Spyre Therapeutics, Inc.
SYRE- Exchange
- Nasdaq
- Industry
- Pharmaceutical Preparations
- SEC CIK
- 0001636282
In the last 90 days, Spyre Therapeutics, Inc. insiders filed 0 open-market purchases and 9 sales; 265 institutions reported holding it in 13F filings for Q2 2026, worth $8.52B in total; no superinvestor holds it.
13F holders, Q3 2025
Institutional positions in Spyre Therapeutics, Inc. as of Sep 30, 2025. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 137
- +9 vs. Q2 2025
- Shares held
- 64.3M
- +693.4K (+1.1%) vs. Q2 2025
- Total value
- $1.08B
- +$125.3M (+13.2%) vs. Q2 2025
- New holders
- 22
- 44 more added
- Sold out
- 13
- 43 more reduced
1 institution that held it in Q2 2025 haven't filed for Q3 2025 yet. Not filing isn't selling, so they aren't counted as sold out or in the changes above.
Compare with Q2 2025: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting SYRE on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 265 | $8.52B |
| Q1 2026 | 198 | $4.16B |
| Q4 2025 | 153 | $2.65B |
| Q3 2025 | 137 | $1.08B |
| Q2 2025 | 129 | $952.6M |
| Q1 2025 | 129 | $1.00B |
| Q4 2024 | 131 | $1.39B |
| Q3 2024 | 119 | $1.51B |
| Q2 2024 | 107 | $1.18B |
| Q1 2024 | 103 | $1.21B |
| Q4 2023 | 54 | $601.0M |
| Q3 2023 | 29 | $43.9M |
| Q2 2023 | 44 | $31.9M |
| Q1 2023 | 45 | $12.0M |
| Q4 2022 | 51 | $19.2M |
| Q3 2022 | 55 | $23.5M |
| Q2 2022 | 67 | $24.8M |
| Q1 2022 | 84 | $95.4M |
| Q4 2021 | 86 | $189.4M |
| Q3 2021 | 77 | $322.5M |
| Q2 2021 | 78 | $285.8M |
| Q1 2021 | 84 | $328.7M |
Institutions, Q3 2025
Shares, value and share of portfolio for each institution holding Spyre Therapeutics, Inc.; share changes are against Q2 2025.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| Victory Capital Management Inc | 326,081 | $5.47M | 0.00% | −28,035−7.9% | Reduced |
| Goldman Sachs Group Inc | 329,533 | $5.52M | 0.00% | −193,883−37.0% | Reduced |
| Morgan Stanley | 334,722 | $5.61M | 0.00% | −336,322−50.1% | Reduced |
| Bank of America Corp | 344,803 | $5.78M | 0.00% | −51,548−13.0% | Reduced |
| Siren, L.L.C. | 368,598 | $6.18M | 0.24% | 00.0% | Unchanged |
| UBS Group AG | 385,589 | $6.46M | 0.00% | −77,274−16.7% | Reduced |
| Candriam Luxembourg S.C.A. | 404,362 | $6.78M | 0.04% | +158,332+64.4% | Added |
| Millennium Management LLC | 408,199 | $6.84M | 0.01% | +408,199 | New |
| Charles Schwab Investment Management Inc | 425,345 | $7.13M | 0.00% | +6,842+1.6% | Added |
| Northern Trust Corp | 442,036 | $7.41M | 0.00% | +5,089+1.2% | Added |
| Blackstone Group Inc. | 500,998 | $8.40M | 0.04% | +11,750+2.4% | Added |
| Emerald Advisers, LLC | 548,712 | $9.20M | 0.29% | −17,151−3.0% | Reduced |
| Deerfield Management Company, L.P. (Series C) | 613,665 | $10.3M | 0.16% | 00.0% | Unchanged |
| Price T Rowe Associates Inc | 620,620 | $10.4M | 0.00% | −309,861−33.3% | Reduced |
| Polar Capital Holdings Plc | 788,788 | $13.2M | 0.06% | +43,788+5.9% | Added |
| Franklin Resources Inc | 795,275 | $13.3M | 0.00% | 00.0% | Unchanged |
| Baker Bros. Advisors LP | 1,000,000 | $16.8M | 0.12% | +373,297+59.6% | Added |
| Pictet Asset Management Holding SA | 1,036,218 | $17.4M | 0.02% | −43,225−4.0% | Reduced |
| TCG Crossover Management, LLC | 1,100,582 | $18.4M | 0.91% | +1,100,582 | New |
| Geode Capital Management, LLC | 1,225,153 | $20.5M | 0.00% | −2,079−0.2% | Reduced |
| Perceptive Advisors LLC | 1,229,445 | $20.6M | 0.60% | −300,000−19.6% | Reduced |
| Jefferies Financial Group Inc. | 1,388,854 | $23.3M | 0.21% | 00.0% | Unchanged |
| Affinity Asset Advisors, LLC | 1,419,299 | $23.8M | 2.21% | +812,621+133.9% | Added |
| Paradigm Biocapital Advisors LP | 1,467,266 | $24.6M | 0.73% | −403,179−21.6% | Reduced |
| Wellington Management Group LLP | 1,640,312 | $27.5M | 0.00% | +126,834+8.4% | Added |
| State Street Corp | 1,785,206 | $29.9M | 0.00% | +189,915+11.9% | Added |
| Commodore Capital LP | 1,988,084 | $33.3M | 1.63% | 00.0% | Unchanged |
| Driehaus Capital Management LLC | 2,060,375 | $34.5M | 0.25% | −25,215−1.2% | Reduced |
| Capital International Investors | 2,392,541 | $40.1M | 0.01% | 00.0% | Unchanged |
| Braidwell LP | 2,578,404 | $43.2M | 1.28% | 00.0% | Unchanged |
| VR Adviser, LLC | 2,685,448 | $45.0M | 2.53% | 00.0% | Unchanged |
| Vanguard Group Inc | 3,050,730 | $51.1M | 0.00% | −15,856−0.5% | Reduced |
| Tang Capital Management LLC | 3,200,000 | $53.6M | 2.06% | 00.0% | Unchanged |
| RTW Investments, LP | 3,621,996 | $60.7M | 0.75% | 00.0% | Unchanged |
| BlackRock, Inc. | 3,982,744 | $66.8M | 0.00% | −24,552−0.6% | Reduced |
| Fairmount Funds Management LLC | 4,018,101 | $67.3M | 6.06% | 00.0% | Unchanged |
| FMR LLC | 9,060,144 | $151.8M | 0.01% | +7,110+0.1% | Added |
| Adage Capital Partners GP, L.L.C. | 0 | $0 | 0.00% | −610,200−100.0% | Sold out |
| Deep Track Capital, LP | 0 | $0 | 0.00% | −219,015−100.0% | Sold out |
| Capitolis Liquid Global Markets LLC | 0 | $0 | 0.00% | −183,000−100.0% | Sold out |
| Foresite Capital Management VI LLC | 0 | $0 | 0.00% | −70,000−100.0% | Sold out |
| Susquehanna International Group, LLP | 0 | $0 | 0.00% | −59,816−100.0% | Sold out |
| Renaissance Technologies LLC | 0 | $0 | 0.00% | −30,936−100.0% | Sold out |
| Natixis | 0 | $0 | 0.00% | −20,040−100.0% | Sold out |
| Voya Investment Management LLC | 0 | $0 | 0.00% | −13,589−100.0% | Sold out |
| Man Group plc | 0 | $0 | 0.00% | −10,843−100.0% | Sold out |
| Skopos Labs, Inc. | 0 | $0 | 0.00% | −520−100.0% | Sold out |
| Simplex Trading, LLC | 0 | $0 | 0.00% | −145−100.0% | Sold out |
| Caitong International Asset Management Co., Ltd | 0 | $0 | 0.00% | −102−100.0% | Sold out |
| Raymond James Financial Inc | 0 | $0 | 0.00% | −16−100.0% | Sold out |
| NBW Capital LLC | – | – | – | – | Not filed |