Ionis Pharmaceuticals Inc
IONS- Exchange
- Nasdaq
- Industry
- Pharmaceutical Preparations
- SEC CIK
- 0000874015
In the last 90 days, Ionis Pharmaceuticals Inc insiders filed 1 open-market purchase and 4 sales; 515 institutions reported holding it in 13F filings for Q2 2026, worth $14.3B in total; ARK Invest is the only superinvestor holding it.
13F holders, Q4 2021
Institutional positions in Ionis Pharmaceuticals Inc as of Dec 31, 2021. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 341
- +20 vs. Q3 2021
- Shares held
- 123.2M
- +1.71M (+1.4%) vs. Q3 2021
- Total value
- $3.75B
- −$326.3M (−8.0%) vs. Q3 2021
- New holders
- 59
- 106 more added
- Sold out
- 39
- 119 more reduced
5 institutions that held it in Q3 2021 haven't filed for Q4 2021 yet. Not filing isn't selling, so they aren't counted as sold out or in the changes above.
Compare with Q3 2021: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting IONS on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 515 | $14.3B |
| Q1 2026 | 497 | $13.0B |
| Q4 2025 | 494 | $13.5B |
| Q3 2025 | 437 | $11.0B |
| Q2 2025 | 363 | $6.67B |
| Q1 2025 | 344 | $5.03B |
| Q4 2024 | 356 | $5.61B |
| Q3 2024 | 354 | $6.31B |
| Q2 2024 | 357 | $6.83B |
| Q1 2024 | 361 | $6.17B |
| Q4 2023 | 365 | $7.21B |
| Q3 2023 | 312 | $6.35B |
| Q2 2023 | 305 | $5.60B |
| Q1 2023 | 315 | $4.69B |
| Q4 2022 | 339 | $4.93B |
| Q3 2022 | 350 | $5.59B |
| Q2 2022 | 351 | $4.61B |
| Q1 2022 | 333 | $4.63B |
| Q4 2021 | 341 | $3.75B |
| Q3 2021 | 326 | $4.08B |
| Q2 2021 | 338 | $4.96B |
| Q1 2021 | 365 | $5.55B |
Institutions, Q4 2021
Shares, value and share of portfolio for each institution holding Ionis Pharmaceuticals Inc; share changes are against Q3 2021.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| Washington Trust Advisors, Inc. | 2,430 | $74.0K | 0.01% | +2,430 | New |
| Spire Wealth Management | 2,490 | $76.0K | 0.00% | +2,195+744.1% | Added |
| American International Group, Inc. | 2,571 | $78.0K | 0.00% | −89−3.3% | Reduced |
| Fifth Third Bancorp | 2,626 | $80.0K | 0.00% | 00.0% | Unchanged |
| Semmax Financial Advisors Inc. | 2,775 | $84.0K | 0.03% | −656−19.1% | Reduced |
| Itau Unibanco Holding S.A. | 2,804 | $86.0K | 0.00% | +1,563+125.9% | Added |
| NEXT Financial Group, Inc | 2,893 | $88.0K | 0.01% | +1,628+128.7% | Added |
| IFP Advisors, Inc | 2,673 | $93.0K | 0.00% | +953+55.4% | Added |
| NuWave Investment Management, LLC | 3,762 | $114.0K | 0.13% | +3,762 | New |
| Caldwell Trust Co | 4,000 | $121.7K | 0.01% | 00.0% | Unchanged |
| Federated Hermes, Inc. | 4,253 | $129.0K | 0.00% | 00.0% | Unchanged |
| Cutler Group LP | 4,290 | $130.0K | 0.01% | +3,490+436.3% | Added |
| Beaird Harris Wealth Management, LLC | 5,000 | $152.0K | 0.06% | +5,000 | New |
| Geneos Wealth Management Inc. | 5,066 | $154.0K | 0.01% | +228+4.7% | Added |
| Quantbot Technologies LP | 5,076 | $154.0K | 0.01% | +5,076 | New |
| Lazard Asset Management LLC | 5,814 | $176.0K | 0.00% | +4,554+361.4% | Added |
| Leonteq Securities AG | 6,236 | $189.8K | 0.01% | +757+13.8% | Added |
| National Asset Management, Inc. | 6,721 | $205.0K | 0.01% | −4,297−39.0% | Reduced |
| Graham Capital Management, L.P. | 6,804 | $207.0K | 0.01% | +6,804 | New |
| Great West Life Assurance Co | 7,043 | $214.0K | 0.00% | +121+1.7% | Added |
| Virginia Retirement Systems Et Al | 7,200 | $219.0K | 0.00% | −4,500−38.5% | Reduced |
| Fox Run Management, L.L.C. | 7,324 | $223.0K | 0.13% | −17−0.2% | Reduced |
| Mitsubishi UFJ Kokusai Asset Management Co., Ltd. | 6,874 | $224.0K | 0.00% | +630+10.1% | Added |
| Kennedy Capital Management, Inc. | 7,533 | $229.0K | 0.00% | −531−6.6% | Reduced |
| Cowen and Company, LLC | 7,730 | $235.0K | 0.02% | −5,113−39.8% | Reduced |
| Northeast Financial Consultants Inc | 7,740 | $236.0K | 0.01% | 00.0% | Unchanged |
| Boston Partners | 7,790 | $237.0K | 0.00% | +7,790 | New |
| IHT Wealth Management, LLC | 7,928 | $241.0K | 0.02% | +7,928 | New |
| Ergoteles LLC | 7,955 | $242.0K | 0.01% | −44,917−85.0% | Reduced |
| Horizon Kinetics Asset Management LLC | 8,000 | $243.0K | 0.01% | 00.0% | Unchanged |
| KBC Group NV | 8,017 | $244.0K | 0.00% | −895−10.0% | Reduced |
| Wrapmanager Inc | 8,318 | $253.0K | 0.06% | −2,006−19.4% | Reduced |
| Brandywine Managers, LLC | 8,460 | $257.0K | 0.29% | 00.0% | Unchanged |
| SG3 Management, LLC | 8,500 | $259.0K | 0.03% | −10,000−54.1% | Reduced |
| Nicollet Investment Management, Inc. | 8,504 | $259.0K | 0.10% | −1,997−19.0% | Reduced |
| Metropolitan Life Insurance Co | 8,813 | $268.2K | 0.00% | −67−0.8% | Reduced |
| The PNC Financial Services Group, Inc. | 8,831 | $269.0K | 0.00% | +32+0.4% | Added |
| Tanaka Capital Management Inc | 8,862 | $270.0K | 0.51% | −7,799−46.8% | Reduced |
| Berkshire Asset Management LLC | 9,239 | $281.0K | 0.02% | −3,821−29.3% | Reduced |
| Regions Financial Corp | 9,323 | $284.0K | 0.00% | −100−1.1% | Reduced |
| Ameriprise Financial Inc | 9,627 | $293.0K | 0.00% | −1,272−11.7% | Reduced |
| Brookfield Asset Management Inc. | 9,638 | $293.0K | 0.00% | +9,638 | New |
| Oppenheimer Asset Management Inc. | 9,782 | $297.0K | 0.00% | −1,100−10.1% | Reduced |
| Maryland State Retirement & Pension System | 9,956 | $303.0K | 0.01% | 00.0% | Unchanged |
| Cambridge Investment Research Advisors, Inc. | 10,447 | $318.0K | 0.00% | −6,420−38.1% | Reduced |
| Walleye Trading LLC | 10,695 | $325.0K | 0.01% | +1,076+11.2% | Added |
| SEI Investments Co | 11,194 | $339.0K | 0.00% | −2,763−19.8% | Reduced |
| Dynamic Technology Lab Private Ltd | 11,134 | $339.0K | 0.04% | −366−3.2% | Reduced |
| Greenup Street Wealth Management LLC | 11,145 | $339.0K | 0.20% | +11,145 | New |
| Plancorp, LLC | 11,274 | $343.0K | 0.02% | +140+1.3% | Added |
| Vontobel Holding Ltd. | 11,310 | $344.0K | 0.00% | +11,310 | New |
| Baird Financial Group, Inc. | 11,356 | $346.0K | 0.00% | +2,407+26.9% | Added |
| Teza Capital Management LLC | 11,845 | $360.0K | 0.10% | +11,845 | New |
| Rockefeller Capital Management L.P. | 12,092 | $366.0K | 0.00% | −1,320,688−99.1% | Reduced |
| Caption Management, LLC | 12,000 | $366.0K | 0.02% | −108,993−90.1% | Reduced |
| Comerica Bank | 11,755 | $370.0K | 0.00% | −75−0.6% | Reduced |
| Virtus ETF Advisers LLC | 12,296 | $374.0K | 0.14% | +194+1.6% | Added |
| Shell Asset Management Co | 12,651 | $385.0K | 0.01% | +48+0.4% | Added |
| Cetera Advisor Networks LLC | 12,825 | $390.0K | 0.00% | +273+2.2% | Added |
| SG Americas Securities, LLC | 12,932 | $394.0K | 0.00% | −6,789−34.4% | Reduced |
| Brown Advisory Securities, LLC | 13,000 | $394.0K | 0.17% | −2,500−16.1% | Reduced |
| Wellington Management Group LLP | 13,134 | $399.0K | 0.00% | +13,134 | New |
| Victory Capital Management Inc | 13,147 | $400.0K | 0.00% | −192−1.4% | Reduced |
| Gsa Capital Partners LLP | 13,368 | $407.0K | 0.05% | +13,368 | New |
| North Star Asset Management Inc | 13,680 | $416.0K | 0.02% | 00.0% | Unchanged |
| Verition Fund Management LLC | 13,740 | $418.0K | 0.01% | +13,740 | New |
| Brookstone Capital Management | 13,947 | $424.0K | 0.01% | +2,550+22.4% | Added |
| Deutsche Bank AG | 14,087 | $428.0K | 0.00% | −36,859−72.3% | Reduced |
| Lincoln National Corp | 14,070 | $428.0K | 0.01% | −200−1.4% | Reduced |
| Blair William & Co | 14,464 | $440.0K | 0.00% | −50−0.3% | Reduced |
| Xponance, Inc. | 14,890 | $453.0K | 0.01% | +318+2.2% | Added |
| Creative Planning | 15,116 | $460.0K | 0.00% | +201+1.3% | Added |
| Castle Rock Wealth Management, LLC | 15,593 | $466.0K | 0.19% | 00.0% | Unchanged |
| Arden Trust Co | 15,554 | $474.0K | 0.08% | −543−3.4% | Reduced |
| Natixis Advisors, L.P. | 15,895 | $484.0K | 0.00% | −1,833−10.3% | Reduced |
| State of Wisconsin Investment Board | 17,054 | $519.0K | 0.00% | −525−3.0% | Reduced |
| Campbell & CO Investment Adviser LLC | 17,346 | $528.0K | 0.18% | −2,550−12.8% | Reduced |
| Quantamental Technologies LLC | 17,671 | $538.0K | 0.27% | +17,671 | New |
| Stephens Inc | 17,701 | $539.0K | 0.01% | −3,440−16.3% | Reduced |
| Oppenheimer & Co Inc | 18,358 | $559.0K | 0.01% | −2,769−13.1% | Reduced |
| Vestmark Advisory Solutions, Inc. | 18,578 | $565.0K | 0.03% | −1,455−7.3% | Reduced |
| US Bancorp | 19,115 | $582.0K | 0.00% | +2,732+16.7% | Added |
| Advisor Group Holdings, Inc. | 19,147 | $583.0K | 0.00% | +706+3.8% | Added |
| Profund Advisors LLC | 19,417 | $591.0K | 0.02% | −3,474−15.2% | Reduced |
| Public Employees Retirement Association of Colorado | 19,604 | $597.0K | 0.00% | 00.0% | Unchanged |
| Kestra Advisory Services, LLC | 19,681 | $599.0K | 0.01% | −8,243−29.5% | Reduced |
| ExodusPoint Capital Management, LP | 19,788 | $602.0K | 0.01% | +11,615+142.1% | Added |
| Skandinaviska Enskilda Banken AB (publ) | 20,878 | $638.0K | 0.00% | 00.0% | Unchanged |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 22,121 | $673.0K | 0.00% | +9,304+72.6% | Added |
| Storebrand Asset Management AS | 22,462 | $683.5K | 0.00% | −12,204−35.2% | Reduced |
| ProShare Advisors LLC | 23,432 | $713.0K | 0.00% | −10,067−30.1% | Reduced |
| Handelsbanken Fonder AB | 24,411 | $743.0K | 0.00% | 00.0% | Unchanged |
| Teacher Retirement System of Texas | 24,454 | $744.0K | 0.00% | +4,694+23.8% | Added |
| MML Investors Services, LLC | 25,217 | $767.0K | 0.01% | +603+2.4% | Added |
| Utah Retirement Systems | 25,409 | $773.0K | 0.01% | +100+0.4% | Added |
| Janus Henderson Group PLC | 25,716 | $783.0K | 0.00% | +11,968+87.1% | Added |
| AE Wealth Management LLC | 26,085 | $794.0K | 0.01% | +26,085 | New |
| Grandfield & Dodd, LLC | 26,771 | $810.0K | 0.05% | +5,080+23.4% | Added |
| Occudo Quantitative Strategies LP | 26,650 | $811.0K | 0.07% | +26,650 | New |
| HighTower Advisors, LLC | 27,138 | $826.0K | 0.00% | +17,281+175.3% | Added |