Ionis Pharmaceuticals Inc
IONS- Exchange
- Nasdaq
- Industry
- Pharmaceutical Preparations
- SEC CIK
- 0000874015
In the last 90 days, Ionis Pharmaceuticals Inc insiders filed 1 open-market purchase and 4 sales; 515 institutions reported holding it in 13F filings for Q2 2026, worth $14.3B in total; ARK Invest is the only superinvestor holding it.
13F holders, Q4 2025
Institutional positions in Ionis Pharmaceuticals Inc as of Dec 31, 2025. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 494
- +68 vs. Q3 2025
- Shares held
- 170.2M
- +2.78M (+1.7%) vs. Q3 2025
- Total value
- $13.5B
- +$2.50B (+22.8%) vs. Q3 2025
- New holders
- 112
- 167 more added
- Sold out
- 44
- 142 more reduced
11 institutions that held it in Q3 2025 haven't filed for Q4 2025 yet. Not filing isn't selling, so they aren't counted as sold out or in the changes above.
Compare with Q3 2025: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting IONS on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 515 | $14.3B |
| Q1 2026 | 497 | $13.0B |
| Q4 2025 | 494 | $13.5B |
| Q3 2025 | 437 | $11.0B |
| Q2 2025 | 363 | $6.67B |
| Q1 2025 | 344 | $5.03B |
| Q4 2024 | 356 | $5.61B |
| Q3 2024 | 354 | $6.31B |
| Q2 2024 | 357 | $6.83B |
| Q1 2024 | 361 | $6.17B |
| Q4 2023 | 365 | $7.21B |
| Q3 2023 | 312 | $6.35B |
| Q2 2023 | 305 | $5.60B |
| Q1 2023 | 315 | $4.69B |
| Q4 2022 | 339 | $4.93B |
| Q3 2022 | 350 | $5.59B |
| Q2 2022 | 351 | $4.61B |
| Q1 2022 | 333 | $4.63B |
| Q4 2021 | 341 | $3.75B |
| Q3 2021 | 326 | $4.08B |
| Q2 2021 | 338 | $4.96B |
| Q1 2021 | 365 | $5.55B |
Institutions, Q4 2025
Shares, value and share of portfolio for each institution holding Ionis Pharmaceuticals Inc; share changes are against Q3 2025.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| Manufacturers Life Insurance Company, The | 153,241 | $12.1M | 0.01% | +55,218+56.3% | Added |
| CenterBook Partners LP | 153,949 | $12.2M | 0.60% | +153,949 | New |
| Rhenman & Partners Asset Management AB | 158,500 | $12.5M | 1.17% | −151,500−48.9% | Reduced |
| Sicart Associates LLC | 163,557 | $12.9M | 3.43% | −761−0.5% | Reduced |
| Man Group plc | 166,042 | $13.1M | 0.03% | −167,778−50.3% | Reduced |
| DZ BANK AG Deutsche Zentral Genossenschafts Bank, Frankfurt am Main | 167,657 | $13.3M | 0.01% | +167,657 | New |
| Rhumbline Advisers | 175,387 | $13.9M | 0.01% | −6,674−3.7% | Reduced |
| Dimensional Fund Advisors LP | 176,035 | $13.9M | 0.00% | +133,818+317.0% | Added |
| Colony Group, LLC | 181,817 | $14.4M | 0.02% | +181,817 | New |
| Sector Gamma AS | 184,977 | $14.6M | 3.34% | −85,986−31.7% | Reduced |
| Stifel Financial Corp | 198,863 | $15.7M | 0.01% | −3,765−1.9% | Reduced |
| Ikarian Capital, LLC | 202,038 | $16.0M | 2.07% | −213,125−51.3% | Reduced |
| Tocqueville Asset Management L.P. | 203,730 | $16.1M | 0.24% | +10,685+5.5% | Added |
| California Public Employees Retirement System | 213,368 | $16.9M | 0.01% | −2,477−1.1% | Reduced |
| CI Private Wealth, LLC | 216,438 | $17.1M | 0.02% | +209,848+3,184.3% | Added |
| Davenport & Co LLC | 217,897 | $17.2M | 0.09% | +155,334+248.3% | Added |
| Universal- Beteiligungs- und Servicegesellschaft mbH | 219,574 | $17.4M | 0.03% | +22,140+11.2% | Added |
| Renaissance Technologies LLC | 223,607 | $17.7M | 0.03% | −263,107−54.1% | Reduced |
| Orion Investment Co | 225,161 | $17.8M | 5.45% | +456+0.2% | Added |
| Davern Capital Partners, LP | 238,477 | $18.9M | 6.10% | +238,477 | New |
| Privium Fund Management B.V. | 240,824 | $19.1M | 3.51% | −8,070−3.2% | Reduced |
| New York State Common Retirement Fund | 241,853 | $19.1M | 0.03% | +73,631+43.8% | Added |
| Marshall Wace, LLP | 256,933 | $20.3M | 0.02% | −701,896−73.2% | Reduced |
| Raymond James Financial Inc | 257,210 | $20.3M | 0.01% | +16,786+7.0% | Added |
| Zurich Insurance Group Ltd | 261,820 | $20.7M | 0.14% | +261,820 | New |
| Wells Fargo & Company | 280,045 | $22.2M | 0.00% | −5,248−1.8% | Reduced |
| Swiss National Bank | 298,500 | $23.6M | 0.01% | +5,400+1.8% | Added |
| Norges Bank | 320,160 | $25.3M | 0.00% | +320,160 | New |
| Legal & General Group Plc | 325,148 | $25.7M | 0.01% | +5,583+1.7% | Added |
| D. E. Shaw & Co., Inc. | 332,803 | $26.3M | 0.02% | −298,135−47.3% | Reduced |
| BNP Paribas Arbitrage, SA | 334,608 | $26.5M | 0.02% | −48,618−12.7% | Reduced |
| Alliancebernstein L.P. | 341,849 | $27.0M | 0.01% | +287,587+530.0% | Added |
| Jain Global LLC | 356,259 | $28.2M | 0.28% | +130,520+57.8% | Added |
| C WorldWide Group Holding A/S | 366,000 | $29.0M | 0.51% | −60,000−14.1% | Reduced |
| Boone Capital Management LLC | 417,833 | $33.1M | 10.37% | 00.0% | Unchanged |
| Teacher Retirement System of Texas | 422,899 | $33.5M | 0.12% | −51,046−10.8% | Reduced |
| ARK Investment Management LLCSuperinvestorARK Invest | 422,968 | $33.5M | 0.22% | −208,247−33.0% | Reduced |
| Squarepoint Ops LLC | 436,279 | $34.5M | 0.07% | +52,487+13.7% | Added |
| Amundi | 460,947 | $36.5M | 0.01% | +359,416+354.0% | Added |
| Pinnacle Associates Ltd | 461,968 | $36.5M | 0.47% | −19,783−4.1% | Reduced |
| Hudson Bay Capital Management LP | 475,000 | $37.6M | 0.22% | −40,000−7.8% | Reduced |
| Alyeska Investment Group, L.P. | 481,711 | $38.1M | 0.11% | +170,453+54.8% | Added |
| First Trust Advisors LP | 525,239 | $41.6M | 0.03% | +450,015+598.2% | Added |
| Bank of New York Mellon Corp | 537,886 | $42.6M | 0.01% | +5,772+1.1% | Added |
| Eversept Partners, LP | 538,218 | $42.6M | 2.39% | −443−0.1% | Reduced |
| Tri Locum Partners LP | 557,174 | $44.1M | 5.72% | +557,174 | New |
| Eventide Asset Management, LLC | 575,000 | $45.5M | 0.71% | +575,000 | New |
| Voloridge Investment Management, LLC | 584,970 | $46.3M | 0.16% | −218,077−27.2% | Reduced |
| Ameriprise Financial Inc | 598,748 | $47.4M | 0.01% | −167,074−21.8% | Reduced |
| Nuveen, LLC | 660,769 | $52.3M | 0.01% | +245,151+59.0% | Added |
| Candriam Luxembourg S.C.A. | 677,629 | $53.6M | 0.27% | +66,392+10.9% | Added |
| Groupama Asset Managment | 766,889 | $60.7M | 0.89% | +205,112+36.5% | Added |
| TD Asset Management Inc | 773,184 | $61.2M | 0.05% | −187,088−19.5% | Reduced |
| Bank of America Corp | 783,579 | $62.0M | 0.00% | −71,716−8.4% | Reduced |
| GW&K Investment Management, LLC | 786,668 | $62.2M | 0.54% | +522,661+198.0% | Added |
| Massachusetts Financial Services Co | 812,747 | $64.3M | 0.02% | −49,846−5.8% | Reduced |
| Barclays PLC | 842,871 | $66.7M | 0.03% | +128,823+18.0% | Added |
| Northern Trust Corp | 846,718 | $67.0M | 0.01% | +1,775+0.2% | Added |
| Nomura Holdings Inc | 848,815 | $67.1M | 0.19% | +115,417+15.7% | Added |
| Goldman Sachs Group Inc | 855,966 | $67.7M | 0.01% | +78,396+10.1% | Added |
| Nomura Asset Management International Inc. | 864,892 | $68.4M | 0.10% | +864,892 | New |
| Morgan Stanley | 1,019,906 | $80.7M | 0.00% | −160,410−13.6% | Reduced |
| UBS Group AG | 1,045,041 | $82.7M | 0.02% | −1,949−0.2% | Reduced |
| Arrowstreet Capital, Limited Partnership | 1,063,327 | $84.1M | 0.05% | +433,191+68.7% | Added |
| Connor, Clark & Lunn Investment Management Ltd. | 1,076,370 | $85.2M | 0.22% | +198,215+22.6% | Added |
| Royal Bank of Canada | 1,118,797 | $88.5M | 0.02% | −107,827−8.8% | Reduced |
| Artisan Partners Limited Partnership | 1,181,416 | $93.5M | 0.14% | +291,344+32.7% | Added |
| Invesco Ltd. | 1,269,290 | $100.4M | 0.01% | +750,220+144.5% | Added |
| Franklin Resources Inc | 1,321,345 | $104.5M | 0.03% | +1,314,752+19,941.6% | Added |
| Polar Capital Holdings Plc | 1,333,424 | $105.5M | 0.48% | +299,802+29.0% | Added |
| BNP PARIBAS ASSET MANAGEMENT Holding S.A. | 1,352,837 | $107.0M | 0.12% | +293,116+27.7% | Added |
| UBS Asset Management Americas Inc | 1,388,567 | $109.8M | 0.02% | +234,401+20.3% | Added |
| Pictet Asset Management Holding SA | 1,418,491 | $112.5M | 0.11% | +25,367+1.8% | Added |
| Summit Partners Public Asset Management, LLC | 1,462,706 | $115.7M | 3.26% | +712,706+95.0% | Added |
| Charles Schwab Investment Management Inc | 1,541,841 | $122.0M | 0.02% | +21,890+1.4% | Added |
| American Century Companies Inc | 1,617,106 | $127.9M | 0.06% | +244,881+17.8% | Added |
| Deep Track Capital, LP | 1,700,000 | $134.5M | 3.07% | −2,108,144−55.4% | Reduced |
| Baker Bros. Advisors LP | 1,791,841 | $141.8M | 0.83% | +1,225,043+216.1% | Added |
| Deerfield Management Company, L.P. (Series C) | 1,979,669 | $156.6M | 2.01% | 00.0% | Unchanged |
| Citadel Advisors LLC | 2,134,636 | $168.9M | 0.11% | −267,429−11.1% | Reduced |
| JPMorgan Chase & Co | 2,304,792 | $182.3M | 0.01% | +1,760,324+323.3% | Added |
| Tweedy, Browne Co LLC | 2,464,930 | $195.0M | 15.74% | −436,286−15.0% | Reduced |
| Two Sigma Investments, LP | 2,658,646 | $210.3M | 0.31% | +1,082,703+68.7% | Added |
| Price T Rowe Associates Inc | 2,987,840 | $236.4M | 0.03% | +258,155+9.5% | Added |
| Two Sigma Advisers, LP | 3,052,111 | $241.5M | 0.47% | +979,000+47.2% | Added |
| Geode Capital Management, LLC | 3,148,849 | $249.2M | 0.02% | +82,560+2.7% | Added |
| State Street Corp | 3,974,865 | $314.5M | 0.01% | −413,786−9.4% | Reduced |
| Bellevue Group AG | 4,802,199 | $379.9M | 7.20% | −1,442,252−23.1% | Reduced |
| Wellington Management Group LLP | 6,260,325 | $495.3M | 0.09% | −328,486−5.0% | Reduced |
| T. Rowe Price Investment Management, Inc. | 9,108,019 | $720.5M | 0.45% | −4,048,910−30.8% | Reduced |
| BlackRock, Inc. | 10,647,863 | $842.4M | 0.01% | +199,923+1.9% | Added |
| Vanguard Group Inc | 16,440,459 | $1.30B | 0.02% | −41,271−0.3% | Reduced |
| Capital World Investors | 17,961,299 | $1.42B | 0.19% | +5,238,571+41.2% | Added |
| FMR LLC | 24,072,101 | $1.90B | 0.10% | +383,063+1.6% | Added |
| Macquarie Group Ltd | 0 | $0 | 0.00% | −1,131,936−100.0% | Sold out |
| Vestal Point Capital, LP | 0 | $0 | 0.00% | −1,075,000−100.0% | Sold out |
| Tang Capital Management LLC | 0 | $0 | 0.00% | −550,000−100.0% | Sold out |
| Schonfeld Strategic Advisors LLC | 0 | $0 | 0.00% | −200,839−100.0% | Sold out |
| Sovran Advisors, LLC | 0 | $0 | 0.00% | −150,856−100.0% | Sold out |
| Capricorn Fund Managers Ltd | 0 | $0 | 0.00% | −162,800−100.0% | Sold out |