Xenon Pharmaceuticals Inc.
XENE- Exchange
- Nasdaq
- Industry
- Pharmaceutical Preparations
- SEC CIK
- 0001582313
In the last 90 days, Xenon Pharmaceuticals Inc. insiders filed 0 open-market purchases and 2 sales; 315 institutions reported holding it in 13F filings for Q2 2026, worth $6.10B in total; Duquesne Family Office is the only superinvestor holding it.
13F holders, Q3 2025
Institutional positions in Xenon Pharmaceuticals Inc. as of Sep 30, 2025. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 219
- +15 vs. Q2 2025
- Shares held
- 84.3M
- +1.20M (+1.4%) vs. Q2 2025
- Total value
- $3.39B
- +$783.3M (+30.1%) vs. Q2 2025
- New holders
- 35
- 68 more added
- Sold out
- 20
- 71 more reduced
2 institutions that held it in Q2 2025 haven't filed for Q3 2025 yet. Not filing isn't selling, so they aren't counted as sold out or in the changes above.
Compare with Q2 2025: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting XENE on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 315 | $6.10B |
| Q1 2026 | 290 | $5.80B |
| Q4 2025 | 245 | $3.78B |
| Q3 2025 | 219 | $3.39B |
| Q2 2025 | 206 | $2.60B |
| Q1 2025 | 206 | $2.58B |
| Q4 2024 | 209 | $2.99B |
| Q3 2024 | 203 | $2.95B |
| Q2 2024 | 213 | $2.89B |
| Q1 2024 | 220 | $3.16B |
| Q4 2023 | 204 | $3.32B |
| Q3 2023 | 181 | $2.10B |
| Q2 2023 | 175 | $2.36B |
| Q1 2023 | 163 | $2.19B |
| Q4 2022 | 159 | $2.38B |
| Q3 2022 | 154 | $2.09B |
| Q2 2022 | 151 | $1.73B |
| Q1 2022 | 132 | $1.50B |
| Q4 2021 | 130 | $1.49B |
| Q3 2021 | 118 | $521.7M |
| Q2 2021 | 103 | $620.0M |
| Q1 2021 | 91 | $590.0M |
Institutions, Q3 2025
Shares, value and share of portfolio for each institution holding Xenon Pharmaceuticals Inc.; share changes are against Q2 2025.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| Manufacturers Life Insurance Company, The | 23,932 | $960.9K | 0.00% | −2,147−8.2% | Reduced |
| NJ State Employees Deferred Compensation Plan | 25,000 | $1.00M | 0.11% | 00.0% | Unchanged |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 25,589 | $1.03M | 0.00% | +1,723+7.2% | Added |
| HighMark Wealth Management LLC | 26,100 | $1.05M | 0.46% | 00.0% | Unchanged |
| Campbell & CO Investment Adviser LLC | 28,669 | $1.15M | 0.09% | +28,669 | New |
| Boothbay Fund Management, LLC | 28,859 | $1.16M | 0.03% | +28,859 | New |
| Bamco Inc | 30,000 | $1.20M | 0.00% | −26,000−46.4% | Reduced |
| J. Safra Sarasin Holding AG | 30,168 | $1.21M | 0.02% | −51,880−63.2% | Reduced |
| TLS Advisors LLC | 32,956 | $1.38M | 4.02% | 00.0% | Unchanged |
| Mirae Asset Global ETFs Holdings Ltd. | 35,301 | $1.42M | 0.00% | −6,347−15.2% | Reduced |
| Alps Advisors Inc | 37,300 | $1.50M | 0.01% | −4,080−9.9% | Reduced |
| Envestnet Asset Management Inc | 37,448 | $1.50M | 0.00% | −1,955−5.0% | Reduced |
| DekaBank Deutsche Girozentrale | 39,000 | $1.51M | 0.00% | 00.0% | Unchanged |
| Atika Capital Management LLC | 38,000 | $1.53M | 0.13% | +38,000 | New |
| Artia Global Partners LP | 40,000 | $1.61M | 0.28% | 00.0% | Unchanged |
| Price T Rowe Associates Inc | 41,692 | $1.68M | 0.00% | +3,757+9.9% | Added |
| MetLife Investment Management | 44,221 | $1.78M | 0.01% | −1,326−2.9% | Reduced |
| Susquehanna International Group, LLP | 45,907 | $1.84M | 0.00% | −176,445−79.4% | Reduced |
| D. E. Shaw & Co., Inc. | 48,455 | $1.95M | 0.00% | −93,328−65.8% | Reduced |
| Erste Asset Management GmbH | 50,000 | $1.95M | 0.02% | 00.0% | Unchanged |
| Neo Ivy Capital Management | 49,838 | $2.00M | 0.49% | +49,838 | New |
| Avidity Partners Management LP | 53,400 | $2.14M | 0.49% | −54,491−50.5% | Reduced |
| Algert Global LLC | 54,255 | $2.18M | 0.04% | −48,090−47.0% | Reduced |
| State of New Jersey Common Pension Fund D | 55,711 | $2.24M | 0.01% | −6,061−9.8% | Reduced |
| Invesco Ltd. | 56,064 | $2.25M | 0.00% | −3,534−5.9% | Reduced |
| Verition Fund Management LLC | 57,117 | $2.29M | 0.01% | +57,117 | New |
| California State Teachers Retirement System | 60,237 | $2.42M | 0.00% | +40.0% | Added |
| Voya Investment Management LLC | 60,858 | $2.44M | 0.00% | +1,393+2.3% | Added |
| Russell Investments Group, Ltd. | 69,892 | $2.81M | 0.00% | +17,756+34.1% | Added |
| Raymond James Financial Inc | 69,922 | $2.81M | 0.00% | +4,708+7.2% | Added |
| Tudor Investment Corp Et Al | 76,824 | $3.08M | 0.02% | +76,824 | New |
| Schroder Investment Management Group | 81,156 | $3.17M | 0.00% | −47,947−37.1% | Reduced |
| Legal & General Group Plc | 79,848 | $3.21M | 0.00% | −1,944−2.4% | Reduced |
| Rhenman & Partners Asset Management AB | 81,000 | $3.25M | 0.36% | +46,000+131.4% | Added |
| HighVista Strategies LLC | 82,190 | $3.30M | 0.81% | +36,570+80.2% | Added |
| Granahan Investment Management Inc | 87,470 | $3.51M | 0.14% | −152,568−63.6% | Reduced |
| Jane Street Group, LLC | 89,879 | $3.61M | 0.00% | +46,203+105.8% | Added |
| Mutual of America Capital Management LLC | 94,935 | $3.81M | 0.04% | −633−0.7% | Reduced |
| Ameriprise Financial Inc | 97,567 | $3.92M | 0.00% | −24,459−20.0% | Reduced |
| UBS Group AG | 106,744 | $4.29M | 0.00% | −46,314−30.3% | Reduced |
| Rhumbline Advisers | 106,791 | $4.29M | 0.00% | −2,909−2.7% | Reduced |
| Barclays PLC | 111,300 | $4.47M | 0.00% | −41,470−27.1% | Reduced |
| Deutsche Bank AG | 112,951 | $4.53M | 0.00% | +8,417+8.1% | Added |
| Wells Fargo & Company | 115,221 | $4.63M | 0.00% | +2,659+2.4% | Added |
| Nicholas Investment Partners, LP | 119,098 | $4.78M | 0.37% | +50,202+72.9% | Added |
| Royal Bank of Canada | 120,545 | $4.84M | 0.00% | −26,681−18.1% | Reduced |
| Swiss National Bank | 126,400 | $5.07M | 0.00% | +2,100+1.7% | Added |
| Moore Capital Management, LP | 140,000 | $5.62M | 0.11% | +50,000+55.6% | Added |
| Nan Fung Trinity (HK) Ltd | 158,605 | $6.37M | 0.64% | 00.0% | Unchanged |
| BNP Paribas Arbitrage, SA | 159,238 | $6.39M | 0.00% | +141,394+792.4% | Added |
| Foresite Capital Management IV, LLC | 160,000 | $6.42M | 3.52% | 00.0% | Unchanged |
| New York State Common Retirement Fund | 171,708 | $6.89M | 0.01% | +5,236+3.1% | Added |
| Neuberger Berman Group LLC | 172,354 | $6.92M | 0.01% | +24,943+16.9% | Added |
| Parkman Healthcare Partners LLC | 176,137 | $7.07M | 0.78% | +25,764+17.1% | Added |
| AXA Investment Managers S.A. | 176,157 | $7.07M | 0.02% | +176,157 | New |
| Charles Schwab Investment Management Inc | 188,747 | $7.58M | 0.00% | −3,495−1.8% | Reduced |
| ADAR1 Capital Management, LLC | 189,098 | $7.59M | 0.75% | −70,405−27.1% | Reduced |
| StemPoint Capital LP | 192,295 | $7.72M | 1.56% | +192,295 | New |
| Bank of America Corp | 199,106 | $7.99M | 0.00% | −159,326−44.5% | Reduced |
| Great Point Partners LLC | 200,000 | $8.03M | 3.35% | 00.0% | Unchanged |
| Perceptive Advisors LLC | 200,791 | $8.06M | 0.23% | 00.0% | Unchanged |
| State of Wisconsin Investment Board | 208,372 | $8.37M | 0.02% | +33,522+19.2% | Added |
| Nuveen, LLC | 224,289 | $9.01M | 0.00% | −4,278−1.9% | Reduced |
| Federated Hermes, Inc. | 232,500 | $9.33M | 0.02% | 00.0% | Unchanged |
| DnB Asset Management AS | 249,081 | $10.0M | 0.04% | +14,924+6.4% | Added |
| Jain Global LLC | 252,379 | $10.1M | 0.13% | +252,379 | New |
| DAFNA Capital Management LLC | 287,939 | $11.6M | 2.86% | 00.0% | Unchanged |
| Balyasny Asset Management LLC | 322,456 | $12.9M | 0.03% | +253,587+368.2% | Added |
| Tri Locum Partners LP | 366,102 | $14.7M | 3.38% | +366,102 | New |
| Morgan Stanley | 366,572 | $14.7M | 0.00% | −21,024−5.4% | Reduced |
| Baker Bros. Advisors LP | 370,208 | $14.9M | 0.11% | 00.0% | Unchanged |
| Candriam Luxembourg S.C.A. | 396,636 | $15.9M | 0.08% | 00.0% | Unchanged |
| Bank of New York Mellon Corp | 418,416 | $16.8M | 0.00% | −17,604−4.0% | Reduced |
| OrbiMed Advisors LLC | 419,600 | $16.8M | 0.40% | −528,277−55.7% | Reduced |
| Caligan Partners LP | 444,565 | $17.8M | 2.48% | +444,565 | New |
| Dimensional Fund Advisors LP | 454,023 | $18.2M | 0.00% | +74,035+19.5% | Added |
| Northern Trust Corp | 498,147 | $20.0M | 0.00% | +8,207+1.7% | Added |
| MPM Oncology Impact Management LP | 503,398 | $20.2M | 3.31% | +180,000+55.7% | Added |
| Saturn V Capital Management LLC | 503,701 | $20.2M | 4.44% | +35,337+7.5% | Added |
| Fiera Capital Corp | 519,999 | $20.9M | 0.07% | −10,684−2.0% | Reduced |
| Deerfield Management Company, L.P. (Series C) | 542,020 | $21.8M | 0.33% | 00.0% | Unchanged |
| TimesSquare Capital Management, LLC | 556,800 | $22.4M | 0.32% | −14,442−2.5% | Reduced |
| Standard Life Aberdeen plc | 579,145 | $23.3M | 0.04% | +57,653+11.1% | Added |
| T. Rowe Price Investment Management, Inc. | 599,113 | $24.1M | 0.01% | +522,170+678.6% | Added |
| Marshall Wace, LLP | 611,982 | $24.6M | 0.03% | −408,272−40.0% | Reduced |
| Loomis Sayles & Co L P | 640,626 | $25.7M | 0.03% | −16,539−2.5% | Reduced |
| Capital World Investors | 655,737 | $26.3M | 0.00% | 00.0% | Unchanged |
| American Century Companies Inc | 659,257 | $26.5M | 0.01% | −20,600−3.0% | Reduced |
| BNP PARIBAS ASSET MANAGEMENT Holding S.A. | 670,257 | $26.9M | 0.07% | +9,175+1.4% | Added |
| Franklin Resources Inc | 695,900 | $27.9M | 0.01% | +29,434+4.4% | Added |
| Goldman Sachs Group Inc | 720,659 | $28.9M | 0.00% | +158,859+28.3% | Added |
| First Turn Management, LLC | 799,743 | $32.1M | 4.82% | +139,126+21.1% | Added |
| Siren, L.L.C. | 812,761 | $32.6M | 1.28% | 00.0% | Unchanged |
| Adage Capital Partners GP, L.L.C. | 835,100 | $33.5M | 0.05% | −455,000−35.3% | Reduced |
| Vanguard Group Inc | 851,386 | $34.2M | 0.00% | −21,842−2.5% | Reduced |
| Rock Springs Capital Management LP | 851,744 | $34.2M | 2.00% | −79,937−8.6% | Reduced |
| Citadel Advisors LLC | 959,098 | $38.5M | 0.03% | +839,053+698.9% | Added |
| Geode Capital Management, LLC | 977,435 | $39.2M | 0.00% | +7,092+0.7% | Added |
| Vestal Point Capital, LP | 1,100,000 | $44.2M | 2.00% | −900,000−45.0% | Reduced |
| Jennison Associates LLC | 1,135,235 | $45.6M | 0.03% | +438,852+63.0% | Added |