Protagonist Therapeutics, Inc
PTGX- Exchange
- Nasdaq
- Industry
- Pharmaceutical Preparations
- SEC CIK
- 0001377121
In the last 90 days, Protagonist Therapeutics, Inc insiders filed 0 open-market purchases and 3 sales; 346 institutions reported holding it in 13F filings for Q2 2026, worth $9.30B in total; Duquesne Family Office is the only superinvestor holding it.
13F holders, Q4 2025
Institutional positions in Protagonist Therapeutics, Inc as of Dec 31, 2025. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 319
- +48 vs. Q3 2025
- Shares held
- 71.0M
- +458.8K (+0.7%) vs. Q3 2025
- Total value
- $6.18B
- +$1.49B (+31.8%) vs. Q3 2025
- New holders
- 84
- 99 more added
- Sold out
- 36
- 104 more reduced
4 institutions that held it in Q3 2025 haven't filed for Q4 2025 yet. Not filing isn't selling, so they aren't counted as sold out or in the changes above.
Compare with Q3 2025: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting PTGX on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 346 | $9.30B |
| Q1 2026 | 322 | $8.31B |
| Q4 2025 | 319 | $6.18B |
| Q3 2025 | 275 | $4.70B |
| Q2 2025 | 274 | $3.92B |
| Q1 2025 | 275 | $3.15B |
| Q4 2024 | 241 | $2.44B |
| Q3 2024 | 240 | $2.78B |
| Q2 2024 | 188 | $2.05B |
| Q1 2024 | 185 | $1.73B |
| Q4 2023 | 157 | $1.32B |
| Q3 2023 | 144 | $945.9M |
| Q2 2023 | 167 | $1.57B |
| Q1 2023 | 138 | $1.22B |
| Q4 2022 | 137 | $533.3M |
| Q3 2022 | 133 | $398.9M |
| Q2 2022 | 131 | $422.1M |
| Q1 2022 | 140 | $1.19B |
| Q4 2021 | 149 | $1.68B |
| Q3 2021 | 132 | $820.8M |
| Q2 2021 | 139 | $2.16B |
| Q1 2021 | 127 | $1.15B |
Institutions, Q4 2025
Shares, value and share of portfolio for each institution holding Protagonist Therapeutics, Inc; share changes are against Q3 2025.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| Goldman Sachs Group Inc | 961,149 | $83.9M | 0.01% | +179,438+23.0% | Added |
| Marshall Wace, LLP | 1,024,925 | $89.5M | 0.09% | −60,639−5.6% | Reduced |
| ADAR1 Capital Management, LLC | 1,049,168 | $91.6M | 6.85% | +59,986+6.1% | Added |
| Driehaus Capital Management LLC | 1,099,170 | $96.0M | 0.65% | −40,684−3.6% | Reduced |
| Citadel Advisors LLC | 1,126,687 | $98.4M | 0.07% | +888,806+373.6% | Added |
| Perceptive Advisors LLC | 1,350,425 | $117.9M | 2.16% | +320,291+31.1% | Added |
| Price T Rowe Associates Inc | 1,400,738 | $122.3M | 0.01% | +180,302+14.8% | Added |
| Woodline Partners LP | 1,408,772 | $123.0M | 0.48% | −29,475−2.0% | Reduced |
| Geode Capital Management, LLC | 1,452,928 | $126.9M | 0.01% | +36,282+2.6% | Added |
| Invesco Ltd. | 1,567,840 | $136.9M | 0.01% | +564,134+56.2% | Added |
| Johnson & Johnson | 2,449,183 | $213.9M | 38.54% | 00.0% | Unchanged |
| Janus Henderson Group PLC | 2,649,981 | $231.4M | 0.10% | +1,549,160+140.7% | Added |
| UBS Group AG | 2,770,021 | $241.9M | 0.05% | +874,013+46.1% | Added |
| Wellington Management Group LLP | 3,171,423 | $277.0M | 0.05% | +1,262,977+66.2% | Added |
| State Street Corp | 3,199,729 | $279.5M | 0.01% | +33,934+1.1% | Added |
| RTW Investments, LP | 5,059,053 | $441.9M | 4.43% | −697,224−12.1% | Reduced |
| Vanguard Group Inc | 5,413,690 | $472.8M | 0.01% | +1,156,461+27.2% | Added |
| Farallon Capital Management, L.L.C. | 6,144,006 | $536.6M | 2.79% | −52,000−0.8% | Reduced |
| BlackRock, Inc. | 9,715,999 | $848.6M | 0.01% | +311,767+3.3% | Added |
| BVF Inc | 0 | $0 | 0.00% | −2,560,916−100.0% | Sold out |
| Deep Track Capital, LP | 0 | $0 | 0.00% | −1,715,691−100.0% | Sold out |
| Lynx1 Capital Management LP | 0 | $0 | 0.00% | −700,014−100.0% | Sold out |
| Mangrove Partners | 0 | $0 | 0.00% | −478,413−100.0% | Sold out |
| Colony Group, LLC | 0 | $0 | 0.00% | −448,988−100.0% | Sold out |
| Toronto Dominion Bank | 0 | $0 | 0.00% | −445,440−100.0% | Sold out |
| Logos Global Management LP | 0 | $0 | 0.00% | −300,000−100.0% | Sold out |
| ExodusPoint Capital Management, LP | 0 | $0 | 0.00% | −124,929−100.0% | Sold out |
| Schonfeld Strategic Advisors LLC | 0 | $0 | 0.00% | −95,190−100.0% | Sold out |
| Assenagon Asset Management S.A. | 0 | $0 | 0.00% | −65,756−100.0% | Sold out |
| Alps Advisors Inc | 0 | $0 | 0.00% | −29,203−100.0% | Sold out |
| Superstring Capital Management LP | 0 | $0 | 0.00% | −20,358−100.0% | Sold out |
| Capital Fund Management S.A. | 0 | $0 | 0.00% | −20,348−100.0% | Sold out |
| Moran Wealth Management, LLC | 0 | $0 | 0.00% | −16,212−100.0% | Sold out |
| Weiss Asset Management LP | 0 | $0 | 0.00% | −14,310−100.0% | Sold out |
| HRT Financial LP | 0 | $0 | 0.00% | −9,470−100.0% | Sold out |
| Toroso Investments, LLC | 0 | $0 | 0.00% | −8,945−100.0% | Sold out |
| Resona Asset Management Co.,Ltd. | 0 | $0 | 0.00% | −8,731−100.0% | Sold out |
| Capstone Investment Advisors, LLC | 0 | $0 | 0.00% | −7,676−100.0% | Sold out |
| Brevan Howard Capital Management LP | 0 | $0 | 0.00% | −7,598−100.0% | Sold out |
| XTX Topco Ltd | 0 | $0 | 0.00% | −7,260−100.0% | Sold out |
| Gsa Capital Partners LLP | 0 | $0 | 0.00% | −5,884−100.0% | Sold out |
| Advantage Alpha Capital Partners LP | 0 | $0 | 0.00% | −5,804−100.0% | Sold out |
| Baader Bank INC | 0 | $0 | 0.00% | −4,300−100.0% | Sold out |
| Verdence Capital Advisors LLC | 0 | $0 | 0.00% | −3,038−100.0% | Sold out |
| Quantbot Technologies LP | 0 | $0 | 0.00% | −3,303−100.0% | Sold out |
| ISAM Funds (UK) Ltd | 0 | $0 | 0.00% | −3,118−100.0% | Sold out |
| Wexford Capital LP | 0 | $0 | 0.00% | −941−100.0% | Sold out |
| Rise Advisors, LLC | 0 | $0 | 0.00% | −224−100.0% | Sold out |
| Optiver Holding B.V. | 0 | $0 | 0.00% | −169−100.0% | Sold out |
| Aster Capital Management (DIFC) Ltd | 0 | $0 | 0.00% | −83−100.0% | Sold out |
| Wealthspire Advisors, LLC | 0 | $0 | 0.00% | −48−100.0% | Sold out |
| Principal Securities, Inc. | 0 | $0 | 0.00% | −32−100.0% | Sold out |
| Montag A & Associates Inc | 0 | $0 | 0.00% | −25−100.0% | Sold out |
| Atlantic Trust, LLC | 0 | $0 | 0.00% | −21−100.0% | Sold out |
| Advisory Services Network, LLC | 0 | $0 | 0.00% | −9−100.0% | Sold out |
| EFG Asset Management (North America) Corp. | – | – | – | – | Not filed |
| Glenmede Investment Management, LP | – | – | – | – | Not filed |
| CIBC Bancorp USA Inc. | – | – | – | – | Not filed |
| Abich Financial Wealth Management LLC | – | – | – | – | Not filed |