Definium Therapeutics, Inc.
DFTX- Exchange
- Nasdaq
- Industry
- Medicinal Chemicals & Botanical Products
- SEC CIK
- 0001813814
In the last 90 days, Definium Therapeutics, Inc. insiders filed 0 open-market purchases and 1 sale; 362 institutions reported holding it in 13F filings for Q2 2026, worth $5.35B in total; Duquesne Family Office is the only superinvestor holding it.
13F holders, Q2 2026
Institutional positions in Definium Therapeutics, Inc. as of Jun 30, 2026. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 362
- +119 vs. Q1 2026
- Shares held
- 114.8M
- +40.3M (+54.1%) vs. Q1 2026
- Total value
- $5.35B
- +$3.94B (+280.1%) vs. Q1 2026
- New holders
- 148
- 117 more added
- Sold out
- 29
- 64 more reduced
5 institutions that held it in Q1 2026 haven't filed for Q2 2026 yet. Not filing isn't selling, so they aren't counted as sold out or in the changes above.
Compare with Q1 2026: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting DFTX on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 362 | $5.35B |
| Q1 2026 | 248 | $1.47B |
| Q4 2025 | 209 | $908.7M |
| Q3 2025 | 196 | $468.6M |
| Q2 2025 | 183 | $271.0M |
| Q1 2025 | 191 | $240.5M |
| Q4 2024 | 174 | $288.9M |
| Q3 2024 | 158 | $281.6M |
| Q2 2024 | 152 | $299.3M |
| Q1 2024 | 135 | $327.2M |
| Q4 2023 | 104 | $17.9M |
| Q3 2023 | 93 | $12.1M |
| Q2 2023 | 84 | $13.9M |
| Q1 2023 | 89 | $12.6M |
| Q4 2022 | 104 | $11.1M |
| Q3 2022 | 101 | $20.5M |
| Q2 2022 | 156 | $15.1M |
| Q1 2022 | 159 | $53.6M |
| Q4 2021 | 176 | $72.0M |
| Q3 2021 | 175 | $104.8M |
| Q2 2021 | 156 | $131.0M |
| Q1 2021 | 8 | $932.0K |
Institutions, Q2 2026
Shares, value and share of portfolio for each institution holding Definium Therapeutics, Inc.; share changes are against Q1 2026.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| JPMorgan Chase & Co | 265,955 | $12.4M | 0.00% | +1,410+0.5% | Added |
| Millennium Management LLC | 266,076 | $12.5M | 0.01% | −580,820−68.6% | Reduced |
| Polygon Management Ltd. | 286,990 | $13.5M | 2.20% | +86,996+43.5% | Added |
| D. E. Shaw & Co., Inc. | 315,410 | $14.8M | 0.01% | +43,693+16.1% | Added |
| Duquesne Family Office LLCSuperinvestorDuquesne Family Office | 356,600 | $16.8M | 0.39% | +356,600 | New |
| OrbiMed Advisors LLC | 365,400 | $17.2M | 0.33% | −438,600−54.6% | Reduced |
| Assetmark, Inc | 396,542 | $18.7M | 0.03% | +396,542 | New |
| RTW Investments, LP | 400,000 | $18.8M | 0.16% | +100,000+33.3% | Added |
| Cormorant Asset Management, LP | 400,000 | $18.8M | 0.96% | +400,000 | New |
| Silverarc Capital Management, LLC | 400,000 | $18.8M | 2.09% | +400,000 | New |
| Great Point Partners LLC | 425,000 | $20.0M | 4.71% | +425,000 | New |
| Morgan Stanley | 454,912 | $21.4M | 0.00% | +16,339+3.7% | Added |
| Ensign Peak Advisors, Inc | 466,106 | $21.9M | 0.04% | −80,677−14.8% | Reduced |
| Point72 Asset Management, L.P. | 483,980 | $22.8M | 0.03% | +308,490+175.8% | Added |
| Franklin Resources Inc | 486,219 | $22.9M | 0.00% | +486,219 | New |
| UBS Group AG | 499,467 | $23.5M | 0.00% | +5,490+1.1% | Added |
| Bamco Inc | 520,108 | $24.5M | 0.04% | +520,108 | New |
| Integral Health Asset Management, LLC | 550,000 | $25.9M | 1.06% | +150,000+37.5% | Added |
| Blackstone Group Inc. | 561,612 | $26.4M | 0.09% | +52,944+10.4% | Added |
| Catalio Capital Management, LP | 562,672 | $26.5M | 4.97% | −475,312−45.8% | Reduced |
| ArrowMark Colorado Holdings LLC | 564,069 | $26.5M | 1.10% | −1,030,648−64.6% | Reduced |
| Candriam Luxembourg S.C.A. | 614,425 | $28.9M | 0.13% | −679,204−52.5% | Reduced |
| Qube Research & Technologies Ltd | 682,901 | $32.1M | 0.04% | +256,846+60.3% | Added |
| Neuberger Berman Group LLC | 687,539 | $32.3M | 0.02% | +554,170+415.5% | Added |
| Eventide Asset Management, LLC | 710,000 | $33.4M | 0.45% | +23,838+3.5% | Added |
| Alliancebernstein L.P. | 1,803,287 | $34.1M | 0.01% | +1,711,584+1,866.4% | Added |
| Polar Capital Holdings Plc | 777,253 | $36.6M | 0.10% | +777,253 | New |
| Bank of New York Mellon Corp | 777,271 | $36.6M | 0.01% | +24,349+3.2% | Added |
| AWM Investment Company, Inc. | 784,800 | $36.9M | 3.20% | −292,093−27.1% | Reduced |
| Holocene Advisors, LP | 796,574 | $37.5M | 0.09% | −295,393−27.1% | Reduced |
| Vanguard Fiduciary Trust Co | 827,693 | $38.9M | 0.01% | +251,756+43.7% | Added |
| Balyasny Asset Management LLC | 897,658 | $42.2M | 0.08% | −376,563−29.6% | Reduced |
| Two Sigma Investments, LP | 921,818 | $43.4M | 0.03% | −279,792−23.3% | Reduced |
| Boxer Capital Management, LLC | 998,500 | $47.0M | 3.54% | +400,000+66.8% | Added |
| Adage Capital Partners GP, L.L.C. | 1,000,000 | $47.0M | 0.07% | −150,000−13.0% | Reduced |
| Woodline Partners LP | 1,003,641 | $47.2M | 0.15% | +250,849+33.3% | Added |
| Charles Schwab Investment Management Inc | 1,083,576 | $51.0M | 0.01% | +274,861+34.0% | Added |
| Nuveen, LLC | 1,105,314 | $52.0M | 0.01% | +407,184+58.3% | Added |
| Ameriprise Financial Inc | 1,148,363 | $54.0M | 0.01% | +181,755+18.8% | Added |
| Northern Trust Corp | 1,169,238 | $55.0M | 0.01% | +370,251+46.3% | Added |
| Marshall Wace, LLP | 1,298,946 | $61.1M | 0.05% | +98,121+8.2% | Added |
| Siren, L.L.C. | 1,419,493 | $66.8M | 1.36% | +500,000+54.4% | Added |
| Vanguard Capital Management LLC | 1,486,454 | $69.9M | 0.00% | +389,476+35.5% | Added |
| Ra Capital Management, L.P. | 1,500,000 | $70.6M | 0.61% | +1,500,000 | New |
| Vanguard Portfolio Management LLC | 1,648,426 | $77.5M | 0.00% | +775,761+88.9% | Added |
| Citadel Advisors LLC | 1,688,587 | $79.4M | 0.05% | +355,145+26.6% | Added |
| Goldman Sachs Group Inc | 1,800,852 | $84.7M | 0.01% | +125,441+7.5% | Added |
| Commodore Capital LP | 2,000,000 | $94.1M | 5.60% | 00.0% | Unchanged |
| Deep Track Capital, LP | 2,750,000 | $129.4M | 1.91% | −250,000−8.3% | Reduced |
| Wellington Management Group LLP | 2,949,734 | $138.8M | 0.02% | +1,644,985+126.1% | Added |
| Octagon Capital Advisors LP | 2,950,000 | $138.8M | 12.74% | +510,000+20.9% | Added |
| Capital International Investors | 2,963,410 | $139.4M | 0.03% | +2,963,410 | New |
| State Street Corp | 3,065,390 | $144.2M | 0.00% | +593,517+24.0% | Added |
| Geode Capital Management, LLC | 3,644,813 | $171.5M | 0.01% | +1,149,414+46.1% | Added |
| Price T Rowe Associates Inc | 4,652,032 | $218.8M | 0.02% | +4,582,031+6,545.7% | Added |
| FMR LLC | 4,752,921 | $223.6M | 0.01% | +2,943,311+162.6% | Added |
| Capital World Investors | 5,367,723 | $252.5M | 0.03% | +5,367,723 | New |
| Jupiter Topco LLC | 5,615,645 | $264.0M | 0.11% | +5,615,645 | New |
| Driehaus Capital Management LLC | 6,845,276 | $322.0M | 1.87% | +933,387+15.8% | Added |
| Avoro Capital Advisors LLC | 7,188,888 | $338.2M | 3.04% | +2,188,888+43.8% | Added |
| BlackRock, Inc. | 11,232,834 | $528.4M | 0.01% | +2,752,604+32.5% | Added |
| Coppell Advisory Solutions LLC | 1 | – | – | +1 | New |
| Trails Edge Capital Partners, LP | 0 | $0 | 0.00% | −1,738,110−100.0% | Sold out |
| Patient Square Capital LP | 0 | $0 | 0.00% | −331,000−100.0% | Sold out |
| Jane Street Group, LLC | 0 | $0 | 0.00% | −260,241−100.0% | Sold out |
| Soviero Asset Management, LP | 0 | $0 | 0.00% | −140,000−100.0% | Sold out |
| Squarepoint Ops LLC | 0 | $0 | 0.00% | −125,522−100.0% | Sold out |
| Rosalind Advisors, Inc. | 0 | $0 | 0.00% | −125,000−100.0% | Sold out |
| ExodusPoint Capital Management, LP | 0 | $0 | 0.00% | −104,915−100.0% | Sold out |
| HRT Financial LP | 0 | $0 | 0.00% | −89,141−100.0% | Sold out |
| Ikarian Capital, LLC | 0 | $0 | 0.00% | −58,803−100.0% | Sold out |
| Twinbeech Capital LP | 0 | $0 | 0.00% | −42,100−100.0% | Sold out |
| Caxton Associates LLP | 0 | $0 | 0.00% | −37,255−100.0% | Sold out |
| Campbell & CO Investment Adviser LLC | 0 | $0 | 0.00% | −24,755−100.0% | Sold out |
| Virtu Financial LLC | 0 | $0 | 0.00% | −14,460−100.0% | Sold out |
| Boothbay Fund Management, LLC | 0 | $0 | 0.00% | −14,096−100.0% | Sold out |
| Fox Run Management, L.L.C. | 0 | $0 | 0.00% | −14,557−100.0% | Sold out |
| Magnetar Financial LLC | 0 | $0 | 0.00% | −13,178−100.0% | Sold out |
| Summit Trail Advisors, LLC | 0 | $0 | 0.00% | −13,000−100.0% | Sold out |
| RPS Advisory Solutions LLC | 0 | $0 | 0.00% | −11,355−100.0% | Sold out |
| Dynamic Technology Lab Private Ltd | 0 | $0 | 0.00% | −10,880−100.0% | Sold out |
| Verition Fund Management LLC | 0 | $0 | 0.00% | −10,384−100.0% | Sold out |
| Sound Income Strategies, LLC | 0 | $0 | 0.00% | −3,690−100.0% | Sold out |
| Advisory Services Network, LLC | 0 | $0 | 0.00% | −2,659−100.0% | Sold out |
| Opal Wealth Advisors, LLC | 0 | $0 | 0.00% | −1,101−100.0% | Sold out |
| Private Wealth Management Group, LLC | 0 | $0 | 0.00% | −450−100.0% | Sold out |
| Meeder Asset Management Inc | 0 | $0 | 0.00% | −353−100.0% | Sold out |
| Federated Hermes, Inc. | 0 | $0 | 0.00% | −207−100.0% | Sold out |
| Louisbourg Investments Inc. | 0 | $0 | 0.00% | −52−100.0% | Sold out |
| RMG Wealth Management LLC | 0 | $0 | 0.00% | −30−100.0% | Sold out |
| CoreCap Advisors, LLC | 0 | $0 | 0.00% | −5−100.0% | Sold out |
| Janus Henderson Group PLC | – | – | – | – | Not filed |
| CWM, LLC | – | – | – | – | Not filed |
| Sunbelt Securities, Inc. | – | – | – | – | Not filed |
| Anfield Capital Management, LLC | – | – | – | – | Not filed |
| Sofos Investments, Inc. | – | – | – | – | Not filed |