Denali Therapeutics Inc.
DNLI- Exchange
- Nasdaq
- Industry
- Biological Products, (No Diagnostic Substances)
- SEC CIK
- 0001714899
In the last 90 days, Denali Therapeutics Inc. insiders filed 0 open-market purchases and 4 sales; 294 institutions reported holding it in 13F filings for Q2 2026, worth $4.00B in total; no superinvestor holds it.
13F holders, Q4 2025
Institutional positions in Denali Therapeutics Inc. as of Dec 31, 2025. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 250
- +17 vs. Q3 2025
- Shares held
- 151.1M
- +16.2M (+12.0%) vs. Q3 2025
- Total value
- $2.50B
- +$536.1M (+27.4%) vs. Q3 2025
- New holders
- 51
- 86 more added
- Sold out
- 34
- 71 more reduced
7 institutions that held it in Q3 2025 haven't filed for Q4 2025 yet. Not filing isn't selling, so they aren't counted as sold out or in the changes above.
Compare with Q3 2025: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting DNLI on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 294 | $4.00B |
| Q1 2026 | 269 | $2.82B |
| Q4 2025 | 250 | $2.50B |
| Q3 2025 | 240 | $1.97B |
| Q2 2025 | 231 | $1.93B |
| Q1 2025 | 222 | $1.85B |
| Q4 2024 | 224 | $2.61B |
| Q3 2024 | 217 | $3.69B |
| Q2 2024 | 203 | $2.88B |
| Q1 2024 | 211 | $2.51B |
| Q4 2023 | 209 | $2.47B |
| Q3 2023 | 195 | $2.24B |
| Q2 2023 | 203 | $3.18B |
| Q1 2023 | 202 | $2.49B |
| Q4 2022 | 199 | $2.94B |
| Q3 2022 | 200 | $2.84B |
| Q2 2022 | 188 | $2.73B |
| Q1 2022 | 190 | $2.79B |
| Q4 2021 | 213 | $3.80B |
| Q3 2021 | 214 | $4.28B |
| Q2 2021 | 210 | $6.32B |
| Q1 2021 | 218 | $4.60B |
Institutions, Q4 2025
Shares, value and share of portfolio for each institution holding Denali Therapeutics Inc.; share changes are against Q3 2025.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| Two Sigma Investments, LP | 430,177 | $7.10M | 0.01% | +163,885+61.5% | Added |
| Schroder Investment Management Group | 450,985 | $7.40M | 0.01% | +241,390+115.2% | Added |
| Hudson Bay Capital Management LP | 450,000 | $7.43M | 0.04% | +145,000+47.5% | Added |
| Vestal Point Capital, LP | 465,000 | $7.68M | 0.28% | +465,000 | New |
| Ensign Peak Advisors, Inc | 515,721 | $8.51M | 0.02% | −18,350−3.4% | Reduced |
| Segall Bryant & Hamill, LLC | 537,000 | $8.87M | 0.12% | +24,042+4.7% | Added |
| Qube Research & Technologies Ltd | 590,314 | $9.75M | 0.01% | +362,324+158.9% | Added |
| Voloridge Investment Management, LLC | 591,461 | $9.77M | 0.03% | −344,769−36.8% | Reduced |
| Cercano Management LLC | 625,000 | $10.3M | 0.39% | 00.0% | Unchanged |
| Palo Alto Investors LP | 641,239 | $10.6M | 1.47% | +233,233+57.2% | Added |
| Defilade Capital Management, L.P. | 656,713 | $10.8M | 1.47% | +656,713 | New |
| Bank of New York Mellon Corp | 762,087 | $12.6M | 0.00% | −38,660−4.8% | Reduced |
| Marshall Wace, LLP | 763,892 | $12.6M | 0.01% | −23,137−2.9% | Reduced |
| Citadel Advisors LLC | 779,148 | $12.9M | 0.01% | +90,924+13.2% | Added |
| Alyeska Investment Group, L.P. | 859,108 | $14.2M | 0.04% | +859,108 | New |
| Bank of America Corp | 932,144 | $15.4M | 0.00% | −28,994−3.0% | Reduced |
| Foresite Capital Management VI LLC | 1,000,000 | $16.5M | 4.99% | 00.0% | Unchanged |
| Masters Capital Management LLC | 1,000,000 | $16.5M | 2.28% | +250,000+33.3% | Added |
| ExodusPoint Capital Management, LP | 1,023,253 | $16.9M | 0.19% | +1,023,253 | New |
| Candriam Luxembourg S.C.A. | 1,166,379 | $19.3M | 0.10% | +332,797+39.9% | Added |
| Northern Trust Corp | 1,199,744 | $19.8M | 0.00% | −34,435−2.8% | Reduced |
| Charles Schwab Investment Management Inc | 1,200,475 | $19.8M | 0.00% | +49,091+4.3% | Added |
| Morgan Stanley | 1,219,854 | $20.1M | 0.00% | −469,638−27.8% | Reduced |
| Pictet Asset Management Holding SA | 1,329,108 | $22.0M | 0.02% | +829,946+166.3% | Added |
| Siren, L.L.C. | 1,396,513 | $23.1M | 0.69% | +575,000+70.0% | Added |
| Principal Financial Group Inc | 1,524,123 | $25.2M | 0.01% | +252,933+19.9% | Added |
| Point72 Asset Management, L.P. | 1,700,000 | $28.1M | 0.04% | −819,535−32.5% | Reduced |
| Lynx1 Capital Management LP | 1,738,750 | $28.7M | 5.81% | +1,477,063+564.4% | Added |
| Casdin Capital, LLC | 1,840,000 | $30.4M | 1.89% | +950,000+106.7% | Added |
| Standard Life Aberdeen plc | 2,032,967 | $33.6M | 0.05% | +919,381+82.6% | Added |
| Dimensional Fund Advisors LP | 2,374,303 | $39.2M | 0.01% | +17,089+0.7% | Added |
| UBS Group AG | 2,404,704 | $39.7M | 0.01% | +392,351+19.5% | Added |
| Fisher Asset Management, LLC | 2,589,403 | $42.8M | 0.01% | +957,907+58.7% | Added |
| Crestline Management, LP | 2,810,732 | $46.4M | 87.02% | −600,000−17.6% | Reduced |
| Holocene Advisors, LP | 3,152,734 | $52.1M | 0.11% | +17,022+0.5% | Added |
| Geode Capital Management, LLC | 3,458,131 | $57.1M | 0.00% | −7,926−0.2% | Reduced |
| Alliancebernstein L.P. | 3,557,935 | $58.7M | 0.02% | +37,521+1.1% | Added |
| Capital Research Global Investors | 3,729,244 | $61.6M | 0.01% | −1,031,614−21.7% | Reduced |
| Baker Bros. Advisors LP | 3,731,695 | $61.6M | 0.36% | 00.0% | Unchanged |
| Goldman Sachs Group Inc | 3,835,803 | $63.3M | 0.01% | +1,672,098+77.3% | Added |
| Price T Rowe Associates Inc | 3,915,951 | $64.7M | 0.01% | −652,417−14.3% | Reduced |
| UBS Asset Management Americas Inc | 4,983,726 | $82.3M | 0.02% | −481,311−8.8% | Reduced |
| Norges Bank | 5,119,622 | $84.5M | 0.01% | +5,119,622 | New |
| FMR LLC | 6,097,211 | $100.7M | 0.01% | −243,105−3.8% | Reduced |
| State Street Corp | 6,263,371 | $103.4M | 0.00% | +799,110+14.6% | Added |
| Temasek Holdings (Private) Ltd | 7,012,974 | $115.8M | 0.37% | +1,657,142+30.9% | Added |
| T. Rowe Price Investment Management, Inc. | 7,254,132 | $119.8M | 0.08% | +1,615,565+28.7% | Added |
| Baillie Gifford & Co | 12,310,889 | $203.3M | 0.17% | +719,304+6.2% | Added |
| BlackRock, Inc. | 12,715,201 | $209.9M | 0.00% | +425,575+3.5% | Added |
| Vanguard Group Inc | 13,057,890 | $215.6M | 0.00% | +1,064,972+8.9% | Added |
| Yiheng Capital Management, L.P. | 0 | $0 | 0.00% | −469,981−100.0% | Sold out |
| Pier Capital, LLC | 0 | $0 | 0.00% | −301,171−100.0% | Sold out |
| Boxer Capital Management, LLC | 0 | $0 | 0.00% | −250,000−100.0% | Sold out |
| Schonfeld Strategic Advisors LLC | 0 | $0 | 0.00% | −226,203−100.0% | Sold out |
| Campbell & CO Investment Adviser LLC | 0 | $0 | 0.00% | −216,774−100.0% | Sold out |
| Edgestream Partners, L.P. | 0 | $0 | 0.00% | −123,819−100.0% | Sold out |
| Squarepoint Ops LLC | 0 | $0 | 0.00% | −80,518−100.0% | Sold out |
| Engineers Gate Manager LP | 0 | $0 | 0.00% | −69,216−100.0% | Sold out |
| XTX Topco Ltd | 0 | $0 | 0.00% | −65,345−100.0% | Sold out |
| Aquatic Capital Management LLC | 0 | $0 | 0.00% | −56,237−100.0% | Sold out |
| Jacobs Levy Equity Management, Inc | 0 | $0 | 0.00% | −45,969−100.0% | Sold out |
| Jennison Associates LLC | 0 | $0 | 0.00% | −45,445−100.0% | Sold out |
| Cantor Fitzgerald, L. P. | 0 | $0 | 0.00% | −45,000−100.0% | Sold out |
| Cinctive Capital Management LP | 0 | $0 | 0.00% | −27,792−100.0% | Sold out |
| EntryPoint Capital, LLC | 0 | $0 | 0.00% | −24,058−100.0% | Sold out |
| Oxford Asset Management LLP | 0 | $0 | 0.00% | −22,231−100.0% | Sold out |
| Verition Fund Management LLC | 0 | $0 | 0.00% | −17,629−100.0% | Sold out |
| Jain Global LLC | 0 | $0 | 0.00% | −17,414−100.0% | Sold out |
| Prudential Financial Inc | 0 | $0 | 0.00% | −16,938−100.0% | Sold out |
| HSBC Holdings PLC | 0 | $0 | 0.00% | −14,004−100.0% | Sold out |
| MONECO Advisors, LLC | 0 | $0 | 0.00% | −12,478−100.0% | Sold out |
| Aigen Investment Management, LP | 0 | $0 | 0.00% | −12,075−100.0% | Sold out |
| Caption Management, LLC | 0 | $0 | 0.00% | −7,366−100.0% | Sold out |
| Caitong International Asset Management Co., Ltd | 0 | $0 | 0.00% | −1,528−100.0% | Sold out |
| Groupe la Francaise | 0 | $0 | 0.00% | −620−100.0% | Sold out |
| Meeder Asset Management Inc | 0 | $0 | 0.00% | −206−100.0% | Sold out |
| Halbert Hargrove Global Advisors, LLC | 0 | $0 | 0.00% | −104−100.0% | Sold out |
| Harbour Investments, Inc. | 0 | $0 | 0.00% | −100−100.0% | Sold out |
| Rise Advisors, LLC | 0 | $0 | 0.00% | −74−100.0% | Sold out |
| National Bank of Canada | 0 | $0 | 0.00% | −50−100.0% | Sold out |
| Advisory Services Network, LLC | 0 | $0 | 0.00% | −39−100.0% | Sold out |
| Truvestments Capital LLC | 0 | $0 | 0.00% | −1−100.0% | Sold out |
| Simplex Trading, LLC | 0 | $0 | 0.00% | −41−100.0% | Sold out |
| Cloud Capital Management, LLC | 0 | $0 | 0.00% | −2−100.0% | Sold out |
| AXA Investment Managers S.A. | – | – | – | – | Not filed |
| Cubist Systematic Strategies, LLC | – | – | – | – | Not filed |
| CIBC Bancorp USA Inc. | – | – | – | – | Not filed |
| Shell Asset Management Co | – | – | – | – | Not filed |
| Guerra Advisors Inc | – | – | – | – | Not filed |
| Point72 (DIFC) Ltd | – | – | – | – | Not filed |
| Hemington Wealth Management | – | – | – | – | Not filed |