K | 0.00% | +2,272+32.9% | Added |
| MetLife Investment Management | 9,224 | $692.6K | 0.00% | −450−4.7% | Reduced |
| Vident Advisory, LLC | 9,489 | $712.5K | 0.01% | −746−7.3% | Reduced |
| Assetmark, Inc | 9,574 | $718.9K | 0.00% | +924+10.7% | Added |
| Thrivent Financial for Lutherans | 9,962 | $748.0K | 0.00% | 00.0% | Unchanged |
| Federation des caisses Desjardins du Quebec | 10,005 | $751.3K | 0.00% | −2,548−20.3% | Reduced |
| Virginia Retirement Systems Et Al | 10,300 | $773.4K | 0.01% | −300−2.8% | Reduced |
| Virtus Investment Advisers, Inc. | 10,445 | $784.3K | 0.22% | +1,991+23.6% | Added |
| Suvretta Capital Management, LLC | 10,800 | $811.0K | 0.02% | 00.0% | Unchanged |
| Wiley Bros.-Aintree Capital, LLC | 10,909 | $819.2K | 0.00% | +1,186+12.2% | Added |
| Fifth Third Bancorp | 11,011 | $826.8K | 0.00% | +3,123+39.6% | Added |
| Capstone Capital Management Ltd | 21,447 | $832.4K | 0.84% | +21,447 | New |
| Northwestern Mutual Wealth Management Co | 11,123 | $835.2K | 0.00% | −875−7.3% | Reduced |
| Plancorp, LLC | 11,208 | $842.5K | 0.02% | 00.0% | Unchanged |
| Cetera Investment Advisers | 11,280 | $847.0K | 0.00% | +424+3.9% | Added |
| JustInvest LLC | 11,414 | $857.1K | 0.01% | −1,047−8.4% | Reduced |
| Horizon Kinetics Asset Management LLC | 11,428 | $858.1K | 0.01% | −524−4.4% | Reduced |
| Summit Trail Advisors, LLC | 11,549 | $867.2K | 0.01% | +1,606+16.2% | Added |
| Oppenheimer Asset Management Inc. | 11,853 | $890.0K | 0.01% | +589+5.2% | Added |
| Amalgamated Bank | 12,054 | $905.0K | 0.01% | −401−3.2% | Reduced |
| SBI Okasan Asset Management Co.Ltd. | 12,600 | $913.8K | 0.04% | 00.0% | Unchanged |
| Susquehanna International Group, LLP | 12,359 | $928.0K | 0.00% | −20,145−62.0% | Reduced |
| Allianz Asset Management GmbH | 12,601 | $946.2K | 0.00% | −4,115−24.6% | Reduced |
| Annis Gardner Whiting Capital Advisors, LLC | 12,801 | $961.2K | 0.15% | 00.0% | Unchanged |
| Highland Capital Management, LLC | 12,819 | $962.6K | 0.05% | +12,819 | New |
| Truist Financial Corp | 12,846 | $964.6K | 0.00% | +187+1.5% | Added |
| Westmount Partners, LLC | 12,961 | $973.2K | 0.24% | 00.0% | Unchanged |
| The PNC Financial Services Group, Inc. | 13,545 | $1.02M | 0.00% | −271−2.0% | Reduced |
| Dynasty Wealth Management, LLC | 14,080 | $1.06M | 0.01% | +90+0.6% | Added |
| Canada Pension Plan Investment Board | 14,100 | $1.06M | 0.00% | +14,100 | New |
| Bleakley Financial Group, LLC | 14,316 | $1.07M | 0.02% | +441+3.2% | Added |
| Davy Global Fund Management Ltd | 14,389 | $1.08M | 0.08% | −779−5.1% | Reduced |
| M&G Plc | 14,423 | $1.08M | 0.01% | 00.0% | Unchanged |
| LMR Partners LLP | 15,000 | $1.13M | 0.01% | 00.0% | Unchanged |
| Brown Advisory Inc | 15,105 | $1.13M | 0.00% | +140+0.9% | Added |
| Caption Management, LLC | 15,591 | $1.17M | 0.06% | +15,591 | New |
| Public Employees Retirement Association of Colorado | 15,589 | $1.17M | 0.00% | 00.0% | Unchanged |
| North Star Asset Management Inc | 16,610 | $1.25M | 0.05% | 00.0% | Unchanged |
| Inceptionr LLC | 16,821 | $1.26M | 0.30% | −1,029−5.8% | Reduced |
| Dana Investment Advisors, Inc. | 18,487 | $1.39M | 0.04% | +461+2.6% | Added |
| DnB Asset Management AS | 19,060 | $1.43M | 0.01% | +4,222+28.5% | Added |
| AlphaCentric Advisors LLC | 19,587 | $1.47M | 1.47% | +1,064+5.7% | Added |
| Nicollet Investment Management, Inc. | 19,646 | $1.48M | 0.51% | −877−4.3% | Reduced |
| FORA Capital, LLC | 19,693 | $1.48M | 0.11% | +19,693 | New |
| Calamos Advisors LLC | 19,781 | $1.49M | 0.01% | −13,408−40.4% | Reduced |
| Legato Capital Management LLC | 19,840 | $1.49M | 0.14% | +13,685+222.3% | Added |
| Landscape Capital Management, L.L.C. | 20,146 | $1.51M | 0.10% | −4,009−16.6% | Reduced |
| Readystate Asset Management LP | 20,436 | $1.53M | 0.09% | +20,436 | New |
| Allstate Corp | 20,565 | $1.54M | 0.02% | +20,565 | New |
| EAM Investors, LLC | 20,608 | $1.55M | 0.18% | −33,306−61.8% | Reduced |
| Great West Life Assurance Co | 22,135 | $1.67M | 0.00% | +1,241+5.9% | Added |
| Wolverine Asset Management LLC | 22,815 | $1.71M | 0.03% | −7,700−25.2% | Reduced |
| Voleon Capital Management LP | 23,047 | $1.73M | 0.04% | +18,759+437.5% | Added |
| Natixis Advisors, L.P. | 23,721 | $1.78M | 0.00% | +1,830+8.4% | Added |
| Amundi | 23,958 | $1.80M | 0.00% | −436,989−94.8% | Reduced |
| Man Group plc | 24,013 | $1.80M | 0.00% | −142,029−85.5% | Reduced |
| Teachers Retirement System of the State of Kentucky | 24,083 | $1.81M | 0.01% | 00.0% | Unchanged |
| Lazard Asset Management LLC | 25,410 | $1.91M | 0.00% | −20,992−45.2% | Reduced |
| Jones Financial Companies LLLP | 26,723 | $1.93M | 0.00% | +20,240+312.2% | Added |
| Qsemble Capital Management, LP | 25,758 | $1.93M | 0.15% | −1,821−6.6% | Reduced |
| Florida Financial Advisors, LLC | 25,886 | $1.94M | 0.47% | +25,886 | New |
| Jain Global LLC | 26,285 | $1.97M | 0.03% | −329,974−92.6% | Reduced |
| Profund Advisors LLC | 26,287 | $1.97M | 0.07% | −386−1.4% | Reduced |
| Xponance, Inc. | 26,384 | $1.98M | 0.01% | +3,443+15.0% | Added |
| StemPoint Capital LP | 26,385 | $1.98M | 0.38% | +26,385 | New |
| Bank of Montreal | 26,585 | $2.00M | 0.00% | −9,777−26.9% | Reduced |
| Entropy Technologies, LP | 27,207 | $2.04M | 0.09% | +27,207 | New |
| DeepCurrents Investment Group LLC | 27,422 | $2.06M | 0.08% | +27,422 | New |
| Worldquant Millennium Advisors LLC | 27,924 | $2.10M | 0.01% | +10,514+60.4% | Added |
| Mutual of America Capital Management LLC | 28,126 | $2.11M | 0.02% | −3,333−10.6% | Reduced |
| Fred Alger Management, LLC | 28,452 | $2.14M | 0.01% | −9,971−26.0% | Reduced |
| STRS Ohio | 28,782 | $2.16M | 0.01% | +24,994+659.8% | Added |
| AQR Capital Management LLC | 28,783 | $2.16M | 0.00% | +10,021+53.4% | Added |
| Kornitzer Capital Management Inc | 29,105 | $2.19M | 0.05% | 00.0% | Unchanged |
| Prelude Capital Management, LLC | 29,658 | $2.23M | 0.17% | −2,823−8.7% | Reduced |
| KBC Group NV | 30,213 | $2.27M | 0.01% | +21,161+233.8% | Added |