Ionis Pharmaceuticals Inc
IONS- Exchange
- Nasdaq
- Industry
- Pharmaceutical Preparations
- SEC CIK
- 0000874015
In the last 90 days, Ionis Pharmaceuticals Inc insiders filed 1 open-market purchase and 4 sales; 515 institutions reported holding it in 13F filings for Q2 2026, worth $14.3B in total; ARK Invest is the only superinvestor holding it.
13F holders, Q4 2023
Institutional positions in Ionis Pharmaceuticals Inc as of Dec 31, 2023. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 365
- +57 vs. Q3 2023
- Shares held
- 142.5M
- +2.89M (+2.1%) vs. Q3 2023
- Total value
- $7.21B
- +$870.9M (+13.7%) vs. Q3 2023
- New holders
- 85
- 108 more added
- Sold out
- 28
- 116 more reduced
4 institutions that held it in Q3 2023 haven't filed for Q4 2023 yet. Not filing isn't selling, so they aren't counted as sold out or in the changes above.
Compare with Q3 2023: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting IONS on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 515 | $14.3B |
| Q1 2026 | 497 | $13.0B |
| Q4 2025 | 494 | $13.5B |
| Q3 2025 | 437 | $11.0B |
| Q2 2025 | 363 | $6.67B |
| Q1 2025 | 344 | $5.03B |
| Q4 2024 | 356 | $5.61B |
| Q3 2024 | 354 | $6.31B |
| Q2 2024 | 357 | $6.83B |
| Q1 2024 | 361 | $6.17B |
| Q4 2023 | 365 | $7.21B |
| Q3 2023 | 312 | $6.35B |
| Q2 2023 | 305 | $5.60B |
| Q1 2023 | 315 | $4.69B |
| Q4 2022 | 339 | $4.93B |
| Q3 2022 | 350 | $5.59B |
| Q2 2022 | 351 | $4.61B |
| Q1 2022 | 333 | $4.63B |
| Q4 2021 | 341 | $3.75B |
| Q3 2021 | 326 | $4.08B |
| Q2 2021 | 338 | $4.96B |
| Q1 2021 | 365 | $5.55B |
Institutions, Q4 2023
Shares, value and share of portfolio for each institution holding Ionis Pharmaceuticals Inc; share changes are against Q3 2023.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| Mariner, LLC | 20,672 | $1.05M | 0.00% | +2,784+15.6% | Added |
| Commonwealth Equity Services, LLC | 21,462 | $1.09M | 0.00% | −80.0% | Reduced |
| ExodusPoint Capital Management, LP | 23,484 | $1.19M | 0.01% | +23,484 | New |
| Fred Alger Management, LLC | 24,054 | $1.22M | 0.01% | +10,488+77.3% | Added |
| HealthInvest Partners AB | 24,243 | $1.23M | 0.96% | +24,243 | New |
| STRS Ohio | 24,779 | $1.25M | 0.01% | +24,779 | New |
| Creative Planning | 25,299 | $1.28M | 0.00% | +3,727+17.3% | Added |
| Ameriprise Financial Inc | 25,625 | $1.30M | 0.00% | +17,810+227.9% | Added |
| Handelsbanken Fonder AB | 27,011 | $1.37M | 0.01% | +3,200+13.4% | Added |
| Victory Capital Management Inc | 27,793 | $1.41M | 0.00% | +12,357+80.1% | Added |
| Janney Montgomery Scott LLC | 28,379 | $1.44M | 0.00% | −1,239−4.2% | Reduced |
| UBS Oconnor LLC | 28,624 | $1.45M | 0.05% | −33,435−53.9% | Reduced |
| Engineers Gate Manager LP | 28,877 | $1.46M | 0.04% | +28,877 | New |
| Amalgamated Bank | 28,995 | $1.47M | 0.01% | −91−0.3% | Reduced |
| Profund Advisors LLC | 29,073 | $1.47M | 0.06% | −6,397−18.0% | Reduced |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 29,440 | $1.49M | 0.01% | +6,101+26.1% | Added |
| Twinbeech Capital LP | 29,729 | $1.50M | 0.02% | +29,729 | New |
| Teacher Retirement System of Texas | 29,844 | $1.51M | 0.01% | −6,734−18.4% | Reduced |
| Nicholas Investment Partners, LP | 30,445 | $1.54M | 0.18% | +30,445 | New |
| Principal Financial Group Inc | 31,139 | $1.58M | 0.00% | −3,512−10.1% | Reduced |
| Estate Counselors, LLC | 32,800 | $1.66M | 0.20% | 00.0% | Unchanged |
| Grandfield & Dodd, LLC | 33,104 | $1.67M | 0.12% | +242+0.7% | Added |
| Guggenheim Capital LLC | 33,151 | $1.68M | 0.01% | −7,324−18.1% | Reduced |
| Deutsche Bank AG | 35,702 | $1.81M | 0.00% | +26,213+276.2% | Added |
| Arizona State Retirement System | 36,059 | $1.82M | 0.01% | −609−1.7% | Reduced |
| Comerica Bank | 39,614 | $2.00M | 0.01% | −334−0.8% | Reduced |
| Capital Counsel LLC | 40,080 | $2.03M | 0.10% | −150−0.4% | Reduced |
| Great West Life Assurance Co | 40,781 | $2.05M | 0.00% | +3,980+10.8% | Added |
| NJ State Employees Deferred Compensation Plan | 42,000 | $2.12M | 0.29% | 00.0% | Unchanged |
| Schroder Investment Management Group | 43,000 | $2.18M | 0.00% | +43,000 | New |
| Ensign Peak Advisors, Inc | 46,310 | $2.34M | 0.00% | 00.0% | Unchanged |
| Private Advisor Group, LLC | 48,807 | $2.47M | 0.02% | +189+0.4% | Added |
| Erste Asset Management GmbH | 51,300 | $2.59M | 0.04% | 00.0% | Unchanged |
| Cowen and Company, LLC | 51,415 | $2.60M | 0.17% | +51,415 | New |
| Susquehanna International Group, LLP | 54,133 | $2.74M | 0.00% | −34,606−39.0% | Reduced |
| HighVista Strategies LLC | 57,348 | $2.90M | 1.05% | +8,828+18.2% | Added |
| Squarepoint Ops LLC | 59,204 | $3.00M | 0.01% | −80,316−57.6% | Reduced |
| Public Employees Retirement System of Ohio | 59,630 | $3.02M | 0.01% | +1,630+2.8% | Added |
| Skandinaviska Enskilda Banken AB (publ) | 59,626 | $3.02M | 0.02% | 00.0% | Unchanged |
| Janus Henderson Group PLC | 59,703 | $3.02M | 0.00% | −103−0.2% | Reduced |
| Jump Financial, LLC | 61,739 | $3.12M | 0.10% | −57,661−48.3% | Reduced |
| Lisanti Capital Growth, LLC | 62,415 | $3.16M | 0.74% | +62,415 | New |
| Treasurer of the State of North Carolina | 63,152 | $3.19M | 0.02% | +620+1.0% | Added |
| Van Eck Associates Corp | 65,831 | $3.33M | 0.01% | +1,144+1.8% | Added |
| Commerce Bank | 67,017 | $3.39M | 0.02% | −10,630−13.7% | Reduced |
| SEI Investments Co | 70,173 | $3.55M | 0.01% | +5,462+8.4% | Added |
| Cinctive Capital Management LP | 73,256 | $3.71M | 0.26% | +73,256 | New |
| Aigen Investment Management, LP | 73,720 | $3.73M | 0.67% | +73,720 | New |
| Nicola Wealth Management Ltd. | 56,000 | $3.75M | 0.39% | +26,000+86.7% | Added |
| Voya Investment Management LLC | 76,911 | $3.89M | 0.00% | +19,238+33.4% | Added |
| Man Group plc | 78,475 | $3.97M | 0.01% | – | – |
| State of New Jersey Common Pension Fund D | 81,847 | $4.14M | 0.01% | +4,586+5.9% | Added |
| Davenport & Co LLC | 86,328 | $4.37M | 0.03% | −549−0.6% | Reduced |
| LPL Financial LLC | 87,299 | $4.42M | 0.00% | +5,483+6.7% | Added |
| DekaBank Deutsche Girozentrale | 91,614 | $4.61M | 0.01% | 00.0% | Unchanged |
| Citigroup Inc | 100,245 | $5.07M | 0.01% | −89,375−47.1% | Reduced |
| State of Wisconsin Investment Board | 103,565 | $5.24M | 0.01% | −2,200−2.1% | Reduced |
| New York State Common Retirement Fund | 105,329 | $5.33M | 0.01% | −12,900−10.9% | Reduced |
| Peregrine Capital Management LLC | 107,824 | $5.45M | 0.16% | −18,569−14.7% | Reduced |
| Parkwood LLC | 108,554 | $5.49M | 0.88% | +108,554 | New |
| Renaissance Technologies LLC | 112,414 | $5.69M | 0.01% | −157,386−58.3% | Reduced |
| Trexquant Investment LP | 112,987 | $5.72M | 0.13% | −70,362−38.4% | Reduced |
| D. E. Shaw & Co., Inc. | 119,158 | $6.03M | 0.01% | −242,887−67.1% | Reduced |
| Granite Investment Partners, LLC | 119,946 | $6.07M | 0.24% | +119,946 | New |
| Dimensional Fund Advisors LP | 125,217 | $6.33M | 0.00% | −66,943−34.8% | Reduced |
| Connor, Clark & Lunn Investment Management Ltd. | 127,954 | $6.47M | 0.03% | −1,858−1.4% | Reduced |
| Envestnet Asset Management Inc | 133,484 | $6.75M | 0.00% | +6,748+5.3% | Added |
| Marshall Wace, LLP | 133,549 | $6.76M | 0.01% | +65,422+96.0% | Added |
| Senator Investment Group LP | 135,000 | $6.83M | 0.29% | +135,000 | New |
| Standard Life Aberdeen plc | 136,419 | $6.90M | 0.01% | +136,419 | New |
| California State Teachers Retirement System | 138,532 | $7.01M | 0.01% | −7,050−4.8% | Reduced |
| Swedbank AB | 140,998 | $7.13M | 0.01% | +4,059+3.0% | Added |
| Verition Fund Management LLC | 142,854 | $7.23M | 0.07% | +6,823+5.0% | Added |
| Hudson Bay Capital Management LP | 145,000 | $7.34M | 0.06% | −45,000−23.7% | Reduced |
| Sector Gamma AS | 145,012 | $7.34M | 1.78% | −20,604−12.4% | Reduced |
| BLB&B Advisors, LLC | 147,100 | $7.44M | 0.47% | −550−0.4% | Reduced |
| Sonora Investment Management Group, LLC | 149,338 | $7.56M | 0.61% | +888+0.6% | Added |
| State Board of Administration of Florida Retirement System | 151,055 | $7.64M | 0.02% | +670.0% | Added |
| Jane Street Group, LLC | 154,164 | $7.80M | 0.01% | −99,327−39.2% | Reduced |
| Legal & General Group Plc | 155,348 | $7.86M | 0.00% | −9,687−5.9% | Reduced |
| Russell Investments Group, Ltd. | 157,802 | $7.98M | 0.01% | +71,807+83.5% | Added |
| UBS Group AG | 159,739 | $8.08M | 0.00% | +50,705+46.5% | Added |
| Tocqueville Asset Management L.P. | 159,780 | $8.08M | 0.15% | −1,950−1.2% | Reduced |
| Susquehanna Portfolio Strategies, LLC | 169,678 | $8.58M | 0.15% | +169,678 | New |
| Raymond James & Associates | 183,676 | $9.29M | 0.01% | −10,953−5.6% | Reduced |
| Rafferty Asset Management, LLC | 184,396 | $9.33M | 0.04% | −31,575−14.6% | Reduced |
| Assenagon Asset Management S.A. | 184,401 | $9.33M | 0.03% | +184,401 | New |
| UBS Asset Management Americas Inc | 186,327 | $9.43M | 0.00% | +9,213+5.2% | Added |
| Superstring Capital Management LP | 189,618 | $9.59M | 6.85% | +189,618 | New |
| Credit Suisse AG | 189,722 | $9.60M | 0.01% | −40,621−17.6% | Reduced |
| Sicart Associates LLC | 194,293 | $9.83M | 3.76% | −8,839−4.4% | Reduced |
| Rhumbline Advisers | 199,416 | $10.1M | 0.01% | +1,956+1.0% | Added |
| Cubist Systematic Strategies, LLC | 199,477 | $10.1M | 0.12% | +199,477 | New |
| Tang Capital Management LLC | 200,000 | $10.1M | 0.93% | 00.0% | Unchanged |
| Jefferies Financial Group Inc. | 202,300 | $10.2M | 0.16% | +42,090+26.3% | Added |
| Invesco Ltd. | 205,901 | $10.4M | 0.00% | +74,734+57.0% | Added |
| Altrinsic Global Advisors LLC | 209,152 | $10.6M | 0.45% | −83,032−28.4% | Reduced |
| California Public Employees Retirement System | 209,436 | $10.6M | 0.01% | −445,935−68.0% | Reduced |
| Parkman Healthcare Partners LLC | 211,400 | $10.7M | 1.51% | +51,897+32.5% | Added |
| Bank of Montreal | 223,389 | $11.3M | 0.01% | −3,432−1.5% | Reduced |