Denali Therapeutics Inc.
DNLI- Exchange
- Nasdaq
- Industry
- Biological Products, (No Diagnostic Substances)
- SEC CIK
- 0001714899
In the last 90 days, Denali Therapeutics Inc. insiders filed 0 open-market purchases and 4 sales; 294 institutions reported holding it in 13F filings for Q2 2026, worth $4.00B in total; no superinvestor holds it.
13F holders, Q1 2026
Institutional positions in Denali Therapeutics Inc. as of Mar 31, 2026. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 269
- +25 vs. Q4 2025
- Shares held
- 147.4M
- +14.8M (+11.2%) vs. Q4 2025
- Total value
- $2.82B
- +$631.6M (+28.8%) vs. Q4 2025
- New holders
- 55
- 104 more added
- Sold out
- 30
- 58 more reduced
6 institutions that held it in Q4 2025 haven't filed for Q1 2026 yet. Not filing isn't selling, so they aren't counted as sold out or in the changes above.
Compare with Q4 2025: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting DNLI on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 294 | $4.00B |
| Q1 2026 | 269 | $2.82B |
| Q4 2025 | 250 | $2.50B |
| Q3 2025 | 240 | $1.97B |
| Q2 2025 | 231 | $1.93B |
| Q1 2025 | 222 | $1.85B |
| Q4 2024 | 224 | $2.61B |
| Q3 2024 | 217 | $3.69B |
| Q2 2024 | 203 | $2.88B |
| Q1 2024 | 211 | $2.51B |
| Q4 2023 | 209 | $2.47B |
| Q3 2023 | 195 | $2.24B |
| Q2 2023 | 203 | $3.18B |
| Q1 2023 | 202 | $2.49B |
| Q4 2022 | 199 | $2.94B |
| Q3 2022 | 200 | $2.84B |
| Q2 2022 | 188 | $2.73B |
| Q1 2022 | 190 | $2.79B |
| Q4 2021 | 213 | $3.80B |
| Q3 2021 | 214 | $4.28B |
| Q2 2021 | 210 | $6.32B |
| Q1 2021 | 218 | $4.60B |
Institutions, Q1 2026
Shares, value and share of portfolio for each institution holding Denali Therapeutics Inc.; share changes are against Q4 2025.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| Balyasny Asset Management LLC | 195,108 | $3.75M | 0.01% | +195,108 | New |
| SCS Capital Management LLC | 197,998 | $3.80M | 0.04% | 00.0% | Unchanged |
| Rhenman & Partners Asset Management AB | 199,000 | $3.82M | 0.47% | +99,000+99.0% | Added |
| Burkehill Global Management, LP | 200,000 | $3.84M | 0.19% | 00.0% | Unchanged |
| Groupama Asset Managment | 207,130 | $3.98M | 0.06% | +55,539+36.6% | Added |
| Edmond de Rothschild Holding S.A. | 225,680 | $4.33M | 0.06% | 00.0% | Unchanged |
| Great Lakes Advisors, LLC | 227,110 | $4.36M | 0.04% | +227,110 | New |
| Palo Alto Investors LP | 234,582 | $4.50M | 0.69% | −406,657−63.4% | Reduced |
| Privium Fund Management B.V. | 254,857 | $4.89M | 1.02% | +254,857 | New |
| TD Asset Management Inc | 255,766 | $4.91M | 0.00% | −83,644−24.6% | Reduced |
| Schroder Investment Management Group | 285,820 | $5.17M | 0.00% | −165,165−36.6% | Reduced |
| Swiss National Bank | 273,800 | $5.26M | 0.00% | 00.0% | Unchanged |
| Marex Group plc | 287,000 | $5.51M | 0.06% | −10.0% | Reduced |
| Nuveen, LLC | 295,586 | $5.68M | 0.00% | +20,078+7.3% | Added |
| Braidwell LP | 296,324 | $5.69M | 0.19% | +296,324 | New |
| BNP PARIBAS ASSET MANAGEMENT Holding S.A. | 296,503 | $5.69M | 0.01% | −2,289−0.8% | Reduced |
| JPMorgan Chase & Co | 323,989 | $5.86M | 0.00% | +152,041+88.4% | Added |
| Invesco Ltd. | 310,196 | $5.96M | 0.00% | +18,260+6.3% | Added |
| DAFNA Capital Management LLC | 318,500 | $6.12M | 1.39% | 00.0% | Unchanged |
| Hudson Bay Capital Management LP | 346,360 | $6.65M | 0.04% | −103,640−23.0% | Reduced |
| Woodline Partners LP | 364,082 | $6.99M | 0.03% | +250,000+219.1% | Added |
| StemPoint Capital LP | 426,561 | $8.19M | 1.57% | +7,503+1.8% | Added |
| Segall Bryant & Hamill, LLC | 510,543 | $9.80M | 0.14% | −26,457−4.9% | Reduced |
| Ensign Peak Advisors, Inc | 515,721 | $9.90M | 0.02% | 00.0% | Unchanged |
| Masters Capital Management LLC | 600,000 | $11.5M | 1.70% | −400,000−40.0% | Reduced |
| Cercano Management LLC | 625,000 | $12.0M | 0.52% | 00.0% | Unchanged |
| Clearstead Advisors, LLC | 737,990 | $14.2M | 0.13% | +737,990 | New |
| Bank of New York Mellon Corp | 768,039 | $14.7M | 0.00% | +5,952+0.8% | Added |
| American Century Companies Inc | 935,692 | $18.0M | 0.01% | +556,641+146.9% | Added |
| Vanguard Fiduciary Trust Co | 949,695 | $18.2M | 0.00% | +949,695 | New |
| Marshall Wace, LLP | 991,268 | $19.0M | 0.02% | +227,376+29.8% | Added |
| Artisan Partners Limited Partnership | 1,099,719 | $21.1M | 0.03% | +1,099,719 | New |
| Candriam Luxembourg S.C.A. | 1,099,845 | $21.1M | 0.11% | −66,534−5.7% | Reduced |
| Morgan Stanley | 1,104,757 | $21.2M | 0.00% | −115,097−9.4% | Reduced |
| Bank of America Corp | 1,134,183 | $21.8M | 0.00% | +202,039+21.7% | Added |
| Charles Schwab Investment Management Inc | 1,207,399 | $23.2M | 0.00% | +6,924+0.6% | Added |
| Foresite Capital Management VI LLC | 1,209,971 | $23.2M | 5.05% | +209,971+21.0% | Added |
| Millennium Management LLC | 1,257,950 | $24.2M | 0.02% | +888,183+240.2% | Added |
| Northern Trust Corp | 1,310,656 | $25.2M | 0.00% | +110,912+9.2% | Added |
| Defilade Capital Management, L.P. | 1,359,969 | $26.1M | 3.67% | +703,256+107.1% | Added |
| Siren, L.L.C. | 1,396,513 | $26.8M | 0.74% | 00.0% | Unchanged |
| Principal Financial Group Inc | 1,478,486 | $28.4M | 0.02% | −45,637−3.0% | Reduced |
| Vestal Point Capital, LP | 1,773,326 | $34.0M | 0.95% | +1,308,326+281.4% | Added |
| Casdin Capital, LLC | 1,840,000 | $35.3M | 2.68% | 00.0% | Unchanged |
| Standard Life Aberdeen plc | 1,854,446 | $35.6M | 0.06% | −178,521−8.8% | Reduced |
| ADAR1 Capital Management, LLC | 1,871,455 | $35.9M | 2.16% | +1,819,339+3,490.9% | Added |
| Lynx1 Capital Management LP | 1,880,303 | $36.1M | 5.71% | +141,553+8.1% | Added |
| Alyeska Investment Group, L.P. | 1,941,123 | $37.3M | 0.11% | +1,082,015+125.9% | Added |
| Crestline Management, LP | 2,210,732 | $42.4M | 91.74% | −600,000−21.3% | Reduced |
| Fisher Asset Management, LLC | 2,436,895 | $46.8M | 0.02% | −152,508−5.9% | Reduced |
| Price T Rowe Associates Inc | 2,464,146 | $47.3M | 0.01% | −1,451,805−37.1% | Reduced |
| Alliancebernstein L.P. | 2,893,618 | $47.8M | 0.02% | −664,317−18.7% | Reduced |
| Capital Research Global Investors | 2,514,588 | $48.3M | 0.01% | −1,214,656−32.6% | Reduced |
| Pictet Asset Management Holding SA | 2,558,865 | $48.4M | 0.05% | +1,229,757+92.5% | Added |
| UBS Group AG | 2,571,344 | $49.4M | 0.01% | +166,640+6.9% | Added |
| Dimensional Fund Advisors LP | 2,692,175 | $51.7M | 0.01% | +317,872+13.4% | Added |
| Holocene Advisors, LP | 3,195,429 | $61.4M | 0.15% | +42,695+1.4% | Added |
| Geode Capital Management, LLC | 3,727,114 | $71.6M | 0.00% | +268,983+7.8% | Added |
| Baker Bros. Advisors LP | 3,731,695 | $71.6M | 0.41% | 00.0% | Unchanged |
| Goldman Sachs Group Inc | 4,407,255 | $84.6M | 0.01% | +571,452+14.9% | Added |
| UBS Asset Management Americas Inc | 4,432,314 | $85.1M | 0.02% | −551,412−11.1% | Reduced |
| FMR LLC | 4,575,374 | $87.8M | 0.00% | −1,521,837−25.0% | Reduced |
| Vanguard Portfolio Management LLC | 6,120,160 | $117.5M | 0.01% | +6,120,160 | New |
| Vanguard Capital Management LLC | 6,147,957 | $118.0M | 0.00% | +6,147,957 | New |
| State Street Corp | 6,272,001 | $120.4M | 0.00% | +8,630+0.1% | Added |
| Temasek Holdings (Private) Ltd | 7,012,974 | $134.6M | 0.45% | 00.0% | Unchanged |
| T. Rowe Price Investment Management, Inc. | 8,519,192 | $163.6M | 0.11% | +1,265,060+17.4% | Added |
| Baillie Gifford & Co | 12,066,479 | $231.7M | 0.24% | −244,410−2.0% | Reduced |
| BlackRock, Inc. | 13,034,434 | $250.3M | 0.00% | +319,233+2.5% | Added |
| Point72 Asset Management, L.P. | 0 | $0 | 0.00% | −1,700,000−100.0% | Sold out |
| ExodusPoint Capital Management, LP | 0 | $0 | 0.00% | −1,023,253−100.0% | Sold out |
| Voloridge Investment Management, LLC | 0 | $0 | 0.00% | −591,461−100.0% | Sold out |
| Qube Research & Technologies Ltd | 0 | $0 | 0.00% | −590,314−100.0% | Sold out |
| Two Sigma Investments, LP | 0 | $0 | 0.00% | −430,177−100.0% | Sold out |
| Trexquant Investment LP | 0 | $0 | 0.00% | −209,609−100.0% | Sold out |
| Two Sigma Advisers, LP | 0 | $0 | 0.00% | −154,800−100.0% | Sold out |
| Algert Global LLC | 0 | $0 | 0.00% | −127,030−100.0% | Sold out |
| Monashee Investment Management LLC | 0 | $0 | 0.00% | −91,620−100.0% | Sold out |
| HRT Financial LP | 0 | $0 | 0.00% | −78,352−100.0% | Sold out |
| Ishara Investments LP | 0 | $0 | 0.00% | −70,000−100.0% | Sold out |
| Capricorn Fund Managers Ltd | 0 | $0 | 0.00% | −62,197−100.0% | Sold out |
| Tudor Investment Corp Et Al | 0 | $0 | 0.00% | −53,683−100.0% | Sold out |
| Clough Capital Partners L P | 0 | $0 | 0.00% | −51,830−100.0% | Sold out |
| Quest Partners LLC | 0 | $0 | 0.00% | −42,909−100.0% | Sold out |
| Jump Financial, LLC | 0 | $0 | 0.00% | −40,608−100.0% | Sold out |
| Savvy Advisors, Inc. | 0 | $0 | 0.00% | −39,030−100.0% | Sold out |
| PSP Research LLC | 0 | $0 | 0.00% | −31,762−100.0% | Sold out |
| TT International Asset Management LTD | 0 | $0 | 0.00% | −27,000−100.0% | Sold out |
| Graham Capital Management, L.P. | 0 | $0 | 0.00% | −18,121−100.0% | Sold out |
| Walleye Capital LLC | 0 | $0 | 0.00% | −12,652−100.0% | Sold out |
| Renaissance Technologies LLC | 0 | $0 | 0.00% | −10,700−100.0% | Sold out |
| Quarry LP | 0 | $0 | 0.00% | −7,000−100.0% | Sold out |
| Persistent Asset Partners Ltd | 0 | $0 | 0.00% | −5,670−100.0% | Sold out |
| Amalgamated Bank | 0 | $0 | 0.00% | −4,161−100.0% | Sold out |
| State of Wyoming | 0 | $0 | 0.00% | −2,686−100.0% | Sold out |
| Daiwa Securities Group Inc. | 0 | $0 | 0.00% | −475−100.0% | Sold out |
| Westside Investment Management, Inc. | 0 | $0 | 0.00% | −33−100.0% | Sold out |
| SageView Advisory Group, LLC | 0 | $0 | 0.00% | −25−100.0% | Sold out |
| Private Wealth Asset Management, LLC | 0 | $0 | 0.00% | −8−100.0% | Sold out |
| Vanguard Group Inc | – | – | – | – | Not filed |