Denali Therapeutics Inc.
DNLI- Exchange
- Nasdaq
- Industry
- Biological Products, (No Diagnostic Substances)
- SEC CIK
- 0001714899
In the last 90 days, Denali Therapeutics Inc. insiders filed 0 open-market purchases and 4 sales; 294 institutions reported holding it in 13F filings for Q2 2026, worth $4.00B in total; no superinvestor holds it.
13F holders, Q1 2026
Institutional positions in Denali Therapeutics Inc. as of Mar 31, 2026. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 269
- +25 vs. Q4 2025
- Shares held
- 147.4M
- +14.8M (+11.2%) vs. Q4 2025
- Total value
- $2.82B
- +$631.6M (+28.8%) vs. Q4 2025
- New holders
- 55
- 104 more added
- Sold out
- 30
- 58 more reduced
6 institutions that held it in Q4 2025 haven't filed for Q1 2026 yet. Not filing isn't selling, so they aren't counted as sold out or in the changes above.
Compare with Q4 2025: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting DNLI on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 294 | $4.00B |
| Q1 2026 | 269 | $2.82B |
| Q4 2025 | 250 | $2.50B |
| Q3 2025 | 240 | $1.97B |
| Q2 2025 | 231 | $1.93B |
| Q1 2025 | 222 | $1.85B |
| Q4 2024 | 224 | $2.61B |
| Q3 2024 | 217 | $3.69B |
| Q2 2024 | 203 | $2.88B |
| Q1 2024 | 211 | $2.51B |
| Q4 2023 | 209 | $2.47B |
| Q3 2023 | 195 | $2.24B |
| Q2 2023 | 203 | $3.18B |
| Q1 2023 | 202 | $2.49B |
| Q4 2022 | 199 | $2.94B |
| Q3 2022 | 200 | $2.84B |
| Q2 2022 | 188 | $2.73B |
| Q1 2022 | 190 | $2.79B |
| Q4 2021 | 213 | $3.80B |
| Q3 2021 | 214 | $4.28B |
| Q2 2021 | 210 | $6.32B |
| Q1 2021 | 218 | $4.60B |
Institutions, Q1 2026
Shares, value and share of portfolio for each institution holding Denali Therapeutics Inc.; share changes are against Q4 2025.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| Capstone Investment Advisors, LLC | 12,963 | $248.9K | 0.00% | −25,849−66.6% | Reduced |
| Perbak Capital Partners LLP | 13,175 | $253.0K | 0.06% | +564+4.5% | Added |
| Xponance, Inc. | 13,240 | $254.2K | 0.00% | +2,743+26.1% | Added |
| Great West Life Assurance Co | 13,434 | $259.0K | 0.00% | 00.0% | Unchanged |
| Guggenheim Capital LLC | 13,825 | $265.4K | 0.00% | +1,357+10.9% | Added |
| Russell Investments Group, Ltd. | 14,058 | $269.9K | 0.00% | +591+4.4% | Added |
| Intrust Bank NA | 14,339 | $275.3K | 0.02% | +3,175+28.4% | Added |
| Contravisory Investment Management, Inc. | 14,451 | $277.5K | 0.06% | +14,451 | New |
| Virtus Investment Advisers, Inc. | 15,166 | $291.2K | 0.08% | +371+2.5% | Added |
| Breakwater Capital Group | 15,586 | $299.3K | 0.04% | −780−4.8% | Reduced |
| Empowered Funds, LLC | 15,787 | $303.1K | 0.00% | +4,462+39.4% | Added |
| Caitong International Asset Management Co., Ltd | 15,861 | $304.5K | 0.06% | +15,861 | New |
| Engineers Gate Manager LP | 16,110 | $309.3K | 0.00% | +16,110 | New |
| Victory Capital Management Inc | 16,194 | $310.9K | 0.00% | +1,130+7.5% | Added |
| Advisor Group Holdings, Inc. | 16,413 | $315.1K | 0.00% | +15,339+1,428.2% | Added |
| Bellevue Group AG | 17,766 | $341.1K | 0.01% | +10,628+148.9% | Added |
| Teacher Retirement System of Texas | 17,882 | $343.3K | 0.00% | −2,658−12.9% | Reduced |
| Mariner, LLC | 18,131 | $348.1K | 0.00% | +18,131 | New |
| Martingale Asset Management L P | 18,535 | $355.9K | 0.01% | 00.0% | Unchanged |
| Amundi | 18,604 | $357.2K | 0.00% | +18,604 | New |
| E Fund Management Co., Ltd. | 18,942 | $363.7K | 0.01% | +18,942 | New |
| Tower Research Capital LLC (TRC) | 20,978 | $402.8K | 0.01% | +8,037+62.1% | Added |
| Twinbeech Capital LP | 23,000 | $441.6K | 0.05% | +23,000 | New |
| Voya Investment Management LLC | 23,672 | $454.5K | 0.00% | −133−0.6% | Reduced |
| Erste Asset Management GmbH | 26,900 | $486.4K | 0.00% | 00.0% | Unchanged |
| Rockefeller Capital Management L.P. | 25,935 | $498.0K | 0.00% | +24,670+1,950.2% | Added |
| ProShare Advisors LLC | 27,737 | $532.5K | 0.00% | −2,945−9.6% | Reduced |
| SBI Okasan Asset Management Co.Ltd. | 29,500 | $533.4K | 0.02% | +11,500+63.9% | Added |
| Quantinno Capital Management LP | 30,170 | $579.3K | 0.00% | +3,857+14.7% | Added |
| Prudential Financial Inc | 30,570 | $586.9K | 0.00% | +30,570 | New |
| KLP Kapitalforvaltning AS | 30,900 | $593.3K | 0.00% | +1,000+3.3% | Added |
| Jane Street Group, LLC | 32,147 | $617.2K | 0.00% | −10,775−25.1% | Reduced |
| Thrivent Financial for Lutherans | 32,555 | $626.0K | 0.00% | 00.0% | Unchanged |
| State Board of Administration of Florida Retirement System | 34,168 | $656.0K | 0.00% | 00.0% | Unchanged |
| Raymond James Financial Inc | 34,383 | $660.2K | 0.00% | +8,791+34.4% | Added |
| Jefferies Financial Group Inc. | 34,425 | $661.0K | 0.01% | +34,425 | New |
| Seven Fleet Capital Management LP | 35,286 | $677.5K | 0.21% | +35,286 | New |
| Nomura Asset Management Co Ltd | 36,732 | $705.3K | 0.00% | +36,732 | New |
| Vanguard Investments Australia, Ltd. | 37,410 | $718.3K | 0.00% | +37,410 | New |
| Arizona State Retirement System | 38,153 | $732.5K | 0.00% | −492−1.3% | Reduced |
| Police & Firemen's Retirement System of New Jersey | 38,545 | $740.1K | 0.01% | +1,938+5.3% | Added |
| Intech Investment Management LLC | 38,931 | $747.5K | 0.01% | −13,701−26.0% | Reduced |
| Citigroup Inc | 39,278 | $754.1K | 0.00% | +8,333+26.9% | Added |
| BNP Paribas Arbitrage, SA | 39,893 | $765.9K | 0.00% | +24,396+157.4% | Added |
| China Universal Asset Management Co., Ltd. | 40,643 | $780.3K | 0.06% | +16,745+70.1% | Added |
| Virtu Financial LLC | 43,362 | $833.0K | 0.03% | +43,362 | New |
| Handelsbanken Fonder AB | 43,800 | $841.0K | 0.00% | 00.0% | Unchanged |
| MAI Capital Management | 46,590 | $894.5K | 0.01% | +64+0.1% | Added |
| SG Americas Securities, LLC | 46,642 | $896.0K | 0.00% | −102,950−68.8% | Reduced |
| Employees Retirement System of Texas | 47,177 | $906.0K | 0.01% | 00.0% | Unchanged |
| State of New Jersey Common Pension Fund D | 47,471 | $911.4K | 0.00% | +61+0.1% | Added |
| Franklin Resources Inc | 48,732 | $935.7K | 0.00% | −11,538−19.1% | Reduced |
| Susquehanna International Group, LLP | 50,475 | $969.1K | 0.00% | +15,707+45.2% | Added |
| Envestnet Asset Management Inc | 50,900 | $977.3K | 0.00% | +12,231+31.6% | Added |
| Dana Investment Advisors, Inc. | 51,922 | $996.9K | 0.03% | +1,340+2.6% | Added |
| Ironwood Investment Management LLC | 52,062 | $999.6K | 0.42% | +1,129+2.2% | Added |
| Barclays PLC | 52,084 | $1.00M | 0.00% | −355,275−87.2% | Reduced |
| SEI Investments Co | 52,235 | $1.00M | 0.00% | +52,235 | New |
| Wellington Management Group LLP | 53,363 | $1.02M | 0.00% | −1,180−2.2% | Reduced |
| Pathstone Holdings, LLC | 56,325 | $1.08M | 0.00% | +4,901+9.5% | Added |
| Knights of Columbus Asset Advisors LLC | 56,329 | $1.08M | 0.06% | +7,322+14.9% | Added |
| Vanguard Global Advisers, LLC | 58,779 | $1.13M | 0.00% | +58,779 | New |
| Janus Henderson Group PLC | 60,028 | $1.15M | 0.00% | 00.0% | Unchanged |
| DekaBank Deutsche Girozentrale | 59,800 | $1.15M | 0.00% | 00.0% | Unchanged |
| Pier 88 Investment Partners LLC | 64,800 | $1.24M | 0.32% | −3,400−5.0% | Reduced |
| Polen Capital Management LLC | 65,301 | $1.25M | 0.01% | +38,401+142.8% | Added |
| 1492 Capital Management LLC | 67,417 | $1.29M | 0.49% | −70−0.1% | Reduced |
| Profund Advisors LLC | 68,227 | $1.31M | 0.05% | −3,407−4.8% | Reduced |
| Winton Group Ltd | 71,179 | $1.37M | 0.05% | +58,479+460.5% | Added |
| Creative Planning | 74,069 | $1.42M | 0.00% | +13,303+21.9% | Added |
| MetLife Investment Management | 77,558 | $1.49M | 0.01% | +2,394+3.2% | Added |
| Y-Intercept (Hong Kong) Ltd | 78,007 | $1.50M | 0.03% | −15,580−16.6% | Reduced |
| XTX Topco Ltd | 78,567 | $1.51M | 0.03% | +78,567 | New |
| State of Wisconsin Investment Board | 82,357 | $1.58M | 0.00% | +8,776+11.9% | Added |
| Ameriprise Financial Inc | 89,534 | $1.72M | 0.00% | −90,687−50.3% | Reduced |
| Mirae Asset Global ETFs Holdings Ltd. | 95,193 | $1.82M | 0.00% | −33,607−26.1% | Reduced |
| Lumbard & Kellner, LLC | 94,782 | $1.82M | 0.63% | +94,782 | New |
| Universal- Beteiligungs- und Servicegesellschaft mbH | 99,503 | $1.91M | 0.00% | +28,673+40.5% | Added |
| Integrated Wealth Concepts LLC | 99,554 | $1.91M | 0.02% | +4,972+5.3% | Added |
| Ghisallo Capital Management LLC | 100,000 | $1.92M | 0.05% | 00.0% | Unchanged |
| AQR Capital Management LLC | 102,579 | $1.97M | 0.00% | +64,141+166.9% | Added |
| Wells Fargo & Company | 107,657 | $2.07M | 0.00% | −86,024−44.4% | Reduced |
| D.A. Davidson & Co. | 110,235 | $2.12M | 0.01% | +3,302+3.1% | Added |
| Legal & General Group Plc | 110,250 | $2.12M | 0.00% | −20,973−16.0% | Reduced |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 111,694 | $2.14M | 0.00% | +64,235+135.3% | Added |
| B. Metzler seel. Sohn & Co. AG | 112,300 | $2.16M | 0.02% | 00.0% | Unchanged |
| Nomura Asset Management International Inc. | 114,524 | $2.20M | 0.00% | +7,031+6.5% | Added |
| Deutsche Bank AG | 120,368 | $2.31M | 0.00% | +15,282+14.5% | Added |
| Vanguard Asset Management, Ltd | 125,243 | $2.40M | 0.00% | +125,243 | New |
| Manufacturers Life Insurance Company, The | 125,442 | $2.41M | 0.00% | −58,796−31.9% | Reduced |
| New York State Common Retirement Fund | 128,119 | $2.46M | 0.00% | +89,641+233.0% | Added |
| Alps Advisors Inc | 129,105 | $2.48M | 0.01% | +8,387+6.9% | Added |
| Man Group plc | 139,045 | $2.67M | 0.01% | +90,051+183.8% | Added |
| Rafferty Asset Management, LLC | 150,687 | $2.89M | 0.01% | −40,880−21.3% | Reduced |
| Susquehanna Portfolio Strategies, LLC | 157,896 | $3.03M | 0.05% | −9,817−5.9% | Reduced |
| California State Teachers Retirement System | 162,576 | $3.12M | 0.00% | +33,167+25.6% | Added |
| Sector Gamma AS | 162,710 | $3.12M | 0.74% | +162,710 | New |
| Teachers Retirement System of the State of Kentucky | 166,181 | $3.19M | 0.02% | +12,400+8.1% | Added |
| Citadel Advisors LLC | 181,417 | $3.48M | 0.00% | −597,731−76.7% | Reduced |
| Rhumbline Advisers | 184,248 | $3.54M | 0.00% | +1,248+0.7% | Added |