Definium Therapeutics, Inc.
DFTX- Exchange
- Nasdaq
- Industry
- Medicinal Chemicals & Botanical Products
- SEC CIK
- 0001813814
In the last 90 days, Definium Therapeutics, Inc. insiders filed 0 open-market purchases and 1 sale; 362 institutions reported holding it in 13F filings for Q2 2026, worth $5.35B in total; Duquesne Family Office is the only superinvestor holding it.
13F holders, Q4 2025
Institutional positions in Definium Therapeutics, Inc. as of Dec 31, 2025. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 209
- +20 vs. Q3 2025
- Shares held
- 67.9M
- +28.3M (+71.7%) vs. Q3 2025
- Total value
- $908.7M
- +$442.6M (+95.0%) vs. Q3 2025
- New holders
- 50
- 92 more added
- Sold out
- 30
- 31 more reduced
7 institutions that held it in Q3 2025 haven't filed for Q4 2025 yet. Not filing isn't selling, so they aren't counted as sold out or in the changes above.
Compare with Q3 2025: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting DFTX on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 362 | $5.35B |
| Q1 2026 | 248 | $1.47B |
| Q4 2025 | 209 | $908.7M |
| Q3 2025 | 196 | $468.6M |
| Q2 2025 | 183 | $271.0M |
| Q1 2025 | 191 | $240.5M |
| Q4 2024 | 174 | $288.9M |
| Q3 2024 | 158 | $281.6M |
| Q2 2024 | 152 | $299.3M |
| Q1 2024 | 135 | $327.2M |
| Q4 2023 | 104 | $17.9M |
| Q3 2023 | 93 | $12.1M |
| Q2 2023 | 84 | $13.9M |
| Q1 2023 | 89 | $12.6M |
| Q4 2022 | 104 | $11.1M |
| Q3 2022 | 101 | $20.5M |
| Q2 2022 | 156 | $15.1M |
| Q1 2022 | 159 | $53.6M |
| Q4 2021 | 176 | $72.0M |
| Q3 2021 | 175 | $104.8M |
| Q2 2021 | 156 | $131.0M |
| Q1 2021 | 8 | $932.0K |
Institutions, Q4 2025
Shares, value and share of portfolio for each institution holding Definium Therapeutics, Inc.; share changes are against Q3 2025.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| Rafferty Asset Management, LLC | 18,885 | $252.9K | 0.00% | +6,210+49.0% | Added |
| ExodusPoint Capital Management, LP | 18,948 | $253.7K | 0.00% | +18,948 | New |
| Marex Group plc | 20,000 | $267.8K | 0.00% | +20,000 | New |
| Mariner, LLC | 20,166 | $270.7K | 0.00% | +2,082+11.5% | Added |
| EntryPoint Capital, LLC | 20,219 | $270.7K | 0.11% | +20,219 | New |
| Mercer Global Advisors Inc | 20,392 | $273.0K | 0.00% | −1,539−7.0% | Reduced |
| Concurrent Investment Advisors, LLC | 20,397 | $273.1K | 0.00% | +20,397 | New |
| Raymond James Financial Inc | 21,121 | $282.8K | 0.00% | +3,329+18.7% | Added |
| Virtus Investment Advisers, Inc. | 21,198 | $283.8K | 0.08% | +5,611+36.0% | Added |
| ProShare Advisors LLC | 21,539 | $288.4K | 0.00% | +5,947+38.1% | Added |
| Profund Advisors LLC | 21,989 | $294.4K | 0.01% | +3,323+17.8% | Added |
| Arizona State Retirement System | 22,242 | $297.8K | 0.00% | +4,375+24.5% | Added |
| BNP Paribas Arbitrage, SA | 22,383 | $299.7K | 0.00% | +7,063+46.1% | Added |
| Dynamic Technology Lab Private Ltd | 22,964 | $308.0K | 0.07% | +12,612+121.8% | Added |
| Police & Firemen's Retirement System of New Jersey | 25,207 | $337.5K | 0.00% | +4,174+19.8% | Added |
| HRT Financial LP | 26,282 | $351.0K | 0.00% | −31,283−54.3% | Reduced |
| Manufacturers Life Insurance Company, The | 28,322 | $379.2K | 0.00% | +3,004+11.9% | Added |
| New York State Common Retirement Fund | 29,600 | $396.3K | 0.00% | +12,500+73.1% | Added |
| Intech Investment Management LLC | 29,655 | $397.1K | 0.00% | +2,521+9.3% | Added |
| Rathbone Brothers plc | 30,200 | $404.4K | 0.00% | 00.0% | Unchanged |
| Schonfeld Strategic Advisors LLC | 30,456 | $407.8K | 0.00% | −5,054−14.2% | Reduced |
| Dark Forest Capital Management LP | 30,661 | $410.6K | 0.02% | +30,661 | New |
| Fox Run Management, L.L.C. | 30,708 | $411.2K | 0.06% | −20,984−40.6% | Reduced |
| Scientech Research LLC | 31,699 | $424.4K | 0.27% | +7,460+30.8% | Added |
| PSP Research LLC | 34,841 | $466.5K | 0.41% | +34,841 | New |
| Palumbo Wealth Management LLC | 39,002 | $522.2K | 0.13% | +6,073+18.4% | Added |
| Quantinno Capital Management LP | 39,324 | $526.5K | 0.00% | +3,582+10.0% | Added |
| Citigroup Inc | 41,463 | $555.2K | 0.00% | +18,000+76.7% | Added |
| Mirae Asset Global ETFs Holdings Ltd. | 43,736 | $585.6K | 0.00% | +8,339+23.6% | Added |
| Squarepoint Ops LLC | 45,402 | $607.9K | 0.00% | +45,402 | New |
| Simplex Trading, LLC | 48,226 | $645.7K | 0.02% | +7,061+17.2% | Added |
| Nisa Investment Advisors, LLC | 48,378 | $647.8K | 0.00% | 00.0% | Unchanged |
| Scotia Capital Inc. | 49,677 | $663.7K | 0.00% | −4,254−7.9% | Reduced |
| Kestra Private Wealth Services, LLC | 50,140 | $671.4K | 0.01% | 00.0% | Unchanged |
| Gsa Capital Partners LLP | 52,255 | $700.0K | 0.06% | −3,234−5.8% | Reduced |
| Price T Rowe Associates Inc | 52,230 | $700.0K | 0.00% | +11,025+26.8% | Added |
| MetLife Investment Management | 52,580 | $704.0K | 0.00% | +3,384+6.9% | Added |
| Invesco Ltd. | 53,382 | $714.8K | 0.00% | +13,253+33.0% | Added |
| Jennison Associates LLC | 53,785 | $720.2K | 0.00% | +53,785 | New |
| AQR Capital Management LLC | 58,298 | $780.6K | 0.00% | +36,702+169.9% | Added |
| California State Teachers Retirement System | 58,383 | $781.7K | 0.00% | +1,092+1.9% | Added |
| State of Wisconsin Investment Board | 58,602 | $784.7K | 0.00% | +58,602 | New |
| Ikarian Capital, LLC | 58,803 | $787.4K | 0.10% | −3,888−6.2% | Reduced |
| Two Sigma Advisers, LP | 65,281 | $874.1K | 0.00% | −16,202−19.9% | Reduced |
| Legal & General Group Plc | 66,975 | $896.8K | 0.00% | +11,956+21.7% | Added |
| Platinum Investment Management Ltd | 70,000 | $937.3K | 0.22% | +70,000 | New |
| Alliancebernstein L.P. | 74,837 | $1.00M | 0.00% | +70.0% | Added |
| LPL Financial LLC | 77,236 | $1.03M | 0.00% | +1,289+1.7% | Added |
| Royal Bank of Canada | 93,626 | $1.25M | 0.00% | +41,867+80.9% | Added |
| Burkehill Global Management, LP | 100,000 | $1.34M | 0.09% | +100,000 | New |
| Data Collective IV GP, LLC | 100,350 | $1.34M | 2.30% | 00.0% | Unchanged |
| AdvisorShares Investments LLC | 102,838 | $1.38M | 0.23% | −18,826−15.5% | Reduced |
| Wells Fargo & Company | 107,057 | $1.43M | 0.00% | +50,562+89.5% | Added |
| Bank of America Corp | 110,467 | $1.48M | 0.00% | +26,456+31.5% | Added |
| Rhumbline Advisers | 110,747 | $1.48M | 0.00% | −1,371−1.2% | Reduced |
| Verition Fund Management LLC | 132,263 | $1.77M | 0.01% | +132,263 | New |
| CenterBook Partners LP | 138,815 | $1.86M | 0.09% | −20,606−12.9% | Reduced |
| Soviero Asset Management, LP | 150,000 | $2.01M | 1.05% | +150,000 | New |
| Woodline Partners LP | 150,570 | $2.02M | 0.01% | +150,570 | New |
| JPMorgan Chase & Co | 153,722 | $2.06M | 0.00% | +110,540+256.0% | Added |
| Swiss National Bank | 158,400 | $2.12M | 0.00% | +41,300+35.3% | Added |
| FMR LLC | 162,053 | $2.17M | 0.00% | +146,495+941.6% | Added |
| Royce & Associates LP | 164,041 | $2.20M | 0.02% | +83,017+102.5% | Added |
| Point72 Asset Management, L.P. | 180,441 | $2.42M | 0.00% | −43,859−19.6% | Reduced |
| Barclays PLC | 183,623 | $2.46M | 0.00% | +33,018+21.9% | Added |
| Citadel Advisors LLC | 209,944 | $2.81M | 0.00% | −129,494−38.1% | Reduced |
| Seven Grand Managers, LLC | 225,000 | $3.01M | 0.23% | +225,000 | New |
| Ensign Peak Advisors, Inc | 262,000 | $3.51M | 0.01% | +262,000 | New |
| Nuveen, LLC | 276,454 | $3.70M | 0.00% | +42,950+18.4% | Added |
| Universal- Beteiligungs- und Servicegesellschaft mbH | 278,720 | $3.73M | 0.01% | +278,720 | New |
| D. E. Shaw & Co., Inc. | 293,722 | $3.93M | 0.00% | +77,388+35.8% | Added |
| Bank of New York Mellon Corp | 298,660 | $4.00M | 0.00% | +69,629+30.4% | Added |
| RTW Investments, LP | 300,000 | $4.02M | 0.04% | +300,000 | New |
| Integral Health Asset Management, LLC | 350,000 | $4.69M | 0.24% | +350,000 | New |
| Morgan Stanley | 366,695 | $4.91M | 0.00% | −128,923−26.0% | Reduced |
| Deutsche Bank AG | 398,269 | $5.33M | 0.00% | +343,109+622.0% | Added |
| Superstring Capital Management LP | 425,202 | $5.69M | 3.05% | +425,202 | New |
| Two Sigma Investments, LP | 425,207 | $5.69M | 0.01% | +128,764+43.4% | Added |
| Susquehanna International Group, LLP | 477,112 | $6.39M | 0.01% | +459,839+2,662.2% | Added |
| Ameriprise Financial Inc | 504,241 | $6.75M | 0.00% | +504,241 | New |
| Jane Street Group, LLC | 536,002 | $7.18M | 0.01% | +261,154+95.0% | Added |
| Boxer Capital Management, LLC | 598,500 | $8.01M | 1.75% | +435,000+266.1% | Added |
| Vestal Point Capital, LP | 637,000 | $8.53M | 0.31% | +637,000 | New |
| UBS Group AG | 683,802 | $9.16M | 0.00% | +131,993+23.9% | Added |
| Northern Trust Corp | 734,660 | $9.84M | 0.00% | +106,122+16.9% | Added |
| Rosalind Advisors, Inc. | 750,000 | $10.0M | 3.85% | 00.0% | Unchanged |
| Siren, L.L.C. | 800,000 | $10.7M | 0.32% | +800,000 | New |
| Charles Schwab Investment Management Inc | 807,249 | $10.8M | 0.00% | +173,547+27.4% | Added |
| Goldman Sachs Group Inc | 925,332 | $12.4M | 0.00% | +374,702+68.0% | Added |
| Candriam Luxembourg S.C.A. | 971,218 | $13.0M | 0.06% | +971,218 | New |
| Adage Capital Partners GP, L.L.C. | 1,150,000 | $15.4M | 0.02% | +850,000+283.3% | Added |
| Wellington Management Group LLP | 1,220,667 | $16.3M | 0.00% | +964,301+376.1% | Added |
| OrbiMed Advisors LLC | 1,226,700 | $16.4M | 0.34% | +858,876+233.5% | Added |
| Balyasny Asset Management LLC | 1,308,115 | $17.5M | 0.03% | +1,308,115 | New |
| Millennium Management LLC | 1,383,175 | $18.5M | 0.01% | +1,084,970+363.8% | Added |
| AWM Investment Company, Inc. | 1,390,662 | $18.6M | 1.80% | +175,000+14.4% | Added |
| Deep Track Capital, LP | 1,676,540 | $22.4M | 0.51% | +176,540+11.8% | Added |
| Commodore Capital LP | 2,000,000 | $26.8M | 1.78% | −1,225,000−38.0% | Reduced |
| Blackstone Group Inc. | 2,059,805 | $27.6M | 0.12% | −716,756−25.8% | Reduced |
| Octagon Capital Advisors LP | 2,230,000 | $29.9M | 3.74% | +100,000+4.7% | Added |