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Ionis Pharmaceuticals Inc

IONS
Exchange
Nasdaq
Industry
Pharmaceutical Preparations
SEC CIK
0000874015

In the last 90 days, Ionis Pharmaceuticals Inc insiders filed 1 open-market purchase and 4 sales; 515 institutions reported holding it in 13F filings for Q2 2026, worth $14.3B in total; ARK Invest is the only superinvestor holding it.

13F holders, Q3 2024

Institutional positions in Ionis Pharmaceuticals Inc as of Sep 30, 2024. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works

Institutional holders
354
+1 vs. Q2 2024
Shares held
157.5M
+24.6M (+18.5%) vs. Q2 2024
Total value
$6.31B
−$23.0M (−0.4%) vs. Q2 2024
New holders
53
131 more added
Sold out
52
107 more reduced

4 institutions that held it in Q2 2024 haven't filed for Q3 2024 yet. Not filing isn't selling, so they aren't counted as sold out or in the changes above.

Compare with Q2 2024: new holders, sold out and not filed yet

Holders and value by quarter

Institutions reporting IONS on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.

Institutional holdersQ3 2024: 354 institutions
Q1 2021: 365 institutionsQ2 2021: 338 institutionsQ3 2021: 326 institutionsQ4 2021: 341 institutionsQ1 2022: 333 institutionsQ2 2022: 351 institutionsQ3 2022: 350 institutionsQ4 2022: 339 institutionsQ1 2023: 315 institutionsQ2 2023: 305 institutionsQ3 2023: 312 institutionsQ4 2023: 365 institutionsQ1 2024: 361 institutionsQ2 2024: 357 institutionsQ3 2024: 354 institutionsQ4 2024: 356 institutionsQ1 2025: 344 institutionsQ2 2025: 363 institutionsQ3 2025: 437 institutionsQ4 2025: 494 institutionsQ1 2026: 497 institutionsQ2 2026: 515 institutions
Value heldQ3 2024: $6.31B
Q1 2021: $5.55BQ2 2021: $4.96BQ3 2021: $4.08BQ4 2021: $3.75BQ1 2022: $4.63BQ2 2022: $4.61BQ3 2022: $5.59BQ4 2022: $4.93BQ1 2023: $4.69BQ2 2023: $5.60BQ3 2023: $6.35BQ4 2023: $7.21BQ1 2024: $6.17BQ2 2024: $6.83BQ3 2024: $6.31BQ4 2024: $5.61BQ1 2025: $5.03BQ2 2025: $6.67BQ3 2025: $11.0BQ4 2025: $13.5BQ1 2026: $13.0BQ2 2026: $14.3B
Institutions holding IONS and their total value by quarter
QuarterHoldersValue
Q2 2026515$14.3B
Q1 2026497$13.0B
Q4 2025494$13.5B
Q3 2025437$11.0B
Q2 2025363$6.67B
Q1 2025344$5.03B
Q4 2024356$5.61B
Q3 2024354$6.31B
Q2 2024357$6.83B
Q1 2024361$6.17B
Q4 2023365$7.21B
Q3 2023312$6.35B
Q2 2023305$5.60B
Q1 2023315$4.69B
Q4 2022339$4.93B
Q3 2022350$5.59B
Q2 2022351$4.61B
Q1 2022333$4.63B
Q4 2021341$3.75B
Q3 2021326$4.08B
Q2 2021338$4.96B
Q1 2021365$5.55B

Institutions, Q3 2024

Shares, value and share of portfolio for each institution holding Ionis Pharmaceuticals Inc; share changes are against Q2 2024.

Institutions holding IONS in Q3 2024
InstitutionSharesValue% of portfolioChange in sharesAction
SpiderRock Advisors, LLC12,036$482.2K0.01%+10+0.1%Added
Horizon Kinetics Asset Management LLC11,952$478.8K0.01%−524−4.2%Reduced
Wolverine Trading, LLC11,611$474.3K0.01%−9,717−45.6%Reduced
Aigen Investment Management, LP11,612$465.2K0.09%+11,612New
Plancorp, LLC11,286$452.1K0.02%00.0%Unchanged
Janney Montgomery Scott LLC11,294$452.0K0.00%−6,240−35.6%Reduced
Northwestern Mutual Wealth Management Co11,263$451.2K0.00%+50+0.4%Added
Canada Pension Plan Investment Board11,200$448.7K0.00%+11,200New
Bridgefront Capital, LLC11,196$448.5K0.17%+5,637+101.4%Added
Midwest Professional Planners, LTD.11,106$444.9K0.14%+966+9.5%Added
Susquehanna Portfolio Strategies, LLC10,894$436.4K0.03%−32,134−74.7%Reduced
Suvretta Capital Management, LLC10,800$432.6K0.02%00.0%Unchanged
Teza Capital Management LLC10,600$424.6K0.05%−14,559−57.9%Reduced
Cypress Capital, LLC10,000$400.6K0.10%00.0%Unchanged
Advent Capital Management10,000$400.6K0.01%+10,000New
Troluce Capital Advisors LLC10,000$400.6K0.07%+10,000New
Amalgamated Bank9,957$399.0K0.00%+300+3.1%Added
Annis Gardner Whiting Capital Advisors, LLC9,936$398.0K0.11%+540+5.7%Added
The PNC Financial Services Group, Inc.9,893$396.3K0.00%+532+5.7%Added
Franklin Resources Inc10,155$392.3K0.00%+133+1.3%Added
Cambridge Investment Research Advisors, Inc.9,738$390.0K0.00%−310−3.1%Reduced
Wiley Bros.-Aintree Capital, LLC9,606$384.8K0.01%+9,606New
Fifth Third Bancorp9,572$383.5K0.00%+110+1.2%Added
Sectoral Asset Management Inc9,440$378.2K0.22%−220−2.3%Reduced
MetLife Investment Management9,363$375.1K0.00%+514+5.8%Added
Two Sigma Securities, LLC8,940$358.1K0.03%−71,258−88.9%Reduced
M&T Bank Corp8,896$356.6K0.00%+70+0.8%Added
Ariadne Wealth Management, LP9,147$351.8K0.19%+9,147New
ProShare Advisors LLC8,640$346.1K0.00%−371−4.1%Reduced
JustInvest LLC8,404$336.6K0.01%+780+10.2%Added
Utah Retirement Systems8,400$336.5K0.00%+500+6.3%Added
Clearstead Advisors, LLC8,285$331.9K0.01%00.0%Unchanged
Maryland State Retirement & Pension System8,284$331.9K0.01%−2,666−24.3%Reduced
Virtus ETF Advisers LLC8,009$320.8K0.15%00.0%Unchanged
Mirae Asset Global ETFs Holdings Ltd.7,825$319.7K0.00%+1,468+23.1%Added
Sanctuary Advisors, LLC9,277$315.5K0.00%−7,164−43.6%Reduced
Comerica Bank7,615$305.0K0.00%−13,809−64.5%Reduced
SG Americas Securities, LLC7,419$297.0K0.00%+7,419New
Truist Financial Corp7,348$294.4K0.00%−655−8.2%Reduced
Simplex Trading, LLC6,944$278.0K0.01%−56,403−89.0%Reduced
Jones Financial Companies LLLP6,724$274.7K0.00%+3,323+97.7%Added
Castle Rock Wealth Management, LLC6,972$264.0K0.06%00.0%Unchanged
Acadian Asset Management LLC6,328$253.0K0.00%+6,328New
American Century Companies Inc6,293$252.1K0.00%−7,148−53.2%Reduced
Gotham Asset Management, LLC6,262$250.9K0.00%00.0%Unchanged
Advisors Asset Management, Inc.6,140$246.0K0.00%+1,066+21.0%Added
US Bancorp5,730$229.5K0.00%−5,320−48.1%Reduced
Colony Group, LLC5,696$228.2K0.00%+5,696New
Mitsubishi UFJ Kokusai Asset Management Co., Ltd.5,585$223.7K0.00%−489−8.1%Reduced
HighTower Advisors, LLC5,559$223.0K0.00%−75−1.3%Reduced
Vontobel Holding Ltd.5,502$220.4K0.00%−2,483−31.1%Reduced
Harbor Advisors LLC5,500$220.3K0.04%+5,500New
Mirae Asset Global Investments Co., Ltd.5,288$216.0K0.00%+930+21.3%Added
O'Shaughnessy Asset Management, LLC5,273$203.7K0.00%+5,273New
FORA Capital, LLC5,081$203.5K0.02%+5,081New
GTS Securities LLC5,056$202.5K0.00%−55,874−91.7%Reduced
Sandia Investment Management LP5,000$200.3K0.32%+5,000New
Torno Capital, LLC5,000$200.3K0.26%+5,000New
Tower Research Capital LLC (TRC)4,301$172.3K0.00%−45,685−91.4%Reduced
KBC Group NV3,808$153.0K0.00%+419+12.4%Added
Walleye Trading LLC3,613$144.7K0.00%+3,613New
Ci Investments Inc.3,380$135.0K0.00%−272−7.4%Reduced
Sterling Capital Management LLC3,045$122.0K0.00%+3,045New
Corebridge Financial, Inc.2,876$115.2K0.00%+115+4.2%Added
Quest Partners LLC2,674$107.1K0.01%+1,301+94.8%Added
CIBC Private Wealth Group, LLC2,425$97.1K0.00%+300+14.1%Added
Danske Bank A/S2,100$84.1K0.00%+1,700+425.0%Added
Steward Partners Investment Advisory, LLC2,055$82.3K0.00%+1,426+226.7%Added
GWM Advisors LLC1,820$72.9K0.00%−330−15.3%Reduced
CWM, LLC1,741$70.0K0.00%−476−21.5%Reduced
Twin Lakes Capital Management, LLC1,500$60.1K0.04%00.0%Unchanged
Quantbot Technologies LP1,267$50.8K0.00%+1,267New
IFP Advisors, Inc1,226$49.1K0.00%+156+14.6%Added
Horizon Investments, LLC1,101$44.1K0.00%−393−26.3%Reduced
Itau Unibanco Holding S.A.1,081$43.3K0.00%+314+40.9%Added
Reuter James Wealth Management, LLC1,049$42.0K0.01%+1,049New
Parallel Advisors, LLC1,028$41.2K0.00%+396+62.7%Added
Sunbelt Securities, Inc.1,014$40.6K0.00%00.0%Unchanged
Capital Performance Advisors LLP1,000$40.1K0.01%+1,000New
Harbour Investments, Inc.900$36.1K0.00%00.0%Unchanged
Quadrant Capital Group LLC870$34.9K0.00%+10+1.2%Added
Manchester Capital Management LLC845$33.9K0.00%+150+21.6%Added
Allworth Financial LP830$33.3K0.00%+21+2.6%Added
ADAR1 Capital Management, LLC700$28.0K0.00%−800−53.3%Reduced
GAMMA Investing LLC664$26.6K0.00%+303+83.9%Added
Farther Finance Advisors, LLC621$24.9K0.00%+58+10.3%Added
Laurel Wealth Advisors LLC600$24.0K0.00%00.0%Unchanged
Archer Investment Corp600$24.0K0.01%00.0%Unchanged
Daiwa Securities Group Inc.541$22.0K0.00%00.0%Unchanged
Mather Group, LLC.516$20.7K0.00%−395−43.4%Reduced
Riverview Trust Co487$19.5K0.02%+11+2.3%Added
Global Trust Asset Management, LLC474$19.0K0.01%00.0%Unchanged
Elequin Capital LP437$17.5K0.00%+437New
Smartleaf Asset Management LLC427$17.4K0.00%+368+623.7%Added
ORG Wealth Partners, LLC400$16.0K0.01%+400New
AlphaMark Advisors, LLC369$15.0K0.01%−201−35.3%Reduced
Lindbrook Capital, LLC365$14.6K0.00%−24−6.2%Reduced
Signaturefd, LLC365$14.6K0.00%+25+7.4%Added
Ronald Blue Trust, Inc.286$13.6K0.00%+179+167.3%Added
Huntington National Bank324$13.0K0.00%+2+0.6%Added