Ionis Pharmaceuticals Inc
IONS- Exchange
- Nasdaq
- Industry
- Pharmaceutical Preparations
- SEC CIK
- 0000874015
In the last 90 days, Ionis Pharmaceuticals Inc insiders filed 1 open-market purchase and 4 sales; 515 institutions reported holding it in 13F filings for Q2 2026, worth $14.3B in total; ARK Invest is the only superinvestor holding it.
13F holders, Q1 2025
Institutional positions in Ionis Pharmaceuticals Inc as of Mar 31, 2025. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 344
- −6 vs. Q4 2024
- Shares held
- 166.7M
- +6.69M (+4.2%) vs. Q4 2024
- Total value
- $5.03B
- −$564.9M (−10.1%) vs. Q4 2024
- New holders
- 54
- 102 more added
- Sold out
- 60
- 123 more reduced
6 institutions that held it in Q4 2024 haven't filed for Q1 2025 yet. Not filing isn't selling, so they aren't counted as sold out or in the changes above.
Compare with Q4 2024: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting IONS on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 515 | $14.3B |
| Q1 2026 | 497 | $13.0B |
| Q4 2025 | 494 | $13.5B |
| Q3 2025 | 437 | $11.0B |
| Q2 2025 | 363 | $6.67B |
| Q1 2025 | 344 | $5.03B |
| Q4 2024 | 356 | $5.61B |
| Q3 2024 | 354 | $6.31B |
| Q2 2024 | 357 | $6.83B |
| Q1 2024 | 361 | $6.17B |
| Q4 2023 | 365 | $7.21B |
| Q3 2023 | 312 | $6.35B |
| Q2 2023 | 305 | $5.60B |
| Q1 2023 | 315 | $4.69B |
| Q4 2022 | 339 | $4.93B |
| Q3 2022 | 350 | $5.59B |
| Q2 2022 | 351 | $4.61B |
| Q1 2022 | 333 | $4.63B |
| Q4 2021 | 341 | $3.75B |
| Q3 2021 | 326 | $4.08B |
| Q2 2021 | 338 | $4.96B |
| Q1 2021 | 365 | $5.55B |
Institutions, Q1 2025
Shares, value and share of portfolio for each institution holding Ionis Pharmaceuticals Inc; share changes are against Q4 2024.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| Eversept Partners, LP | 517,021 | $15.6M | 1.77% | +302,069+140.5% | Added |
| Bank of New York Mellon Corp | 544,633 | $16.4M | 0.00% | −71,438−11.6% | Reduced |
| Schonfeld Strategic Advisors LLC | 560,359 | $16.9M | 0.11% | +188,978+50.9% | Added |
| AXA S.A. | 566,486 | $17.1M | 0.06% | −38,859−6.4% | Reduced |
| Groupama Asset Managment | 569,211 | $18.2M | 0.36% | +52,020+10.1% | Added |
| Pinnacle Associates Ltd | 608,517 | $18.4M | 0.27% | +60,875+11.1% | Added |
| Royal Bank of Canada | 616,081 | $18.6M | 0.00% | −27,111−4.2% | Reduced |
| Millennium Management LLC | 635,370 | $19.2M | 0.02% | −138,845−17.9% | Reduced |
| Pictet Asset Management Holding SA | 618,550 | $19.2M | 0.02% | −2,248−0.4% | Reduced |
| Goldman Sachs Group Inc | 652,518 | $19.7M | 0.00% | +274,310+72.5% | Added |
| UBS Asset Management Americas Inc | 659,435 | $19.9M | 0.01% | +39,794+6.4% | Added |
| Camber Capital Management LP | 725,000 | $21.9M | 1.36% | +100,000+16.0% | Added |
| Bank of America Corp | 767,432 | $23.2M | 0.00% | +344,571+81.5% | Added |
| Bank of Montreal | 782,835 | $23.6M | 0.01% | +470,689+150.8% | Added |
| Northern Trust Corp | 834,847 | $25.2M | 0.00% | −5,424−0.6% | Reduced |
| Norges Bank | 858,228 | $25.9M | 0.00% | −856,534−50.0% | Reduced |
| Invesco Ltd. | 874,834 | $26.4M | 0.01% | +86,235+10.9% | Added |
| Candriam Luxembourg S.C.A. | 993,704 | $30.0M | 0.19% | +143,880+16.9% | Added |
| ARK Investment Management LLCSuperinvestorARK Invest | 1,000,527 | $30.2M | 0.30% | −24,733−2.4% | Reduced |
| Hudson Bay Capital Management LP | 1,049,900 | $31.7M | 0.20% | +228,700+27.8% | Added |
| Adage Capital Partners GP, L.L.C. | 1,075,600 | $32.5M | 0.06% | +800,600+291.1% | Added |
| TD Asset Management Inc | 1,100,466 | $33.2M | 0.03% | +50,476+4.8% | Added |
| Morgan Stanley | 1,144,181 | $34.5M | 0.00% | −185,748−14.0% | Reduced |
| BNP PARIBAS ASSET MANAGEMENT Holding S.A. | 1,196,392 | $36.1M | 0.10% | +116,051+10.7% | Added |
| Charles Schwab Investment Management Inc | 1,443,629 | $43.6M | 0.01% | −37,811−2.6% | Reduced |
| Macquarie Group Ltd | 1,667,194 | $50.3M | 0.06% | −102,549−5.8% | Reduced |
| Two Sigma Investments, LP | 1,685,853 | $50.9M | 0.11% | +764,414+83.0% | Added |
| UBS Group AG | 1,890,602 | $57.0M | 0.01% | −27,006−1.4% | Reduced |
| BVF Inc | 1,913,385 | $57.7M | 2.35% | +1,913,385 | New |
| Two Sigma Advisers, LP | 2,092,011 | $63.1M | 0.14% | +742,800+55.1% | Added |
| OrbiMed Advisors LLC | 2,540,136 | $76.6M | 1.84% | −277,211−9.8% | Reduced |
| Geode Capital Management, LLC | 2,842,954 | $85.8M | 0.01% | +155,706+5.8% | Added |
| Tweedy, Browne Co LLC | 2,983,518 | $90.0M | 7.98% | −265,345−8.2% | Reduced |
| Price T Rowe Associates Inc | 3,265,034 | $98.5M | 0.01% | −561,905−14.7% | Reduced |
| Citadel Advisors LLC | 3,480,062 | $105.0M | 0.10% | +1,314,146+60.7% | Added |
| Deep Track Capital, LP | 4,564,207 | $137.7M | 4.46% | +2,630,279+136.0% | Added |
| State Street Corp | 4,845,133 | $146.2M | 0.01% | −581,280−10.7% | Reduced |
| Bellevue Group AG | 7,853,198 | $236.9M | 5.31% | −15,502−0.2% | Reduced |
| Wellington Management Group LLP | 8,416,421 | $253.9M | 0.05% | −255,727−2.9% | Reduced |
| BlackRock, Inc. | 11,264,442 | $339.8M | 0.01% | −401,106−3.4% | Reduced |
| Capital World Investors | 12,361,994 | $373.0M | 0.06% | +896,581+7.8% | Added |
| T. Rowe Price Investment Management, Inc. | 16,175,533 | $488.0M | 0.32% | +2,006,334+14.2% | Added |
| Vanguard Group Inc | 16,383,934 | $494.3M | 0.01% | −88,605−0.5% | Reduced |
| FMR LLC | 23,613,585 | $712.4M | 0.05% | +924,094+4.1% | Added |
| Activest Wealth Management | 0 | $0 | 0.00% | −1−100.0% | Sold out |
| Clearbridge Investments, LLC | 0 | $0 | 0.00% | −1,618,220−100.0% | Sold out |
| Vestal Point Capital, LP | 0 | $0 | 0.00% | −595,000−100.0% | Sold out |
| Jacobs Levy Equity Management, Inc | 0 | $0 | 0.00% | −281,813−100.0% | Sold out |
| Siren, L.L.C. | 0 | $0 | 0.00% | −250,000−100.0% | Sold out |
| Driehaus Capital Management LLC | 0 | $0 | 0.00% | −180,002−100.0% | Sold out |
| Alyeska Investment Group, L.P. | 0 | $0 | 0.00% | −150,000−100.0% | Sold out |
| Assenagon Asset Management S.A. | 0 | $0 | 0.00% | −141,917−100.0% | Sold out |
| Woodline Partners LP | 0 | $0 | 0.00% | −107,610−100.0% | Sold out |
| Ghisallo Capital Management LLC | 0 | $0 | 0.00% | −100,000−100.0% | Sold out |
| Dimensional Fund Advisors LP | 0 | $0 | 0.00% | −94,157−100.0% | Sold out |
| Trexquant Investment LP | 0 | $0 | 0.00% | −84,913−100.0% | Sold out |
| Fieldview Capital Management, LLC | 0 | $0 | 0.00% | −51,282−100.0% | Sold out |
| Qsemble Capital Management, LP | 0 | $0 | 0.00% | −46,573−100.0% | Sold out |
| D. E. Shaw & Co., Inc. | 0 | $0 | 0.00% | −23,123−100.0% | Sold out |
| Canada Pension Plan Investment Board | 0 | $0 | 0.00% | −19,900−100.0% | Sold out |
| Aigen Investment Management, LP | 0 | $0 | 0.00% | −17,723−100.0% | Sold out |
| Natixis | 0 | $0 | 0.00% | −16,626−100.0% | Sold out |
| Campbell & CO Investment Adviser LLC | 0 | $0 | 0.00% | −15,681−100.0% | Sold out |
| Inceptionr LLC | 0 | $0 | 0.00% | −14,390−100.0% | Sold out |
| Natixis Advisors, L.P. | 0 | $0 | 0.00% | −14,313−100.0% | Sold out |
| Franklin Resources Inc | 0 | $0 | 0.00% | −13,301−100.0% | Sold out |
| Stratos Wealth Partners, LTD. | 0 | $0 | 0.00% | −12,813−100.0% | Sold out |
| Essential Planning, LLC. | 0 | $0 | 0.00% | −11,440−100.0% | Sold out |
| Landscape Capital Management, L.L.C. | 0 | $0 | 0.00% | −10,270−100.0% | Sold out |
| Syon Capital LLC | 0 | $0 | 0.00% | −10,119−100.0% | Sold out |
| Janney Montgomery Scott LLC | 0 | $0 | 0.00% | −9,840−100.0% | Sold out |
| Torno Capital, LLC | 0 | $0 | 0.00% | −9,500−100.0% | Sold out |
| Virtus ETF Advisers LLC | 0 | $0 | 0.00% | −9,448−100.0% | Sold out |
| Y-Intercept (Hong Kong) Ltd | 0 | $0 | 0.00% | −9,407−100.0% | Sold out |
| Wolverine Trading, LLC | 0 | $0 | 0.00% | −8,847−100.0% | Sold out |
| Truist Financial Corp | 0 | $0 | 0.00% | −6,847−100.0% | Sold out |
| EntryPoint Capital, LLC | 0 | $0 | 0.00% | −6,382−100.0% | Sold out |
| Gotham Asset Management, LLC | 0 | $0 | 0.00% | −6,260−100.0% | Sold out |
| Castle Rock Wealth Management, LLC | 0 | $0 | 0.00% | −6,972−100.0% | Sold out |
| M&T Bank Corp | 0 | $0 | 0.00% | −6,096−100.0% | Sold out |
| Vontobel Holding Ltd. | 0 | $0 | 0.00% | −5,865−100.0% | Sold out |
| Stevens Capital Management LP | 0 | $0 | 0.00% | −5,860−100.0% | Sold out |
| Caption Management, LLC | 0 | $0 | 0.00% | −5,417−100.0% | Sold out |
| Venturi Wealth Management, LLC | 0 | $0 | 0.00% | −3,061−100.0% | Sold out |
| Horizon Investments, LLC | 0 | $0 | 0.00% | −1,174−100.0% | Sold out |
| Elequin Capital LP | 0 | $0 | 0.00% | −325−100.0% | Sold out |
| Global X Japan Co., Ltd. | 0 | $0 | 0.00% | −297−100.0% | Sold out |
| Tidemark, LLC | 0 | $0 | 0.00% | −200−100.0% | Sold out |
| Capital Advisors, Ltd. LLC | 0 | $0 | 0.00% | −179−100.0% | Sold out |
| Whittier Trust Co of Nevada Inc | 0 | $0 | 0.00% | −157−100.0% | Sold out |
| LRI Investments, LLC | 0 | $0 | 0.00% | −136−100.0% | Sold out |
| Transce3nd, LLC | 0 | $0 | 0.00% | −100−100.0% | Sold out |
| Bryn Mawr Trust Co | 0 | $0 | 0.00% | −92−100.0% | Sold out |
| Raleigh Capital Management Inc. | 0 | $0 | 0.00% | −72−100.0% | Sold out |
| Coppell Advisory Solutions LLC | 0 | $0 | 0.00% | −51−100.0% | Sold out |
| Private Trust Co NA | 0 | $0 | 0.00% | −48−100.0% | Sold out |
| Cornerstone Planning Group LLC | 0 | $0 | 0.00% | −25−100.0% | Sold out |
| Lee Danner & Bass Inc | 0 | $0 | 0.00% | −22−100.0% | Sold out |
| Front Row Advisors LLC | 0 | $0 | 0.00% | −20−100.0% | Sold out |
| Central Trust Co | 0 | $0 | 0.00% | −15−100.0% | Sold out |