Denali Therapeutics Inc.
DNLI- Exchange
- Nasdaq
- Industry
- Biological Products, (No Diagnostic Substances)
- SEC CIK
- 0001714899
In the last 90 days, Denali Therapeutics Inc. insiders filed 0 open-market purchases and 4 sales; 294 institutions reported holding it in 13F filings for Q2 2026, worth $4.00B in total; no superinvestor holds it.
13F holders, Q3 2025
Institutional positions in Denali Therapeutics Inc. as of Sep 30, 2025. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 240
- +13 vs. Q2 2025
- Shares held
- 135.5M
- +2.28M (+1.7%) vs. Q2 2025
- Total value
- $1.97B
- +$103.6M (+5.6%) vs. Q2 2025
- New holders
- 35
- 91 more added
- Sold out
- 22
- 67 more reduced
4 institutions that held it in Q2 2025 haven't filed for Q3 2025 yet. Not filing isn't selling, so they aren't counted as sold out or in the changes above.
Compare with Q2 2025: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting DNLI on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 294 | $4.00B |
| Q1 2026 | 269 | $2.82B |
| Q4 2025 | 250 | $2.50B |
| Q3 2025 | 240 | $1.97B |
| Q2 2025 | 231 | $1.93B |
| Q1 2025 | 222 | $1.85B |
| Q4 2024 | 224 | $2.61B |
| Q3 2024 | 217 | $3.69B |
| Q2 2024 | 203 | $2.88B |
| Q1 2024 | 211 | $2.51B |
| Q4 2023 | 209 | $2.47B |
| Q3 2023 | 195 | $2.24B |
| Q2 2023 | 203 | $3.18B |
| Q1 2023 | 202 | $2.49B |
| Q4 2022 | 199 | $2.94B |
| Q3 2022 | 200 | $2.84B |
| Q2 2022 | 188 | $2.73B |
| Q1 2022 | 190 | $2.79B |
| Q4 2021 | 213 | $3.80B |
| Q3 2021 | 214 | $4.28B |
| Q2 2021 | 210 | $6.32B |
| Q1 2021 | 218 | $4.60B |
Institutions, Q3 2025
Shares, value and share of portfolio for each institution holding Denali Therapeutics Inc.; share changes are against Q2 2025.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| Quantinno Capital Management LP | 24,707 | $358.7K | 0.00% | +24,707 | New |
| Raymond James Financial Inc | 25,326 | $367.7K | 0.00% | −1,270−4.8% | Reduced |
| China Universal Asset Management Co., Ltd. | 25,629 | $372.1K | 0.03% | −3,549−12.2% | Reduced |
| Universal- Beteiligungs- und Servicegesellschaft mbH | 26,223 | $380.8K | 0.00% | +4,739+22.1% | Added |
| Erste Asset Management GmbH | 26,900 | $390.6K | 0.00% | 00.0% | Unchanged |
| Cinctive Capital Management LP | 27,792 | $403.5K | 0.02% | +3,482+14.3% | Added |
| ProShare Advisors LLC | 27,855 | $404.5K | 0.00% | −4,727−14.5% | Reduced |
| KLP Kapitalforvaltning AS | 29,900 | $434.1K | 0.00% | +3,800+14.6% | Added |
| Envestnet Asset Management Inc | 32,415 | $470.7K | 0.00% | −1,123−3.3% | Reduced |
| Teacher Retirement System of Texas | 33,827 | $491.2K | 0.00% | −1,394−4.0% | Reduced |
| State Board of Administration of Florida Retirement System | 34,168 | $496.1K | 0.00% | 00.0% | Unchanged |
| Thrivent Financial for Lutherans | 35,619 | $517.0K | 0.00% | −32,298−47.6% | Reduced |
| Police & Firemen's Retirement System of New Jersey | 36,663 | $532.3K | 0.00% | +6,269+20.6% | Added |
| SG Americas Securities, LLC | 38,201 | $555.0K | 0.00% | +38,201 | New |
| Handelsbanken Fonder AB | 38,300 | $556.0K | 0.00% | 00.0% | Unchanged |
| New York State Common Retirement Fund | 38,478 | $558.7K | 0.00% | 00.0% | Unchanged |
| Graham Capital Management, L.P. | 39,319 | $570.9K | 0.02% | −25,480−39.3% | Reduced |
| Profund Advisors LLC | 40,156 | $583.1K | 0.02% | +13,433+50.3% | Added |
| Arizona State Retirement System | 40,813 | $592.6K | 0.00% | +2,699+7.1% | Added |
| Susquehanna International Group, LLP | 40,986 | $595.1K | 0.00% | −120,150−74.6% | Reduced |
| Employees Retirement System of Texas | 43,769 | $636.0K | 0.01% | 00.0% | Unchanged |
| Cantor Fitzgerald, L. P. | 45,000 | $653.4K | 0.01% | +45,000 | New |
| Jennison Associates LLC | 45,445 | $659.9K | 0.00% | +45,445 | New |
| Pathstone Holdings, LLC | 45,830 | $665.4K | 0.00% | +790+1.8% | Added |
| Jacobs Levy Equity Management, Inc | 45,969 | $667.5K | 0.00% | +45,969 | New |
| MAI Capital Management | 46,526 | $675.6K | 0.00% | 00.0% | Unchanged |
| Intech Investment Management LLC | 46,797 | $679.5K | 0.01% | −25,069−34.9% | Reduced |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 47,459 | $689.1K | 0.00% | +3,872+8.9% | Added |
| Guggenheim Capital LLC | 49,525 | $719.1K | 0.01% | −2,335−4.5% | Reduced |
| Knights of Columbus Asset Advisors LLC | 50,190 | $728.8K | 0.04% | +11,711+30.4% | Added |
| Dana Investment Advisors, Inc. | 50,716 | $736.4K | 0.02% | +15,155+42.6% | Added |
| ADAR1 Capital Management, LLC | 51,516 | $748.0K | 0.07% | +15,800+44.2% | Added |
| Ironwood Investment Management LLC | 52,786 | $766.5K | 0.33% | −426−0.8% | Reduced |
| Creative Planning | 54,834 | $796.2K | 0.00% | −2,844−4.9% | Reduced |
| Aquatic Capital Management LLC | 56,237 | $816.6K | 0.02% | +56,237 | New |
| Tudor Investment Corp Et Al | 56,368 | $818.5K | 0.01% | +920+1.7% | Added |
| Wellington Management Group LLP | 59,234 | $860.1K | 0.00% | −5,605,499−99.0% | Reduced |
| DekaBank Deutsche Girozentrale | 59,800 | $864.0K | 0.00% | 00.0% | Unchanged |
| Renaissance Technologies LLC | 59,800 | $868.3K | 0.00% | −135,900−69.4% | Reduced |
| Janus Henderson Group PLC | 60,028 | $871.9K | 0.00% | 00.0% | Unchanged |
| Franklin Resources Inc | 64,634 | $938.5K | 0.00% | +109+0.2% | Added |
| TT International Asset Management LTD | 65,000 | $943.8K | 0.18% | 00.0% | Unchanged |
| XTX Topco Ltd | 65,345 | $948.8K | 0.05% | +65,345 | New |
| Pier 88 Investment Partners LLC | 67,440 | $979.2K | 0.18% | +10,290+18.0% | Added |
| Engineers Gate Manager LP | 69,216 | $1.01M | 0.01% | −46,885−40.4% | Reduced |
| Alps Advisors Inc | 70,230 | $1.02M | 0.01% | −8,126−10.4% | Reduced |
| Quest Partners LLC | 74,422 | $1.08M | 0.07% | +51,458+224.1% | Added |
| Savvy Advisors, Inc. | 77,093 | $1.12M | 0.05% | −20,700−21.2% | Reduced |
| MetLife Investment Management | 79,075 | $1.15M | 0.01% | 00.0% | Unchanged |
| State of Wisconsin Investment Board | 80,126 | $1.16M | 0.00% | +499+0.6% | Added |
| Squarepoint Ops LLC | 80,518 | $1.17M | 0.00% | +80,518 | New |
| Two Sigma Advisers, LP | 90,000 | $1.31M | 0.00% | +62,400+226.1% | Added |
| Integrated Wealth Concepts LLC | 91,074 | $1.32M | 0.01% | −4,972−5.2% | Reduced |
| Ameriprise Financial Inc | 99,561 | $1.45M | 0.00% | −2,472−2.4% | Reduced |
| Rhenman & Partners Asset Management AB | 100,000 | $1.45M | 0.16% | 00.0% | Unchanged |
| Algert Global LLC | 101,260 | $1.47M | 0.02% | +15,420+18.0% | Added |
| Wells Fargo & Company | 104,179 | $1.51M | 0.00% | +14,540+16.2% | Added |
| Woodline Partners LP | 113,517 | $1.65M | 0.01% | 00.0% | Unchanged |
| Edgestream Partners, L.P. | 123,819 | $1.80M | 0.05% | −219,104−63.9% | Reduced |
| California State Teachers Retirement System | 129,526 | $1.88M | 0.00% | +10,199+8.5% | Added |
| Mirae Asset Global ETFs Holdings Ltd. | 129,887 | $1.89M | 0.00% | −4,816−3.6% | Reduced |
| Groupama Asset Managment | 135,758 | $1.97M | 0.03% | −39,773−22.7% | Reduced |
| State of New Jersey Common Pension Fund D | 139,663 | $2.03M | 0.01% | +1,783+1.3% | Added |
| Legal & General Group Plc | 143,952 | $2.09M | 0.00% | +12,197+9.3% | Added |
| Jump Financial, LLC | 166,399 | $2.42M | 0.03% | +166,399 | New |
| DAFNA Capital Management LLC | 168,500 | $2.45M | 0.60% | 00.0% | Unchanged |
| Teachers Retirement System of the State of Kentucky | 171,553 | $2.49M | 0.02% | 00.0% | Unchanged |
| JPMorgan Chase & Co | 175,021 | $2.54M | 0.00% | −16,592−8.7% | Reduced |
| Rafferty Asset Management, LLC | 182,886 | $2.66M | 0.01% | +60,624+49.6% | Added |
| SCS Capital Management LLC | 197,998 | $2.87M | 0.03% | 00.0% | Unchanged |
| Rhumbline Advisers | 201,565 | $2.93M | 0.00% | −10,938−5.1% | Reduced |
| Edmond de Rothschild Holding S.A. | 205,680 | $2.99M | 0.05% | 00.0% | Unchanged |
| Manufacturers Life Insurance Company, The | 205,845 | $2.99M | 0.00% | −109,257−34.7% | Reduced |
| Deutsche Bank AG | 207,594 | $3.01M | 0.00% | +71,625+52.7% | Added |
| Schroder Investment Management Group | 209,595 | $3.04M | 0.00% | −176,944−45.8% | Reduced |
| Campbell & CO Investment Adviser LLC | 216,774 | $3.15M | 0.24% | +74,066+51.9% | Added |
| Jane Street Group, LLC | 224,903 | $3.27M | 0.00% | +139,571+163.6% | Added |
| Schonfeld Strategic Advisors LLC | 226,203 | $3.28M | 0.02% | +226,203 | New |
| Qube Research & Technologies Ltd | 227,990 | $3.31M | 0.00% | +227,990 | New |
| Cubist Systematic Strategies, LLC | 230,968 | $3.35M | 0.05% | −165,618−41.8% | Reduced |
| Invesco Ltd. | 249,467 | $3.62M | 0.00% | +29,672+13.5% | Added |
| Boxer Capital Management, LLC | 250,000 | $3.63M | 1.16% | +250,000 | New |
| Lynx1 Capital Management LP | 261,687 | $3.80M | 0.77% | +261,687 | New |
| BNP Paribas Arbitrage, SA | 264,061 | $3.83M | 0.00% | +244,979+1,283.8% | Added |
| Two Sigma Investments, LP | 266,292 | $3.87M | 0.01% | +246,992+1,279.8% | Added |
| Swiss National Bank | 267,500 | $3.88M | 0.00% | +16,600+6.6% | Added |
| Nuveen, LLC | 284,777 | $4.13M | 0.00% | −310,440−52.2% | Reduced |
| Marex Group plc | 291,000 | $4.23M | 0.05% | +29,000+11.1% | Added |
| AXA Investment Managers S.A. | 294,732 | $4.28M | 0.01% | +294,732 | New |
| Pier Capital, LLC | 301,171 | $4.37M | 0.68% | −13,625−4.3% | Reduced |
| Hudson Bay Capital Management LP | 305,000 | $4.43M | 0.03% | +15,000+5.2% | Added |
| American Century Companies Inc | 357,341 | $5.19M | 0.00% | +39,148+12.3% | Added |
| Clarius Group, LLC | 359,745 | $5.22M | 0.31% | −9,250−2.5% | Reduced |
| Royal Bank of Canada | 372,176 | $5.40M | 0.00% | −17,979−4.6% | Reduced |
| TD Asset Management Inc | 394,600 | $5.73M | 0.00% | −101,690−20.5% | Reduced |
| Palo Alto Investors LP | 408,006 | $5.92M | 1.10% | +168,197+70.1% | Added |
| Trexquant Investment LP | 430,566 | $6.25M | 0.06% | +321,324+294.1% | Added |
| Barclays PLC | 437,001 | $6.35M | 0.00% | +11,020+2.6% | Added |
| Yiheng Capital Management, L.P. | 469,981 | $6.82M | 2.26% | 00.0% | Unchanged |
| Pictet Asset Management Holding SA | 499,162 | $7.25M | 0.01% | +84,050+20.2% | Added |