Ionis Pharmaceuticals Inc
IONS- Exchange
- Nasdaq
- Industry
- Pharmaceutical Preparations
- SEC CIK
- 0000874015
In the last 90 days, Ionis Pharmaceuticals Inc insiders filed 1 open-market purchase and 4 sales; 515 institutions reported holding it in 13F filings for Q2 2026, worth $14.3B in total; ARK Invest is the only superinvestor holding it.
13F holders, Q3 2025
Institutional positions in Ionis Pharmaceuticals Inc as of Sep 30, 2025. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 437
- +78 vs. Q2 2025
- Shares held
- 168.2M
- −221.1K (−0.1%) vs. Q2 2025
- Total value
- $11.0B
- +$4.36B (+65.5%) vs. Q2 2025
- New holders
- 115
- 136 more added
- Sold out
- 37
- 116 more reduced
4 institutions that held it in Q2 2025 haven't filed for Q3 2025 yet. Not filing isn't selling, so they aren't counted as sold out or in the changes above.
Compare with Q2 2025: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting IONS on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 515 | $14.3B |
| Q1 2026 | 497 | $13.0B |
| Q4 2025 | 494 | $13.5B |
| Q3 2025 | 437 | $11.0B |
| Q2 2025 | 363 | $6.67B |
| Q1 2025 | 344 | $5.03B |
| Q4 2024 | 356 | $5.61B |
| Q3 2024 | 354 | $6.31B |
| Q2 2024 | 357 | $6.83B |
| Q1 2024 | 361 | $6.17B |
| Q4 2023 | 365 | $7.21B |
| Q3 2023 | 312 | $6.35B |
| Q2 2023 | 305 | $5.60B |
| Q1 2023 | 315 | $4.69B |
| Q4 2022 | 339 | $4.93B |
| Q3 2022 | 350 | $5.59B |
| Q2 2022 | 351 | $4.61B |
| Q1 2022 | 333 | $4.63B |
| Q4 2021 | 341 | $3.75B |
| Q3 2021 | 326 | $4.08B |
| Q2 2021 | 338 | $4.96B |
| Q1 2021 | 365 | $5.55B |
Institutions, Q3 2025
Shares, value and share of portfolio for each institution holding Ionis Pharmaceuticals Inc; share changes are against Q2 2025.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| Millennium Management LLC | 779,570 | $51.0M | 0.04% | −1,869,957−70.6% | Reduced |
| Voloridge Investment Management, LLC | 803,047 | $52.5M | 0.18% | −51,587−6.0% | Reduced |
| Northern Trust Corp | 844,943 | $55.3M | 0.01% | +30,693+3.8% | Added |
| Bank of America Corp | 855,295 | $56.0M | 0.00% | −140,595−14.1% | Reduced |
| Massachusetts Financial Services Co | 862,593 | $56.4M | 0.02% | +343,409+66.1% | Added |
| Connor, Clark & Lunn Investment Management Ltd. | 878,155 | $57.4M | 0.18% | +612,362+230.4% | Added |
| Artisan Partners Limited Partnership | 890,072 | $58.2M | 0.08% | +535,110+150.8% | Added |
| Marshall Wace, LLP | 958,829 | $62.7M | 0.07% | +945,729+7,219.3% | Added |
| TD Asset Management Inc | 960,272 | $62.8M | 0.05% | −144,418−13.1% | Reduced |
| Polar Capital Holdings Plc | 1,033,622 | $67.6M | 0.33% | +33,622+3.4% | Added |
| UBS Group AG | 1,046,990 | $68.5M | 0.01% | −482,333−31.5% | Reduced |
| BNP PARIBAS ASSET MANAGEMENT Holding S.A. | 1,059,721 | $69.3M | 0.18% | −291,158−21.6% | Reduced |
| Vestal Point Capital, LP | 1,075,000 | $70.3M | 3.19% | +575,000+115.0% | Added |
| Macquarie Group Ltd | 1,131,936 | $74.1M | 0.09% | −302,137−21.1% | Reduced |
| UBS Asset Management Americas Inc | 1,154,166 | $75.5M | 0.02% | +363,094+45.9% | Added |
| Morgan Stanley | 1,180,316 | $77.2M | 0.00% | −181,893−13.4% | Reduced |
| Royal Bank of Canada | 1,226,624 | $80.2M | 0.01% | +426,712+53.3% | Added |
| Adage Capital Partners GP, L.L.C. | 1,315,000 | $86.0M | 0.14% | −2,485,000−65.4% | Reduced |
| American Century Companies Inc | 1,372,225 | $89.8M | 0.05% | +899,476+190.3% | Added |
| Pictet Asset Management Holding SA | 1,393,124 | $90.5M | 0.09% | +784,484+128.9% | Added |
| Charles Schwab Investment Management Inc | 1,519,951 | $99.4M | 0.02% | +32,133+2.2% | Added |
| Two Sigma Investments, LP | 1,575,943 | $103.1M | 0.16% | −212,424−11.9% | Reduced |
| Deerfield Management Company, L.P. (Series C) | 1,979,669 | $129.5M | 1.98% | +1,979,669 | New |
| Two Sigma Advisers, LP | 2,073,111 | $135.6M | 0.27% | −594,500−22.3% | Reduced |
| Citadel Advisors LLC | 2,402,065 | $157.1M | 0.13% | +907,084+60.7% | Added |
| Price T Rowe Associates Inc | 2,729,685 | $178.6M | 0.02% | −396,388−12.7% | Reduced |
| Tweedy, Browne Co LLC | 2,901,216 | $189.8M | 16.48% | +9,268+0.3% | Added |
| Geode Capital Management, LLC | 3,066,289 | $200.6M | 0.01% | +175,194+6.1% | Added |
| Deep Track Capital, LP | 3,808,144 | $249.1M | 6.95% | −1,083,400−22.1% | Reduced |
| State Street Corp | 4,388,651 | $287.1M | 0.01% | −141,747−3.1% | Reduced |
| Bellevue Group AG | 6,244,451 | $408.5M | 8.49% | −1,608,747−20.5% | Reduced |
| Wellington Management Group LLP | 6,588,811 | $431.0M | 0.08% | +243,035+3.8% | Added |
| BlackRock, Inc. | 10,447,940 | $683.5M | 0.01% | −448,997−4.1% | Reduced |
| Capital World Investors | 12,722,728 | $832.3M | 0.11% | +182,540+1.5% | Added |
| T. Rowe Price Investment Management, Inc. | 13,156,929 | $860.7M | 0.53% | −2,891,792−18.0% | Reduced |
| Vanguard Group Inc | 16,481,730 | $1.08B | 0.02% | −233,116−1.4% | Reduced |
| FMR LLC | 23,689,038 | $1.55B | 0.08% | +46,048+0.2% | Added |
| BVF Inc | 0 | $0 | 0.00% | −1,913,385−100.0% | Sold out |
| Woodline Partners LP | 0 | $0 | 0.00% | −732,813−100.0% | Sold out |
| AXA S.A. | 0 | $0 | 0.00% | −566,883−100.0% | Sold out |
| Point72 Asset Management, L.P. | 0 | $0 | 0.00% | −292,647−100.0% | Sold out |
| Superstring Capital Management LP | 0 | $0 | 0.00% | −98,267−100.0% | Sold out |
| UBS Oconnor LLC | 0 | $0 | 0.00% | −81,251−100.0% | Sold out |
| Worldquant Millennium Advisors LLC | 0 | $0 | 0.00% | −74,438−100.0% | Sold out |
| Walleye Capital LLC | 0 | $0 | 0.00% | −66,482−100.0% | Sold out |
| Schroder Investment Management Group | 0 | $0 | 0.00% | −45,950−100.0% | Sold out |
| Y-Intercept (Hong Kong) Ltd | 0 | $0 | 0.00% | −37,649−100.0% | Sold out |
| Capital Fund Management S.A. | 0 | $0 | 0.00% | −31,219−100.0% | Sold out |
| Oxford Asset Management LLP | 0 | $0 | 0.00% | −22,405−100.0% | Sold out |
| SummitTX Capital, L.P. | 0 | $0 | 0.00% | −17,149−100.0% | Sold out |
| Corton Capital Inc. | 0 | $0 | 0.00% | −14,424−100.0% | Sold out |
| Vestmark Advisory Solutions, Inc. | 0 | $0 | 0.00% | −14,341−100.0% | Sold out |
| Paloma Partners Management Co | 0 | $0 | 0.00% | −12,557−100.0% | Sold out |
| Fox Run Management, L.L.C. | 0 | $0 | 0.00% | −10,988−100.0% | Sold out |
| Harbor Advisors LLC | 0 | $0 | 0.00% | −10,500−100.0% | Sold out |
| Colony Group, LLC | 0 | $0 | 0.00% | −10,056−100.0% | Sold out |
| Semanteon Capital Management, LP | 0 | $0 | 0.00% | −9,536−100.0% | Sold out |
| Jump Financial, LLC | 0 | $0 | 0.00% | −9,018−100.0% | Sold out |
| Jacobs Levy Equity Management, Inc | 0 | $0 | 0.00% | −6,813−100.0% | Sold out |
| Teza Capital Management LLC | 0 | $0 | 0.00% | −6,604−100.0% | Sold out |
| Cambridge Investment Research Advisors, Inc. | 0 | $0 | 0.00% | −5,682−100.0% | Sold out |
| Castle Rock Wealth Management, LLC | 0 | $0 | 0.00% | −5,122−100.0% | Sold out |
| Callan Family Office, LLC | 0 | $0 | 0.00% | −5,400−100.0% | Sold out |
| Empowered Funds, LLC | 0 | $0 | 0.00% | −5,067−100.0% | Sold out |
| Allianz SE | 0 | $0 | 0.00% | −2,100−100.0% | Sold out |
| Skopos Labs, Inc. | 0 | $0 | 0.00% | −268−100.0% | Sold out |
| Twin Peaks Wealth Advisors, LLC | 0 | $0 | 0.00% | −215−100.0% | Sold out |
| Riggs Asset Managment Co. Inc. | 0 | $0 | 0.00% | −187−100.0% | Sold out |
| SRS Capital Advisors, Inc. | 0 | $0 | 0.00% | −156−100.0% | Sold out |
| Geneos Wealth Management Inc. | 0 | $0 | 0.00% | −139−100.0% | Sold out |
| MPWM Advisory Solutions, LLC | 0 | $0 | 0.00% | −110−100.0% | Sold out |
| Kestra Investment Management, LLC | 0 | $0 | 0.00% | −137−100.0% | Sold out |
| Asset Dedication, LLC | 0 | $0 | 0.00% | −59−100.0% | Sold out |
| WealthTrak Capital Management LLC | 0 | $0 | 0.00% | −5−100.0% | Sold out |
| Norges Bank | – | – | – | – | Not filed |
| E Fund Management Co., Ltd. | – | – | – | – | Not filed |
| Semmax Financial Advisors Inc. | – | – | – | – | Not filed |
| Parkworth Wealth Management, Inc. | – | – | – | – | Not filed |