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Ionis Pharmaceuticals Inc

IONS
Exchange
Nasdaq
Industry
Pharmaceutical Preparations
SEC CIK
0000874015

In the last 90 days, Ionis Pharmaceuticals Inc insiders filed 1 open-market purchase and 4 sales; 515 institutions reported holding it in 13F filings for Q2 2026, worth $14.3B in total; ARK Invest is the only superinvestor holding it.

13F holders, Q2 2021

Institutional positions in Ionis Pharmaceuticals Inc as of Jun 30, 2021. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works

Institutional holders
338
−24 vs. Q1 2021
Shares held
124.4M
+2.62M (+2.2%) vs. Q1 2021
Total value
$4.96B
−$516.2M (−9.4%) vs. Q1 2021
New holders
51
116 more added
Sold out
75
103 more reduced

3 institutions that held it in Q1 2021 haven't filed for Q2 2021 yet. Not filing isn't selling, so they aren't counted as sold out or in the changes above.

Compare with Q1 2021: new holders, sold out and not filed yet

Holders and value by quarter

Institutions reporting IONS on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.

Institutional holdersQ2 2021: 338 institutions
Q1 2021: 365 institutionsQ2 2021: 338 institutionsQ3 2021: 326 institutionsQ4 2021: 341 institutionsQ1 2022: 333 institutionsQ2 2022: 351 institutionsQ3 2022: 350 institutionsQ4 2022: 339 institutionsQ1 2023: 315 institutionsQ2 2023: 305 institutionsQ3 2023: 312 institutionsQ4 2023: 365 institutionsQ1 2024: 361 institutionsQ2 2024: 357 institutionsQ3 2024: 354 institutionsQ4 2024: 356 institutionsQ1 2025: 344 institutionsQ2 2025: 363 institutionsQ3 2025: 437 institutionsQ4 2025: 494 institutionsQ1 2026: 497 institutionsQ2 2026: 515 institutions
Value heldQ2 2021: $4.96B
Q1 2021: $5.55BQ2 2021: $4.96BQ3 2021: $4.08BQ4 2021: $3.75BQ1 2022: $4.63BQ2 2022: $4.61BQ3 2022: $5.59BQ4 2022: $4.93BQ1 2023: $4.69BQ2 2023: $5.60BQ3 2023: $6.35BQ4 2023: $7.21BQ1 2024: $6.17BQ2 2024: $6.83BQ3 2024: $6.31BQ4 2024: $5.61BQ1 2025: $5.03BQ2 2025: $6.67BQ3 2025: $11.0BQ4 2025: $13.5BQ1 2026: $13.0BQ2 2026: $14.3B
Institutions holding IONS and their total value by quarter
QuarterHoldersValue
Q2 2026515$14.3B
Q1 2026497$13.0B
Q4 2025494$13.5B
Q3 2025437$11.0B
Q2 2025363$6.67B
Q1 2025344$5.03B
Q4 2024356$5.61B
Q3 2024354$6.31B
Q2 2024357$6.83B
Q1 2024361$6.17B
Q4 2023365$7.21B
Q3 2023312$6.35B
Q2 2023305$5.60B
Q1 2023315$4.69B
Q4 2022339$4.93B
Q3 2022350$5.59B
Q2 2022351$4.61B
Q1 2022333$4.63B
Q4 2021341$3.75B
Q3 2021326$4.08B
Q2 2021338$4.96B
Q1 2021365$5.55B

Institutions, Q2 2021

Shares, value and share of portfolio for each institution holding Ionis Pharmaceuticals Inc; share changes are against Q1 2021.

Institutions holding IONS in Q2 2021
InstitutionSharesValue% of portfolioChange in sharesAction
Gradient Investments LLC91$4.00K0.00%00.0%Unchanged
Blume Capital Management, Inc.90$4.00K0.00%00.0%Unchanged
McCarthy Asset Management, Inc.110$4.00K0.00%+110New
Global Wealth Management Investment Advisory, Inc.80$3.00K0.00%00.0%Unchanged
Eagle Bay Advisors LLC75$3.00K0.00%+75New
Mitsubishi UFJ Trust & Banking Corp50$2.00K0.00%−79,901−99.9%Reduced
Benjamin F. Edwards & Company, Inc.56$2.00K0.00%−2,033−97.3%Reduced
Quadrant Capital Group LLC58$2.00K0.00%−207−78.1%Reduced
Prestige Wealth Management Group LLC60$2.00K0.00%−42−41.2%Reduced
Trustcore Financial Services, LLC58$2.00K0.00%00.0%Unchanged
Rockbridge Investment Management, LCC58$2.00K0.00%00.0%Unchanged
Earnest Partners LLC49$2.00K0.00%00.0%Unchanged
Harbor Investment Advisory, LLC38$2.00K0.00%00.0%Unchanged
Sargent Bickham Lagudis LLC43$2.00K0.00%00.0%Unchanged
Bedel Financial Consulting, Inc.38$2.00K0.00%00.0%Unchanged
Versant Capital Management, Inc46$2.00K0.00%00.0%Unchanged
Liberty Wealth Management LLC44$2.00K0.00%00.0%Unchanged
Orion Capital Management LLC38$2.00K0.00%00.0%Unchanged
Loring Wolcott & Coolidge Fiduciary Advisors LLP45$2.00K0.00%+45New
Clean Yield Group50$2.00K0.00%+50New
Raffa Wealth Management, LLC28$1.12K0.00%00.0%Unchanged
Lindbrook Capital, LLC16$1.00K0.00%−30−65.2%Reduced
Meeder Asset Management Inc14$1.00K0.00%00.0%Unchanged
AdvisorNet Financial, Inc29$1.00K0.00%00.0%Unchanged
Allworth Financial LP17$1.00K0.00%00.0%Unchanged
Cranbrook Wealth Management, LLC25$1.00K0.00%00.0%Unchanged
BDO Wealth Advisors, LLC33$1.00K0.00%00.0%Unchanged
Private Capital Group, LLC31$1.00K0.00%00.0%Unchanged
Enterprise Financial Services Corp23$1.00K0.00%+12+109.1%Added
Covington Capital Management36$1.00K0.00%+36New
Parkside Financial Bank & Trust23$1.00K0.00%+23New
Stonebridge Capital Advisors LLC29$1.00K0.00%+29New
Sound Income Strategies, LLC20$1.00K0.00%+20New
Kelly Financial Services LLC1,197$300.00%+567+90.0%Added
Huntington National Bank1$00.00%−62−98.4%Reduced
First Horizon Corp6$00.00%00.0%Unchanged
Gemmer Asset Management LLC3$00.00%00.0%Unchanged
Aspire Private Capital, LLC8$00.00%00.0%Unchanged
BVF Inc0$00.00%−1,364,461−100.0%Sold out
Farallon Capital Management, L.L.C.0$00.00%−630,500−100.0%Sold out
Alyeska Investment Group, L.P.0$00.00%−427,990−100.0%Sold out
Verition Fund Management LLC0$00.00%−319,539−100.0%Sold out
AXA S.A.0$00.00%−192,629−100.0%Sold out
Sphera Funds Management Ltd.0$00.00%−145,476−100.0%Sold out
Edmond de Rothschild Holding S.A.0$00.00%−86,250−100.0%Sold out
Janus Henderson Group PLC0$00.00%−76,644−100.0%Sold out
Asset Management One Co.,Ltd.0$00.00%−60,617−100.0%Sold out
Andra AP-fonden0$00.00%−59,700−100.0%Sold out
Fjarde Ap-Fonden /Fourth Swedish National Pension Fund0$00.00%−57,500−100.0%Sold out
DnB Asset Management AS0$00.00%−56,658−100.0%Sold out
Connor, Clark & Lunn Investment Management Ltd.0$00.00%−51,579−100.0%Sold out
Canada Pension Plan Investment Board0$00.00%−36,762−100.0%Sold out
AMP Capital Investors Ltd0$00.00%−31,333−100.0%Sold out
Korea Investment CORP0$00.00%−29,900−100.0%Sold out
Engineers Gate Manager LP0$00.00%−29,160−100.0%Sold out
Gulf International Bank (UK) Ltd0$00.00%−23,940−100.0%Sold out
Twinbeech Capital LP0$00.00%−22,750−100.0%Sold out
Gyon Technologies Capital Management, LP0$00.00%−22,376−100.0%Sold out
British Columbia Investment Management Corp0$00.00%−21,768−100.0%Sold out
Schonfeld Strategic Advisors LLC0$00.00%−21,101−100.0%Sold out
AtonRa Partners0$00.00%−20,146−100.0%Sold out
Toronto Dominion Bank0$00.00%−17,977−100.0%Sold out
IFM Investors Pty Ltd0$00.00%−15,830−100.0%Sold out
Virtu Financial LLC0$00.00%−14,360−100.0%Sold out
Nissay Asset Management Corp0$00.00%−14,204−100.0%Sold out
NN Investment Partners Holdings N.V.0$00.00%−14,118−100.0%Sold out
Migdal Insurance & Financial Holdings Ltd.0$00.00%−13,305−100.0%Sold out
Ritholtz Wealth Management0$00.00%−12,501−100.0%Sold out
Voya Financial Advisors, Inc.0$00.00%−12,433−100.0%Sold out
Reynders McVeigh Capital Management, LLC0$00.00%−12,174−100.0%Sold out
Echo Street Capital Management LLC0$00.00%−10,613−100.0%Sold out
Westpac Banking Corp0$00.00%−10,594−100.0%Sold out
Quantitative Investment Management, LLC0$00.00%−9,931−100.0%Sold out
CSS LLC0$00.00%−9,605−100.0%Sold out
NewEdge Wealth, LLC0$00.00%−8,224−100.0%Sold out
Magnetar Financial LLC0$00.00%−7,865−100.0%Sold out
Mirae Asset Global Investments Co., Ltd.0$00.00%−7,772−100.0%Sold out
Meiji Yasuda Asset Management Co Ltd.0$00.00%−7,730−100.0%Sold out
Keybank National Association0$00.00%−7,500−100.0%Sold out
Sumitomo Mitsui DS Asset Management Company, Ltd0$00.00%−7,251−100.0%Sold out
ETF Managers Group, LLC0$00.00%−6,975−100.0%Sold out
Bridgefront Capital, LLC0$00.00%−6,798−100.0%Sold out
TD Ameritrade Investment Management, LLC0$00.00%−5,000−100.0%Sold out
Illinois Municipal Retirement Fund0$00.00%−6,118−100.0%Sold out
Argent Trust Co0$00.00%−5,736−100.0%Sold out
Cresset Asset Management, LLC0$00.00%−5,728−100.0%Sold out
Standard Life Aberdeen plc0$00.00%−5,197−100.0%Sold out
Nordea Investment Management AB0$00.00%−5,156−100.0%Sold out
Robeco Institutional Asset Management B.V.0$00.00%−5,038−100.0%Sold out
IBM Retirement Fund0$00.00%−4,462−100.0%Sold out
E. Ohman J:or Asset Management AB0$00.00%−3,400−100.0%Sold out
Acadian Asset Management LLC0$00.00%−2,378−100.0%Sold out
First Quadrant L P0$00.00%−2,082−100.0%Sold out
Livforsakringsbolaget Skandia, Omsesidigt0$00.00%−1,500−100.0%Sold out
Pacer Advisors, Inc.0$00.00%−1,471−100.0%Sold out
STRS Ohio0$00.00%−1,454−100.0%Sold out
Federation des caisses Desjardins du Quebec0$00.00%−1,271−100.0%Sold out
Archer Investment Corp0$00.00%−917−100.0%Sold out
Sowell Financial Services LLC0$00.00%−1,059−100.0%Sold out
Allred Capital Management, LLC0$00.00%−771−100.0%Sold out