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Denali Therapeutics Inc.

DNLI
Exchange
Nasdaq
Industry
Biological Products, (No Diagnostic Substances)
SEC CIK
0001714899

In the last 90 days, Denali Therapeutics Inc. insiders filed 0 open-market purchases and 4 sales; 294 institutions reported holding it in 13F filings for Q2 2026, worth $4.00B in total; no superinvestor holds it.

13F holders, Q2 2021

Institutional positions in Denali Therapeutics Inc. as of Jun 30, 2021. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works

Institutional holders
210
−7 vs. Q1 2021
Shares held
80.6M
+149.8K (+0.2%) vs. Q1 2021
Total value
$6.32B
+$1.72B (+37.5%) vs. Q1 2021
New holders
34
81 more added
Sold out
41
59 more reduced

1 institution that held it in Q1 2021 haven't filed for Q2 2021 yet. Not filing isn't selling, so they aren't counted as sold out or in the changes above.

Compare with Q1 2021: new holders, sold out and not filed yet

Holders and value by quarter

Institutions reporting DNLI on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.

Institutional holdersQ2 2021: 210 institutions
Q1 2021: 218 institutionsQ2 2021: 210 institutionsQ3 2021: 214 institutionsQ4 2021: 213 institutionsQ1 2022: 190 institutionsQ2 2022: 188 institutionsQ3 2022: 200 institutionsQ4 2022: 199 institutionsQ1 2023: 202 institutionsQ2 2023: 203 institutionsQ3 2023: 195 institutionsQ4 2023: 209 institutionsQ1 2024: 211 institutionsQ2 2024: 203 institutionsQ3 2024: 217 institutionsQ4 2024: 224 institutionsQ1 2025: 222 institutionsQ2 2025: 231 institutionsQ3 2025: 240 institutionsQ4 2025: 250 institutionsQ1 2026: 269 institutionsQ2 2026: 294 institutions
Value heldQ2 2021: $6.32B
Q1 2021: $4.60BQ2 2021: $6.32BQ3 2021: $4.28BQ4 2021: $3.80BQ1 2022: $2.79BQ2 2022: $2.73BQ3 2022: $2.84BQ4 2022: $2.94BQ1 2023: $2.49BQ2 2023: $3.18BQ3 2023: $2.24BQ4 2023: $2.47BQ1 2024: $2.51BQ2 2024: $2.88BQ3 2024: $3.69BQ4 2024: $2.61BQ1 2025: $1.85BQ2 2025: $1.93BQ3 2025: $1.97BQ4 2025: $2.50BQ1 2026: $2.82BQ2 2026: $4.00B
Institutions holding DNLI and their total value by quarter
QuarterHoldersValue
Q2 2026294$4.00B
Q1 2026269$2.82B
Q4 2025250$2.50B
Q3 2025240$1.97B
Q2 2025231$1.93B
Q1 2025222$1.85B
Q4 2024224$2.61B
Q3 2024217$3.69B
Q2 2024203$2.88B
Q1 2024211$2.51B
Q4 2023209$2.47B
Q3 2023195$2.24B
Q2 2023203$3.18B
Q1 2023202$2.49B
Q4 2022199$2.94B
Q3 2022200$2.84B
Q2 2022188$2.73B
Q1 2022190$2.79B
Q4 2021213$3.80B
Q3 2021214$4.28B
Q2 2021210$6.32B
Q1 2021218$4.60B

Institutions, Q2 2021

Shares, value and share of portfolio for each institution holding Denali Therapeutics Inc.; share changes are against Q1 2021.

Institutions holding DNLI in Q2 2021
InstitutionSharesValue% of portfolioChange in sharesAction
Virginia Retirement Systems Et Al22,200$1.74M0.02%+1,600+7.8%Added
Arizona State Retirement System21,188$1.66M0.01%−1,502−6.6%Reduced
ExodusPoint Capital Management, LP20,959$1.64M0.03%+20,959New
Public Employees Retirement System of Ohio20,201$1.58M0.01%00.0%Unchanged
Connor, Clark & Lunn Investment Management Ltd.19,993$1.57M0.01%−17,913−47.3%Reduced
Millennium Management LLC19,443$1.52M0.00%+4,731+32.2%Added
Concentric Wealth Management, LLC19,346$1.52M0.46%−5,092−20.8%Reduced
Susquehanna International Group, LLP19,225$1.51M0.00%+4,101+27.1%Added
Ironwood Investment Management LLC19,074$1.50M0.76%−446−2.3%Reduced
Squarepoint Ops LLC18,350$1.44M0.01%+13,022+244.4%Added
Handelsbanken Fonder AB18,000$1.41M0.01%−200−1.1%Reduced
SG Americas Securities, LLC17,270$1.35M0.01%−9,908−36.5%Reduced
Hillsdale Investment Management Inc.17,200$1.35M0.11%−1,000−5.5%Reduced
Amalgamated Bank17,181$1.35M0.01%+8,228+91.9%Added
Cubist Systematic Strategies, LLC15,068$1.18M0.01%−68,573−82.0%Reduced
Vontobel Holding Ltd.14,254$1.12M0.01%+254+1.8%Added
Pier 88 Investment Partners LLC14,120$1.11M0.32%+6,560+86.8%Added
Stifel Financial Corp13,050$1.02M0.00%+84+0.6%Added
Marshall Wace North America L.P.12,915$1.01M0.00%−263,011−95.3%Reduced
Utah Retirement Systems12,500$981.0K0.01%+3,800+43.7%Added
Public Employees Retirement Association of Colorado12,238$960.0K0.00%00.0%Unchanged
DuPont Capital Management Corp12,111$950.0K0.02%+12,111New
Capital Fund Management S.A.11,801$925.7K0.02%−40,518−77.4%Reduced
Renaissance Technologies LLC11,500$902.0K0.00%−254,400−95.7%Reduced
Royal Bank of Canada11,364$892.0K0.00%−24,617−68.4%Reduced
Teacher Retirement System of Texas10,259$805.0K0.00%+1,526+17.5%Added
Gotham Asset Management, LLC9,539$748.0K0.03%−15,702−62.2%Reduced
Zurcher Kantonalbank (Zurich Cantonalbank)8,837$693.0K0.00%−446−4.8%Reduced
SEI Investments Co8,611$675.0K0.00%−11,119−56.4%Reduced
Brandywine Managers, LLC8,551$671.0K0.77%+8,551New
GAM Holding AG8,403$659.0K0.03%+3,903+86.7%Added
Zebra Capital Management LLC8,043$631.0K0.74%−869−9.8%Reduced
Jacobs Levy Equity Management, Inc7,679$602.0K0.00%−37,617−83.0%Reduced
Bellecapital International Ltd.7,644$600.0K0.18%00.0%Unchanged
Nomura Asset Management Co Ltd7,210$565.5K0.00%00.0%Unchanged
Rockefeller Capital Management L.P.7,207$564.0K0.00%+2,817+64.2%Added
Ameritas Investment Partners, Inc.7,134$560.0K0.02%+2,019+39.5%Added
O'Shaughnessy Asset Management, LLC7,055$553.0K0.01%−838−10.6%Reduced
Raymond James & Associates6,389$501.0K0.00%−1,096−14.6%Reduced
Nisa Investment Advisors, LLC6,194$486.0K0.00%−100−1.6%Reduced
Brown Brothers Harriman & Co6,053$475.0K0.00%+5,000+474.8%Added
BNP Paribas Arbitrage, SA6,048$474.4K0.00%−4,854−44.5%Reduced
Engineers Gate Manager LP6,030$473.0K0.03%−8,550−58.6%Reduced
JustInvest LLC6,012$472.0K0.05%+6,012New
Mirae Asset Global Investments Co., Ltd.5,856$460.0K0.00%+5,856New
Man Group plc5,464$429.0K0.00%−53,061−90.7%Reduced
Blair William & Co5,100$400.0K0.00%00.0%Unchanged
Walled Lake Planning & Wealth Management, LLC5,020$394.0K0.26%00.0%Unchanged
Xponance, Inc.5,014$393.0K0.01%+5,014New
Saturna Capital CORP5,000$392.0K0.01%00.0%Unchanged
Beacon Investment Advisory Services, Inc.5,000$392.0K0.02%00.0%Unchanged
Prelude Capital Management, LLC4,983$391.0K0.02%+4,983New
PDT Partners, LLC4,734$371.0K0.02%−17,531−78.7%Reduced
Tower Research Capital LLC (TRC)4,527$355.0K0.01%−3,135−40.9%Reduced
Great West Life Assurance Co4,462$350.0K0.00%−441−9.0%Reduced
Illinois Municipal Retirement Fund4,450$349.0K0.01%00.0%Unchanged
CIBC Asset Management Inc4,438$348.0K0.00%00.0%Unchanged
Jane Street Group, LLC4,313$338.0K0.00%−8,668−66.8%Reduced
Quantitative Systematic Strategies LLC4,301$337.0K0.12%−6,699−60.9%Reduced
Raymond James Financial Services Advisors, Inc.4,252$334.0K0.00%−80−1.8%Reduced
Clarius Group, LLC4,133$324.0K0.03%+4,133New
Altfest L J & Co Inc4,064$319.0K0.07%+58+1.4%Added
Broderick Brian C4,000$314.0K0.08%00.0%Unchanged
Commonwealth Equity Services, LLC3,969$311.0K0.00%00.0%Unchanged
Mackenzie Financial Corp3,925$308.0K0.00%+3,925New
Sargent Investment Group, LLC3,817$299.0K0.07%+3,817New
Arthur M. Cohen & Associates, LLC3,408$267.0K0.05%+3,408New
LPL Financial LLC3,266$256.0K0.00%+3,266New
Aigen Investment Management, LP3,243$254.0K0.04%−322−9.0%Reduced
Amundi3,017$237.0K0.00%+3,017New
Grace Capital3,000$235.0K0.16%00.0%Unchanged
Compagnie Lombard Odier SCmA3,000$235.0K0.01%00.0%Unchanged
Fernwood Investment Management, LLC3,000$235.0K0.08%+3,000New
Virtus ETF Advisers LLC2,980$234.0K0.10%−664−18.2%Reduced
Plancorp, LLC2,900$227.0K0.02%+2,900New
Meeder Asset Management Inc2,747$215.0K0.01%+306+12.5%Added
Connable Office Inc2,699$212.0K0.03%+2,699New
Profund Advisors LLC2,671$210.0K0.01%+2,671New
Toroso Investments, LLC2,576$202.0K0.01%+2,576New
UBS Group AG2,437$191.0K0.00%−27,792−91.9%Reduced
Islay Capital Management, LLC2,013$158.0K0.13%+2,013New
Advisory Services Network, LLC1,922$151.0K0.00%−1,717−47.2%Reduced
Bartlett & Co. LLC1,500$118.0K0.00%00.0%Unchanged
Bartlett & Co. Wealth Management LLC1,500$117.7K0.00%00.0%Unchanged
Quantbot Technologies LP1,306$102.0K0.01%−5,823−81.7%Reduced
Group One Trading, L.P.1,193$94.0K0.00%+1,193New
The PNC Financial Services Group, Inc.929$73.0K0.00%+12+1.3%Added
Advisor Group Holdings, Inc.698$54.0K0.00%−135−16.2%Reduced
Sonora Investment Management, LLC619$49.0K0.01%+619New
Brewin Dolphin Ltd500$39.2K0.00%00.0%Unchanged
Asset Management One Co.,Ltd.500$39.0K0.00%+500New
US Bancorp478$37.0K0.00%+12+2.6%Added
Patriot Financial Group Insurance Agency, LLC399$31.0K0.01%+49+14.0%Added
Itau Unibanco Holding S.A.369$29.0K0.00%+369New
State of Wyoming337$26.0K0.02%+60+21.7%Added
Daiwa Securities Group Inc.240$19.0K0.00%00.0%Unchanged
Hoover Financial Advisors, Inc.200$16.0K0.00%00.0%Unchanged
First Manhattan Co200$15.0K0.00%00.0%Unchanged
Sargent Bickham Lagudis LLC165$13.0K0.00%00.0%Unchanged
Bedel Financial Consulting, Inc.154$12.0K0.00%00.0%Unchanged