Protagonist Therapeutics, Inc
PTGX- Exchange
- Nasdaq
- Industry
- Pharmaceutical Preparations
- SEC CIK
- 0001377121
In the last 90 days, Protagonist Therapeutics, Inc insiders filed 0 open-market purchases and 2 sales; 346 institutions reported holding it in 13F filings for Q2 2026, worth $9.30B in total; Duquesne Family Office is the only superinvestor holding it.
13F holders, Q1 2025
Institutional positions in Protagonist Therapeutics, Inc as of Mar 31, 2025. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 275
- +38 vs. Q4 2024
- Shares held
- 65.3M
- +2.28M (+3.6%) vs. Q4 2024
- Total value
- $3.15B
- +$716.0M (+29.4%) vs. Q4 2024
- New holders
- 72
- 86 more added
- Sold out
- 34
- 90 more reduced
4 institutions that held it in Q4 2024 haven't filed for Q1 2025 yet. Not filing isn't selling, so they aren't counted as sold out or in the changes above.
Compare with Q4 2024: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting PTGX on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 346 | $9.30B |
| Q1 2026 | 322 | $8.31B |
| Q4 2025 | 319 | $6.18B |
| Q3 2025 | 275 | $4.70B |
| Q2 2025 | 274 | $3.92B |
| Q1 2025 | 275 | $3.15B |
| Q4 2024 | 241 | $2.44B |
| Q3 2024 | 240 | $2.78B |
| Q2 2024 | 188 | $2.05B |
| Q1 2024 | 185 | $1.73B |
| Q4 2023 | 157 | $1.32B |
| Q3 2023 | 144 | $945.9M |
| Q2 2023 | 167 | $1.57B |
| Q1 2023 | 138 | $1.22B |
| Q4 2022 | 137 | $533.3M |
| Q3 2022 | 133 | $398.9M |
| Q2 2022 | 131 | $422.1M |
| Q1 2022 | 140 | $1.19B |
| Q4 2021 | 149 | $1.68B |
| Q3 2021 | 132 | $820.8M |
| Q2 2021 | 139 | $2.16B |
| Q1 2021 | 127 | $1.15B |
Institutions, Q1 2025
Shares, value and share of portfolio for each institution holding Protagonist Therapeutics, Inc; share changes are against Q4 2024.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| Victory Capital Management Inc | 102,411 | $4.95M | 0.01% | −138,406−57.5% | Reduced |
| Empowered Funds, LLC | 102,532 | $4.96M | 0.07% | +102,532 | New |
| Trexquant Investment LP | 103,983 | $5.03M | 0.06% | +11,195+12.1% | Added |
| Opaleye Management Inc. | 105,000 | $5.08M | 1.13% | 00.0% | Unchanged |
| Barclays PLC | 111,432 | $5.39M | 0.00% | −15,301−12.1% | Reduced |
| Manufacturers Life Insurance Company, The | 120,850 | $5.84M | 0.01% | −3,491−2.8% | Reduced |
| Nan Fung Group Holdings Ltd | 121,400 | $5.87M | 4.79% | +121,400 | New |
| Dimensional Fund Advisors LP | 121,554 | $5.88M | 0.00% | −104,046−46.1% | Reduced |
| Citigroup Inc | 121,844 | $5.89M | 0.00% | +822+0.7% | Added |
| Man Group plc | 128,606 | $6.22M | 0.02% | −29,357−18.6% | Reduced |
| Jacobs Levy Equity Management, Inc | 128,654 | $6.22M | 0.02% | 00.0% | Unchanged |
| Millennium Management LLC | 134,269 | $6.49M | 0.01% | +134,269 | New |
| Ameriprise Financial Inc | 136,842 | $6.62M | 0.00% | −4,545−3.2% | Reduced |
| Kennedy Capital Management, Inc. | 137,504 | $6.65M | 0.16% | −184,022−57.2% | Reduced |
| Legal & General Group Plc | 148,107 | $7.16M | 0.00% | −4,455−2.9% | Reduced |
| New Vernon Capital Holdings II LLC | 348,095 | $7.20M | 0.17% | +345,034+11,271.9% | Added |
| Panagora Asset Management Inc | 149,908 | $7.25M | 0.04% | +149,908 | New |
| Great Lakes Advisors, LLC | 152,318 | $7.37M | 0.07% | +90,371+145.9% | Added |
| Nuveen, LLC | 152,771 | $7.39M | 0.00% | +152,771 | New |
| Citadel Advisors LLC | 154,067 | $7.45M | 0.01% | −10,079−6.1% | Reduced |
| Rhumbline Advisers | 162,065 | $7.84M | 0.01% | +101+0.1% | Added |
| Moody Aldrich Partners LLC | 163,483 | $7.91M | 1.66% | +96,068+142.5% | Added |
| Jupiter Asset Management Ltd | 168,063 | $8.13M | 0.08% | +168,063 | New |
| Soleus Capital Management, L.P. | 169,000 | $8.17M | 0.64% | −106,000−38.5% | Reduced |
| TD Asset Management Inc | 169,932 | $8.22M | 0.01% | −3,770−2.2% | Reduced |
| Checkpoint Capital L.P. | 175,184 | $8.47M | 4.65% | +175,184 | New |
| Public Sector Pension Investment Board | 189,031 | $9.14M | 0.04% | +40,542+27.3% | Added |
| Susquehanna International Group, LLP | 192,239 | $9.30M | 0.02% | +122,302+174.9% | Added |
| Jane Street Group, LLC | 193,300 | $9.35M | 0.02% | +131,749+214.0% | Added |
| Burney Co | 201,985 | $9.77M | 0.36% | +201,985 | New |
| UBS Asset Management Americas Inc | 208,756 | $10.1M | 0.00% | −79,155−27.5% | Reduced |
| Driehaus Capital Management LLC | 235,073 | $11.4M | 0.11% | −104,625−30.8% | Reduced |
| Skandinaviska Enskilda Banken AB (publ) | 248,950 | $12.0M | 0.06% | −61,700−19.9% | Reduced |
| Schonfeld Strategic Advisors LLC | 287,301 | $13.9M | 0.09% | +287,301 | New |
| Pictet Asset Management Holding SA | 295,593 | $14.3M | 0.02% | −918−0.3% | Reduced |
| Raymond James Financial Inc | 298,827 | $14.5M | 0.01% | −4,486−1.5% | Reduced |
| Renaissance Technologies LLC | 323,567 | $15.6M | 0.02% | +102,400+46.3% | Added |
| Artia Global Partners LP | 333,851 | $16.1M | 4.73% | +40,000+13.6% | Added |
| Qube Research & Technologies Ltd | 343,411 | $16.6M | 0.03% | +31,092+10.0% | Added |
| Adage Capital Partners GP, L.L.C. | 343,504 | $16.6M | 0.03% | +343,504 | New |
| Principal Financial Group Inc | 347,095 | $16.8M | 0.01% | +9,286+2.7% | Added |
| UBS Group AG | 352,871 | $17.1M | 0.00% | +220,262+166.1% | Added |
| Bank of New York Mellon Corp | 376,863 | $18.2M | 0.00% | −13,925−3.6% | Reduced |
| BNP PARIBAS ASSET MANAGEMENT Holding S.A. | 379,649 | $18.4M | 0.05% | +253,751+201.6% | Added |
| Mangrove Partners | 395,383 | $19.1M | 2.16% | 00.0% | Unchanged |
| Affinity Asset Advisors, LLC | 400,000 | $19.3M | 3.03% | +270,000+207.7% | Added |
| Colony Group, LLC | 435,097 | $21.0M | 0.05% | +9,540+2.2% | Added |
| Toronto Dominion Bank | 445,440 | $21.5M | 0.06% | +104,466+30.6% | Added |
| JPMorgan Chase & Co | 468,899 | $22.7M | 0.00% | −108,078−18.7% | Reduced |
| Bank of America Corp | 471,745 | $22.8M | 0.00% | +336,873+249.8% | Added |
| FMR LLC | 478,343 | $23.1M | 0.00% | +35,827+8.1% | Added |
| Morgan Stanley | 497,105 | $24.0M | 0.00% | −43,210−8.0% | Reduced |
| 683 Capital Management, LLC | 500,000 | $24.2M | 2.45% | +90,000+22.0% | Added |
| Eversept Partners, LP | 547,116 | $26.5M | 2.99% | −131,671−19.4% | Reduced |
| Goldman Sachs Group Inc | 555,551 | $26.9M | 0.01% | −203,139−26.8% | Reduced |
| Charles Schwab Investment Management Inc | 557,718 | $27.0M | 0.01% | −20,691−3.6% | Reduced |
| Jefferies Financial Group Inc. | 631,893 | $30.6M | 0.53% | −857,602−57.6% | Reduced |
| Northern Trust Corp | 639,507 | $30.9M | 0.00% | +10,927+1.7% | Added |
| American Century Companies Inc | 685,824 | $33.2M | 0.02% | −242,462−26.1% | Reduced |
| Lynx1 Capital Management LP | 733,014 | $35.4M | 12.69% | +733,014 | New |
| Invesco Ltd. | 859,648 | $41.6M | 0.01% | +120,696+16.3% | Added |
| Woodline Partners LP | 897,699 | $43.4M | 0.28% | +315,372+54.2% | Added |
| ADAR1 Capital Management, LLC | 939,669 | $45.4M | 8.74% | −80,664−7.9% | Reduced |
| Wellington Management Group LLP | 987,370 | $47.7M | 0.01% | +47,293+5.0% | Added |
| Perceptive Advisors LLC | 1,091,271 | $52.8M | 1.87% | −180,391−14.2% | Reduced |
| Price T Rowe Associates Inc | 1,322,006 | $63.9M | 0.01% | −70,646−5.1% | Reduced |
| Geode Capital Management, LLC | 1,423,559 | $68.9M | 0.01% | +46,496+3.4% | Added |
| Johnson & Johnson | 2,449,183 | $118.4M | 34.65% | 00.0% | Unchanged |
| BVF Inc | 2,575,015 | $124.5M | 5.08% | +675,000+35.5% | Added |
| State Street Corp | 2,706,619 | $130.9M | 0.01% | −624,442−18.7% | Reduced |
| Deep Track Capital, LP | 3,000,000 | $145.1M | 4.70% | +2,000,000+200.0% | Added |
| Vanguard Group Inc | 4,277,218 | $206.8M | 0.00% | +57,181+1.4% | Added |
| RTW Investments, LP | 5,719,415 | $276.6M | 4.23% | +220,870+4.0% | Added |
| Farallon Capital Management, L.L.C. | 6,107,006 | $295.3M | 1.59% | +177,000+3.0% | Added |
| BlackRock, Inc. | 9,736,767 | $470.9M | 0.01% | −147,850−1.5% | Reduced |
| Pacer Advisors, Inc. | 0 | $0 | 0.00% | −1,876,466−100.0% | Sold out |
| Kynam Capital Management, LP | 0 | $0 | 0.00% | −390,792−100.0% | Sold out |
| Polar Capital Holdings Plc | 0 | $0 | 0.00% | −350,000−100.0% | Sold out |
| Arrowstreet Capital, Limited Partnership | 0 | $0 | 0.00% | −216,069−100.0% | Sold out |
| Caption Management, LLC | 0 | $0 | 0.00% | −98,934−100.0% | Sold out |
| Ikarian Capital, LLC | 0 | $0 | 0.00% | −70,000−100.0% | Sold out |
| Superstring Capital Management LP | 0 | $0 | 0.00% | −68,892−100.0% | Sold out |
| Quantedge Capital Pte Ltd | 0 | $0 | 0.00% | −37,200−100.0% | Sold out |
| Los Angeles Capital Management LLC | 0 | $0 | 0.00% | −31,366−100.0% | Sold out |
| Cavalier Investments, LLC | 0 | $0 | 0.00% | −31,252−100.0% | Sold out |
| ExodusPoint Capital Management, LP | 0 | $0 | 0.00% | −29,870−100.0% | Sold out |
| Capital Fund Management S.A. | 0 | $0 | 0.00% | −28,058−100.0% | Sold out |
| Summit Global Investments | 0 | $0 | 0.00% | −23,557−100.0% | Sold out |
| Sierra Summit Advisors LLC | 0 | $0 | 0.00% | −22,282−100.0% | Sold out |
| Boothbay Fund Management, LLC | 0 | $0 | 0.00% | −20,188−100.0% | Sold out |
| Braidwell LP | 0 | $0 | 0.00% | −20,109−100.0% | Sold out |
| Marshall Wace, LLP | 0 | $0 | 0.00% | −19,716−100.0% | Sold out |
| Crestline Management, LP | 0 | $0 | 0.00% | −12,681−100.0% | Sold out |
| PEAK6 LLC | 0 | $0 | 0.00% | −9,000−100.0% | Sold out |
| Freestone Grove Partners LP | 0 | $0 | 0.00% | −6,644−100.0% | Sold out |
| Contravisory Investment Management, Inc. | 0 | $0 | 0.00% | −6,498−100.0% | Sold out |
| Bleakley Financial Group, LLC | 0 | $0 | 0.00% | −6,367−100.0% | Sold out |
| Allspring Global Investments Holdings, LLC | 0 | $0 | 0.00% | −5,975−100.0% | Sold out |
| Captrust Financial Advisors | 0 | $0 | 0.00% | −5,878−100.0% | Sold out |
| Two Sigma Securities, LLC | 0 | $0 | 0.00% | −5,505−100.0% | Sold out |