Denali Therapeutics Inc.
DNLI- Exchange
- Nasdaq
- Industry
- Biological Products, (No Diagnostic Substances)
- SEC CIK
- 0001714899
In the last 90 days, Denali Therapeutics Inc. insiders filed 0 open-market purchases and 4 sales; 294 institutions reported holding it in 13F filings for Q2 2026, worth $4.00B in total; no superinvestor holds it.
13F holders, Q2 2025
Institutional positions in Denali Therapeutics Inc. as of Jun 30, 2025. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 231
- +10 vs. Q1 2025
- Shares held
- 137.6M
- +1.67M (+1.2%) vs. Q1 2025
- Total value
- $1.93B
- +$76.1M (+4.1%) vs. Q1 2025
- New holders
- 46
- 84 more added
- Sold out
- 36
- 64 more reduced
1 institution that held it in Q1 2025 haven't filed for Q2 2025 yet. Not filing isn't selling, so they aren't counted as sold out or in the changes above.
Compare with Q1 2025: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting DNLI on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 294 | $4.00B |
| Q1 2026 | 269 | $2.82B |
| Q4 2025 | 250 | $2.50B |
| Q3 2025 | 240 | $1.97B |
| Q2 2025 | 231 | $1.93B |
| Q1 2025 | 222 | $1.85B |
| Q4 2024 | 224 | $2.61B |
| Q3 2024 | 217 | $3.69B |
| Q2 2024 | 203 | $2.88B |
| Q1 2024 | 211 | $2.51B |
| Q4 2023 | 209 | $2.47B |
| Q3 2023 | 195 | $2.24B |
| Q2 2023 | 203 | $3.18B |
| Q1 2023 | 202 | $2.49B |
| Q4 2022 | 199 | $2.94B |
| Q3 2022 | 200 | $2.84B |
| Q2 2022 | 188 | $2.73B |
| Q1 2022 | 190 | $2.79B |
| Q4 2021 | 213 | $3.80B |
| Q3 2021 | 214 | $4.28B |
| Q2 2021 | 210 | $6.32B |
| Q1 2021 | 218 | $4.60B |
Institutions, Q2 2025
Shares, value and share of portfolio for each institution holding Denali Therapeutics Inc.; share changes are against Q1 2025.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| Profund Advisors LLC | 26,723 | $373.9K | 0.01% | −1,146−4.1% | Reduced |
| Erste Asset Management GmbH | 26,900 | $379.3K | 0.00% | 00.0% | Unchanged |
| Two Sigma Advisers, LP | 27,600 | $386.1K | 0.00% | −7,700−21.8% | Reduced |
| Dark Forest Capital Management LP | 28,433 | $397.8K | 0.02% | −52,387−64.8% | Reduced |
| China Universal Asset Management Co., Ltd. | 29,178 | $408.2K | 0.04% | +50+0.2% | Added |
| Police & Firemen's Retirement System of New Jersey | 30,394 | $425.2K | 0.00% | +3,915+14.8% | Added |
| ProShare Advisors LLC | 32,582 | $455.8K | 0.00% | −879−2.6% | Reduced |
| Envestnet Asset Management Inc | 33,538 | $469.2K | 0.00% | +2,108+6.7% | Added |
| State Board of Administration of Florida Retirement System | 34,168 | $478.0K | 0.00% | 00.0% | Unchanged |
| Teacher Retirement System of Texas | 35,221 | $492.7K | 0.00% | +364+1.0% | Added |
| Dana Investment Advisors, Inc. | 35,561 | $497.5K | 0.02% | +3,406+10.6% | Added |
| ADAR1 Capital Management, LLC | 35,716 | $499.7K | 0.08% | +21,843+157.4% | Added |
| Voya Investment Management LLC | 35,908 | $502.4K | 0.00% | −15,103−29.6% | Reduced |
| Arizona State Retirement System | 38,114 | $533.2K | 0.00% | +1,002+2.7% | Added |
| Handelsbanken Fonder AB | 38,300 | $536.0K | 0.00% | 00.0% | Unchanged |
| New York State Common Retirement Fund | 38,478 | $538.3K | 0.00% | −31,762−45.2% | Reduced |
| Knights of Columbus Asset Advisors LLC | 38,479 | $538.3K | 0.03% | −1,796−4.5% | Reduced |
| Skandinaviska Enskilda Banken AB (publ) | 43,245 | $605.0K | 0.00% | 00.0% | Unchanged |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 43,587 | $609.8K | 0.00% | +3,830+9.6% | Added |
| Employees Retirement System of Texas | 43,769 | $612.0K | 0.00% | 00.0% | Unchanged |
| Pathstone Holdings, LLC | 45,040 | $630.1K | 0.00% | +6,735+17.6% | Added |
| Victory Capital Management Inc | 45,616 | $638.2K | 0.00% | +3,989+9.6% | Added |
| MAI Capital Management | 46,526 | $650.9K | 0.00% | 00.0% | Unchanged |
| Verition Fund Management LLC | 50,809 | $710.8K | 0.00% | +37,080+270.1% | Added |
| Guggenheim Capital LLC | 51,860 | $725.5K | 0.01% | −4,152−7.4% | Reduced |
| Ironwood Investment Management LLC | 53,212 | $744.4K | 0.36% | +3,907+7.9% | Added |
| Tudor Investment Corp Et Al | 55,448 | $775.7K | 0.01% | −17,149−23.6% | Reduced |
| Pier 88 Investment Partners LLC | 57,150 | $799.5K | 0.15% | +12,240+27.3% | Added |
| Creative Planning | 57,678 | $806.9K | 0.00% | +27,114+88.7% | Added |
| Janus Henderson Group PLC | 60,028 | $839.5K | 0.00% | 00.0% | Unchanged |
| DekaBank Deutsche Girozentrale | 59,800 | $841.0K | 0.00% | −4,410−6.9% | Reduced |
| Franklin Resources Inc | 64,525 | $902.7K | 0.00% | −18,723−22.5% | Reduced |
| Graham Capital Management, L.P. | 64,799 | $906.5K | 0.03% | +21,794+50.7% | Added |
| TT International Asset Management LTD | 65,000 | $909.4K | 0.18% | +65,000 | New |
| Thrivent Financial for Lutherans | 67,917 | $950.0K | 0.00% | 00.0% | Unchanged |
| Man Group plc | 70,028 | $979.7K | 0.00% | −99,357−58.7% | Reduced |
| Intech Investment Management LLC | 71,866 | $1.01M | 0.01% | −5,724−7.4% | Reduced |
| Citigroup Inc | 76,315 | $1.07M | 0.00% | −117,689−60.7% | Reduced |
| Alps Advisors Inc | 78,356 | $1.10M | 0.01% | −33,019−29.6% | Reduced |
| MetLife Investment Management | 79,075 | $1.11M | 0.01% | +4,310+5.8% | Added |
| State of Wisconsin Investment Board | 79,627 | $1.11M | 0.00% | −264−0.3% | Reduced |
| Jane Street Group, LLC | 85,332 | $1.19M | 0.00% | −128,341−60.1% | Reduced |
| Algert Global LLC | 85,840 | $1.20M | 0.03% | +85,840 | New |
| Wells Fargo & Company | 89,639 | $1.25M | 0.00% | +12,357+16.0% | Added |
| Polar Asset Management Partners Inc. | 91,600 | $1.28M | 0.03% | +70,648+337.2% | Added |
| Integrated Wealth Concepts LLC | 96,046 | $1.34M | 0.01% | +96,046 | New |
| Savvy Advisors, Inc. | 97,793 | $1.37M | 0.09% | +97,793 | New |
| Rhenman & Partners Asset Management AB | 100,000 | $1.40M | 0.18% | 00.0% | Unchanged |
| Ameriprise Financial Inc | 102,033 | $1.43M | 0.00% | +102,033 | New |
| Trexquant Investment LP | 109,242 | $1.53M | 0.02% | −3,982−3.5% | Reduced |
| Woodline Partners LP | 113,517 | $1.59M | 0.01% | 00.0% | Unchanged |
| Engineers Gate Manager LP | 116,101 | $1.62M | 0.02% | +98,903+575.1% | Added |
| California State Teachers Retirement System | 119,327 | $1.67M | 0.00% | +1,792+1.5% | Added |
| Rafferty Asset Management, LLC | 122,262 | $1.71M | 0.01% | −6,873−5.3% | Reduced |
| Legal & General Group Plc | 131,755 | $1.84M | 0.00% | −20,207−13.3% | Reduced |
| Mirae Asset Global ETFs Holdings Ltd. | 134,703 | $1.89M | 0.00% | +46,196+52.2% | Added |
| Deutsche Bank AG | 135,969 | $1.90M | 0.00% | −20,283−13.0% | Reduced |
| State of New Jersey Common Pension Fund D | 137,880 | $1.93M | 0.01% | +44,290+47.3% | Added |
| Campbell & CO Investment Adviser LLC | 142,708 | $2.00M | 0.13% | +74,523+109.3% | Added |
| Susquehanna International Group, LLP | 161,136 | $2.25M | 0.00% | −6,061−3.6% | Reduced |
| DAFNA Capital Management LLC | 168,500 | $2.36M | 0.65% | +40,600+31.7% | Added |
| Teachers Retirement System of the State of Kentucky | 171,553 | $2.40M | 0.02% | −11,839−6.5% | Reduced |
| Groupama Asset Managment | 175,531 | $2.47M | 0.04% | +31,043+21.5% | Added |
| Soleus Capital Management, L.P. | 182,110 | $2.55M | 0.18% | +47,110+34.9% | Added |
| JPMorgan Chase & Co | 191,613 | $2.68M | 0.00% | +3,210+1.7% | Added |
| Renaissance Technologies LLC | 195,700 | $2.74M | 0.00% | +22,600+13.1% | Added |
| SCS Capital Management LLC | 197,998 | $2.77M | 0.03% | 00.0% | Unchanged |
| Edmond de Rothschild Holding S.A. | 205,680 | $2.88M | 0.05% | 00.0% | Unchanged |
| Twinbeech Capital LP | 210,370 | $2.94M | 0.07% | +138,348+192.1% | Added |
| Rhumbline Advisers | 212,503 | $2.97M | 0.00% | +22,247+11.7% | Added |
| Invesco Ltd. | 219,795 | $3.07M | 0.00% | +30,368+16.0% | Added |
| Palo Alto Investors LP | 239,809 | $3.35M | 0.71% | +239,809 | New |
| Swiss National Bank | 250,900 | $3.51M | 0.00% | 00.0% | Unchanged |
| Marex Group plc | 262,000 | $3.67M | 0.07% | +262,000 | New |
| Hudson Bay Capital Management LP | 290,000 | $4.06M | 0.03% | +40,000+16.0% | Added |
| AXA S.A. | 293,853 | $4.11M | 0.01% | +472+0.2% | Added |
| Pier Capital, LLC | 314,796 | $4.40M | 0.67% | −20,708−6.2% | Reduced |
| Manufacturers Life Insurance Company, The | 315,102 | $4.41M | 0.00% | +56,970+22.1% | Added |
| American Century Companies Inc | 318,193 | $4.45M | 0.00% | −31,227−8.9% | Reduced |
| Edgestream Partners, L.P. | 342,923 | $4.80M | 0.13% | +342,923 | New |
| Clarius Group, LLC | 368,995 | $5.16M | 0.30% | 00.0% | Unchanged |
| Schroder Investment Management Group | 386,539 | $5.41M | 0.00% | +94,744+32.5% | Added |
| Royal Bank of Canada | 390,155 | $5.46M | 0.00% | +375,719+2,602.7% | Added |
| Cubist Systematic Strategies, LLC | 396,586 | $5.55M | 0.06% | +396,586 | New |
| Camber Capital Management LP | 400,000 | $5.60M | 0.78% | −850,000−68.0% | Reduced |
| Holocene Advisors, LP | 403,172 | $5.64M | 0.01% | +403,172 | New |
| Pictet Asset Management Holding SA | 415,112 | $5.85M | 0.01% | +71,153+20.7% | Added |
| Barclays PLC | 425,981 | $5.96M | 0.00% | +185,333+77.0% | Added |
| Yiheng Capital Management, L.P. | 469,981 | $6.58M | 2.38% | 00.0% | Unchanged |
| Ensign Peak Advisors, Inc | 473,695 | $6.63M | 0.01% | −114,090−19.4% | Reduced |
| TD Asset Management Inc | 496,290 | $6.94M | 0.01% | +187,710+60.8% | Added |
| Segall Bryant & Hamill, LLC | 500,559 | $7.00M | 0.10% | +219,420+78.0% | Added |
| Nuveen, LLC | 595,217 | $8.33M | 0.00% | +272,272+84.3% | Added |
| Masters Capital Management LLC | 600,000 | $8.39M | 1.62% | +600,000 | New |
| Cercano Management LLC | 625,000 | $8.74M | 0.25% | 00.0% | Unchanged |
| Bank of America Corp | 650,222 | $9.10M | 0.00% | +202,465+45.2% | Added |
| StemPoint Capital LP | 707,915 | $9.90M | 3.19% | +40,837+6.1% | Added |
| Voloridge Investment Management, LLC | 770,527 | $10.8M | 0.04% | +468,554+155.2% | Added |
| Bank of New York Mellon Corp | 790,756 | $11.1M | 0.00% | −313,136−28.4% | Reduced |
| Siren, L.L.C. | 821,513 | $11.5M | 0.59% | 00.0% | Unchanged |