Ionis Pharmaceuticals Inc
IONS- Exchange
- Nasdaq
- Industry
- Pharmaceutical Preparations
- SEC CIK
- 0000874015
In the last 90 days, Ionis Pharmaceuticals Inc insiders filed 1 open-market purchase and 4 sales; 515 institutions reported holding it in 13F filings for Q2 2026, worth $14.3B in total; ARK Invest is the only superinvestor holding it.
13F holders, Q4 2024
Institutional positions in Ionis Pharmaceuticals Inc as of Dec 31, 2024. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 356
- +9 vs. Q3 2024
- Shares held
- 160.5M
- +3.10M (+2.0%) vs. Q3 2024
- Total value
- $5.61B
- −$692.3M (−11.0%) vs. Q3 2024
- New holders
- 58
- 119 more added
- Sold out
- 49
- 121 more reduced
7 institutions that held it in Q3 2024 haven't filed for Q4 2024 yet. Not filing isn't selling, so they aren't counted as sold out or in the changes above.
Compare with Q3 2024: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting IONS on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 515 | $14.3B |
| Q1 2026 | 497 | $13.0B |
| Q4 2025 | 494 | $13.5B |
| Q3 2025 | 437 | $11.0B |
| Q2 2025 | 363 | $6.67B |
| Q1 2025 | 344 | $5.03B |
| Q4 2024 | 356 | $5.61B |
| Q3 2024 | 354 | $6.31B |
| Q2 2024 | 357 | $6.83B |
| Q1 2024 | 361 | $6.17B |
| Q4 2023 | 365 | $7.21B |
| Q3 2023 | 312 | $6.35B |
| Q2 2023 | 305 | $5.60B |
| Q1 2023 | 315 | $4.69B |
| Q4 2022 | 339 | $4.93B |
| Q3 2022 | 350 | $5.59B |
| Q2 2022 | 351 | $4.61B |
| Q1 2022 | 333 | $4.63B |
| Q4 2021 | 341 | $3.75B |
| Q3 2021 | 326 | $4.08B |
| Q2 2021 | 338 | $4.96B |
| Q1 2021 | 365 | $5.55B |
Institutions, Q4 2024
Shares, value and share of portfolio for each institution holding Ionis Pharmaceuticals Inc; share changes are against Q3 2024.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| Bank of Montreal | 312,146 | $10.9M | 0.01% | +98,263+45.9% | Added |
| Voloridge Investment Management, LLC | 316,943 | $11.1M | 0.04% | −63,698−16.7% | Reduced |
| Wells Fargo & Company | 331,009 | $11.6M | 0.00% | −11,145−3.3% | Reduced |
| Tocqueville Asset Management L.P. | 352,140 | $12.3M | 0.19% | −54,730−13.5% | Reduced |
| Nomura Holdings Inc | 357,255 | $12.5M | 0.07% | −95,814−21.1% | Reduced |
| Baker Bros. Advisors LP | 357,915 | $12.5M | 0.13% | +134,445+60.2% | Added |
| Schonfeld Strategic Advisors LLC | 371,381 | $13.0M | 0.08% | +8,493+2.3% | Added |
| Goldman Sachs Group Inc | 378,208 | $13.2M | 0.00% | +142,498+60.5% | Added |
| Ameriprise Financial Inc | 387,448 | $13.5M | 0.00% | −10,450−2.6% | Reduced |
| C WorldWide Group Holding A/S | 400,000 | $14.0M | 0.17% | +100,000+33.3% | Added |
| Standard Life Aberdeen plc | 401,501 | $14.0M | 0.03% | +98,227+32.4% | Added |
| JPMorgan Chase & Co | 415,919 | $14.5M | 0.00% | −152,987−26.9% | Reduced |
| Bank of America Corp | 422,861 | $14.8M | 0.00% | −145,799−25.6% | Reduced |
| Great Point Partners LLC | 505,007 | $17.7M | 8.32% | +250,007+98.0% | Added |
| Groupama Asset Managment | 517,191 | $18.6M | 0.38% | +101,131+24.3% | Added |
| Pinnacle Associates Ltd | 547,642 | $19.1M | 0.26% | +88,663+19.3% | Added |
| Vestal Point Capital, LP | 595,000 | $20.8M | 1.23% | +595,000 | New |
| Barclays PLC | 596,072 | $20.8M | 0.01% | −40,960−6.4% | Reduced |
| AXA S.A. | 605,345 | $21.2M | 0.06% | +44,102+7.9% | Added |
| J. Goldman & Co LP | 607,499 | $21.2M | 0.75% | −1,917−0.3% | Reduced |
| Bank of New York Mellon Corp | 616,071 | $21.5M | 0.00% | +5,178+0.8% | Added |
| UBS Asset Management Americas Inc | 619,641 | $21.7M | 0.01% | +333,944+116.9% | Added |
| Pictet Asset Management Holding SA | 620,798 | $21.7M | 0.02% | −682,703−52.4% | Reduced |
| Camber Capital Management LP | 625,000 | $21.9M | 0.85% | +625,000 | New |
| Royal Bank of Canada | 643,192 | $22.5M | 0.00% | −26,957−4.0% | Reduced |
| Millennium Management LLC | 774,215 | $27.1M | 0.02% | +343,492+79.7% | Added |
| Invesco Ltd. | 788,599 | $27.6M | 0.01% | −21,702−2.7% | Reduced |
| Marshall Wace, LLP | 812,306 | $28.4M | 0.04% | −1,108,158−57.7% | Reduced |
| Hudson Bay Capital Management LP | 821,200 | $28.7M | 0.17% | +54,300+7.1% | Added |
| Northern Trust Corp | 840,271 | $29.4M | 0.00% | +97,367+13.1% | Added |
| Candriam Luxembourg S.C.A. | 849,824 | $29.7M | 0.17% | −98,442−10.4% | Reduced |
| Two Sigma Investments, LP | 921,439 | $32.2M | 0.07% | +2,362+0.3% | Added |
| ARK Investment Management LLCSuperinvestorARK Invest | 1,025,260 | $35.8M | 0.30% | −359,009−25.9% | Reduced |
| TD Asset Management Inc | 1,049,990 | $36.7M | 0.03% | −43,000−3.9% | Reduced |
| BNP PARIBAS ASSET MANAGEMENT Holding S.A. | 1,080,341 | $37.8M | 0.09% | +300,620+38.6% | Added |
| Morgan Stanley | 1,329,929 | $46.5M | 0.00% | +19,478+1.5% | Added |
| Two Sigma Advisers, LP | 1,349,211 | $47.2M | 0.11% | +16,800+1.3% | Added |
| Charles Schwab Investment Management Inc | 1,481,440 | $51.8M | 0.01% | +38,420+2.7% | Added |
| Clearbridge Investments, LLC | 1,618,220 | $56.6M | 0.05% | −84,173−4.9% | Reduced |
| Norges Bank | 1,714,762 | $59.9M | 0.01% | −312,399−15.4% | Reduced |
| Macquarie Group Ltd | 1,769,743 | $61.9M | 0.08% | −100,063−5.4% | Reduced |
| UBS Group AG | 1,917,608 | $67.0M | 0.02% | +1,749,728+1,042.2% | Added |
| Deep Track Capital, LP | 1,933,928 | $67.6M | 2.53% | −266,072−12.1% | Reduced |
| Citadel Advisors LLC | 2,165,916 | $75.7M | 0.07% | +1,764,765+439.9% | Added |
| Geode Capital Management, LLC | 2,687,248 | $94.0M | 0.01% | +18,890+0.7% | Added |
| OrbiMed Advisors LLC | 2,817,347 | $98.5M | 2.05% | +492,900+21.2% | Added |
| Tweedy, Browne Co LLC | 3,248,863 | $113.6M | 7.66% | −205,813−6.0% | Reduced |
| Price T Rowe Associates Inc | 3,826,939 | $133.8M | 0.02% | −383,233−9.1% | Reduced |
| State Street Corp | 5,426,413 | $189.7M | 0.01% | +576,276+11.9% | Added |
| Bellevue Group AG | 7,868,700 | $275.1M | 5.30% | −5,700−0.1% | Reduced |
| Wellington Management Group LLP | 8,672,148 | $303.2M | 0.06% | −63,639−0.7% | Reduced |
| Capital World Investors | 11,465,413 | $400.8M | 0.06% | +3,637,041+46.5% | Added |
| BlackRock, Inc. | 11,665,548 | $407.8M | 0.01% | +852,525+7.9% | Added |
| T. Rowe Price Investment Management, Inc. | 14,169,199 | $495.4M | 0.31% | +1,0830.0% | Added |
| Vanguard Group Inc | 16,472,539 | $575.9M | 0.01% | +1,416,781+9.4% | Added |
| FMR LLC | 22,689,491 | $793.2M | 0.05% | +209,962+0.9% | Added |
| Washington Trust Advisors, Inc. | 0 | $0 | 0.00% | −83−100.0% | Sold out |
| BVF Inc | 0 | $0 | 0.00% | −1,451,879−100.0% | Sold out |
| Logos Global Management LP | 0 | $0 | 0.00% | −750,000−100.0% | Sold out |
| EcoR1 Capital, LLC | 0 | $0 | 0.00% | −500,000−100.0% | Sold out |
| First Trust Advisors LP | 0 | $0 | 0.00% | −402,300−100.0% | Sold out |
| Twinbeech Capital LP | 0 | $0 | 0.00% | −235,477−100.0% | Sold out |
| Altrinsic Global Advisors LLC | 0 | $0 | 0.00% | −182,734−100.0% | Sold out |
| Peregrine Capital Management LLC | 0 | $0 | 0.00% | −131,630−100.0% | Sold out |
| Cutter Capital Management, LP | 0 | $0 | 0.00% | −97,300−100.0% | Sold out |
| Prudential Financial Inc | 0 | $0 | 0.00% | −90,017−100.0% | Sold out |
| HealthInvest Partners AB | 0 | $0 | 0.00% | −82,691−100.0% | Sold out |
| Engineers Gate Manager LP | 0 | $0 | 0.00% | −78,874−100.0% | Sold out |
| HBK Investments L P | 0 | $0 | 0.00% | −60,000−100.0% | Sold out |
| Tudor Investment Corp Et Al | 0 | $0 | 0.00% | −53,479−100.0% | Sold out |
| Algert Global LLC | 0 | $0 | 0.00% | −45,430−100.0% | Sold out |
| Baillie Gifford & Co | 0 | $0 | 0.00% | −39,581−100.0% | Sold out |
| Polar Asset Management Partners Inc. | 0 | $0 | 0.00% | −35,400−100.0% | Sold out |
| Capital Fund Management S.A. | 0 | $0 | 0.00% | −30,691−100.0% | Sold out |
| Artia Global Partners LP | 0 | $0 | 0.00% | −30,479−100.0% | Sold out |
| Monashee Investment Management LLC | 0 | $0 | 0.00% | −20,000−100.0% | Sold out |
| Seven Eight Capital, LP | 0 | $0 | 0.00% | −17,394−100.0% | Sold out |
| Capula Management Ltd | 0 | $0 | 0.00% | −17,365−100.0% | Sold out |
| Martingale Asset Management L P | 0 | $0 | 0.00% | −12,809−100.0% | Sold out |
| Midwest Professional Planners, LTD. | 0 | $0 | 0.00% | −11,106−100.0% | Sold out |
| Susquehanna Portfolio Strategies, LLC | 0 | $0 | 0.00% | −10,894−100.0% | Sold out |
| Advent Capital Management | 0 | $0 | 0.00% | −10,000−100.0% | Sold out |
| Troluce Capital Advisors LLC | 0 | $0 | 0.00% | −10,000−100.0% | Sold out |
| Two Sigma Securities, LLC | 0 | $0 | 0.00% | −8,940−100.0% | Sold out |
| Ariadne Wealth Management, LP | 0 | $0 | 0.00% | −9,147−100.0% | Sold out |
| Sanctuary Advisors, LLC | 0 | $0 | 0.00% | −9,277−100.0% | Sold out |
| Simplex Trading, LLC | 0 | $0 | 0.00% | −6,944−100.0% | Sold out |
| Acadian Asset Management LLC | 0 | $0 | 0.00% | −6,328−100.0% | Sold out |
| American Century Companies Inc | 0 | $0 | 0.00% | −6,293−100.0% | Sold out |
| HighTower Advisors, LLC | 0 | $0 | 0.00% | −5,559−100.0% | Sold out |
| O'Shaughnessy Asset Management, LLC | 0 | $0 | 0.00% | −5,273−100.0% | Sold out |
| FORA Capital, LLC | 0 | $0 | 0.00% | −5,081−100.0% | Sold out |
| GTS Securities LLC | 0 | $0 | 0.00% | −5,056−100.0% | Sold out |
| Quest Partners LLC | 0 | $0 | 0.00% | −2,674−100.0% | Sold out |
| Quantbot Technologies LP | 0 | $0 | 0.00% | −1,267−100.0% | Sold out |
| Reuter James Wealth Management, LLC | 0 | $0 | 0.00% | −1,049−100.0% | Sold out |
| Capital Performance Advisors LLP | 0 | $0 | 0.00% | −1,000−100.0% | Sold out |
| ADAR1 Capital Management, LLC | 0 | $0 | 0.00% | −700−100.0% | Sold out |
| Claris Advisors, LLC | 0 | $0 | 0.00% | −250−100.0% | Sold out |
| Allspring Global Investments Holdings, LLC | 0 | $0 | 0.00% | −237−100.0% | Sold out |