Karyopharm Therapeutics Inc.
KPTI- Exchange
- Nasdaq
- Industry
- Pharmaceutical Preparations
- SEC CIK
- 0001503802
In the last 90 days, Karyopharm Therapeutics Inc. insiders filed 0 open-market purchases and 2 sales; 96 institutions reported holding it in 13F filings for Q2 2026, worth $206.8M in total; no superinvestor holds it.
13F holders, Q3 2023
Institutional positions in Karyopharm Therapeutics Inc. as of Sep 30, 2023. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 120
- −18 vs. Q2 2023
- Shares held
- 77.2M
- −4.32M (−5.3%) vs. Q2 2023
- Total value
- $102.8M
- −$42.2M (−29.1%) vs. Q2 2023
- New holders
- 16
- 40 more added
- Sold out
- 34
- 30 more reduced
Compare with Q2 2023: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting KPTI on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 96 | $206.8M |
| Q1 2026 | 77 | $98.4M |
| Q4 2025 | 68 | $69.6M |
| Q3 2025 | 52 | $19.5M |
| Q2 2025 | 50 | $19.0M |
| Q1 2025 | 50 | $13.7M |
| Q4 2024 | 87 | $41.2M |
| Q3 2024 | 91 | $49.2M |
| Q2 2024 | 114 | $58.6M |
| Q1 2024 | 114 | $113.0M |
| Q4 2023 | 120 | $63.5M |
| Q3 2023 | 120 | $102.8M |
| Q2 2023 | 138 | $145.0M |
| Q1 2023 | 132 | $340.1M |
| Q4 2022 | 155 | $334.4M |
| Q3 2022 | 147 | $364.1M |
| Q2 2022 | 150 | $302.8M |
| Q1 2022 | 139 | $501.8M |
| Q4 2021 | 143 | $347.5M |
| Q3 2021 | 134 | $334.4M |
| Q2 2021 | 154 | $608.7M |
| Q1 2021 | 171 | $637.1M |
Institutions, Q3 2023
Shares, value and share of portfolio for each institution holding Karyopharm Therapeutics Inc.; share changes are against Q2 2023.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| Tejara Capital Ltd | 1,077,388 | $1.44M | 0.82% | −66,603−5.8% | Reduced |
| Millennium Management LLC | 1,117,908 | $1.50M | 0.00% | −33,333−2.9% | Reduced |
| AlphaCentric Advisors LLC | 1,125,000 | $1.51M | 0.86% | +315,000+38.9% | Added |
| Candriam Luxembourg S.C.A. | 1,140,694 | $1.53M | 0.01% | −295,000−20.5% | Reduced |
| JPMorgan Chase & Co | 1,141,126 | $1.53M | 0.00% | +1,051,695+1,176.0% | Added |
| Barclays PLC | 1,152,298 | $1.54M | 0.00% | +45,937+4.2% | Added |
| ExodusPoint Capital Management, LP | 1,397,543 | $1.87M | 0.02% | −984,908−41.3% | Reduced |
| C WorldWide Group Holding A/S | 1,500,000 | $2.01M | 0.03% | 00.0% | Unchanged |
| BNP Paribas Arbitrage, SA | 1,660,898 | $2.23M | 0.00% | +1,199,802+260.2% | Added |
| AIGH Capital Management LLC | 1,773,474 | $2.38M | 1.13% | 00.0% | Unchanged |
| Goldman Sachs Group Inc | 1,915,047 | $2.57M | 0.00% | +294,028+18.1% | Added |
| State Street Corp | 2,043,005 | $2.74M | 0.00% | −169,362−7.7% | Reduced |
| Marshall Wace, LLP | 2,183,201 | $2.93M | 0.01% | −260,796−10.7% | Reduced |
| Geode Capital Management, LLC | 2,287,146 | $3.07M | 0.00% | +150,052+7.0% | Added |
| Jacobs Levy Equity Management, Inc | 2,353,528 | $3.15M | 0.02% | +1,676,673+247.7% | Added |
| Citadel Advisors LLC | 3,103,888 | $4.16M | 0.00% | −45,794−1.5% | Reduced |
| Palo Alto Investors LP | 5,675,876 | $7.61M | 0.72% | 00.0% | Unchanged |
| Avidity Partners Management LP | 8,298,570 | $11.1M | 0.45% | −71,530−0.9% | Reduced |
| Vanguard Group Inc | 8,819,929 | $11.8M | 0.00% | +135,801+1.6% | Added |
| BlackRock Inc. | 11,086,533 | $14.9M | 0.00% | −450,748−3.9% | Reduced |
| Opaleye Management Inc. | 0 | $0 | 0.00% | −1,785,000−100.0% | Sold out |
| Rubric Capital Management LP | 0 | $0 | 0.00% | −919,196−100.0% | Sold out |
| Qube Research & Technologies Ltd | 0 | $0 | 0.00% | −703,062−100.0% | Sold out |
| Jane Street Group, LLC | 0 | $0 | 0.00% | −662,363−100.0% | Sold out |
| Wellington Management Group LLP | 0 | $0 | 0.00% | −561,799−100.0% | Sold out |
| Platinum Investment Management Ltd | 0 | $0 | 0.00% | −500,000−100.0% | Sold out |
| Alyeska Investment Group, L.P. | 0 | $0 | 0.00% | −481,696−100.0% | Sold out |
| Two Sigma Investments, LP | 0 | $0 | 0.00% | −347,555−100.0% | Sold out |
| Ergoteles LLC | 0 | $0 | 0.00% | −237,400−100.0% | Sold out |
| HRT Financial LP | 0 | $0 | 0.00% | −225,518−100.0% | Sold out |
| Swiss National Bank | 0 | $0 | 0.00% | −223,350−100.0% | Sold out |
| UBS Asset Management Americas Inc | 0 | $0 | 0.00% | −91,628−100.0% | Sold out |
| Cubist Systematic Strategies, LLC | 0 | $0 | 0.00% | −160,004−100.0% | Sold out |
| Putnam Investments LLC | 0 | $0 | 0.00% | −147,803−100.0% | Sold out |
| Credit Suisse AG | 0 | $0 | 0.00% | −108,539−100.0% | Sold out |
| Acadian Asset Management LLC | 0 | $0 | 0.00% | −98,946−100.0% | Sold out |
| Virginia Retirement Systems Et Al | 0 | $0 | 0.00% | −92,000−100.0% | Sold out |
| Laurion Capital Management LP | 0 | $0 | 0.00% | −57,146−100.0% | Sold out |
| Janus Henderson Group PLC | 0 | $0 | 0.00% | −38,053−100.0% | Sold out |
| Dark Forest Capital Management LP | 0 | $0 | 0.00% | −34,943−100.0% | Sold out |
| Y-Intercept (Hong Kong) Ltd | 0 | $0 | 0.00% | −33,931−100.0% | Sold out |
| State Board of Administration of Florida Retirement System | 0 | $0 | 0.00% | −32,155−100.0% | Sold out |
| Arizona State Retirement System | 0 | $0 | 0.00% | −28,807−100.0% | Sold out |
| Teacher Retirement System of Texas | 0 | $0 | 0.00% | −27,840−100.0% | Sold out |
| Great West Life Assurance Co | 0 | $0 | 0.00% | −23,069−100.0% | Sold out |
| Mariner, LLC | 0 | $0 | 0.00% | −19,984−100.0% | Sold out |
| Dynamic Technology Lab Private Ltd | 0 | $0 | 0.00% | −18,799−100.0% | Sold out |
| Snowden Capital Advisors LLC | 0 | $0 | 0.00% | −16,200−100.0% | Sold out |
| Sawtooth Solutions, LLC | 0 | $0 | 0.00% | −15,966−100.0% | Sold out |
| Bleakley Financial Group, LLC | 0 | $0 | 0.00% | −15,966−100.0% | Sold out |
| Prelude Capital Management, LLC | 0 | $0 | 0.00% | −15,933−100.0% | Sold out |
| Two Sigma Securities, LLC | 0 | $0 | 0.00% | −13,480−100.0% | Sold out |
| Lazard Asset Management LLC | 0 | $0 | 0.00% | −1,000−100.0% | Sold out |
| Huntington National Bank | 0 | $0 | 0.00% | −104−100.0% | Sold out |