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Xenon Pharmaceuticals Inc.

XENE
Exchange
Nasdaq
Industry
Pharmaceutical Preparations
SEC CIK
0001582313

In the last 90 days, Xenon Pharmaceuticals Inc. insiders filed 2 open-market purchases and 2 sales; 315 institutions reported holding it in 13F filings for Q2 2026, worth $6.10B in total; Duquesne Family Office is the only superinvestor holding it.

13F holders, Q3 2026

Institutional positions in Xenon Pharmaceuticals Inc. as of Sep 30, 2026. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works

Q3 2026 data is still coming in (13F filing deadline: Nov 16, 2026), so these numbers are incomplete.

Institutional holders
1
−1 vs. Q2 2026
Shares held
18
−220 (−92.4%) vs. Q2 2026
Total value
$669
−$13.7K (−95.3%) vs. Q2 2026
New holders
0
1 more added
Sold out
1
0 more reduced

313 institutions that held it in Q2 2026 haven't filed for Q3 2026 yet. Not filing isn't selling, so they aren't counted as sold out or in the changes above.

Compare with Q2 2026: new holders, sold out and not filed yet

Holders and value by quarter

Institutions reporting XENE on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.

Institutional holders
Q1 2021: 91 institutionsQ2 2021: 103 institutionsQ3 2021: 118 institutionsQ4 2021: 130 institutionsQ1 2022: 132 institutionsQ2 2022: 151 institutionsQ3 2022: 154 institutionsQ4 2022: 159 institutionsQ1 2023: 163 institutionsQ2 2023: 175 institutionsQ3 2023: 181 institutionsQ4 2023: 204 institutionsQ1 2024: 220 institutionsQ2 2024: 213 institutionsQ3 2024: 203 institutionsQ4 2024: 209 institutionsQ1 2025: 206 institutionsQ2 2025: 206 institutionsQ3 2025: 219 institutionsQ4 2025: 245 institutionsQ1 2026: 290 institutionsQ2 2026: 315 institutions
Value held
Q1 2021: $590.0MQ2 2021: $620.0MQ3 2021: $521.7MQ4 2021: $1.49BQ1 2022: $1.50BQ2 2022: $1.73BQ3 2022: $2.09BQ4 2022: $2.38BQ1 2023: $2.19BQ2 2023: $2.36BQ3 2023: $2.10BQ4 2023: $3.32BQ1 2024: $3.16BQ2 2024: $2.89BQ3 2024: $2.95BQ4 2024: $2.99BQ1 2025: $2.58BQ2 2025: $2.60BQ3 2025: $3.39BQ4 2025: $3.78BQ1 2026: $5.80BQ2 2026: $6.10B
Institutions holding XENE and their total value by quarter
QuarterHoldersValue
Q2 2026315$6.10B
Q1 2026290$5.80B
Q4 2025245$3.78B
Q3 2025219$3.39B
Q2 2025206$2.60B
Q1 2025206$2.58B
Q4 2024209$2.99B
Q3 2024203$2.95B
Q2 2024213$2.89B
Q1 2024220$3.16B
Q4 2023204$3.32B
Q3 2023181$2.10B
Q2 2023175$2.36B
Q1 2023163$2.19B
Q4 2022159$2.38B
Q3 2022154$2.09B
Q2 2022151$1.73B
Q1 2022132$1.50B
Q4 2021130$1.49B
Q3 2021118$521.7M
Q2 2021103$620.0M
Q1 202191$590.0M

Institutions, Q3 2026

Shares, value and share of portfolio for each institution holding Xenon Pharmaceuticals Inc.; share changes are against Q2 2026.

Institutions holding XENE in Q3 2026
InstitutionSharesValue% of portfolioChange in sharesAction
Granahan Investment Management Inc––––Not filed
KBC Group NV––––Not filed
Rhumbline Advisers––––Not filed
Schroder Investment Management Group––––Not filed
SEI Investments Co––––Not filed
Squarepoint Ops LLC––––Not filed
Mutual of America Capital Management LLC––––Not filed
Axiom Investors LLC––––Not filed
Sphera Funds Management Ltd.––––Not filed
Burkehill Global Management, LP––––Not filed
Alps Advisors Inc––––Not filed
Vanguard Fiduciary Trust Co––––Not filed
California State Teachers Retirement System––––Not filed
Citigroup Inc––––Not filed
Raymond James Financial Inc––––Not filed
Royal Bank of Canada––––Not filed
ExodusPoint Capital Management, LP––––Not filed
Capital Fund Management S.A.––––Not filed
Vanguard Asset Management, Ltd––––Not filed
Vanguard Capital Management LLC––––Not filed
Voya Investment Management LLC––––Not filed
Walleye Capital LLC––––Not filed
Swedbank AB––––Not filed
StemPoint Capital LP––––Not filed
Seven Grand Managers, LLC––––Not filed
Legal & General Group Plc––––Not filed
Royce & Associates LP––––Not filed
Artia Global Partners LP––––Not filed
Victory Capital Management Inc––––Not filed
Quantinno Capital Management LP––––Not filed
Engineers Gate Manager LP––––Not filed
Castleark Management LLC––––Not filed
MetLife Investment Management––––Not filed
Nomura Asset Management International Inc.––––Not filed
Legato Capital Management LLC––––Not filed
Palo Alto Investors LP––––Not filed
Erste Asset Management GmbH––––Not filed
EAM Investors, LLC––––Not filed
ACT Capital Management, LLC––––Not filed
Mirae Asset Global ETFs Holdings Ltd.––––Not filed
Lazard Asset Management LLC––––Not filed
Zurcher Kantonalbank (Zurich Cantonalbank)––––Not filed
Verition Fund Management LLC––––Not filed
Prudential Financial Inc––––Not filed
Diversified Trust Co––––Not filed
Oak Ridge Investments LLC––––Not filed
Aquatic Capital Management LLC––––Not filed
Dimensional Fund Advisors LP––––Not filed
Envestnet Asset Management Inc––––Not filed
DekaBank Deutsche Girozentrale––––Not filed
HighVista Strategies LLC––––Not filed
Seven Fleet Capital Management LP––––Not filed
Rhenman & Partners Asset Management AB––––Not filed
BNP Paribas Arbitrage, SA––––Not filed
TLS Advisors LLC––––Not filed
Connor, Clark & Lunn Investment Management Ltd.––––Not filed
Handelsbanken Fonder AB––––Not filed
Headlands Technologies LLC––––Not filed
Police & Firemen's Retirement System of New Jersey––––Not filed
Manufacturers Life Insurance Company, The––––Not filed
CI Private Wealth, LLC––––Not filed
UBS Group AG––––Not filed
State of New Jersey Common Pension Fund D––––Not filed
Bamco Inc––––Not filed
Creative Planning––––Not filed
Vestmark Advisory Solutions, Inc.––––Not filed
Rathbone Brothers plc––––Not filed
HighMark Wealth Management LLC––––Not filed
Arizona State Retirement System––––Not filed
State Board of Administration of Florida Retirement System––––Not filed
Susquehanna International Group, LLP––––Not filed
Dark Forest Capital Management LP––––Not filed
Intech Investment Management LLC––––Not filed
Teachers Retirement System of the State of Kentucky––––Not filed
Birchview Capital, LP––––Not filed
Capricorn Fund Managers Ltd––––Not filed
Barclays PLC––––Not filed
CIBC World Markets Inc.––––Not filed
Vanguard Investments Australia, Ltd.––––Not filed
Assetmark, Inc––––Not filed
XTX Topco Ltd––––Not filed
Martingale Asset Management L P––––Not filed
KLP Kapitalforvaltning AS––––Not filed
Magnetar Financial LLC––––Not filed
J. Safra Sarasin Holding AG––––Not filed
Stifel Financial Corp––––Not filed
ProShare Advisors LLC––––Not filed
China Universal Asset Management Co., Ltd.––––Not filed
Campbell & CO Investment Adviser LLC––––Not filed
IMC-Chicago, LLC––––Not filed
SBI Okasan Asset Management Co.Ltd.––––Not filed
Brinker Capital Investments, LLC––––Not filed
Fieldview Capital Management, LLC––––Not filed
STRS Ohio––––Not filed
EntryPoint Capital, LLC––––Not filed
Amundi––––Not filed
Allianz Asset Management GmbH––––Not filed
Public Employees Retirement Association of Colorado––––Not filed
Brevan Howard Capital Management LP––––Not filed
Elmwood Wealth Management, Inc.––––Not filed