Spyre Therapeutics, Inc.
SYRE- Exchange
- Nasdaq
- Industry
- Pharmaceutical Preparations
- SEC CIK
- 0001636282
In the last 90 days, Spyre Therapeutics, Inc. insiders filed 0 open-market purchases and 9 sales; 265 institutions reported holding it in 13F filings for Q2 2026, worth $8.52B in total; no superinvestor holds it.
13F holders, Q2 2026
Institutional positions in Spyre Therapeutics, Inc. as of Jun 30, 2026. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 265
- +69 vs. Q1 2026
- Shares held
- 95.8M
- +14.8M (+18.3%) vs. Q1 2026
- Total value
- $8.52B
- +$4.44B (+108.8%) vs. Q1 2026
- New holders
- 91
- 105 more added
- Sold out
- 22
- 55 more reduced
2 institutions that held it in Q1 2026 haven't filed for Q2 2026 yet. Not filing isn't selling, so they aren't counted as sold out or in the changes above.
Compare with Q1 2026: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting SYRE on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 265 | $8.52B |
| Q1 2026 | 198 | $4.16B |
| Q4 2025 | 153 | $2.65B |
| Q3 2025 | 137 | $1.08B |
| Q2 2025 | 129 | $952.6M |
| Q1 2025 | 129 | $1.00B |
| Q4 2024 | 131 | $1.39B |
| Q3 2024 | 119 | $1.51B |
| Q2 2024 | 107 | $1.18B |
| Q1 2024 | 103 | $1.21B |
| Q4 2023 | 54 | $601.0M |
| Q3 2023 | 29 | $43.9M |
| Q2 2023 | 44 | $31.9M |
| Q1 2023 | 45 | $12.0M |
| Q4 2022 | 51 | $19.2M |
| Q3 2022 | 55 | $23.5M |
| Q2 2022 | 67 | $24.8M |
| Q1 2022 | 84 | $95.4M |
| Q4 2021 | 86 | $189.4M |
| Q3 2021 | 77 | $322.5M |
| Q2 2021 | 78 | $285.8M |
| Q1 2021 | 84 | $328.7M |
Institutions, Q2 2026
Shares, value and share of portfolio for each institution holding Spyre Therapeutics, Inc.; share changes are against Q1 2026.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| Glenmede Trust Co NA | 9,966 | $884.8K | 0.00% | +9,966 | New |
| Diametric Capital, LP | 10,000 | $887.8K | 0.09% | +10,000 | New |
| Virginia Retirement Systems Et Al | 11,250 | $998.8K | 0.01% | −16,300−59.2% | Reduced |
| Calamos Advisors LLC | 11,323 | $1.01M | 0.00% | +11,323 | New |
| STRS Ohio | 11,500 | $1.02M | 0.00% | +7,000+155.6% | Added |
| Global Endowment Management, LP | 12,123 | $1.08M | 0.11% | −6,061−33.3% | Reduced |
| Atom Investors LP | 12,457 | $1.11M | 0.10% | +12,457 | New |
| ProShare Advisors LLC | 12,599 | $1.12M | 0.00% | −899−6.7% | Reduced |
| SG Americas Securities, LLC | 12,727 | $1.13M | 0.00% | −669−5.0% | Reduced |
| Two Sigma Investments, LP | 12,771 | $1.13M | 0.00% | +12,771 | New |
| KLP Kapitalforvaltning AS | 12,800 | $1.14M | 0.00% | +1,900+17.4% | Added |
| Seven Fleet Capital Management LP | 13,300 | $1.18M | 0.19% | −6,390−32.5% | Reduced |
| Brown Advisory Inc | 13,550 | $1.20M | 0.00% | +1,150+9.3% | Added |
| China Universal Asset Management Co., Ltd. | 13,821 | $1.23M | 0.07% | −117−0.8% | Reduced |
| SEI Investments Co | 13,941 | $1.24M | 0.00% | +4,966+55.3% | Added |
| Allianz Asset Management GmbH | 14,100 | $1.25M | 0.00% | +14,100 | New |
| Neo Ivy Capital Management | 14,551 | $1.29M | 0.30% | +13,953+2,333.3% | Added |
| Vanguard Investments Australia, Ltd. | 14,752 | $1.31M | 0.00% | +1,939+15.1% | Added |
| Diadema Partners LP | 15,000 | $1.33M | 0.47% | +15,000 | New |
| Arizona State Retirement System | 15,471 | $1.37M | 0.01% | +2,033+15.1% | Added |
| Fifth Third Bancorp | 15,638 | $1.39M | 0.00% | +15,633+312,660.0% | Added |
| Algert Global LLC | 16,460 | $1.46M | 0.02% | +16,460 | New |
| Kennedy Capital Management, Inc. | 17,310 | $1.54M | 0.03% | +437+2.6% | Added |
| Intech Investment Management LLC | 17,628 | $1.57M | 0.01% | +1,185+7.2% | Added |
| State Board of Administration of Florida Retirement System | 18,076 | $1.60M | 0.00% | +4,171+30.0% | Added |
| State of New Jersey Common Pension Fund D | 18,129 | $1.61M | 0.01% | +1,409+8.4% | Added |
| Advisor Group Holdings, Inc. | 18,146 | $1.61M | 0.00% | +17,648+3,543.8% | Added |
| Ellsworth Advisors, LLC | 16,553 | $1.69M | 0.28% | −5,410−24.6% | Reduced |
| Schonfeld Strategic Advisors LLC | 19,089 | $1.69M | 0.01% | +19,089 | New |
| Profund Advisors LLC | 19,419 | $1.72M | 0.05% | −6,624−25.4% | Reduced |
| Police & Firemen's Retirement System of New Jersey | 21,968 | $1.95M | 0.01% | +3,608+19.7% | Added |
| Freestone Grove Partners LP | 22,777 | $2.02M | 0.01% | +22,777 | New |
| AQR Capital Management LLC | 22,937 | $2.04M | 0.00% | +2,063+9.9% | Added |
| Aquatic Capital Management LLC | 25,222 | $2.24M | 0.08% | +25,222 | New |
| Warren Averett Asset Management, LLC | 25,512 | $2.26M | 0.01% | −454−1.7% | Reduced |
| Creative Planning | 25,713 | $2.28M | 0.00% | +10,227+66.0% | Added |
| Teachers Retirement System of the State of Kentucky | 25,799 | $2.29M | 0.02% | 00.0% | Unchanged |
| Handelsbanken Fonder AB | 26,000 | $2.31M | 0.01% | +26,000 | New |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 26,143 | $2.32M | 0.00% | +12,188+87.3% | Added |
| New York State Common Retirement Fund | 26,165 | $2.32M | 0.00% | +3,900+17.5% | Added |
| Castleark Management LLC | 26,420 | $2.35M | 0.06% | +26,420 | New |
| D. E. Shaw & Co., Inc. | 26,452 | $2.35M | 0.00% | +26,452 | New |
| Fred Alger Management, LLC | 28,834 | $2.56M | 0.01% | −30,619−51.5% | Reduced |
| Ghisallo Capital Management LLC | 30,000 | $2.66M | 0.05% | +30,000 | New |
| Vanguard Global Advisers, LLC | 34,500 | $3.06M | 0.00% | +3,359+10.8% | Added |
| Caption Management, LLC | 36,000 | $3.20M | 0.11% | +36,000 | New |
| Rafferty Asset Management, LLC | 36,767 | $3.26M | 0.01% | −20,153−35.4% | Reduced |
| Engineers Gate Manager LP | 38,474 | $3.42M | 0.04% | +38,474 | New |
| Mirae Asset Global ETFs Holdings Ltd. | 38,439 | $3.42M | 0.00% | +2,116+5.8% | Added |
| Vanguard Asset Management, Ltd | 39,220 | $3.48M | 0.00% | +5,988+18.0% | Added |
| Susquehanna International Group, LLP | 39,311 | $3.49M | 0.00% | +10,349+35.7% | Added |
| Maven Securities LTD | 40,000 | $3.55M | 0.24% | +40,000 | New |
| Rock Springs Capital Management LP | 42,254 | $3.75M | 0.18% | +42,254 | New |
| Moody Aldrich Partners LLC | 42,458 | $3.77M | 0.68% | +42,458 | New |
| Nomura Asset Management International Inc. | 43,071 | $3.82M | 0.01% | +43,071 | New |
| MetLife Investment Management | 43,316 | $3.85M | 0.02% | +4,909+12.8% | Added |
| State of Wisconsin Investment Board | 45,030 | $4.00M | 0.01% | +18,507+69.8% | Added |
| Schroder Investment Management Group | 44,586 | $4.02M | 0.00% | −19,098−30.0% | Reduced |
| PFM Health Sciences, LP | 46,217 | $4.10M | 0.36% | +46,217 | New |
| Rockefeller Capital Management L.P. | 47,466 | $4.21M | 0.01% | −16,536−25.8% | Reduced |
| Dimensional Fund Advisors LP | 47,698 | $4.23M | 0.00% | +10.0% | Added |
| Cinctive Capital Management LP | 48,978 | $4.35M | 0.17% | +21,548+78.6% | Added |
| Legal & General Group Plc | 49,141 | $4.36M | 0.00% | +4,349+9.7% | Added |
| Monashee Investment Management LLC | 50,000 | $4.44M | 7.45% | +50,000 | New |
| XTX Topco Ltd | 50,483 | $4.48M | 0.06% | +26,048+106.6% | Added |
| Royce & Associates LP | 51,789 | $4.60M | 0.04% | +51,789 | New |
| Alliancebernstein L.P. | 92,540 | $4.67M | 0.00% | +21,640+30.5% | Added |
| Susquehanna Portfolio Strategies, LLC | 53,101 | $4.71M | 0.08% | 00.0% | Unchanged |
| Raymond James Financial Inc | 53,627 | $4.76M | 0.00% | +33,872+171.5% | Added |
| HealthInvest Partners AB | 57,030 | $5.06M | 1.36% | −5,705−9.1% | Reduced |
| Hudson Bay Capital Management LP | 58,387 | $5.18M | 0.02% | +58,387 | New |
| Principal Financial Group Inc | 59,747 | $5.30M | 0.00% | +55,448+1,289.8% | Added |
| Silverarc Capital Management, LLC | 59,959 | $5.32M | 0.59% | −126,659−67.9% | Reduced |
| EAM Investors, LLC | 60,393 | $5.36M | 0.48% | +60,393 | New |
| California State Teachers Retirement System | 64,687 | $5.74M | 0.01% | +5,445+9.2% | Added |
| Trexquant Investment LP | 67,007 | $5.95M | 0.04% | +67,007 | New |
| B Group, Inc. | 70,000 | $6.21M | 3.53% | −30,000−30.0% | Reduced |
| Mercer Global Advisors Inc | 71,145 | $6.32M | 0.01% | +54+0.1% | Added |
| HighVista Strategies LLC | 77,807 | $6.91M | 1.57% | −68,457−46.8% | Reduced |
| Wells Fargo & Company | 82,506 | $7.32M | 0.00% | +49,298+148.5% | Added |
| Citigroup Inc | 82,593 | $7.33M | 0.00% | +70,587+587.9% | Added |
| Granahan Investment Management Inc | 82,991 | $7.37M | 0.26% | +82,991 | New |
| Federated Hermes, Inc. | 85,950 | $7.63M | 0.01% | +85,950 | New |
| Prudential Financial Inc | 87,370 | $7.76M | 0.01% | +27,815+46.7% | Added |
| F/M Investments LLC | 92,618 | $8.22M | 0.42% | −6,842−6.9% | Reduced |
| Barclays PLC | 94,069 | $8.35M | 0.00% | +48,283+105.5% | Added |
| Rhumbline Advisers | 94,763 | $8.41M | 0.01% | +9,642+11.3% | Added |
| Boxer Capital Management, LLC | 100,000 | $8.88M | 0.67% | +100,000 | New |
| Citadel Advisors LLC | 103,100 | $9.15M | 0.01% | −5,035−4.7% | Reduced |
| Manufacturers Life Insurance Company, The | 104,516 | $9.28M | 0.01% | −8,325−7.4% | Reduced |
| StemPoint Capital LP | 106,926 | $9.49M | 1.64% | −60,680−36.2% | Reduced |
| Swiss National Bank | 112,500 | $9.99M | 0.01% | +16,000+16.6% | Added |
| TD Asset Management Inc | 115,990 | $10.3M | 0.01% | −21,400−15.6% | Reduced |
| Rhenman & Partners Asset Management AB | 119,300 | $10.6M | 1.00% | +119,300 | New |
| Blackstone Group Inc. | 120,177 | $10.7M | 0.03% | −172,670−59.0% | Reduced |
| Invesco Ltd. | 120,541 | $10.7M | 0.00% | −11,849−9.0% | Reduced |
| Ensign Peak Advisors, Inc | 126,620 | $11.2M | 0.02% | −21,917−14.8% | Reduced |
| Russell Investments Group, Ltd. | 134,757 | $12.0M | 0.01% | +124,826+1,256.9% | Added |
| Armistice Capital, LLC | 137,588 | $12.2M | 0.34% | +16,657+13.8% | Added |
| Squarepoint Ops LLC | 139,605 | $12.4M | 0.02% | +139,605 | New |