Denali Therapeutics Inc.
DNLI- Exchange
- Nasdaq
- Industry
- Biological Products, (No Diagnostic Substances)
- SEC CIK
- 0001714899
In the last 90 days, Denali Therapeutics Inc. insiders filed 0 open-market purchases and 4 sales; 294 institutions reported holding it in 13F filings for Q2 2026, worth $4.00B in total; no superinvestor holds it.
13F holders, Q4 2025
Institutional positions in Denali Therapeutics Inc. as of Dec 31, 2025. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 250
- +17 vs. Q3 2025
- Shares held
- 151.1M
- +16.2M (+12.0%) vs. Q3 2025
- Total value
- $2.50B
- +$536.1M (+27.4%) vs. Q3 2025
- New holders
- 51
- 86 more added
- Sold out
- 34
- 71 more reduced
7 institutions that held it in Q3 2025 haven't filed for Q4 2025 yet. Not filing isn't selling, so they aren't counted as sold out or in the changes above.
Compare with Q3 2025: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting DNLI on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 294 | $4.00B |
| Q1 2026 | 269 | $2.82B |
| Q4 2025 | 250 | $2.50B |
| Q3 2025 | 240 | $1.97B |
| Q2 2025 | 231 | $1.93B |
| Q1 2025 | 222 | $1.85B |
| Q4 2024 | 224 | $2.61B |
| Q3 2024 | 217 | $3.69B |
| Q2 2024 | 203 | $2.88B |
| Q1 2024 | 211 | $2.51B |
| Q4 2023 | 209 | $2.47B |
| Q3 2023 | 195 | $2.24B |
| Q2 2023 | 203 | $3.18B |
| Q1 2023 | 202 | $2.49B |
| Q4 2022 | 199 | $2.94B |
| Q3 2022 | 200 | $2.84B |
| Q2 2022 | 188 | $2.73B |
| Q1 2022 | 190 | $2.79B |
| Q4 2021 | 213 | $3.80B |
| Q3 2021 | 214 | $4.28B |
| Q2 2021 | 210 | $6.32B |
| Q1 2021 | 218 | $4.60B |
Institutions, Q4 2025
Shares, value and share of portfolio for each institution holding Denali Therapeutics Inc.; share changes are against Q3 2025.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| SBI Okasan Asset Management Co.Ltd. | 18,000 | $298.4K | 0.02% | +18,000 | New |
| Graham Capital Management, L.P. | 18,121 | $299.2K | 0.01% | −21,198−53.9% | Reduced |
| Martingale Asset Management L P | 18,535 | $306.0K | 0.01% | +18,535 | New |
| Bayforest Capital Ltd | 20,433 | $337.3K | 0.25% | +20,433 | New |
| Teacher Retirement System of Texas | 20,540 | $339.1K | 0.00% | −13,287−39.3% | Reduced |
| TT International Asset Management LTD | 27,000 | $353.0K | 0.07% | −38,000−58.5% | Reduced |
| Voya Investment Management LLC | 23,805 | $393.0K | 0.00% | 00.0% | Unchanged |
| China Universal Asset Management Co., Ltd. | 23,898 | $394.6K | 0.03% | −1,731−6.8% | Reduced |
| Raymond James Financial Inc | 25,592 | $422.5K | 0.00% | +266+1.1% | Added |
| Quantinno Capital Management LP | 26,313 | $434.4K | 0.00% | +1,606+6.5% | Added |
| Polen Capital Management LLC | 26,900 | $444.1K | 0.00% | +26,900 | New |
| Erste Asset Management GmbH | 26,900 | $446.0K | 0.00% | 00.0% | Unchanged |
| KLP Kapitalforvaltning AS | 29,900 | $493.6K | 0.00% | 00.0% | Unchanged |
| ProShare Advisors LLC | 30,682 | $506.6K | 0.00% | +2,827+10.1% | Added |
| Citigroup Inc | 30,945 | $510.9K | 0.00% | +16,009+107.2% | Added |
| PSP Research LLC | 31,762 | $524.4K | 0.46% | +31,762 | New |
| Thrivent Financial for Lutherans | 32,555 | $538.0K | 0.00% | −3,064−8.6% | Reduced |
| State Board of Administration of Florida Retirement System | 34,168 | $564.1K | 0.00% | 00.0% | Unchanged |
| Susquehanna International Group, LLP | 34,768 | $574.0K | 0.00% | −6,218−15.2% | Reduced |
| Police & Firemen's Retirement System of New Jersey | 36,607 | $604.4K | 0.01% | −56−0.2% | Reduced |
| AQR Capital Management LLC | 38,438 | $634.6K | 0.00% | +14,299+59.2% | Added |
| New York State Common Retirement Fund | 38,478 | $635.3K | 0.00% | 00.0% | Unchanged |
| Arizona State Retirement System | 38,645 | $638.0K | 0.00% | −2,168−5.3% | Reduced |
| Envestnet Asset Management Inc | 38,669 | $638.4K | 0.00% | +6,254+19.3% | Added |
| Capstone Investment Advisors, LLC | 38,812 | $640.8K | 0.01% | +38,812 | New |
| Savvy Advisors, Inc. | 39,030 | $644.4K | 0.02% | −38,063−49.4% | Reduced |
| Jump Financial, LLC | 40,608 | $670.4K | 0.01% | −125,791−75.6% | Reduced |
| Quest Partners LLC | 42,909 | $708.4K | 0.04% | −31,513−42.3% | Reduced |
| Jane Street Group, LLC | 42,922 | $708.6K | 0.00% | −181,981−80.9% | Reduced |
| Handelsbanken Fonder AB | 43,800 | $723.0K | 0.00% | +5,500+14.4% | Added |
| Headlands Technologies LLC | 46,383 | $765.8K | 0.06% | +46,383 | New |
| MAI Capital Management | 46,526 | $768.1K | 0.00% | 00.0% | Unchanged |
| Employees Retirement System of Texas | 47,177 | $779.0K | 0.01% | +3,408+7.8% | Added |
| State of New Jersey Common Pension Fund D | 47,410 | $782.7K | 0.00% | −92,253−66.1% | Reduced |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 47,459 | $783.5K | 0.00% | 00.0% | Unchanged |
| Man Group plc | 48,994 | $808.9K | 0.00% | +48,994 | New |
| Knights of Columbus Asset Advisors LLC | 49,007 | $809.1K | 0.05% | −1,183−2.4% | Reduced |
| Dana Investment Advisors, Inc. | 50,582 | $835.1K | 0.02% | −134−0.3% | Reduced |
| Ironwood Investment Management LLC | 50,933 | $840.9K | 0.35% | −1,853−3.5% | Reduced |
| Pathstone Holdings, LLC | 51,424 | $849.0K | 0.00% | +5,594+12.2% | Added |
| Clough Capital Partners L P | 51,830 | $855.7K | 0.08% | +51,830 | New |
| ADAR1 Capital Management, LLC | 52,116 | $860.4K | 0.06% | +600+1.2% | Added |
| Intech Investment Management LLC | 52,632 | $869.0K | 0.01% | +5,835+12.5% | Added |
| Tudor Investment Corp Et Al | 53,683 | $886.3K | 0.00% | −2,685−4.8% | Reduced |
| Wellington Management Group LLP | 54,543 | $900.5K | 0.00% | −4,691−7.9% | Reduced |
| Janus Henderson Group PLC | 60,028 | $991.4K | 0.00% | 00.0% | Unchanged |
| Franklin Resources Inc | 60,270 | $995.1K | 0.00% | −4,364−6.8% | Reduced |
| Creative Planning | 60,766 | $1.00M | 0.00% | +5,932+10.8% | Added |
| Capricorn Fund Managers Ltd | 62,197 | $1.03M | 0.25% | +62,197 | New |
| 1492 Capital Management LLC | 67,487 | $1.11M | 0.43% | +67,487 | New |
| Pier 88 Investment Partners LLC | 68,200 | $1.13M | 0.25% | +760+1.1% | Added |
| Ishara Investments LP | 70,000 | $1.16M | 1.35% | +70,000 | New |
| Universal- Beteiligungs- und Servicegesellschaft mbH | 70,830 | $1.17M | 0.00% | +44,607+170.1% | Added |
| Profund Advisors LLC | 71,634 | $1.18M | 0.04% | +31,478+78.4% | Added |
| State of Wisconsin Investment Board | 73,581 | $1.21M | 0.00% | −6,545−8.2% | Reduced |
| MetLife Investment Management | 75,164 | $1.24M | 0.01% | −3,911−4.9% | Reduced |
| HRT Financial LP | 78,352 | $1.29M | 0.00% | +78,352 | New |
| DekaBank Deutsche Girozentrale | 59,800 | $1.35M | 0.00% | 00.0% | Unchanged |
| Monashee Investment Management LLC | 91,620 | $1.51M | 0.85% | +91,620 | New |
| Y-Intercept (Hong Kong) Ltd | 93,587 | $1.55M | 0.03% | +93,587 | New |
| Integrated Wealth Concepts LLC | 94,582 | $1.56M | 0.02% | +3,508+3.9% | Added |
| Rhenman & Partners Asset Management AB | 100,000 | $1.65M | 0.15% | 00.0% | Unchanged |
| Ghisallo Capital Management LLC | 100,000 | $1.65M | 0.07% | +100,000 | New |
| Deutsche Bank AG | 105,086 | $1.73M | 0.00% | −102,508−49.4% | Reduced |
| D.A. Davidson & Co. | 106,933 | $1.77M | 0.01% | +106,933 | New |
| Nomura Asset Management International Inc. | 107,493 | $1.77M | 0.00% | +107,493 | New |
| B. Metzler seel. Sohn & Co. AG | 112,300 | $1.84M | 0.02% | +112,300 | New |
| Woodline Partners LP | 114,082 | $1.88M | 0.01% | +565+0.5% | Added |
| Alps Advisors Inc | 120,718 | $1.99M | 0.01% | +50,488+71.9% | Added |
| Algert Global LLC | 127,030 | $2.10M | 0.03% | +25,770+25.4% | Added |
| Mirae Asset Global ETFs Holdings Ltd. | 128,800 | $2.13M | 0.00% | −1,087−0.8% | Reduced |
| California State Teachers Retirement System | 129,409 | $2.14M | 0.00% | −117−0.1% | Reduced |
| Legal & General Group Plc | 131,223 | $2.17M | 0.00% | −12,729−8.8% | Reduced |
| SG Americas Securities, LLC | 149,592 | $2.47M | 0.00% | +111,391+291.6% | Added |
| Groupama Asset Managment | 151,591 | $2.50M | 0.04% | +15,833+11.7% | Added |
| Teachers Retirement System of the State of Kentucky | 153,781 | $2.54M | 0.02% | −17,772−10.4% | Reduced |
| Two Sigma Advisers, LP | 154,800 | $2.56M | 0.00% | +64,800+72.0% | Added |
| Susquehanna Portfolio Strategies, LLC | 167,713 | $2.77M | 0.04% | +167,713 | New |
| JPMorgan Chase & Co | 171,948 | $2.84M | 0.00% | −3,073−1.8% | Reduced |
| Ameriprise Financial Inc | 180,221 | $2.98M | 0.00% | +80,660+81.0% | Added |
| Rhumbline Advisers | 183,000 | $3.02M | 0.00% | −18,565−9.2% | Reduced |
| Manufacturers Life Insurance Company, The | 184,238 | $3.03M | 0.00% | −21,607−10.5% | Reduced |
| Rafferty Asset Management, LLC | 191,567 | $3.16M | 0.01% | +8,681+4.7% | Added |
| Wells Fargo & Company | 193,681 | $3.20M | 0.00% | +89,502+85.9% | Added |
| SCS Capital Management LLC | 197,998 | $3.27M | 0.03% | 00.0% | Unchanged |
| Burkehill Global Management, LP | 200,000 | $3.30M | 0.22% | +200,000 | New |
| Trexquant Investment LP | 209,609 | $3.46M | 0.03% | −220,957−51.3% | Reduced |
| Edmond de Rothschild Holding S.A. | 225,680 | $3.73M | 0.05% | +20,000+9.7% | Added |
| Swiss National Bank | 273,800 | $4.52M | 0.00% | +6,300+2.4% | Added |
| Nuveen, LLC | 275,508 | $4.55M | 0.00% | −9,269−3.3% | Reduced |
| Marex Group plc | 287,001 | $4.74M | 0.05% | −3,999−1.4% | Reduced |
| Invesco Ltd. | 291,936 | $4.82M | 0.00% | +42,469+17.0% | Added |
| BNP PARIBAS ASSET MANAGEMENT Holding S.A. | 298,792 | $4.93M | 0.01% | +297,521+23,408.4% | Added |
| DAFNA Capital Management LLC | 318,500 | $5.26M | 1.22% | +150,000+89.0% | Added |
| TD Asset Management Inc | 339,410 | $5.60M | 0.00% | −55,190−14.0% | Reduced |
| Clarius Group, LLC | 368,995 | $6.09M | 0.35% | +9,250+2.6% | Added |
| Millennium Management LLC | 369,767 | $6.10M | 0.00% | −937,404−71.7% | Reduced |
| American Century Companies Inc | 379,051 | $6.26M | 0.00% | +21,710+6.1% | Added |
| Barclays PLC | 407,359 | $6.73M | 0.00% | −29,642−6.8% | Reduced |
| StemPoint Capital LP | 419,058 | $6.92M | 1.19% | −1,315,601−75.8% | Reduced |