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Xenon Pharmaceuticals Inc.

XENE
Exchange
Nasdaq
Industry
Pharmaceutical Preparations
SEC CIK
0001582313

In the last 90 days, Xenon Pharmaceuticals Inc. insiders filed 2 open-market purchases and 2 sales; 315 institutions reported holding it in 13F filings for Q2 2026, worth $6.10B in total; Duquesne Family Office is the only superinvestor holding it.

13F holders, Q3 2026

Institutional positions in Xenon Pharmaceuticals Inc. as of Sep 30, 2026. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works

Q3 2026 data is still coming in (13F filing deadline: Nov 16, 2026), so these numbers are incomplete.

Institutional holders
1
−1 vs. Q2 2026
Shares held
18
−220 (−92.4%) vs. Q2 2026
Total value
$669
−$13.7K (−95.3%) vs. Q2 2026
New holders
0
1 more added
Sold out
1
0 more reduced

313 institutions that held it in Q2 2026 haven't filed for Q3 2026 yet. Not filing isn't selling, so they aren't counted as sold out or in the changes above.

Compare with Q2 2026: new holders, sold out and not filed yet

Holders and value by quarter

Institutions reporting XENE on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.

Institutional holders
Q1 2021: 91 institutionsQ2 2021: 103 institutionsQ3 2021: 118 institutionsQ4 2021: 130 institutionsQ1 2022: 132 institutionsQ2 2022: 151 institutionsQ3 2022: 154 institutionsQ4 2022: 159 institutionsQ1 2023: 163 institutionsQ2 2023: 175 institutionsQ3 2023: 181 institutionsQ4 2023: 204 institutionsQ1 2024: 220 institutionsQ2 2024: 213 institutionsQ3 2024: 203 institutionsQ4 2024: 209 institutionsQ1 2025: 206 institutionsQ2 2025: 206 institutionsQ3 2025: 219 institutionsQ4 2025: 245 institutionsQ1 2026: 290 institutionsQ2 2026: 315 institutions
Value held
Q1 2021: $590.0MQ2 2021: $620.0MQ3 2021: $521.7MQ4 2021: $1.49BQ1 2022: $1.50BQ2 2022: $1.73BQ3 2022: $2.09BQ4 2022: $2.38BQ1 2023: $2.19BQ2 2023: $2.36BQ3 2023: $2.10BQ4 2023: $3.32BQ1 2024: $3.16BQ2 2024: $2.89BQ3 2024: $2.95BQ4 2024: $2.99BQ1 2025: $2.58BQ2 2025: $2.60BQ3 2025: $3.39BQ4 2025: $3.78BQ1 2026: $5.80BQ2 2026: $6.10B
Institutions holding XENE and their total value by quarter
QuarterHoldersValue
Q2 2026315$6.10B
Q1 2026290$5.80B
Q4 2025245$3.78B
Q3 2025219$3.39B
Q2 2025206$2.60B
Q1 2025206$2.58B
Q4 2024209$2.99B
Q3 2024203$2.95B
Q2 2024213$2.89B
Q1 2024220$3.16B
Q4 2023204$3.32B
Q3 2023181$2.10B
Q2 2023175$2.36B
Q1 2023163$2.19B
Q4 2022159$2.38B
Q3 2022154$2.09B
Q2 2022151$1.73B
Q1 2022132$1.50B
Q4 2021130$1.49B
Q3 2021118$521.7M
Q2 2021103$620.0M
Q1 202191$590.0M

Institutions, Q3 2026

Shares, value and share of portfolio for each institution holding Xenon Pharmaceuticals Inc.; share changes are against Q2 2026.

Institutions holding XENE in Q3 2026
InstitutionSharesValue% of portfolioChange in sharesAction
Massmutual Trust Co FSB18$6690.00%+1+5.9%Added
Versant Capital Management, Inc0$00.00%−221−100.0%Sold out
FMR LLC––––Not filed
BlackRock, Inc.––––Not filed
Avoro Capital Advisors LLC––––Not filed
Polar Capital Holdings Plc––––Not filed
Driehaus Capital Management LLC––––Not filed
Jupiter Topco LLC––––Not filed
Price T Rowe Associates Inc––––Not filed
JPMorgan Chase & Co––––Not filed
Capital International Investors––––Not filed
T. Rowe Price Investment Management, Inc.––––Not filed
State Street Corp––––Not filed
Two Sigma Investments, LP––––Not filed
Deerfield Management Company, L.P. (Series C)––––Not filed
Affinity Asset Advisors, LLC––––Not filed
Westfield Capital Management Co LP––––Not filed
Alliancebernstein L.P.––––Not filed
Franklin Resources Inc––––Not filed
Wellington Management Group LLP––––Not filed
Citadel Advisors LLC––––Not filed
Geode Capital Management, LLC––––Not filed
Siren, L.L.C.––––Not filed
BNP PARIBAS ASSET MANAGEMENT Holding S.A.––––Not filed
Pictet Asset Management Holding SA––––Not filed
Braidwell LP––––Not filed
Nuveen, LLC––––Not filed
Invesco Ltd.––––Not filed
OrbiMed Advisors LLC––––Not filed
Caligan Partners LP––––Not filed
American Century Companies Inc––––Not filed
Federated Hermes, Inc.––––Not filed
Capital World Investors––––Not filed
Goldman Sachs Group Inc––––Not filed
Vanguard Portfolio Management LLC––––Not filed
Vestal Point Capital, LP––––Not filed
Alyeska Investment Group, L.P.––––Not filed
Marshall Wace, LLP––––Not filed
Rock Springs Capital Management LP––––Not filed
Northern Trust Corp––––Not filed
Panagora Asset Management Inc––––Not filed
First Turn Management, LLC––––Not filed
Tudor Investment Corp Et Al––––Not filed
Loomis Sayles & Co L P––––Not filed
Octagon Capital Advisors LP––––Not filed
Novo Holdings A/S––––Not filed
Candriam Luxembourg S.C.A.––––Not filed
TimesSquare Capital Management, LLC––––Not filed
Logos Global Management LP––––Not filed
Trails Edge Capital Partners, LP––––Not filed
Bank of New York Mellon Corp––––Not filed
Algert Global LLC––––Not filed
Standard Life Aberdeen plc––––Not filed
Morgan Stanley––––Not filed
Fiera Capital Corp––––Not filed
Bank of America Corp––––Not filed
Parkman Healthcare Partners LLC––––Not filed
Nicholas Investment Partners, LP––––Not filed
Millennium Management LLC––––Not filed
UBS Asset Management Americas Inc––––Not filed
Baker Bros. Advisors LP––––Not filed
Jones Hill Capital LP––––Not filed
Ameriprise Financial Inc––––Not filed
Man Group plc––––Not filed
Adage Capital Partners GP, L.L.C.––––Not filed
Soleus Capital Management, L.P.––––Not filed
Jump Financial, LLC––––Not filed
DAFNA Capital Management LLC––––Not filed
Charles Schwab Investment Management Inc––––Not filed
State of Wisconsin Investment Board––––Not filed
Nan Fung Trinity (HK) Ltd––––Not filed
Duquesne Family Office LLCSuperinvestorDuquesne Family Office––––Not filed
Allspring Global Investments Holdings, LLC––––Not filed
Redmile Group, LLC––––Not filed
Schonfeld Strategic Advisors LLC––––Not filed
D. E. Shaw & Co., Inc.––––Not filed
Patient Square Capital LP––––Not filed
New York State Common Retirement Fund––––Not filed
Jennison Associates LLC––––Not filed
Neuberger Berman Group LLC––––Not filed
Trexquant Investment LP––––Not filed
DnB Asset Management AS––––Not filed
Integral Health Asset Management, LLC––––Not filed
Eversept Partners, LP––––Not filed
Balyasny Asset Management LLC––––Not filed
Deutsche Bank AG––––Not filed
Renaissance Technologies LLC––––Not filed
Silverarc Capital Management, LLC––––Not filed
Boothbay Fund Management, LLC––––Not filed
NEXTBio Capital Management LP––––Not filed
Wells Fargo & Company––––Not filed
ADAR1 Capital Management, LLC––––Not filed
Peregrine Capital Management LLC––––Not filed
Swiss National Bank––––Not filed
Foresite Capital Management IV, LLC––––Not filed
Woodline Partners LP––––Not filed
Russell Investments Group, Ltd.––––Not filed
HSBC Holdings PLC––––Not filed
Susquehanna Portfolio Strategies, LLC––––Not filed
Point72 Asset Management, L.P.––––Not filed