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Denali Therapeutics Inc.

DNLI
Exchange
Nasdaq
Industry
Biological Products, (No Diagnostic Substances)
SEC CIK
0001714899

In the last 90 days, Denali Therapeutics Inc. insiders filed 0 open-market purchases and 4 sales; 294 institutions reported holding it in 13F filings for Q2 2026, worth $4.00B in total; no superinvestor holds it.

13F holders, Q4 2024

Institutional positions in Denali Therapeutics Inc. as of Dec 31, 2024. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works

Institutional holders
224
+9 vs. Q3 2024
Shares held
127.9M
+1.24M (+1.0%) vs. Q3 2024
Total value
$2.61B
−$1.08B (−29.3%) vs. Q3 2024
New holders
41
87 more added
Sold out
32
59 more reduced

2 institutions that held it in Q3 2024 haven't filed for Q4 2024 yet. Not filing isn't selling, so they aren't counted as sold out or in the changes above.

Compare with Q3 2024: new holders, sold out and not filed yet

Holders and value by quarter

Institutions reporting DNLI on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.

Institutional holdersQ4 2024: 224 institutions
Q1 2021: 218 institutionsQ2 2021: 210 institutionsQ3 2021: 214 institutionsQ4 2021: 213 institutionsQ1 2022: 190 institutionsQ2 2022: 188 institutionsQ3 2022: 200 institutionsQ4 2022: 199 institutionsQ1 2023: 202 institutionsQ2 2023: 203 institutionsQ3 2023: 195 institutionsQ4 2023: 209 institutionsQ1 2024: 211 institutionsQ2 2024: 203 institutionsQ3 2024: 217 institutionsQ4 2024: 224 institutionsQ1 2025: 222 institutionsQ2 2025: 231 institutionsQ3 2025: 240 institutionsQ4 2025: 250 institutionsQ1 2026: 269 institutionsQ2 2026: 294 institutions
Value heldQ4 2024: $2.61B
Q1 2021: $4.60BQ2 2021: $6.32BQ3 2021: $4.28BQ4 2021: $3.80BQ1 2022: $2.79BQ2 2022: $2.73BQ3 2022: $2.84BQ4 2022: $2.94BQ1 2023: $2.49BQ2 2023: $3.18BQ3 2023: $2.24BQ4 2023: $2.47BQ1 2024: $2.51BQ2 2024: $2.88BQ3 2024: $3.69BQ4 2024: $2.61BQ1 2025: $1.85BQ2 2025: $1.93BQ3 2025: $1.97BQ4 2025: $2.50BQ1 2026: $2.82BQ2 2026: $4.00B
Institutions holding DNLI and their total value by quarter
QuarterHoldersValue
Q2 2026294$4.00B
Q1 2026269$2.82B
Q4 2025250$2.50B
Q3 2025240$1.97B
Q2 2025231$1.93B
Q1 2025222$1.85B
Q4 2024224$2.61B
Q3 2024217$3.69B
Q2 2024203$2.88B
Q1 2024211$2.51B
Q4 2023209$2.47B
Q3 2023195$2.24B
Q2 2023203$3.18B
Q1 2023202$2.49B
Q4 2022199$2.94B
Q3 2022200$2.84B
Q2 2022188$2.73B
Q1 2022190$2.79B
Q4 2021213$3.80B
Q3 2021214$4.28B
Q2 2021210$6.32B
Q1 2021218$4.60B

Institutions, Q4 2024

Shares, value and share of portfolio for each institution holding Denali Therapeutics Inc.; share changes are against Q3 2024.

Institutions holding DNLI in Q4 2024
InstitutionSharesValue% of portfolioChange in sharesAction
Rothschild Investment LLC100$2.04K0.00%−50−33.3%Reduced
Your Advocates Ltd., LLP100$2.04K0.00%00.0%Unchanged
Parallel Advisors, LLC99$2.02K0.00%−13−11.6%Reduced
Bessemer Group Inc110$2.00K0.00%00.0%Unchanged
Sherman Asset Management, Inc.94$1.92K0.00%+94New
Amundi85$1.81K0.00%+85New
Vista Private Wealth Partners. LLC80$1.63K0.00%+80New
Bell Investment Advisors, Inc52$1.06K0.00%00.0%Unchanged
Farther Finance Advisors, LLC35$7130.00%−72−67.3%Reduced
CVA Family Office, LLC30$6110.00%00.0%Unchanged
Steward Partners Investment Advisory, LLC25$5100.00%+25New
First Horizon Advisors, Inc.25$5090.00%00.0%Unchanged
Cassady Schiller Wealth Management, LLC18$3670.00%+18New
Principal Securities, Inc.14$2850.00%−9−39.1%Reduced
Hexagon Capital Partners LLC12$2450.00%+12New
Allworth Financial LP10$2340.00%+10New
WealthTrak Capital Management LLC10$2040.00%+10New
National Bank of Canada7$1430.00%−27−79.4%Reduced
SBI Securities Co., Ltd.5$1020.00%+5New
Global Retirement Partners, LLC3$610.00%00.0%Unchanged
Global Financial Private Client, LLC2$410.00%+2New
IFP Advisors, Inc1$200.00%+1New
Sandy Spring Bank0$100.00%0New
Hemington Wealth Management11$00.00%+8+266.7%Added
Nomura Asset Management Co Ltd0$00.00%−65,033−100.0%Sold out
Wasatch Advisors Inc0$00.00%−238,881−100.0%Sold out
AIA Group Ltd0$00.00%−74,815−100.0%Sold out
Northwest & Ethical Investments L.P.0$00.00%−68,643−100.0%Sold out
Bank of Montreal0$00.00%−42,259−100.0%Sold out
NEOS Investment Management LLC0$00.00%−21,648−100.0%Sold out
Options Solutions, LLC0$00.00%−17,611−100.0%Sold out
HRT Financial LP0$00.00%−16,943−100.0%Sold out
AQR Capital Management LLC0$00.00%−16,018−100.0%Sold out
Cowen and Company, LLC0$00.00%−15,800−100.0%Sold out
Letko, Brosseau & Associates Inc0$00.00%−11,350−100.0%Sold out
nVerses Capital, LLC0$00.00%−9,900−100.0%Sold out
Stifel Financial Corp0$00.00%−9,839−100.0%Sold out
Integrated Advisors Network LLC0$00.00%−9,710−100.0%Sold out
Mackenzie Financial Corp0$00.00%−8,256−100.0%Sold out
Xponance, Inc.0$00.00%−8,135−100.0%Sold out
Life Line Wealth Management LLC0$00.00%−7,812−100.0%Sold out
Breakwater Capital Group0$00.00%−7,642−100.0%Sold out
Colony Group, LLC0$00.00%−7,597−100.0%Sold out
Allspring Global Investments Holdings, LLC0$00.00%−5,676−100.0%Sold out
Point72 Asia (Singapore) Pte. Ltd.0$00.00%−3,764−100.0%Sold out
Simplex Trading, LLC0$00.00%−3,475−100.0%Sold out
Acadian Asset Management LLC0$00.00%−2,749−100.0%Sold out
Catalyst Funds Management Pty Ltd0$00.00%−2,000−100.0%Sold out
Group One Trading, L.P.0$00.00%−1,691−100.0%Sold out
NBC Securities, Inc.0$00.00%−532−100.0%Sold out
Capital Performance Advisors LLP0$00.00%−63−100.0%Sold out
Ronald Blue Trust, Inc.0$00.00%−72−100.0%Sold out
AdvisorNet Financial, Inc0$00.00%−40−100.0%Sold out
Bokf, NA0$00.00%−18−100.0%Sold out
Toronto Dominion Bank0$00.00%−2−100.0%Sold out
Avion Wealth0$00.00%−25−100.0%Sold out
Concentric Wealth Management, LLC––––Not filed
ClariVest Asset Management LLC––––Not filed