Ionis Pharmaceuticals Inc
IONS- Exchange
- Nasdaq
- Industry
- Pharmaceutical Preparations
- SEC CIK
- 0000874015
In the last 90 days, Ionis Pharmaceuticals Inc insiders filed 1 open-market purchase and 4 sales; 515 institutions reported holding it in 13F filings for Q2 2026, worth $14.3B in total; ARK Invest is the only superinvestor holding it.
13F holders, Q2 2021
Institutional positions in Ionis Pharmaceuticals Inc as of Jun 30, 2021. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 338
- −24 vs. Q1 2021
- Shares held
- 124.4M
- +2.62M (+2.2%) vs. Q1 2021
- Total value
- $4.96B
- −$516.2M (−9.4%) vs. Q1 2021
- New holders
- 51
- 116 more added
- Sold out
- 75
- 103 more reduced
3 institutions that held it in Q1 2021 haven't filed for Q2 2021 yet. Not filing isn't selling, so they aren't counted as sold out or in the changes above.
Compare with Q1 2021: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting IONS on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 515 | $14.3B |
| Q1 2026 | 497 | $13.0B |
| Q4 2025 | 494 | $13.5B |
| Q3 2025 | 437 | $11.0B |
| Q2 2025 | 363 | $6.67B |
| Q1 2025 | 344 | $5.03B |
| Q4 2024 | 356 | $5.61B |
| Q3 2024 | 354 | $6.31B |
| Q2 2024 | 357 | $6.83B |
| Q1 2024 | 361 | $6.17B |
| Q4 2023 | 365 | $7.21B |
| Q3 2023 | 312 | $6.35B |
| Q2 2023 | 305 | $5.60B |
| Q1 2023 | 315 | $4.69B |
| Q4 2022 | 339 | $4.93B |
| Q3 2022 | 350 | $5.59B |
| Q2 2022 | 351 | $4.61B |
| Q1 2022 | 333 | $4.63B |
| Q4 2021 | 341 | $3.75B |
| Q3 2021 | 326 | $4.08B |
| Q2 2021 | 338 | $4.96B |
| Q1 2021 | 365 | $5.55B |
Institutions, Q2 2021
Shares, value and share of portfolio for each institution holding Ionis Pharmaceuticals Inc; share changes are against Q1 2021.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| SG3 Management, LLC | 72,300 | $2.88M | 1.23% | +52,300+261.5% | Added |
| Alliancebernstein L.P. | 69,803 | $2.78M | 0.00% | −7,497−9.7% | Reduced |
| Rafferty Asset Management, LLC | 68,772 | $2.74M | 0.02% | +5,888+9.4% | Added |
| Jefferies Group LLC | 66,704 | $2.66M | 0.05% | +46,577+231.4% | Added |
| Jump Financial, LLC | 62,400 | $2.49M | 0.24% | +62,400 | New |
| LPL Financial LLC | 59,316 | $2.37M | 0.00% | +4,033+7.3% | Added |
| Guggenheim Capital LLC | 56,136 | $2.24M | 0.01% | −15,256−21.4% | Reduced |
| Erste Asset Management GmbH | 51,300 | $2.03M | 0.04% | +16,800+48.7% | Added |
| Treasurer of the State of North Carolina | 48,807 | $1.95M | 0.01% | +890+1.9% | Added |
| Principal Financial Group Inc | 47,970 | $1.91M | 0.00% | +3,559+8.0% | Added |
| Squarepoint Ops LLC | 47,745 | $1.91M | 0.01% | +28,158+143.8% | Added |
| Jane Street Group, LLC | 46,417 | $1.85M | 0.00% | +13,554+41.2% | Added |
| Raymond James Financial Services Advisors, Inc. | 44,831 | $1.79M | 0.00% | +9,302+26.2% | Added |
| Voya Investment Management LLC | 43,419 | $1.73M | 0.00% | +12,708+41.4% | Added |
| NJ State Employees Deferred Compensation Plan | 42,000 | $1.68M | 0.22% | 00.0% | Unchanged |
| Capital Counsel LLC | 40,580 | $1.62M | 0.08% | −1,500−3.6% | Reduced |
| Janney Montgomery Scott LLC | 38,646 | $1.54M | 0.01% | +1,834+5.0% | Added |
| Gateway Investment Advisers LLC | 37,600 | $1.50M | 0.02% | 00.0% | Unchanged |
| Storebrand Asset Management AS | 35,422 | $1.41M | 0.01% | −1,931−5.2% | Reduced |
| Arizona State Retirement System | 34,461 | $1.38M | 0.01% | −3,838−10.0% | Reduced |
| First Foundation Advisors | 34,449 | $1.37M | 0.05% | +4,386+14.6% | Added |
| Seeyond | 33,852 | $1.35M | 0.13% | +151+0.4% | Added |
| Great West Life Assurance Co | 33,166 | $1.32M | 0.00% | −24,310−42.3% | Reduced |
| Macquarie Group Ltd | 32,428 | $1.29M | 0.00% | +1,971+6.5% | Added |
| Employees Retirement System of Texas | 32,409 | $1.29M | 0.02% | 00.0% | Unchanged |
| Skandinaviska Enskilda Banken AB (publ) | 32,293 | $1.29M | 0.01% | −22,200−40.7% | Reduced |
| Group One Trading, L.P. | 31,530 | $1.26M | 0.02% | +2,619+9.1% | Added |
| Edgestream Partners, L.P. | 31,262 | $1.25M | 0.07% | +31,262 | New |
| ProShare Advisors LLC | 30,423 | $1.21M | 0.00% | +8,288+37.4% | Added |
| Twin Tree Management, LP | 29,382 | $1.17M | 0.04% | +29,382 | New |
| Cowen and Company, LLC | 27,708 | $1.10M | 0.06% | +20,627+291.3% | Added |
| Eaton Vance Management | 27,074 | $1.08M | 0.00% | +604+2.3% | Added |
| Amalgamated Bank | 26,933 | $1.07M | 0.01% | +7,267+37.0% | Added |
| Utah Retirement Systems | 26,709 | $1.06M | 0.01% | +1,600+6.4% | Added |
| Commonwealth Equity Services, LLC | 25,730 | $1.03M | 0.00% | +7,594+41.9% | Added |
| Stephens Inc | 25,638 | $1.02M | 0.02% | +482+1.9% | Added |
| Truist Financial Corp | 25,101 | $1.00M | 0.00% | +3,437+15.9% | Added |
| Handelsbanken Fonder AB | 24,411 | $974.0K | 0.01% | +1,400+6.1% | Added |
| Profund Advisors LLC | 24,058 | $959.0K | 0.03% | −739−3.0% | Reduced |
| APG Asset Management N.V. | 28,200 | $949.0K | 0.00% | +28,200 | New |
| Private Advisor Group, LLC | 23,441 | $935.0K | 0.01% | +5,399+29.9% | Added |
| Kestra Advisory Services, LLC | 22,846 | $911.0K | 0.01% | −104−0.5% | Reduced |
| MML Investors Services, LLC | 22,786 | $909.0K | 0.01% | +2,890+14.5% | Added |
| Oppenheimer & Co Inc | 21,348 | $852.0K | 0.02% | +21,348 | New |
| Simplex Trading, LLC | 21,354 | $851.0K | 0.03% | +20,579+2,655.4% | Added |
| BNP Paribas Arbitrage, SA | 21,267 | $848.3K | 0.00% | −7,373−25.7% | Reduced |
| Grandfield & Dodd, LLC | 21,053 | $840.0K | 0.06% | +700+3.4% | Added |
| Advisor Group Holdings, Inc. | 20,903 | $833.0K | 0.00% | +4,937+30.9% | Added |
| Vestmark Advisory Solutions, Inc. | 19,887 | $793.0K | 0.06% | −6,622−25.0% | Reduced |
| Allianz Asset Management GmbH | 19,710 | $786.0K | 0.00% | −15,134−43.4% | Reduced |
| Public Employees Retirement Association of Colorado | 19,604 | $782.0K | 0.00% | 00.0% | Unchanged |
| AlphaCrest Capital Management LLC | 19,360 | $772.0K | 0.03% | +19,360 | New |
| Cambridge Investment Research Advisors, Inc. | 19,274 | $769.0K | 0.00% | +4,397+29.6% | Added |
| Natixis Advisors, L.P. | 18,864 | $752.0K | 0.00% | −1,740−8.4% | Reduced |
| Alexandria Capital, LLC | 18,297 | $730.0K | 0.07% | +535+3.0% | Added |
| Emerald Advisers, LLC | 17,621 | $703.0K | 0.03% | 00.0% | Unchanged |
| Teacher Retirement System of Texas | 17,518 | $699.0K | 0.00% | −10,438−37.3% | Reduced |
| AGF Investments LLC | 17,289 | $690.0K | 0.07% | +17,289 | New |
| State of Wisconsin Investment Board | 16,749 | $668.0K | 0.00% | −55,456−76.8% | Reduced |
| Tanaka Capital Management Inc | 16,661 | $665.0K | 0.90% | −3,950−19.2% | Reduced |
| Arden Trust Co | 15,993 | $638.0K | 0.10% | −513−3.1% | Reduced |
| Xponance, Inc. | 15,226 | $607.0K | 0.01% | +8,423+123.8% | Added |
| Castle Rock Wealth Management, LLC | 15,593 | $606.0K | 0.22% | 00.0% | Unchanged |
| Optimal Asset Management, Inc. | 15,118 | $603.0K | 0.07% | 00.0% | Unchanged |
| Lincoln National Corp | 15,070 | $601.0K | 0.01% | −395−2.6% | Reduced |
| Comerica Bank | 15,591 | $590.0K | 0.00% | −105−0.7% | Reduced |
| Victory Capital Management Inc | 14,216 | $567.0K | 0.00% | −12,034−45.8% | Reduced |
| US Bancorp | 14,008 | $558.0K | 0.00% | +422+3.1% | Added |
| North Star Asset Management Inc | 13,753 | $549.0K | 0.03% | 00.0% | Unchanged |
| Brookfield Asset Management Inc. | 13,568 | $541.0K | 0.00% | +13,568 | New |
| Bank of Nova Scotia | 13,535 | $540.0K | 0.00% | +13,535 | New |
| Brown Advisory Securities, LLC | 13,500 | $539.0K | 0.08% | +8,025+146.6% | Added |
| Creative Planning | 13,320 | $531.0K | 0.00% | −30,859−69.8% | Reduced |
| AQR Capital Management LLC | 13,434 | $528.0K | 0.00% | +13,434 | New |
| Virtus ETF Advisers LLC | 13,212 | $527.0K | 0.22% | +128+1.0% | Added |
| Shell Asset Management Co | 13,169 | $525.0K | 0.01% | −32,964−71.5% | Reduced |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 12,817 | $511.0K | 0.00% | −8,404−39.6% | Reduced |
| SEI Investments Co | 14,052 | $492.0K | 0.00% | −13,410−48.8% | Reduced |
| KBC Group NV | 11,811 | $471.0K | 0.00% | +300+2.6% | Added |
| Berkshire Asset Management LLC | 11,399 | $455.0K | 0.03% | −949−7.7% | Reduced |
| National Asset Management, Inc. | 11,206 | $454.0K | 0.01% | −1,792−13.8% | Reduced |
| SG Americas Securities, LLC | 11,249 | $449.0K | 0.00% | −34,559−75.4% | Reduced |
| Plancorp, LLC | 11,120 | $444.0K | 0.03% | +20+0.2% | Added |
| Oppenheimer Asset Management Inc. | 10,717 | $427.0K | 0.01% | −219−2.0% | Reduced |
| Wrapmanager Inc | 10,583 | $422.0K | 0.11% | +71+0.7% | Added |
| Nicollet Investment Management, Inc. | 10,504 | $419.0K | 0.17% | −307−2.8% | Reduced |
| Blair William & Co | 10,288 | $410.0K | 0.00% | −876−7.8% | Reduced |
| Tower Research Capital LLC (TRC) | 10,183 | $406.0K | 0.01% | −2,140−17.4% | Reduced |
| Waddell & Associates, LLC | 10,042 | $401.0K | 0.07% | +10,042 | New |
| Ameriprise Financial Inc | 9,925 | $395.0K | 0.00% | −4,553−31.4% | Reduced |
| Maryland State Retirement & Pension System | 9,956 | $392.0K | 0.01% | 00.0% | Unchanged |
| Mackenzie Financial Corp | 9,783 | $390.0K | 0.00% | 00.0% | Unchanged |
| HSBC Holdings PLC | 9,435 | $376.0K | 0.00% | −4,980−34.5% | Reduced |
| Regions Financial Corp | 9,423 | $376.0K | 0.00% | +9,423 | New |
| The PNC Financial Services Group, Inc. | 9,347 | $373.0K | 0.00% | −11−0.1% | Reduced |
| HighTower Advisors, LLC | 9,303 | $366.0K | 0.00% | −216−2.3% | Reduced |
| Metropolitan Life Insurance Co | 9,173 | $365.9K | 0.01% | +3,158+52.5% | Added |
| Aigen Investment Management, LP | 8,912 | $355.0K | 0.06% | +8,912 | New |
| Natixis | 8,530 | $340.0K | 0.00% | +2,871+50.7% | Added |
| Brandywine Managers, LLC | 8,460 | $337.0K | 0.38% | +1,375+19.4% | Added |