Ionis Pharmaceuticals Inc
IONS- Exchange
- Nasdaq
- Industry
- Pharmaceutical Preparations
- SEC CIK
- 0000874015
In the last 90 days, Ionis Pharmaceuticals Inc insiders filed 1 open-market purchase and 4 sales; 515 institutions reported holding it in 13F filings for Q2 2026, worth $14.3B in total; ARK Invest is the only superinvestor holding it.
13F holders, Q4 2025
Institutional positions in Ionis Pharmaceuticals Inc as of Dec 31, 2025. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 494
- +68 vs. Q3 2025
- Shares held
- 170.2M
- +2.78M (+1.7%) vs. Q3 2025
- Total value
- $13.5B
- +$2.50B (+22.8%) vs. Q3 2025
- New holders
- 112
- 167 more added
- Sold out
- 44
- 142 more reduced
11 institutions that held it in Q3 2025 haven't filed for Q4 2025 yet. Not filing isn't selling, so they aren't counted as sold out or in the changes above.
Compare with Q3 2025: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting IONS on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 515 | $14.3B |
| Q1 2026 | 497 | $13.0B |
| Q4 2025 | 494 | $13.5B |
| Q3 2025 | 437 | $11.0B |
| Q2 2025 | 363 | $6.67B |
| Q1 2025 | 344 | $5.03B |
| Q4 2024 | 356 | $5.61B |
| Q3 2024 | 354 | $6.31B |
| Q2 2024 | 357 | $6.83B |
| Q1 2024 | 361 | $6.17B |
| Q4 2023 | 365 | $7.21B |
| Q3 2023 | 312 | $6.35B |
| Q2 2023 | 305 | $5.60B |
| Q1 2023 | 315 | $4.69B |
| Q4 2022 | 339 | $4.93B |
| Q3 2022 | 350 | $5.59B |
| Q2 2022 | 351 | $4.61B |
| Q1 2022 | 333 | $4.63B |
| Q4 2021 | 341 | $3.75B |
| Q3 2021 | 326 | $4.08B |
| Q2 2021 | 338 | $4.96B |
| Q1 2021 | 365 | $5.55B |
Institutions, Q4 2025
Shares, value and share of portfolio for each institution holding Ionis Pharmaceuticals Inc; share changes are against Q3 2025.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| Natixis | 6,087 | $481.5K | 0.00% | −139,199−95.8% | Reduced |
| Regions Financial Corp | 6,089 | $481.7K | 0.00% | +2,289+60.2% | Added |
| Legato Capital Management LLC | 6,155 | $486.9K | 0.04% | −11,145−64.4% | Reduced |
| Jones Financial Companies LLLP | 6,483 | $512.9K | 0.00% | −351−5.1% | Reduced |
| Coldstream Capital Management Inc | 6,619 | $523.6K | 0.01% | +2,140+47.8% | Added |
| Significant Wealth Partners LLC | 6,764 | $535.1K | 0.60% | −8,203−54.8% | Reduced |
| Everence Capital Management Inc | 6,770 | $536.0K | 0.03% | 00.0% | Unchanged |
| PSP Research LLC | 6,800 | $537.9K | 0.47% | +6,800 | New |
| Swiss Life Asset Management Ltd | 6,903 | $546.1K | 0.00% | +76+1.1% | Added |
| O'Shaughnessy Asset Management, LLC | 7,032 | $556.3K | 0.00% | +1,735+32.8% | Added |
| Callan Family Office, LLC | 7,104 | $562.0K | 0.01% | +7,104 | New |
| ProShare Advisors LLC | 7,154 | $566.0K | 0.00% | +1,476+26.0% | Added |
| Meeder Advisory Services, Inc. | 7,156 | $566.1K | 0.02% | +386+5.7% | Added |
| Savant Capital, LLC | 7,189 | $568.7K | 0.00% | −48−0.7% | Reduced |
| Silvercrest Asset Management Group LLC | 7,242 | $572.9K | 0.00% | +124+1.7% | Added |
| Fiduciary Trust Co | 7,399 | $585.3K | 0.01% | +1,022+16.0% | Added |
| Graham Capital Management, L.P. | 7,596 | $600.9K | 0.02% | −9,567−55.7% | Reduced |
| Stratos Wealth Partners, LTD. | 7,740 | $612.3K | 0.01% | −24−0.3% | Reduced |
| Persistent Asset Partners Ltd | 7,807 | $617.6K | 0.30% | +7,807 | New |
| Fifth Third Bancorp | 7,888 | $624.0K | 0.00% | −56−0.7% | Reduced |
| Commerce Bank | 8,111 | $641.7K | 0.00% | +504+6.6% | Added |
| M&T Bank Corp | 8,150 | $644.1K | 0.00% | +2,140+35.6% | Added |
| Mirae Asset Global Investments Co., Ltd. | 8,266 | $653.9K | 0.00% | +2,104+34.1% | Added |
| Maryland State Retirement & Pension System | 8,284 | $655.3K | 0.01% | 00.0% | Unchanged |
| Utah Retirement Systems | 8,300 | $656.6K | 0.01% | 00.0% | Unchanged |
| denkapparat Operations GmbH | 8,364 | $661.7K | 0.36% | −1,604−16.1% | Reduced |
| Sectoral Asset Management Inc | 8,365 | $661.8K | 0.53% | −840−9.1% | Reduced |
| Virtus Investment Advisers, Inc. | 8,454 | $668.8K | 0.18% | −4,022−32.2% | Reduced |
| Wealth Enhancement Advisory Services, LLC | 8,256 | $672.8K | 0.00% | +817+11.0% | Added |
| NEOS Investment Management LLC | 8,557 | $676.9K | 0.00% | −3,749−30.5% | Reduced |
| Tema ETFs LLC | 8,557 | $676.9K | 0.05% | −3,749−30.5% | Reduced |
| Assetmark, Inc | 8,650 | $684.3K | 0.00% | +8,575+11,433.3% | Added |
| Aigen Investment Management, LP | 8,861 | $701.0K | 0.16% | −4,717−34.7% | Reduced |
| KBC Group NV | 9,052 | $716.0K | 0.00% | +4,353+92.6% | Added |
| Intech Investment Management LLC | 9,602 | $759.6K | 0.01% | +9,602 | New |
| Two Sigma Securities, LLC | 9,649 | $763.3K | 0.10% | +9,649 | New |
| MetLife Investment Management | 9,674 | $765.3K | 0.00% | +246+2.6% | Added |
| Wiley Bros.-Aintree Capital, LLC | 9,723 | $769.2K | 0.00% | −2,940−23.2% | Reduced |
| Ares Systematic Credit Ltd | 9,916 | $784.5K | 0.64% | +9,916 | New |
| Summit Trail Advisors, LLC | 9,943 | $786.6K | 0.01% | +3,738+60.2% | Added |
| Thrivent Financial for Lutherans | 9,962 | $788.0K | 0.00% | 00.0% | Unchanged |
| Cypress Capital, LLC | 10,000 | $791.1K | 0.22% | 00.0% | Unchanged |
| Vident Advisory, LLC | 10,235 | $809.7K | 0.01% | −1,316−11.4% | Reduced |
| Blueshift Asset Management, LLC | 10,443 | $826.1K | 0.24% | −1,017−8.9% | Reduced |
| Virginia Retirement Systems Et Al | 10,600 | $838.6K | 0.00% | +10,600 | New |
| Suvretta Capital Management, LLC | 10,800 | $854.4K | 0.02% | 00.0% | Unchanged |
| Cetera Investment Advisers | 10,856 | $858.8K | 0.00% | +3,983+58.0% | Added |
| Baader Bank INC | 11,097 | $865.8K | 0.07% | +869+8.5% | Added |
| Plancorp, LLC | 11,208 | $886.7K | 0.03% | 00.0% | Unchanged |
| Oppenheimer Asset Management Inc. | 11,264 | $891.1K | 0.01% | +11,264 | New |
| Advisor Group Holdings, Inc. | 11,646 | $921.3K | 0.00% | +1,479+14.5% | Added |
| Commonwealth Equity Services, LLC | 11,806 | $934.0K | 0.00% | −1,543−11.6% | Reduced |
| Horizon Kinetics Asset Management LLC | 11,952 | $945.5K | 0.01% | −524−4.2% | Reduced |
| Northwestern Mutual Wealth Management Co | 11,998 | $949.2K | 0.00% | −784−6.1% | Reduced |
| Amalgamated Bank | 12,455 | $985.0K | 0.01% | +260+2.1% | Added |
| JustInvest LLC | 12,461 | $985.8K | 0.01% | +371+3.1% | Added |
| Federation des caisses Desjardins du Quebec | 12,553 | $993.1K | 0.00% | +12,553 | New |
| Truist Financial Corp | 12,659 | $1.00M | 0.00% | +7,847+163.1% | Added |
| Dark Forest Capital Management LP | 12,691 | $1.00M | 0.05% | −33,401−72.5% | Reduced |
| SBI Okasan Asset Management Co.Ltd. | 12,600 | $1.01M | 0.06% | +12,600 | New |
| Annis Gardner Whiting Capital Advisors, LLC | 12,801 | $1.01M | 0.19% | 00.0% | Unchanged |
| Westmount Partners, LLC | 12,961 | $1.03M | 0.26% | 00.0% | Unchanged |
| Lighthouse Investment Partners, LLC | 13,082 | $1.03M | 0.03% | +13,082 | New |
| Friedenthal Financial | 13,115 | $1.04M | 0.53% | +13,115 | New |
| Cinctive Capital Management LP | 13,726 | $1.09M | 0.06% | −160,093−92.1% | Reduced |
| The PNC Financial Services Group, Inc. | 13,816 | $1.09M | 0.00% | +1,703+14.1% | Added |
| Bleakley Financial Group, LLC | 13,875 | $1.10M | 0.02% | −30.0% | Reduced |
| Dynasty Wealth Management, LLC | 13,990 | $1.11M | 0.01% | −351−2.4% | Reduced |
| M&G Plc | 14,423 | $1.14M | 0.01% | +14,423 | New |
| DnB Asset Management AS | 14,838 | $1.17M | 0.00% | +5,530+59.4% | Added |
| Brown Advisory Inc | 14,965 | $1.18M | 0.00% | +939+6.7% | Added |
| LMR Partners LLP | 15,000 | $1.19M | 0.01% | −22,600−60.1% | Reduced |
| Davy Global Fund Management Ltd | 15,168 | $1.20M | 0.08% | −116−0.8% | Reduced |
| Public Employees Retirement Association of Colorado | 15,589 | $1.23M | 0.00% | 00.0% | Unchanged |
| North Star Asset Management Inc | 16,610 | $1.31M | 0.05% | 00.0% | Unchanged |
| Allianz Asset Management GmbH | 16,716 | $1.32M | 0.00% | +5,216+45.4% | Added |
| XTX Topco Ltd | 16,917 | $1.34M | 0.04% | +16,917 | New |
| J. Safra Sarasin Holding AG | 17,404 | $1.38M | 0.02% | +17,404 | New |
| Worldquant Millennium Advisors LLC | 17,410 | $1.38M | 0.01% | +17,410 | New |
| Inceptionr LLC | 17,850 | $1.41M | 0.39% | +10,229+134.2% | Added |
| Toroso Investments, LLC | 17,908 | $1.42M | 0.01% | +17,908 | New |
| Dana Investment Advisors, Inc. | 18,026 | $1.43M | 0.04% | −792−4.2% | Reduced |
| Elo Mutual Pension Insurance Co | 18,417 | $1.46M | 0.02% | +18,417 | New |
| Quantedge Capital Pte Ltd | 18,500 | $1.46M | 0.70% | +18,500 | New |
| AlphaCentric Advisors LLC | 18,523 | $1.47M | 1.46% | +18,523 | New |
| AQR Capital Management LLC | 18,762 | $1.48M | 0.00% | +11,947+175.3% | Added |
| Gilder Gagnon Howe & Co LLC | 19,275 | $1.52M | 0.02% | +19,275 | New |
| Nicollet Investment Management, Inc. | 20,523 | $1.62M | 0.51% | +115+0.6% | Added |
| Great West Life Assurance Co | 20,894 | $1.65M | 0.00% | −25,234−54.7% | Reduced |
| Exchange Traded Concepts, LLC | 21,094 | $1.67M | 0.01% | +3,024+16.7% | Added |
| Natixis Advisors, L.P. | 21,891 | $1.73M | 0.00% | +21,891 | New |
| Engineers Gate Manager LP | 22,191 | $1.76M | 0.02% | −3,588−13.9% | Reduced |
| Verition Fund Management LLC | 22,685 | $1.79M | 0.01% | −14,511−39.0% | Reduced |
| HRT Financial LP | 22,928 | $1.81M | 0.01% | +22,928 | New |
| Xponance, Inc. | 22,941 | $1.81M | 0.01% | +1,491+7.0% | Added |
| Brinker Capital Investments, LLC | 23,574 | $1.86M | 0.01% | +13,612+136.6% | Added |
| Cerity Partners LLC | 23,927 | $1.89M | 0.00% | +23,927 | New |
| Prudential Financial Inc | 24,008 | $1.90M | 0.00% | +14,664+156.9% | Added |
| Teachers Retirement System of the State of Kentucky | 24,083 | $1.91M | 0.01% | 00.0% | Unchanged |
| Landscape Capital Management, L.L.C. | 24,155 | $1.91M | 0.13% | −2,407−9.1% | Reduced |