Ionis Pharmaceuticals Inc
IONS- Exchange
- Nasdaq
- Industry
- Pharmaceutical Preparations
- SEC CIK
- 0000874015
In the last 90 days, Ionis Pharmaceuticals Inc insiders filed 1 open-market purchase and 4 sales; 515 institutions reported holding it in 13F filings for Q2 2026, worth $14.3B in total; ARK Invest is the only superinvestor holding it.
13F holders, Q3 2021
Institutional positions in Ionis Pharmaceuticals Inc as of Sep 30, 2021. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 326
- −9 vs. Q2 2021
- Shares held
- 121.7M
- −2.53M (−2.0%) vs. Q2 2021
- Total value
- $4.08B
- −$872.0M (−17.6%) vs. Q2 2021
- New holders
- 38
- 108 more added
- Sold out
- 47
- 103 more reduced
3 institutions that held it in Q2 2021 haven't filed for Q3 2021 yet. Not filing isn't selling, so they aren't counted as sold out or in the changes above.
Compare with Q2 2021: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting IONS on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 515 | $14.3B |
| Q1 2026 | 497 | $13.0B |
| Q4 2025 | 494 | $13.5B |
| Q3 2025 | 437 | $11.0B |
| Q2 2025 | 363 | $6.67B |
| Q1 2025 | 344 | $5.03B |
| Q4 2024 | 356 | $5.61B |
| Q3 2024 | 354 | $6.31B |
| Q2 2024 | 357 | $6.83B |
| Q1 2024 | 361 | $6.17B |
| Q4 2023 | 365 | $7.21B |
| Q3 2023 | 312 | $6.35B |
| Q2 2023 | 305 | $5.60B |
| Q1 2023 | 315 | $4.69B |
| Q4 2022 | 339 | $4.93B |
| Q3 2022 | 350 | $5.59B |
| Q2 2022 | 351 | $4.61B |
| Q1 2022 | 333 | $4.63B |
| Q4 2021 | 341 | $3.75B |
| Q3 2021 | 326 | $4.08B |
| Q2 2021 | 338 | $4.96B |
| Q1 2021 | 365 | $5.55B |
Institutions, Q3 2021
Shares, value and share of portfolio for each institution holding Ionis Pharmaceuticals Inc; share changes are against Q2 2021.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| Simplex Trading, LLC | 22,512 | $901.0K | 0.03% | +1,158+5.4% | Added |
| Kestra Advisory Services, LLC | 27,924 | $937.0K | 0.01% | +5,078+22.2% | Added |
| Truist Financial Corp | 30,977 | $1.04M | 0.00% | +5,876+23.4% | Added |
| Group One Trading, L.P. | 31,533 | $1.06M | 0.02% | +30.0% | Added |
| Employees Retirement System of Texas | 32,409 | $1.09M | 0.01% | 00.0% | Unchanged |
| Macquarie Group Ltd | 32,428 | $1.09M | 0.00% | 00.0% | Unchanged |
| ProShare Advisors LLC | 33,499 | $1.12M | 0.00% | +3,076+10.1% | Added |
| Janney Montgomery Scott LLC | 34,153 | $1.15M | 0.00% | −4,493−11.6% | Reduced |
| Arizona State Retirement System | 34,557 | $1.16M | 0.01% | +96+0.3% | Added |
| Storebrand Asset Management AS | 34,666 | $1.16M | 0.01% | −756−2.1% | Reduced |
| Connor, Clark & Lunn Investment Management Ltd. | 35,536 | $1.19M | 0.01% | +35,536 | New |
| First Foundation Advisors | 35,746 | $1.20M | 0.04% | +1,297+3.8% | Added |
| Commonwealth Equity Services, LLC | 38,118 | $1.28M | 0.00% | +12,388+48.1% | Added |
| Gateway Investment Advisers LLC | 38,132 | $1.28M | 0.01% | +532+1.4% | Added |
| Capital Counsel LLC | 40,580 | $1.36M | 0.07% | 00.0% | Unchanged |
| Arrowstreet Capital, Limited Partnership | 41,100 | $1.38M | 0.00% | −51,800−55.8% | Reduced |
| NJ State Employees Deferred Compensation Plan | 42,000 | $1.41M | 0.19% | 00.0% | Unchanged |
| Principal Financial Group Inc | 42,685 | $1.43M | 0.00% | −5,285−11.0% | Reduced |
| Voya Investment Management LLC | 42,700 | $1.43M | 0.00% | −719−1.7% | Reduced |
| Private Advisor Group, LLC | 44,105 | $1.48M | 0.01% | +20,664+88.2% | Added |
| Jefferies Group LLC | 44,137 | $1.48M | 0.04% | −22,567−33.8% | Reduced |
| International Biotechnology Trust PLC | 44,781 | $1.50M | 0.37% | −137,000−75.4% | Reduced |
| Raymond James Financial Services Advisors, Inc. | 46,156 | $1.55M | 0.00% | +1,325+3.0% | Added |
| Treasurer of the State of North Carolina | 50,516 | $1.69M | 0.01% | +1,709+3.5% | Added |
| Deutsche Bank AG | 50,946 | $1.71M | 0.00% | −183,440−78.3% | Reduced |
| Erste Asset Management GmbH | 51,300 | $1.72M | 0.03% | 00.0% | Unchanged |
| AlphaCrest Capital Management LLC | 52,084 | $1.75M | 0.09% | +32,724+169.0% | Added |
| Ergoteles LLC | 52,872 | $1.77M | 0.07% | −123,381−70.0% | Reduced |
| AXA S.A. | 57,200 | $1.92M | 0.01% | +57,200 | New |
| Guggenheim Capital LLC | 62,637 | $2.10M | 0.01% | +6,501+11.6% | Added |
| Jane Street Group, LLC | 64,476 | $2.16M | 0.01% | +18,059+38.9% | Added |
| Alliancebernstein L.P. | 68,451 | $2.30M | 0.00% | −1,352−1.9% | Reduced |
| Rhenman & Partners Asset Management AB | 75,000 | $2.52M | 0.18% | 00.0% | Unchanged |
| PFS Investments Inc. | 76,842 | $2.68M | 0.06% | +1,127+1.5% | Added |
| LPL Financial LLC | 83,615 | $2.80M | 0.00% | +24,299+41.0% | Added |
| Sabby Management, LLC | 84,600 | $2.84M | 0.62% | +6,600+8.5% | Added |
| Cubist Systematic Strategies, LLC | 86,754 | $2.91M | 0.04% | −91,388−51.3% | Reduced |
| State of New Jersey Common Pension Fund D | 87,216 | $2.92M | 0.01% | +471+0.5% | Added |
| Public Employees Retirement System of Ohio | 87,444 | $2.93M | 0.01% | +7,390+9.2% | Added |
| Rafferty Asset Management, LLC | 96,737 | $3.25M | 0.02% | +27,965+40.7% | Added |
| Renaissance Technologies LLC | 97,714 | $3.28M | 0.00% | −678,700−87.4% | Reduced |
| Envestnet Asset Management Inc | 102,422 | $3.44M | 0.00% | +6,702+7.0% | Added |
| Wolverine Trading, LLC | 106,878 | $3.59M | 0.07% | −4,070−3.7% | Reduced |
| DekaBank Deutsche Girozentrale | 107,576 | $3.61M | 0.01% | 00.0% | Unchanged |
| Caption Management, LLC | 120,993 | $4.06M | 0.27% | +24,986+26.0% | Added |
| Citigroup Inc | 121,064 | $4.06M | 0.00% | −121,059−50.0% | Reduced |
| Davenport & Co LLC | 122,303 | $4.10M | 0.03% | +5,340+4.6% | Added |
| D. E. Shaw & Co., Inc. | 126,106 | $4.23M | 0.01% | +51,440+68.9% | Added |
| HRT Financial LP | 128,087 | $4.30M | 0.03% | +128,087 | New |
| UBS Group AG | 132,812 | $4.46M | 0.00% | −22,317−14.4% | Reduced |
| Pictet Asset Management SA | 135,696 | $4.55M | 0.01% | +135,696 | New |
| Peregrine Capital Management LLC | 135,787 | $4.55M | 0.09% | −26,741−16.5% | Reduced |
| Parkman Healthcare Partners LLC | 136,380 | $4.57M | 1.16% | 00.0% | Unchanged |
| Rhumbline Advisers | 138,363 | $4.64M | 0.01% | −1,222−0.9% | Reduced |
| Invesco Ltd. | 141,355 | $4.74M | 0.00% | −199,258−58.5% | Reduced |
| Balyasny Asset Management LLC | 142,015 | $4.76M | 0.02% | −121,271−46.1% | Reduced |
| BLB&B Advisors, LLC | 156,200 | $5.24M | 0.35% | −1,290−0.8% | Reduced |
| State Board of Administration of Florida Retirement System | 161,938 | $5.43M | 0.01% | −2,170−1.3% | Reduced |
| Sonora Investment Management, LLC | 163,703 | $5.49M | 0.69% | −4,962−2.9% | Reduced |
| Legal & General Group Plc | 167,421 | $5.62M | 0.00% | +41,538+33.0% | Added |
| Tocqueville Asset Management L.P. | 168,530 | $5.65M | 0.08% | −3,670−2.1% | Reduced |
| Squarepoint Ops LLC | 169,865 | $5.70M | 0.04% | +122,120+255.8% | Added |
| Susquehanna International Group, LLP | 174,166 | $5.84M | 0.01% | −206,300−54.2% | Reduced |
| Majedie Asset Management Ltd | 175,508 | $5.89M | 0.45% | −8,954−4.9% | Reduced |
| UBS Asset Management Americas Inc | 180,665 | $6.06M | 0.00% | +4,324+2.5% | Added |
| Credit Suisse AG | 182,662 | $6.13M | 0.00% | +23,477+14.7% | Added |
| American Century Companies Inc | 199,346 | $6.69M | 0.00% | −26,834−11.9% | Reduced |
| Tudor Investment Corp Et Al | 201,613 | $6.76M | 0.14% | +101,727+101.8% | Added |
| Morningstar Investment Services LLC | 214,141 | $7.21M | 0.09% | +4,034+1.9% | Added |
| Point72 Asset Management, L.P. | 219,300 | $7.36M | 0.03% | −757,600−77.6% | Reduced |
| California State Teachers Retirement System | 225,991 | $7.58M | 0.01% | −17,731−7.3% | Reduced |
| Parametric Portfolio Associates LLC | 231,506 | $7.76M | 0.00% | +11,294+5.1% | Added |
| Russell Investments Group, Ltd. | 231,865 | $7.77M | 0.01% | +10,311+4.7% | Added |
| New York State Common Retirement Fund | 241,159 | $8.09M | 0.01% | 00.0% | Unchanged |
| Bank of Montreal | 249,704 | $8.49M | 0.00% | −131,781−34.5% | Reduced |
| Sector Gamma AS | 263,870 | $8.85M | 1.77% | +382+0.1% | Added |
| Hudson Bay Capital Management LP | 265,000 | $8.89M | 0.13% | +80,000+43.2% | Added |
| Swiss National Bank | 279,900 | $9.39M | 0.01% | 00.0% | Unchanged |
| Millennium Management LLC | 282,854 | $9.49M | 0.01% | −512,988−64.5% | Reduced |
| California Public Employees Retirement System | 288,128 | $9.66M | 0.01% | −32,552−10.2% | Reduced |
| Sicart Associates LLC | 291,254 | $9.77M | 2.66% | −77,155−20.9% | Reduced |
| Raymond James & Associates | 301,449 | $10.1M | 0.01% | +7,511+2.6% | Added |
| Baillie Gifford & Co | 302,003 | $10.1M | 0.01% | +30,607+11.3% | Added |
| Dowling & Yahnke LLC | 302,521 | $10.1M | 0.56% | −629−0.2% | Reduced |
| Two Sigma Investments, LP | 314,134 | $10.5M | 0.03% | +7,646+2.5% | Added |
| Tekla Capital Management LLC | 322,521 | $10.8M | 0.35% | 00.0% | Unchanged |
| Barclays PLC | 330,291 | $11.1M | 0.01% | −33,705−9.3% | Reduced |
| Dimensional Fund Advisors LP | 355,839 | $11.9M | 0.00% | −54,378−13.3% | Reduced |
| Nomura Holdings Inc | 376,748 | $12.6M | 0.10% | −980−0.3% | Reduced |
| Stifel Financial Corp | 376,219 | $12.6M | 0.02% | −1,466−0.4% | Reduced |
| Woodline Partners LP | 405,461 | $13.6M | 0.23% | −558,327−57.9% | Reduced |
| TD Asset Management Inc | 421,964 | $14.2M | 0.01% | +1000.0% | Added |
| Two Sigma Advisers, LP | 432,211 | $14.5M | 0.04% | −93,600−17.8% | Reduced |
| Altrinsic Global Advisors LLC | 444,887 | $14.9M | 0.45% | −11,339−2.5% | Reduced |
| Eversept Partners, LP | 450,501 | $15.1M | 1.21% | +8,501+1.9% | Added |
| Royal Bank of Canada | 489,561 | $16.4M | 0.00% | +4,595+0.9% | Added |
| Morgan Stanley | 497,936 | $16.7M | 0.00% | −29,673−5.6% | Reduced |
| Pinnacle Associates Ltd | 543,226 | $18.2M | 0.34% | +1,884+0.3% | Added |
| Bank of New York Mellon Corp | 560,566 | $18.8M | 0.00% | +20,037+3.7% | Added |
| Goldman Sachs Group Inc | 601,836 | $20.2M | 0.01% | −77,593−11.4% | Reduced |