Ionis Pharmaceuticals Inc
IONS- Exchange
- Nasdaq
- Industry
- Pharmaceutical Preparations
- SEC CIK
- 0000874015
In the last 90 days, Ionis Pharmaceuticals Inc insiders filed 1 open-market purchase and 4 sales; 515 institutions reported holding it in 13F filings for Q2 2026, worth $14.3B in total; ARK Invest is the only superinvestor holding it.
13F holders, Q1 2022
Institutional positions in Ionis Pharmaceuticals Inc as of Mar 31, 2022. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 333
- −3 vs. Q4 2021
- Shares held
- 125.0M
- +1.76M (+1.4%) vs. Q4 2021
- Total value
- $4.63B
- +$876.1M (+23.4%) vs. Q4 2021
- New holders
- 47
- 107 more added
- Sold out
- 50
- 109 more reduced
5 institutions that held it in Q4 2021 haven't filed for Q1 2022 yet. Not filing isn't selling, so they aren't counted as sold out or in the changes above.
Compare with Q4 2021: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting IONS on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 515 | $14.3B |
| Q1 2026 | 497 | $13.0B |
| Q4 2025 | 494 | $13.5B |
| Q3 2025 | 437 | $11.0B |
| Q2 2025 | 363 | $6.67B |
| Q1 2025 | 344 | $5.03B |
| Q4 2024 | 356 | $5.61B |
| Q3 2024 | 354 | $6.31B |
| Q2 2024 | 357 | $6.83B |
| Q1 2024 | 361 | $6.17B |
| Q4 2023 | 365 | $7.21B |
| Q3 2023 | 312 | $6.35B |
| Q2 2023 | 305 | $5.60B |
| Q1 2023 | 315 | $4.69B |
| Q4 2022 | 339 | $4.93B |
| Q3 2022 | 350 | $5.59B |
| Q2 2022 | 351 | $4.61B |
| Q1 2022 | 333 | $4.63B |
| Q4 2021 | 341 | $3.75B |
| Q3 2021 | 326 | $4.08B |
| Q2 2021 | 338 | $4.96B |
| Q1 2021 | 365 | $5.55B |
Institutions, Q1 2022
Shares, value and share of portfolio for each institution holding Ionis Pharmaceuticals Inc; share changes are against Q4 2021.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| Royal Bank of Canada | 444,502 | $16.5M | 0.00% | −36,146−7.5% | Reduced |
| Candriam Luxembourg S.C.A. | 499,547 | $18.5M | 0.13% | −437,088−46.7% | Reduced |
| Morgan Stanley | 519,477 | $19.2M | 0.00% | +54,592+11.7% | Added |
| Pinnacle Associates Ltd | 521,968 | $19.3M | 0.34% | −19,076−3.5% | Reduced |
| Bank of New York Mellon Corp | 549,247 | $20.3M | 0.00% | −7,330−1.3% | Reduced |
| Nikko Asset Management Americas, Inc. | 599,616 | $21.5M | 0.16% | −6,286−1.0% | Reduced |
| Sumitomo Mitsui Trust Holdings, Inc. | 599,616 | $22.2M | 0.01% | −6,286−1.0% | Reduced |
| Two Sigma Advisers, LP | 611,611 | $22.7M | 0.06% | +114,200+23.0% | Added |
| Northern Trust Corp | 648,534 | $24.0M | 0.00% | −12,356−1.9% | Reduced |
| Bank of America Corp | 762,158 | $28.2M | 0.00% | +149,323+24.4% | Added |
| Two Sigma Investments, LP | 780,256 | $28.9M | 0.09% | +185,371+31.2% | Added |
| Norges Bank | 785,561 | $29.1M | 0.01% | −45,658−5.5% | Reduced |
| TD Asset Management Inc | 820,164 | $30.4M | 0.03% | +77,000+10.4% | Added |
| Wells Fargo & Company | 842,284 | $31.2M | 0.01% | +31,318+3.9% | Added |
| Goldman Sachs Group Inc | 954,326 | $35.3M | 0.01% | +365,028+61.9% | Added |
| Swedbank AB | 1,117,339 | $41.4M | 0.08% | 00.0% | Unchanged |
| Charles Schwab Investment Management Inc | 1,137,827 | $42.1M | 0.01% | +44,388+4.1% | Added |
| JPMorgan Chase & Co | 1,181,557 | $43.8M | 0.01% | −87,095−6.9% | Reduced |
| Citadel Advisors LLC | 1,244,524 | $46.1M | 0.05% | +22,953+1.9% | Added |
| Thrivent Financial for Lutherans | 1,561,513 | $57.8M | 0.11% | +27,514+1.8% | Added |
| First Trust Advisors LP | 1,616,290 | $59.9M | 0.06% | −63,722−3.8% | Reduced |
| Jacobs Levy Equity Management, Inc | 1,618,267 | $59.9M | 0.40% | +210,879+15.0% | Added |
| Geode Capital Management, LLC | 1,897,492 | $70.3M | 0.01% | +72,266+4.0% | Added |
| Tweedy, Browne Co LLC | 2,925,102 | $108.3M | 3.50% | +2,925,102 | New |
| Camber Capital Management LP | 3,000,000 | $111.1M | 4.02% | +1,610,000+115.8% | Added |
| State Street Corp | 4,030,646 | $149.3M | 0.01% | +124,271+3.2% | Added |
| ARK Investment Management LLCSuperinvestorARK Invest | 6,171,308 | $228.6M | 0.95% | −911,948−12.9% | Reduced |
| Clearbridge Investments, LLC | 6,476,033 | $239.9M | 0.18% | +593,051+10.1% | Added |
| BlackRock Inc. | 8,443,843 | $312.8M | 0.01% | −95,439−1.1% | Reduced |
| Bellevue Group AG | 9,918,073 | $367.4M | 4.27% | −437,050−4.2% | Reduced |
| Vanguard Group Inc | 12,099,034 | $448.1M | 0.01% | +91,958+0.8% | Added |
| Price T Rowe Associates Inc | 14,350,460 | $531.5M | 0.05% | +1,860,180+14.9% | Added |
| FMR LLC | 21,320,886 | $789.7M | 0.06% | +139,384+0.7% | Added |
| Bank of Nova Scotia | 0 | $0 | 0.00% | −601,883−100.0% | Sold out |
| Natixis | 0 | $0 | 0.00% | −300,797−100.0% | Sold out |
| MUFG Securities EMEA plc | 0 | $0 | 0.00% | −200,000−100.0% | Sold out |
| Balyasny Asset Management LLC | 0 | $0 | 0.00% | −193,120−100.0% | Sold out |
| D. E. Shaw & Co., Inc. | 0 | $0 | 0.00% | −160,659−100.0% | Sold out |
| Wolverine Trading, LLC | 0 | $0 | 0.00% | −108,529−100.0% | Sold out |
| Parkman Healthcare Partners LLC | 0 | $0 | 0.00% | −80,238−100.0% | Sold out |
| National Bank of Canada | 0 | $0 | 0.00% | −70,000−100.0% | Sold out |
| Point72 Asset Management, L.P. | 0 | $0 | 0.00% | −53,981−100.0% | Sold out |
| Alpha DNA Investment Management LLC | 0 | $0 | 0.00% | −50,614−100.0% | Sold out |
| Pura Vida Investments, LLC | 0 | $0 | 0.00% | −48,544−100.0% | Sold out |
| Jefferies Group LLC | 0 | $0 | 0.00% | −44,000−100.0% | Sold out |
| Group One Trading, L.P. | 0 | $0 | 0.00% | −36,268−100.0% | Sold out |
| Healthcare of Ontario Pension Plan Trust Fund | 0 | $0 | 0.00% | −34,069−100.0% | Sold out |
| Occudo Quantitative Strategies LP | 0 | $0 | 0.00% | −26,650−100.0% | Sold out |
| AE Wealth Management LLC | 0 | $0 | 0.00% | −26,085−100.0% | Sold out |
| ExodusPoint Capital Management, LP | 0 | $0 | 0.00% | −19,788−100.0% | Sold out |
| Quantamental Technologies LLC | 0 | $0 | 0.00% | −17,671−100.0% | Sold out |
| Campbell & CO Investment Adviser LLC | 0 | $0 | 0.00% | −17,346−100.0% | Sold out |
| Verition Fund Management LLC | 0 | $0 | 0.00% | −13,740−100.0% | Sold out |
| Gsa Capital Partners LLP | 0 | $0 | 0.00% | −13,368−100.0% | Sold out |
| Wellington Management Group LLP | 0 | $0 | 0.00% | −13,134−100.0% | Sold out |
| Caption Management, LLC | 0 | $0 | 0.00% | −12,000−100.0% | Sold out |
| Dynamic Technology Lab Private Ltd | 0 | $0 | 0.00% | −11,134−100.0% | Sold out |
| Greenup Street Wealth Management LLC | 0 | $0 | 0.00% | −11,145−100.0% | Sold out |
| Walleye Trading LLC | 0 | $0 | 0.00% | −10,695−100.0% | Sold out |
| Brookfield Asset Management Inc. | 0 | $0 | 0.00% | −9,638−100.0% | Sold out |
| Metropolitan Life Insurance Co | 0 | $0 | 0.00% | −8,813−100.0% | Sold out |
| Virginia Retirement Systems Et Al | 0 | $0 | 0.00% | −7,200−100.0% | Sold out |
| Quantbot Technologies LP | 0 | $0 | 0.00% | −5,076−100.0% | Sold out |
| NuWave Investment Management, LLC | 0 | $0 | 0.00% | −3,762−100.0% | Sold out |
| Macroview Investment Management LLC | 0 | $0 | 0.00% | −616−100.0% | Sold out |
| FSB Premier Wealth Management, Inc. | 0 | $0 | 0.00% | −482−100.0% | Sold out |
| Confluence Wealth Services, Inc. | 0 | $0 | 0.00% | −384−100.0% | Sold out |
| Heritage Wealth Advisors | 0 | $0 | 0.00% | −334−100.0% | Sold out |
| Jones Financial Companies LLLP | 0 | $0 | 0.00% | −300−100.0% | Sold out |
| Amplius Wealth Advisors, LLC | 0 | $0 | 0.00% | −300−100.0% | Sold out |
| Logan Capital Management Inc | 0 | $0 | 0.00% | −178−100.0% | Sold out |
| Pinnacle Bancorp, Inc. | 0 | $0 | 0.00% | −179−100.0% | Sold out |
| Cornerstone Advisory, LLC | 0 | $0 | 0.00% | −100−100.0% | Sold out |
| SkyView Investment Advisors, LLC | 0 | $0 | 0.00% | −91−100.0% | Sold out |
| CoreCap Advisors, LLC | 0 | $0 | 0.00% | −102−100.0% | Sold out |
| Motley Fool Asset Management LLC | 0 | $0 | 0.00% | −66−100.0% | Sold out |
| SRS Capital Advisors, Inc. | 0 | $0 | 0.00% | −38−100.0% | Sold out |
| Signet Financial Management, LLC | 0 | $0 | 0.00% | −48−100.0% | Sold out |
| Bedel Financial Consulting, Inc. | 0 | $0 | 0.00% | −38−100.0% | Sold out |
| Sound Income Strategies, LLC | 0 | $0 | 0.00% | −20−100.0% | Sold out |
| Private Capital Group, LLC | 0 | $0 | 0.00% | −31−100.0% | Sold out |
| KB Financial Partners, LLC | 0 | $0 | 0.00% | −34−100.0% | Sold out |
| Gemmer Asset Management LLC | 0 | $0 | 0.00% | −3−100.0% | Sold out |
| NEXT Financial Group, Inc | – | – | – | – | Not filed |
| Harbour Investments, Inc. | – | – | – | – | Not filed |
| Carroll Financial Associates, Inc. | – | – | – | – | Not filed |
| Reilly Financial Advisors, LLC | – | – | – | – | Not filed |
| Bell Investment Advisors, Inc | – | – | – | – | Not filed |