Xenon Pharmaceuticals Inc.
XENE- Exchange
- Nasdaq
- Industry
- Pharmaceutical Preparations
- SEC CIK
- 0001582313
In the last 90 days, Xenon Pharmaceuticals Inc. insiders filed 0 open-market purchases and 2 sales; 315 institutions reported holding it in 13F filings for Q2 2026, worth $6.10B in total; Duquesne Family Office is the only superinvestor holding it.
13F holders, Q3 2025
Institutional positions in Xenon Pharmaceuticals Inc. as of Sep 30, 2025. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 219
- +15 vs. Q2 2025
- Shares held
- 84.3M
- +1.20M (+1.4%) vs. Q2 2025
- Total value
- $3.39B
- +$783.3M (+30.1%) vs. Q2 2025
- New holders
- 35
- 68 more added
- Sold out
- 20
- 71 more reduced
2 institutions that held it in Q2 2025 haven't filed for Q3 2025 yet. Not filing isn't selling, so they aren't counted as sold out or in the changes above.
Compare with Q2 2025: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting XENE on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 315 | $6.10B |
| Q1 2026 | 290 | $5.80B |
| Q4 2025 | 245 | $3.78B |
| Q3 2025 | 219 | $3.39B |
| Q2 2025 | 206 | $2.60B |
| Q1 2025 | 206 | $2.58B |
| Q4 2024 | 209 | $2.99B |
| Q3 2024 | 203 | $2.95B |
| Q2 2024 | 213 | $2.89B |
| Q1 2024 | 220 | $3.16B |
| Q4 2023 | 204 | $3.32B |
| Q3 2023 | 181 | $2.10B |
| Q2 2023 | 175 | $2.36B |
| Q1 2023 | 163 | $2.19B |
| Q4 2022 | 159 | $2.38B |
| Q3 2022 | 154 | $2.09B |
| Q2 2022 | 151 | $1.73B |
| Q1 2022 | 132 | $1.50B |
| Q4 2021 | 130 | $1.49B |
| Q3 2021 | 118 | $521.7M |
| Q2 2021 | 103 | $620.0M |
| Q1 2021 | 91 | $590.0M |
Institutions, Q3 2025
Shares, value and share of portfolio for each institution holding Xenon Pharmaceuticals Inc.; share changes are against Q2 2025.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| Deep Track Capital, LP | 1,200,000 | $48.2M | 1.34% | −150,000−11.1% | Reduced |
| Westfield Capital Management Co LP | 1,206,066 | $48.4M | 0.20% | +53,461+4.6% | Added |
| Pictet Asset Management Holding SA | 1,262,579 | $50.6M | 0.05% | −211,870−14.4% | Reduced |
| Millennium Management LLC | 1,384,007 | $55.6M | 0.04% | +501,172+56.8% | Added |
| JPMorgan Chase & Co | 1,399,033 | $56.2M | 0.00% | +142,452+11.3% | Added |
| Affinity Asset Advisors, LLC | 1,400,000 | $56.2M | 5.23% | +300,000+27.3% | Added |
| State Street Corp | 1,466,467 | $58.9M | 0.00% | +86,007+6.2% | Added |
| Alliancebernstein L.P. | 1,654,417 | $66.4M | 0.02% | +135,890+8.9% | Added |
| Holocene Advisors, LP | 1,976,553 | $79.4M | 0.18% | +167,078+9.2% | Added |
| Polar Capital Holdings Plc | 2,546,766 | $102.3M | 0.49% | −156,490−5.8% | Reduced |
| Commodore Capital LP | 2,700,000 | $108.4M | 5.29% | −325,000−10.7% | Reduced |
| Capital International Investors | 3,181,493 | $127.7M | 0.02% | −560.0% | Reduced |
| Braidwell LP | 3,605,029 | $144.7M | 4.29% | 00.0% | Unchanged |
| Wellington Management Group LLP | 3,609,857 | $144.9M | 0.03% | +1,435,096+66.0% | Added |
| Janus Henderson Group PLC | 3,943,885 | $158.3M | 0.07% | +366,150+10.2% | Added |
| Driehaus Capital Management LLC | 4,169,114 | $167.4M | 1.20% | −166,534−3.8% | Reduced |
| BlackRock, Inc. | 4,770,951 | $191.6M | 0.00% | −594,376−11.1% | Reduced |
| Avoro Capital Advisors LLC | 5,400,000 | $216.8M | 2.80% | 00.0% | Unchanged |
| FMR LLC | 8,918,907 | $358.1M | 0.02% | +34,544+0.4% | Added |
| Assenagon Asset Management S.A. | 0 | $0 | 0.00% | −436,974−100.0% | Sold out |
| UBS Asset Management Americas Inc | 0 | $0 | 0.00% | −404,384−100.0% | Sold out |
| First Light Asset Management, LLC | 0 | $0 | 0.00% | −188,367−100.0% | Sold out |
| AXA S.A. | 0 | $0 | 0.00% | −175,632−100.0% | Sold out |
| Foresite Capital Management VI LLC | 0 | $0 | 0.00% | −160,000−100.0% | Sold out |
| Caption Management, LLC | 0 | $0 | 0.00% | −100,940−100.0% | Sold out |
| Soleus Capital Management, L.P. | 0 | $0 | 0.00% | −78,800−100.0% | Sold out |
| Nebula Research & Development LLC | 0 | $0 | 0.00% | −60,223−100.0% | Sold out |
| Skandinaviska Enskilda Banken AB (publ) | 0 | $0 | 0.00% | −47,457−100.0% | Sold out |
| Woodline Partners LP | 0 | $0 | 0.00% | −43,380−100.0% | Sold out |
| Polar Asset Management Partners Inc. | 0 | $0 | 0.00% | −25,300−100.0% | Sold out |
| Readystate Asset Management LP | 0 | $0 | 0.00% | −24,814−100.0% | Sold out |
| PEAK6 LLC | 0 | $0 | 0.00% | −15,000−100.0% | Sold out |
| L1 Capital Pty Ltd | 0 | $0 | 0.00% | −1,296−100.0% | Sold out |
| Mount Yale Investment Advisors, LLC | 0 | $0 | 0.00% | −1,015−100.0% | Sold out |
| Spire Wealth Management | 0 | $0 | 0.00% | −200−100.0% | Sold out |
| Caitong International Asset Management Co., Ltd | 0 | $0 | 0.00% | −104−100.0% | Sold out |
| Skopos Labs, Inc. | 0 | $0 | 0.00% | −103−100.0% | Sold out |
| Whittier Trust Co of Nevada Inc | 0 | $0 | 0.00% | −36−100.0% | Sold out |
| Twin Peaks Wealth Advisors, LLC | 0 | $0 | 0.00% | −1−100.0% | Sold out |
| CIBC World Markets Corp | – | – | – | – | Not filed |
| First Horizon Advisors, Inc. | – | – | – | – | Not filed |