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Xenon Pharmaceuticals Inc.

XENE
Exchange
Nasdaq
Industry
Pharmaceutical Preparations
SEC CIK
0001582313

In the last 90 days, Xenon Pharmaceuticals Inc. insiders filed 0 open-market purchases and 2 sales; 315 institutions reported holding it in 13F filings for Q2 2026, worth $6.10B in total; Duquesne Family Office is the only superinvestor holding it.

13F holders, Q1 2023

Institutional positions in Xenon Pharmaceuticals Inc. as of Mar 31, 2023. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works

Institutional holders
163
+4 vs. Q4 2022
Shares held
61.1M
+745.1K (+1.2%) vs. Q4 2022
Total value
$2.19B
−$195.6M (−8.2%) vs. Q4 2022
New holders
29
52 more added
Sold out
25
46 more reduced

Compare with Q4 2022: new holders, sold out and not filed yet

Holders and value by quarter

Institutions reporting XENE on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.

Institutional holdersQ1 2023: 163 institutions
Q1 2021: 91 institutionsQ2 2021: 103 institutionsQ3 2021: 118 institutionsQ4 2021: 130 institutionsQ1 2022: 132 institutionsQ2 2022: 151 institutionsQ3 2022: 154 institutionsQ4 2022: 159 institutionsQ1 2023: 163 institutionsQ2 2023: 175 institutionsQ3 2023: 181 institutionsQ4 2023: 204 institutionsQ1 2024: 220 institutionsQ2 2024: 213 institutionsQ3 2024: 203 institutionsQ4 2024: 209 institutionsQ1 2025: 206 institutionsQ2 2025: 206 institutionsQ3 2025: 219 institutionsQ4 2025: 245 institutionsQ1 2026: 290 institutionsQ2 2026: 315 institutions
Value heldQ1 2023: $2.19B
Q1 2021: $590.0MQ2 2021: $620.0MQ3 2021: $521.7MQ4 2021: $1.49BQ1 2022: $1.50BQ2 2022: $1.73BQ3 2022: $2.09BQ4 2022: $2.38BQ1 2023: $2.19BQ2 2023: $2.36BQ3 2023: $2.10BQ4 2023: $3.32BQ1 2024: $3.16BQ2 2024: $2.89BQ3 2024: $2.95BQ4 2024: $2.99BQ1 2025: $2.58BQ2 2025: $2.60BQ3 2025: $3.39BQ4 2025: $3.78BQ1 2026: $5.80BQ2 2026: $6.10B
Institutions holding XENE and their total value by quarter
QuarterHoldersValue
Q2 2026315$6.10B
Q1 2026290$5.80B
Q4 2025245$3.78B
Q3 2025219$3.39B
Q2 2025206$2.60B
Q1 2025206$2.58B
Q4 2024209$2.99B
Q3 2024203$2.95B
Q2 2024213$2.89B
Q1 2024220$3.16B
Q4 2023204$3.32B
Q3 2023181$2.10B
Q2 2023175$2.36B
Q1 2023163$2.19B
Q4 2022159$2.38B
Q3 2022154$2.09B
Q2 2022151$1.73B
Q1 2022132$1.50B
Q4 2021130$1.49B
Q3 2021118$521.7M
Q2 2021103$620.0M
Q1 202191$590.0M

Institutions, Q1 2023

Shares, value and share of portfolio for each institution holding Xenon Pharmaceuticals Inc.; share changes are against Q4 2022.

Institutions holding XENE in Q1 2023
InstitutionSharesValue% of portfolioChange in sharesAction
Nan Fung Group Holdings Ltd114,380$4.09M2.79%00.0%Unchanged
Bank of America Corp134,111$4.80M0.00%+45,363+51.1%Added
Putnam Investments LLC153,455$5.49M0.01%+795+0.5%Added
Ikarian Capital, LLC160,486$5.74M2.38%00.0%Unchanged
Ensign Peak Advisors, Inc164,380$5.88M0.01%00.0%Unchanged
Franklin Resources Inc172,609$6.18M0.00%+172,609New
AXA S.A.190,380$6.81M0.02%−414−0.2%Reduced
Bank of New York Mellon Corp199,387$7.14M0.00%−188,973−48.7%Reduced
Ghost Tree Capital, LLC200,000$7.16M2.71%+200,000New
Eversept Partners, LP203,272$7.28M0.65%−72,432−26.3%Reduced
D. E. Shaw & Co., Inc.206,672$7.40M0.01%−153,749−42.7%Reduced
State Street Corp207,456$7.42M0.00%+10,020+5.1%Added
State of Wisconsin Investment Board214,056$7.66M0.02%−3,564−1.6%Reduced
Nomura Holdings Inc221,095$7.91M0.08%+221,095New
Millennium Management LLC221,470$7.93M0.01%−373,071−62.7%Reduced
Tri Locum Partners LP221,730$7.94M2.42%+128,366+137.5%Added
Morgan Stanley242,981$8.70M0.00%+154,847+175.7%Added
Wellington Management Group LLP247,437$8.86M0.00%+247,437New
Vanguard Group Inc249,354$8.92M0.00%+57,278+29.8%Added
Ally Bridge Group (NY) LLC266,961$9.55M12.52%+266,961New
Granahan Investment Management Inc276,012$9.88M0.30%−48,238−14.9%Reduced
Parkman Healthcare Partners LLC277,283$9.92M2.16%+41,792+17.7%Added
First Light Asset Management, LLC279,444$10.0M0.90%+279,444New
Goldman Sachs Group Inc285,423$10.2M0.00%+1,882+0.7%Added
Schonfeld Strategic Advisors LLC300,119$10.7M0.10%+131,706+78.2%Added
ExodusPoint Capital Management, LP302,980$10.8M0.12%+302,980New
DAFNA Capital Management LLC316,092$11.3M3.39%00.0%Unchanged
Janus Henderson Group PLC321,465$11.5M0.01%+29,679+10.2%Added
Norges Bank365,830$13.1M0.00%+365,830New
TimesSquare Capital Management, LLC407,795$14.6M0.21%−74,385−15.4%Reduced
Woodline Partners LP420,029$15.0M0.21%+121,589+40.7%Added
Nicholas Investment Partners, LP436,715$15.6M1.19%+184,413+73.1%Added
Point72 Asset Management, L.P.504,624$18.1M0.06%−673,700−57.2%Reduced
Boxer Capital, LLC600,000$21.5M1.05%00.0%Unchanged
Eventide Asset Management, LLC641,200$22.9M0.42%00.0%Unchanged
Paradigm Biocapital Advisors LP651,068$23.3M2.21%+651,068New
Candriam Luxembourg S.C.A.719,206$23.7M0.16%−16,678−2.3%Reduced
Adage Capital Partners GP, L.L.C.750,000$26.8M0.06%+25,000+3.4%Added
Baker Bros. Advisors LP751,639$26.9M0.15%00.0%Unchanged
Loomis Sayles & Co L P760,567$27.2M0.05%+83,402+12.3%Added
Great Point Partners LLC818,505$29.3M5.79%−31,495−3.7%Reduced
Citadel Advisors LLC871,234$31.2M0.03%−293,173−25.2%Reduced
BlackRock Inc.899,154$32.2M0.00%−26,469−2.9%Reduced
Logos Global Management LP900,000$32.2M4.61%00.0%Unchanged
Holocene Advisors, LP986,195$35.3M0.18%−205,443−17.2%Reduced
OrbiMed Advisors LLC1,149,100$41.1M0.81%00.0%Unchanged
Samlyn Capital, LLC1,158,994$41.5M0.76%−34,820−2.9%Reduced
Rock Springs Capital Management LP1,178,002$42.2M1.01%+2,330+0.2%Added
Redmile Group, LLC1,325,832$47.5M2.06%−1,034,582−43.8%Reduced
Lord, Abbett & Co. LLC1,782,611$63.8M0.23%−341,398−16.1%Reduced
BVF Inc1,827,958$65.4M2.39%+556,715+43.8%Added
Perceptive Advisors LLC1,832,174$65.6M1.94%−89,099−4.6%Reduced
Commodore Capital LP1,845,000$66.0M10.05%+185,889+11.2%Added
Pictet Asset Management SA2,004,297$71.7M0.09%−115,322−5.4%Reduced
Braidwell LP2,137,110$76.5M2.52%+589,000+38.0%Added
Capital World Investors2,274,974$81.4M0.02%00.0%Unchanged
Marshall Wace, LLP2,320,586$83.1M0.20%−45,592−1.9%Reduced
Capital International Investors2,321,991$83.1M0.02%+222,412+10.6%Added
Polar Capital Holdings Plc3,016,818$108.0M0.79%−29,056−1.0%Reduced
Driehaus Capital Management LLC4,654,925$166.6M2.34%−26,872−0.6%Reduced
FMR LLC4,727,849$169.2M0.02%+37,020+0.8%Added
Avoro Capital Advisors LLC4,900,000$175.4M2.60%00.0%Unchanged
Mirabella Financial Services LLP11,802––−19,657−62.5%Reduced
Balyasny Asset Management LLC0$00.00%−162,828−100.0%Sold out
EAM Global Investors LLC0$00.00%−146,387−100.0%Sold out
Twinbeech Capital LP0$00.00%−101,717−100.0%Sold out
LMR Partners LLP0$00.00%−50,000−100.0%Sold out
Cheyne Capital Management (UK) LLP0$00.00%−42,500−100.0%Sold out
Soleus Capital Management, L.P.0$00.00%−38,000−100.0%Sold out
Scotia Capital Inc.0$00.00%−26,859−100.0%Sold out
Two Sigma Advisers, LP0$00.00%−22,700−100.0%Sold out
Ameriprise Financial Inc0$00.00%−22,626−100.0%Sold out
Sanders Morris Harris LLC0$00.00%−21,500−100.0%Sold out
Velan Capital Investment Management LP0$00.00%−20,000−100.0%Sold out
Jefferies Financial Group Inc.0$00.00%−19,500−100.0%Sold out
Employees Retirement System of Texas0$00.00%−16,001−100.0%Sold out
Engineers Gate Manager LP0$00.00%−14,383−100.0%Sold out
Ergoteles LLC0$00.00%−13,516−100.0%Sold out
Fox Run Management, L.L.C.0$00.00%−12,975−100.0%Sold out
Main Street Research LLC0$00.00%−10,000−100.0%Sold out
Jump Financial, LLC0$00.00%−7,725−100.0%Sold out
Group One Trading, L.P.0$00.00%−6,552−100.0%Sold out
Connor, Clark & Lunn Investment Management Ltd.0$00.00%−5,799−100.0%Sold out
Virtu Financial LLC0$00.00%−5,604−100.0%Sold out
ProShare Advisors LLC0$00.00%−5,172−100.0%Sold out
High Net Worth Advisory Group LLC0$00.00%−2,000−100.0%Sold out
Cutler Group LP0$00.00%−100−100.0%Sold out
Ronald Blue Trust, Inc.0$00.00%−29−100.0%Sold out