Spyre Therapeutics, Inc.
SYRE- Exchange
- Nasdaq
- Industry
- Pharmaceutical Preparations
- SEC CIK
- 0001636282
In the last 90 days, Spyre Therapeutics, Inc. insiders filed 0 open-market purchases and 6 sales; 265 institutions reported holding it in 13F filings for Q2 2026, worth $8.52B in total; no superinvestor holds it.
13F holders, Q1 2025
Institutional positions in Spyre Therapeutics, Inc. as of Mar 31, 2025. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 129
- −1 vs. Q4 2024
- Shares held
- 62.1M
- +2.35M (+3.9%) vs. Q4 2024
- Total value
- $1.00B
- −$386.9M (−27.8%) vs. Q4 2024
- New holders
- 20
- 52 more added
- Sold out
- 21
- 35 more reduced
1 institution that held it in Q4 2024 haven't filed for Q1 2025 yet. Not filing isn't selling, so they aren't counted as sold out or in the changes above.
Compare with Q4 2024: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting SYRE on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 265 | $8.52B |
| Q1 2026 | 198 | $4.16B |
| Q4 2025 | 153 | $2.65B |
| Q3 2025 | 137 | $1.08B |
| Q2 2025 | 129 | $952.6M |
| Q1 2025 | 129 | $1.00B |
| Q4 2024 | 131 | $1.39B |
| Q3 2024 | 119 | $1.51B |
| Q2 2024 | 107 | $1.18B |
| Q1 2024 | 103 | $1.21B |
| Q4 2023 | 54 | $601.0M |
| Q3 2023 | 29 | $43.9M |
| Q2 2023 | 44 | $31.9M |
| Q1 2023 | 45 | $12.0M |
| Q4 2022 | 51 | $19.2M |
| Q3 2022 | 55 | $23.5M |
| Q2 2022 | 67 | $24.8M |
| Q1 2022 | 84 | $95.4M |
| Q4 2021 | 86 | $189.4M |
| Q3 2021 | 77 | $322.5M |
| Q2 2021 | 78 | $285.8M |
| Q1 2021 | 84 | $328.7M |
Institutions, Q1 2025
Shares, value and share of portfolio for each institution holding Spyre Therapeutics, Inc.; share changes are against Q4 2024.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| Bank of America Corp | 427,075 | $6.89M | 0.00% | +419,933+5,879.8% | Added |
| Deerfield Management Company, L.P. (Series C) | 450,000 | $7.26M | 0.14% | 00.0% | Unchanged |
| Woodline Partners LP | 464,808 | $7.50M | 0.05% | +112,128+31.8% | Added |
| Affinity Asset Advisors, LLC | 481,678 | $7.77M | 1.22% | −342,650−41.6% | Reduced |
| Blackstone Group Inc. | 489,248 | $7.89M | 0.03% | +40,047+8.9% | Added |
| Emerald Advisers, LLC | 547,827 | $8.84M | 0.40% | +1,036+0.2% | Added |
| UBS Group AG | 552,243 | $8.91M | 0.00% | +160,046+40.8% | Added |
| Franklin Resources Inc | 760,628 | $12.3M | 0.00% | −140.0% | Reduced |
| Adage Capital Partners GP, L.L.C. | 803,200 | $13.0M | 0.02% | −226,800−22.0% | Reduced |
| Polar Capital Holdings Plc | 825,000 | $13.3M | 0.08% | +75,000+10.0% | Added |
| Geode Capital Management, LLC | 1,059,563 | $17.1M | 0.00% | +93,434+9.7% | Added |
| Pictet Asset Management Holding SA | 1,068,892 | $17.2M | 0.02% | −23,232−2.1% | Reduced |
| Janus Henderson Group PLC | 1,041,410 | $18.7M | 0.01% | −415,330−28.5% | Reduced |
| Jefferies Financial Group Inc. | 1,248,854 | $20.2M | 0.35% | +31,900+2.6% | Added |
| Wellington Management Group LLP | 1,593,678 | $25.7M | 0.00% | −10,830−0.7% | Reduced |
| State Street Corp | 1,697,115 | $27.4M | 0.00% | +16,179+1.0% | Added |
| Commodore Capital LP | 1,988,084 | $32.1M | 2.36% | 00.0% | Unchanged |
| Tang Capital Management LLC | 2,050,000 | $33.1M | 1.83% | +2,050,000 | New |
| Paradigm Biocapital Advisors LP | 2,127,205 | $34.3M | 1.58% | +600,000+39.3% | Added |
| Perceptive Advisors LLC | 2,313,272 | $37.3M | 1.32% | −261,451−10.2% | Reduced |
| Capital International Investors | 2,392,541 | $38.6M | 0.01% | +2,392,541 | New |
| Braidwell LP | 2,578,404 | $41.6M | 1.46% | 00.0% | Unchanged |
| VR Adviser, LLC | 2,685,448 | $43.3M | 3.69% | 00.0% | Unchanged |
| Driehaus Capital Management LLC | 2,717,312 | $43.8M | 0.42% | −86,343−3.1% | Reduced |
| Vanguard Group Inc | 2,898,267 | $46.8M | 0.00% | +51,794+1.8% | Added |
| BlackRock, Inc. | 3,572,674 | $57.6M | 0.00% | +173,083+5.1% | Added |
| RTW Investments, LP | 3,621,996 | $58.4M | 0.89% | 00.0% | Unchanged |
| Fairmount Funds Management LLC | 4,018,101 | $64.8M | 10.06% | 00.0% | Unchanged |
| FMR LLC | 9,038,553 | $145.8M | 0.01% | +237,287+2.7% | Added |
| Logos Global Management LP | 0 | $0 | 0.00% | −500,000−100.0% | Sold out |
| Boxer Capital Management, LLC | 0 | $0 | 0.00% | −466,680−100.0% | Sold out |
| Ikarian Capital, LLC | 0 | $0 | 0.00% | −282,159−100.0% | Sold out |
| Millennium Management LLC | 0 | $0 | 0.00% | −167,804−100.0% | Sold out |
| Boothbay Fund Management, LLC | 0 | $0 | 0.00% | −85,618−100.0% | Sold out |
| Ensign Peak Advisors, Inc | 0 | $0 | 0.00% | −82,475−100.0% | Sold out |
| First Trust Advisors LP | 0 | $0 | 0.00% | −23,550−100.0% | Sold out |
| Cinctive Capital Management LP | 0 | $0 | 0.00% | −19,567−100.0% | Sold out |
| Brevan Howard Capital Management LP | 0 | $0 | 0.00% | −16,899−100.0% | Sold out |
| Teacher Retirement System of Texas | 0 | $0 | 0.00% | −10,383−100.0% | Sold out |
| Two Sigma Investments, LP | 0 | $0 | 0.00% | −9,638−100.0% | Sold out |
| Carlyle Group Inc. | 0 | $0 | 0.00% | −9,620−100.0% | Sold out |
| State Board of Administration of Florida Retirement System | 0 | $0 | 0.00% | −9,030−100.0% | Sold out |
| Virtus ETF Advisers LLC | 0 | $0 | 0.00% | −2,972−100.0% | Sold out |
| R Squared Ltd | 0 | $0 | 0.00% | −710−100.0% | Sold out |
| Venturi Wealth Management, LLC | 0 | $0 | 0.00% | −231−100.0% | Sold out |
| Sugar Maple Asset Management, LLC | 0 | $0 | 0.00% | −180−100.0% | Sold out |
| Skopos Labs, Inc. | 0 | $0 | 0.00% | −120−100.0% | Sold out |
| Signaturefd, LLC | 0 | $0 | 0.00% | −68−100.0% | Sold out |
| Simplex Trading, LLC | 0 | $0 | 0.00% | −55−100.0% | Sold out |
| Pacific Capital Wealth Advisors, Inc | 0 | $0 | 0.00% | −8−100.0% | Sold out |
| Nuveen Asset Management, LLC | – | – | – | – | Not filed |