Tyra Biosciences, Inc.
TYRA- Exchange
- Nasdaq
- Industry
- Pharmaceutical Preparations
- SEC CIK
- 0001863127
In the last 90 days, Tyra Biosciences, Inc. insiders filed 1 open-market purchase and 0 sales; 168 institutions reported holding it in 13F filings for Q2 2026, worth $2.22B in total; no superinvestor holds it.
13F holders, Q4 2025
Institutional positions in Tyra Biosciences, Inc. as of Dec 31, 2025. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 133
- +19 vs. Q3 2025
- Shares held
- 56.8M
- +1.36M (+2.4%) vs. Q3 2025
- Total value
- $1.49B
- +$717.9M (+92.5%) vs. Q3 2025
- New holders
- 29
- 43 more added
- Sold out
- 10
- 38 more reduced
2 institutions that held it in Q3 2025 haven't filed for Q4 2025 yet. Not filing isn't selling, so they aren't counted as sold out or in the changes above.
Compare with Q3 2025: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting TYRA on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 168 | $2.22B |
| Q1 2026 | 164 | $2.52B |
| Q4 2025 | 133 | $1.49B |
| Q3 2025 | 116 | $778.4M |
| Q2 2025 | 121 | $541.5M |
| Q1 2025 | 117 | $499.5M |
| Q4 2024 | 113 | $675.8M |
| Q3 2024 | 95 | $1.11B |
| Q2 2024 | 79 | $748.6M |
| Q1 2024 | 77 | $768.4M |
| Q4 2023 | 62 | $495.2M |
| Q3 2023 | 59 | $502.1M |
| Q2 2023 | 59 | $616.7M |
| Q1 2023 | 51 | $573.0M |
| Q4 2022 | 46 | $267.8M |
| Q3 2022 | 49 | $313.8M |
| Q2 2022 | 48 | $255.6M |
| Q1 2022 | 46 | $386.6M |
| Q4 2021 | 45 | $494.2M |
| Q3 2021 | 26 | $456.8M |
| Q2 2021 | 0 | $0 |
| Q1 2021 | 0 | $0 |
Institutions, Q4 2025
Shares, value and share of portfolio for each institution holding Tyra Biosciences, Inc.; share changes are against Q3 2025.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| Jacobs Levy Equity Management, Inc | 129,753 | $3.41M | 0.01% | −121,809−48.4% | Reduced |
| BNP PARIBAS ASSET MANAGEMENT Holding S.A. | 129,779 | $3.41M | 0.00% | +129,779 | New |
| Raymond James Financial Inc | 170,032 | $4.47M | 0.00% | +43,658+34.5% | Added |
| Goldman Sachs Group Inc | 182,387 | $4.79M | 0.00% | +82,237+82.1% | Added |
| Charles Schwab Investment Management Inc | 199,426 | $5.24M | 0.00% | −2,161−1.1% | Reduced |
| Northern Trust Corp | 200,956 | $5.28M | 0.00% | −7,530−3.6% | Reduced |
| Logos Global Management LP | 210,000 | $5.52M | 0.37% | +210,000 | New |
| Boothbay Fund Management, LLC | 221,177 | $5.81M | 0.15% | +34,507+18.5% | Added |
| Eversept Partners, LP | 278,564 | $7.32M | 0.41% | +5,858+2.1% | Added |
| Elmind Capital, LP | 350,000 | $9.20M | 2.72% | +350,000 | New |
| Boone Capital Management LLC | 398,482 | $10.5M | 3.29% | +398,482 | New |
| Sio Capital Management, LLC | 526,002 | $13.8M | 2.29% | +11,055+2.1% | Added |
| Geode Capital Management, LLC | 657,756 | $17.3M | 0.00% | +60,302+10.1% | Added |
| Trails Edge Capital Partners, LP | 700,000 | $18.4M | 4.55% | +700,000 | New |
| Marshall Wace, LLP | 711,891 | $18.7M | 0.02% | +109,876+18.3% | Added |
| State Street Corp | 749,463 | $19.7M | 0.00% | +320,991+74.9% | Added |
| Balyasny Asset Management LLC | 818,326 | $21.5M | 0.04% | −28,259−3.3% | Reduced |
| Point72 Asset Management, L.P. | 874,192 | $23.0M | 0.04% | +592,160+210.0% | Added |
| Caligan Partners LP | 944,257 | $24.8M | 2.27% | +247,432+35.5% | Added |
| 5AM Venture Management, LLC | 1,029,298 | $27.1M | 8.51% | +90,000+9.6% | Added |
| Kynam Capital Management, LP | 1,564,492 | $41.1M | 2.68% | −765,506−32.9% | Reduced |
| Vanguard Group Inc | 1,572,785 | $41.3M | 0.00% | +52,600+3.5% | Added |
| Farallon Capital Management, L.L.C. | 2,066,818 | $54.3M | 0.28% | +923,000+80.7% | Added |
| BlackRock, Inc. | 2,086,423 | $54.9M | 0.00% | +216,949+11.6% | Added |
| BVF Inc | 2,127,665 | $55.9M | 1.88% | −1,522,129−41.7% | Reduced |
| Vestal Point Capital, LP | 2,425,000 | $63.8M | 2.34% | 00.0% | Unchanged |
| TCG Crossover Management, LLC | 2,898,103 | $76.2M | 2.52% | 00.0% | Unchanged |
| Janus Henderson Group PLC | 2,935,442 | $77.1M | 0.03% | +60,638+2.1% | Added |
| Canaan Partners XI LLC | 3,374,329 | $88.7M | 64.85% | −233,780−6.5% | Reduced |
| Commodore Capital LP | 3,375,000 | $88.7M | 5.91% | 00.0% | Unchanged |
| Alta Partners Management Company, L.P. | 3,823,425 | $100.5M | 97.03% | −256,871−6.3% | Reduced |
| Nextech Invest, Ltd. | 4,055,861 | $106.6M | 10.31% | 00.0% | Unchanged |
| Ra Capital Management, L.P. | 12,198,625 | $320.7M | 3.29% | 00.0% | Unchanged |
| Walleye Capital LLC | 0 | $0 | 0.00% | −297,808−100.0% | Sold out |
| Renaissance Technologies LLC | 0 | $0 | 0.00% | −170,100−100.0% | Sold out |
| Citadel Advisors LLC | 0 | $0 | 0.00% | −111,293−100.0% | Sold out |
| Jump Financial, LLC | 0 | $0 | 0.00% | −62,000−100.0% | Sold out |
| Jane Street Group, LLC | 0 | $0 | 0.00% | −44,680−100.0% | Sold out |
| Brevan Howard Capital Management LP | 0 | $0 | 0.00% | −31,101−100.0% | Sold out |
| Trexquant Investment LP | 0 | $0 | 0.00% | −15,758−100.0% | Sold out |
| Tudor Investment Corp Et Al | 0 | $0 | 0.00% | −10,761−100.0% | Sold out |
| SG Americas Securities, LLC | 0 | $0 | 0.00% | −9,542−100.0% | Sold out |
| Rise Advisors, LLC | 0 | $0 | 0.00% | −49−100.0% | Sold out |
| AXA Investment Managers S.A. | – | – | – | – | Not filed |
| Cubist Systematic Strategies, LLC | – | – | – | – | Not filed |