Praxis Precision Medicines, Inc.
PRAX- Exchange
- Nasdaq
- Industry
- Pharmaceutical Preparations
- SEC CIK
- 0001689548
No open-market purchases or sales by Praxis Precision Medicines, Inc. insiders were filed in the last 90 days; 309 institutions reported holding it in 13F filings for Q2 2026, worth $11.3B in total; no superinvestor holds it.
13F holders, Q4 2025
Institutional positions in Praxis Precision Medicines, Inc. as of Dec 31, 2025. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 250
- +100 vs. Q3 2025
- Shares held
- 29.5M
- +4.80M (+19.5%) vs. Q3 2025
- Total value
- $8.69B
- +$7.38B (+564.4%) vs. Q3 2025
- New holders
- 115
- 87 more added
- Sold out
- 15
- 44 more reduced
2 institutions that held it in Q3 2025 haven't filed for Q4 2025 yet. Not filing isn't selling, so they aren't counted as sold out or in the changes above.
Compare with Q3 2025: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting PRAX on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 309 | $11.3B |
| Q1 2026 | 291 | $10.2B |
| Q4 2025 | 250 | $8.69B |
| Q3 2025 | 152 | $1.31B |
| Q2 2025 | 144 | $1.02B |
| Q1 2025 | 150 | $889.3M |
| Q4 2024 | 162 | $1.67B |
| Q3 2024 | 134 | $1.09B |
| Q2 2024 | 113 | $762.1M |
| Q1 2024 | 111 | $971.3M |
| Q4 2023 | 60 | $178.6M |
| Q3 2023 | 74 | $195.6M |
| Q2 2023 | 78 | $134.6M |
| Q1 2023 | 87 | $43.1M |
| Q4 2022 | 104 | $108.1M |
| Q3 2022 | 108 | $95.7M |
| Q2 2022 | 95 | $105.5M |
| Q1 2022 | 103 | $463.4M |
| Q4 2021 | 100 | $863.1M |
| Q3 2021 | 93 | $791.5M |
| Q2 2021 | 80 | $751.0M |
| Q1 2021 | 68 | $1.19B |
Institutions, Q4 2025
Shares, value and share of portfolio for each institution holding Praxis Precision Medicines, Inc.; share changes are against Q3 2025.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| Janus Henderson Group PLC | 3,240,086 | $954.8M | 0.43% | +476,227+17.2% | Added |
| BlackRock, Inc. | 2,078,500 | $612.6M | 0.01% | +277,420+15.4% | Added |
| Perceptive Advisors LLC | 1,995,986 | $588.3M | 10.78% | +431,432+27.6% | Added |
| Vanguard Group Inc | 1,460,933 | $430.6M | 0.01% | +193,647+15.3% | Added |
| FMR LLC | 1,358,675 | $400.5M | 0.02% | +1,315,464+3,044.3% | Added |
| Orbis Allan Gray Ltd | 1,255,162 | $369.9M | 1.55% | +1,255,162 | New |
| Baker Bros. Advisors LP | 1,126,488 | $332.0M | 1.94% | +437,000+63.4% | Added |
| Adage Capital Partners GP, L.L.C. | 965,313 | $284.5M | 0.43% | −1,408,772−59.3% | Reduced |
| Cormorant Asset Management, LP | 950,000 | $280.0M | 15.87% | −50,000−5.0% | Reduced |
| Driehaus Capital Management LLC | 933,061 | $275.0M | 1.87% | +432,510+86.4% | Added |
| Deerfield Management Company, L.P. (Series C) | 903,351 | $266.3M | 3.41% | +62,500+7.4% | Added |
| Morgan Stanley | 889,889 | $262.3M | 0.02% | +246,394+38.3% | Added |
| State Street Corp | 882,215 | $260.0M | 0.01% | −24,893−2.7% | Reduced |
| Price T Rowe Associates Inc | 785,987 | $231.7M | 0.02% | −217,503−21.7% | Reduced |
| Goldman Sachs Group Inc | 716,184 | $211.1M | 0.03% | +123,163+20.8% | Added |
| Geode Capital Management, LLC | 562,379 | $165.8M | 0.01% | +105,347+23.1% | Added |
| Barclays PLC | 530,751 | $156.4M | 0.06% | +454,114+592.6% | Added |
| Bank of America Corp | 522,763 | $154.1M | 0.01% | +39,902+8.3% | Added |
| Point72 Asset Management, L.P. | 492,346 | $145.1M | 0.23% | −1,003,640−67.1% | Reduced |
| Assenagon Asset Management S.A. | 408,787 | $120.5M | 0.18% | −992−0.2% | Reduced |
| Logos Global Management LP | 375,000 | $110.5M | 7.37% | +250,000+200.0% | Added |
| Ra Capital Management, L.P. | 373,787 | $110.2M | 1.13% | +373,787 | New |
| Soleus Capital Management, L.P. | 362,966 | $107.0M | 4.54% | −496,200−57.8% | Reduced |
| Franklin Resources Inc | 356,074 | $104.9M | 0.03% | +41,917+13.3% | Added |
| Vivo Capital, LLC | 328,895 | $96.9M | 6.27% | +130,000+65.4% | Added |
| Hood River Capital Management LLC | 289,467 | $85.3M | 0.94% | +289,467 | New |
| T. Rowe Price Investment Management, Inc. | 276,392 | $81.5M | 0.05% | +276,392 | New |
| Pictet Asset Management Holding SA | 240,588 | $71.1M | 0.07% | +240,588 | New |
| Charles Schwab Investment Management Inc | 198,301 | $58.4M | 0.01% | +36,640+22.7% | Added |
| Northern Trust Corp | 192,284 | $56.7M | 0.01% | +23,931+14.2% | Added |
| Affinity Asset Advisors, LLC | 185,000 | $54.5M | 3.92% | +185,000 | New |
| Wellington Management Group LLP | 176,562 | $52.0M | 0.01% | +115,321+188.3% | Added |
| Qube Research & Technologies Ltd | 168,897 | $49.8M | 0.07% | +111,593+194.7% | Added |
| Standard Life Aberdeen plc | 134,992 | $39.8M | 0.06% | +134,992 | New |
| Sofinnova Investments, Inc. | 125,722 | $37.1M | 1.60% | −47,111−27.3% | Reduced |
| Candriam Luxembourg S.C.A. | 110,590 | $32.6M | 0.16% | +47,724+75.9% | Added |
| Woodline Partners LP | 105,412 | $31.1M | 0.12% | −312,257−74.8% | Reduced |
| Velan Capital Investment Management LP | 100,781 | $29.7M | 17.28% | −32,024−24.1% | Reduced |
| OrbiMed Advisors LLC | 94,500 | $27.9M | 0.57% | +94,500 | New |
| UBS Group AG | 89,200 | $26.3M | 0.01% | −7,612−7.9% | Reduced |
| First Trust Advisors LP | 88,704 | $26.1M | 0.02% | +59,738+206.2% | Added |
| Ikarian Capital, LLC | 86,581 | $25.5M | 3.30% | +58,010+203.0% | Added |
| Acuta Capital Partners, LLC | 83,036 | $24.5M | 16.62% | +33,285+66.9% | Added |
| Silverarc Capital Management, LLC | 82,465 | $24.3M | 3.52% | +31,255+61.0% | Added |
| Algert Global LLC | 80,640 | $23.8M | 0.37% | −80,178−49.9% | Reduced |
| Bank of New York Mellon Corp | 77,897 | $23.0M | 0.00% | +21,609+38.4% | Added |
| Invesco Ltd. | 77,088 | $22.7M | 0.00% | +56,220+269.4% | Added |
| American Century Companies Inc | 75,366 | $22.2M | 0.01% | +60,098+393.6% | Added |
| Alyeska Investment Group, L.P. | 74,376 | $21.9M | 0.06% | −67,140−47.4% | Reduced |
| Canada Pension Plan Investment Board | 69,712 | $20.5M | 0.01% | +69,712 | New |
| Marshall Wace, LLP | 69,242 | $20.4M | 0.02% | +1,101+1.6% | Added |
| Eventide Asset Management, LLC | 67,100 | $19.8M | 0.31% | +67,100 | New |
| Renaissance Technologies LLC | 66,230 | $19.5M | 0.03% | +66,230 | New |
| 72 Investment Holdings, LLC | 65,933 | $19.4M | 38.42% | 00.0% | Unchanged |
| Ensign Peak Advisors, Inc | 64,283 | $18.9M | 0.03% | +64,283 | New |
| Exome Asset Management LLC | 58,122 | $17.1M | 8.46% | −43,874−43.0% | Reduced |
| JPMorgan Chase & Co | 55,300 | $16.3M | 0.00% | +29,092+111.0% | Added |
| Deutsche Bank AG | 50,811 | $15.0M | 0.00% | +36,955+266.7% | Added |
| Nuveen, LLC | 49,970 | $14.7M | 0.00% | +11,421+29.6% | Added |
| Boxer Capital Management, LLC | 46,457 | $13.7M | 3.00% | +46,457 | New |
| TD Asset Management Inc | 46,146 | $13.6M | 0.01% | +5,262+12.9% | Added |
| KVP Capital Advisors, LP | 42,900 | $12.6M | 13.06% | +42,900 | New |
| Moody Aldrich Partners LLC | 41,731 | $12.3M | 2.30% | +41,731 | New |
| SummitTX Capital, L.P. | 41,629 | $12.3M | 0.37% | +6,701+19.2% | Added |
| Swiss National Bank | 40,500 | $11.9M | 0.01% | +5,000+14.1% | Added |
| Integral Health Asset Management, LLC | 40,000 | $11.8M | 0.60% | +40,000 | New |
| Ishara Investments LP | 40,000 | $11.8M | 13.72% | +40,000 | New |
| D. E. Shaw & Co., Inc. | 37,481 | $11.0M | 0.01% | +17,685+89.3% | Added |
| Universal- Beteiligungs- und Servicegesellschaft mbH | 37,377 | $11.0M | 0.02% | +37,377 | New |
| Empowered Funds, LLC | 36,852 | $10.9M | 0.18% | +36,852 | New |
| Readystate Asset Management LP | 36,792 | $10.8M | 0.48% | −72,385−66.3% | Reduced |
| First Turn Management, LLC | 35,749 | $10.5M | 1.20% | +35,749 | New |
| UBS Asset Management Americas Inc | 35,288 | $10.4M | 0.00% | +11,532+48.5% | Added |
| Citadel Advisors LLC | 34,917 | $10.3M | 0.01% | +27,119+347.8% | Added |
| Manufacturers Life Insurance Company, The | 33,291 | $9.86M | 0.01% | −2,538−7.1% | Reduced |
| Caption Management, LLC | 33,300 | $9.81M | 0.43% | +26,943+423.8% | Added |
| B Group, Inc. | 33,237 | $9.80M | 7.26% | +1,737+5.5% | Added |
| Congress Asset Management Co | 31,246 | $9.21M | 0.06% | +807+2.7% | Added |
| PFM Health Sciences, LP | 31,163 | $9.18M | 0.93% | −29,415−48.6% | Reduced |
| Lord, Abbett & Co. LLC | 30,756 | $9.06M | 0.03% | +30,756 | New |
| ArrowMark Colorado Holdings LLC | 30,000 | $8.84M | 0.19% | +30,000 | New |
| AQR Capital Management LLC | 28,828 | $8.50M | 0.00% | +6,924+31.6% | Added |
| Rhumbline Advisers | 28,324 | $8.35M | 0.01% | +1,530+5.7% | Added |
| HighVista Strategies LLC | 25,841 | $7.62M | 1.96% | −69,161−72.8% | Reduced |
| Neuberger Berman Group LLC | 25,678 | $7.57M | 0.01% | +25,678 | New |
| Mirae Asset Global ETFs Holdings Ltd. | 25,559 | $7.54M | 0.01% | +2,723+11.9% | Added |
| Wells Fargo & Company | 25,235 | $7.44M | 0.00% | +11,630+85.5% | Added |
| Alliancebernstein L.P. | 25,070 | $7.39M | 0.00% | +7,010+38.8% | Added |
| Burkehill Global Management, LP | 25,000 | $7.37M | 0.49% | +25,000 | New |
| Dimensional Fund Advisors LP | 23,543 | $6.94M | 0.00% | −13,871−37.1% | Reduced |
| Susquehanna Portfolio Strategies, LLC | 23,251 | $6.85M | 0.11% | 00.0% | Unchanged |
| Two Sigma Investments, LP | 23,098 | $6.81M | 0.01% | +17,590+319.4% | Added |
| Polygon Management Ltd. | 22,952 | $6.76M | 1.43% | +22,952 | New |
| Ameriprise Financial Inc | 22,715 | $6.70M | 0.00% | +22,715 | New |
| Rafferty Asset Management, LLC | 22,240 | $6.56M | 0.02% | −15,333−40.8% | Reduced |
| Man Group plc | 21,170 | $6.24M | 0.01% | +21,170 | New |
| StemPoint Capital LP | 21,067 | $6.21M | 1.07% | +21,067 | New |
| Boothbay Fund Management, LLC | 20,974 | $6.18M | 0.16% | −18,686−47.1% | Reduced |
| EAM Investors, LLC | 20,941 | $6.17M | 0.69% | +20,941 | New |
| Russell Investments Group, Ltd. | 20,612 | $6.08M | 0.01% | +16,208+368.0% | Added |