Definium Therapeutics, Inc.
DFTX- Exchange
- Nasdaq
- Industry
- Medicinal Chemicals & Botanical Products
- SEC CIK
- 0001813814
In the last 90 days, Definium Therapeutics, Inc. insiders filed 0 open-market purchases and 6 sales; 362 institutions reported holding it in 13F filings for Q2 2026, worth $5.35B in total; Duquesne Family Office is the only superinvestor holding it.
13F holders, Q1 2025
Institutional positions in Definium Therapeutics, Inc. as of Mar 31, 2025. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 191
- +18 vs. Q4 2024
- Shares held
- 41.2M
- −58.8K (−0.1%) vs. Q4 2024
- Total value
- $240.5M
- −$46.4M (−16.2%) vs. Q4 2024
- New holders
- 39
- 50 more added
- Sold out
- 21
- 46 more reduced
1 institution that held it in Q4 2024 haven't filed for Q1 2025 yet. Not filing isn't selling, so they aren't counted as sold out or in the changes above.
Compare with Q4 2024: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting DFTX on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 362 | $5.35B |
| Q1 2026 | 248 | $1.47B |
| Q4 2025 | 209 | $908.7M |
| Q3 2025 | 196 | $468.6M |
| Q2 2025 | 183 | $271.0M |
| Q1 2025 | 191 | $240.5M |
| Q4 2024 | 174 | $288.9M |
| Q3 2024 | 158 | $281.6M |
| Q2 2024 | 152 | $299.3M |
| Q1 2024 | 135 | $327.2M |
| Q4 2023 | 104 | $17.9M |
| Q3 2023 | 93 | $12.1M |
| Q2 2023 | 84 | $13.9M |
| Q1 2023 | 89 | $12.6M |
| Q4 2022 | 104 | $11.1M |
| Q3 2022 | 101 | $20.5M |
| Q2 2022 | 156 | $15.1M |
| Q1 2022 | 159 | $53.6M |
| Q4 2021 | 176 | $72.0M |
| Q3 2021 | 175 | $104.8M |
| Q2 2021 | 156 | $131.0M |
| Q1 2021 | 8 | $932.0K |
Institutions, Q1 2025
Shares, value and share of portfolio for each institution holding Definium Therapeutics, Inc.; share changes are against Q4 2024.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| Sequoia Financial Advisors, LLC | 16,579 | $97.0K | 0.00% | 00.0% | Unchanged |
| HRT Financial LP | 16,703 | $97.0K | 0.00% | +16,703 | New |
| Gruss & Co., LLC | 16,939 | $99.1K | 0.43% | +16,939 | New |
| New York State Common Retirement Fund | 17,100 | $100.0K | 0.00% | 00.0% | Unchanged |
| Profund Advisors LLC | 17,509 | $102.4K | 0.00% | +5,216+42.4% | Added |
| Advisor Group Holdings, Inc. | 17,523 | $102.5K | 0.00% | +7,277+71.0% | Added |
| Boothbay Fund Management, LLC | 17,984 | $105.2K | 0.00% | 00.0% | Unchanged |
| Commonwealth Equity Services, LLC | 18,292 | $107.0K | 0.00% | −3,200−14.9% | Reduced |
| Raymond James Financial Inc | 18,479 | $108.1K | 0.00% | +2,475+15.5% | Added |
| Police & Firemen's Retirement System of New Jersey | 18,554 | $108.5K | 0.00% | +4,080+28.2% | Added |
| ProShare Advisors LLC | 19,209 | $112.4K | 0.00% | −6,958−26.6% | Reduced |
| Mercer Global Advisors Inc | 19,580 | $114.5K | 0.00% | +3,580+22.4% | Added |
| Mitchell McLeod Pugh & Williams Inc | 20,000 | $117.0K | 0.02% | 00.0% | Unchanged |
| Voya Investment Management LLC | 21,115 | $123.5K | 0.00% | −2,551−10.8% | Reduced |
| Federation des caisses Desjardins du Quebec | 22,422 | $131.2K | 0.00% | +1,000+4.7% | Added |
| Palumbo Wealth Management LLC | 22,628 | $132.4K | 0.04% | +22,628 | New |
| EntryPoint Capital, LLC | 22,708 | $132.8K | 0.06% | +22,708 | New |
| Virtus Investment Advisers, Inc. | 23,388 | $136.8K | 0.04% | +23,388 | New |
| Squarepoint Ops LLC | 23,471 | $137.3K | 0.00% | −18,497−44.1% | Reduced |
| Massar Capital Management, LP | 24,583 | $143.8K | 0.17% | +24,583 | New |
| Algert Global LLC | 24,770 | $144.9K | 0.00% | +24,770 | New |
| Manufacturers Life Insurance Company, The | 27,364 | $160.1K | 0.00% | +256+0.9% | Added |
| Rathbone Brothers plc | 28,200 | $165.0K | 0.00% | +8,000+39.6% | Added |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 28,867 | $168.9K | 0.00% | +1,669+6.1% | Added |
| XTX Topco Ltd | 29,544 | $172.8K | 0.01% | −6,595−18.2% | Reduced |
| Janus Henderson Group PLC | 28,000 | $173.5K | 0.00% | 00.0% | Unchanged |
| Price T Rowe Associates Inc | 30,945 | $182.0K | 0.00% | −368−1.2% | Reduced |
| Virtu Financial LLC | 32,836 | $192.0K | 0.01% | +32,836 | New |
| Clough Capital Partners L P | 33,900 | $198.3K | 0.03% | 00.0% | Unchanged |
| Caxton Corp | 34,073 | $199.3K | 3.92% | 00.0% | Unchanged |
| Janney Montgomery Scott LLC | 34,685 | $203.0K | 0.00% | +34,685 | New |
| Corebridge Financial, Inc. | 35,986 | $210.5K | 0.00% | −4,078−10.2% | Reduced |
| Moloney Securities Asset Management, LLC | 36,011 | $210.7K | 0.03% | −80,500−69.1% | Reduced |
| Wells Fargo & Company | 37,416 | $218.9K | 0.00% | −2,558−6.4% | Reduced |
| Invesco Ltd. | 39,100 | $228.7K | 0.00% | −2,300−5.6% | Reduced |
| Fore Capital, LLC | 40,000 | $234.0K | 0.28% | +2,461+6.6% | Added |
| Mirae Asset Global ETFs Holdings Ltd. | 43,550 | $254.8K | 0.00% | −2,140−4.7% | Reduced |
| UBS Asset Management Americas Inc | 45,621 | $266.9K | 0.00% | −39,423−46.4% | Reduced |
| JPMorgan Chase & Co | 46,145 | $269.9K | 0.00% | −2,013−4.2% | Reduced |
| Simplex Trading, LLC | 47,856 | $279.0K | 0.01% | +37,628+367.9% | Added |
| Cerity Partners LLC | 48,485 | $283.6K | 0.00% | +48,485 | New |
| MetLife Investment Management | 49,196 | $287.8K | 0.00% | −466−0.9% | Reduced |
| DRW Securities, LLC | 50,000 | $292.5K | 0.02% | +50,000 | New |
| Kestra Private Wealth Services, LLC | 50,206 | $293.7K | 0.00% | −1,000−2.0% | Reduced |
| Scotia Capital Inc. | 53,975 | $314.8K | 0.00% | +200.0% | Added |
| Intech Investment Management LLC | 54,990 | $321.7K | 0.00% | +25,428+86.0% | Added |
| Legal & General Group Plc | 57,293 | $335.2K | 0.00% | −1,144−2.0% | Reduced |
| California State Teachers Retirement System | 58,498 | $342.2K | 0.00% | 00.0% | Unchanged |
| Two Sigma Investments, LP | 59,222 | $346.4K | 0.00% | −121,071−67.2% | Reduced |
| Deutsche Bank AG | 59,226 | $346.5K | 0.00% | −12,369−17.3% | Reduced |
| Ikarian Capital, LLC | 62,691 | $366.7K | 0.12% | 00.0% | Unchanged |
| D. E. Shaw & Co., Inc. | 63,249 | $370.0K | 0.00% | +63,249 | New |
| Creative Planning | 64,442 | $377.0K | 0.00% | +64,442 | New |
| Royal Bank of Canada | 65,237 | $382.0K | 0.00% | +6,148+10.4% | Added |
| LPL Financial LLC | 67,433 | $394.5K | 0.00% | +5,099+8.2% | Added |
| Oppenheimer & Co Inc | 71,115 | $416.0K | 0.01% | +5,574+8.5% | Added |
| Citigroup Inc | 71,175 | $416.4K | 0.00% | −5,733−7.5% | Reduced |
| Jane Street Group, LLC | 73,989 | $432.8K | 0.00% | +57,432+346.9% | Added |
| Alliancebernstein L.P. | 75,580 | $442.1K | 0.00% | +7,650+11.3% | Added |
| Bank of America Corp | 88,222 | $516.1K | 0.00% | −184,707−67.7% | Reduced |
| Data Collective IV GP, LLC | 100,350 | $587.0K | 0.68% | 00.0% | Unchanged |
| Swiss National Bank | 106,600 | $623.6K | 0.00% | −13,300−11.1% | Reduced |
| UBS Group AG | 108,026 | $632.0K | 0.00% | −6,412−5.6% | Reduced |
| Rhumbline Advisers | 108,457 | $634.5K | 0.00% | +7,762+7.7% | Added |
| AdvisorShares Investments LLC | 119,593 | $662.5K | 0.13% | +15,884+15.3% | Added |
| Barclays PLC | 119,573 | $699.5K | 0.00% | −35,861−23.1% | Reduced |
| Balyasny Asset Management LLC | 169,558 | $991.9K | 0.00% | +169,558 | New |
| Goldman Sachs Group Inc | 192,195 | $1.12M | 0.00% | −104,611−35.2% | Reduced |
| Bank of New York Mellon Corp | 200,197 | $1.17M | 0.00% | +760.0% | Added |
| Wellington Management Group LLP | 225,928 | $1.32M | 0.00% | +31,437+16.2% | Added |
| Nuveen, LLC | 266,051 | $1.56M | 0.00% | +266,051 | New |
| Susquehanna International Group, LLP | 345,204 | $2.02M | 0.00% | +146,784+74.0% | Added |
| Ally Bridge Group (NY) LLC | 390,143 | $2.28M | 2.06% | +59,868+18.1% | Added |
| Tang Capital Management LLC | 400,200 | $2.34M | 0.13% | +200,200+100.1% | Added |
| Citadel Advisors LLC | 413,390 | $2.42M | 0.00% | +291,630+239.5% | Added |
| Rosalind Advisors, Inc. | 420,000 | $2.46M | 1.20% | +420,000 | New |
| Charles Schwab Investment Management Inc | 563,304 | $3.30M | 0.00% | −30,052−5.1% | Reduced |
| Northern Trust Corp | 642,783 | $3.76M | 0.00% | −42,053−6.1% | Reduced |
| Morgan Stanley | 659,892 | $3.86M | 0.00% | +163,240+32.9% | Added |
| Woodline Partners LP | 1,005,198 | $5.88M | 0.04% | 00.0% | Unchanged |
| AWM Investment Company, Inc. | 1,208,162 | $7.07M | 0.97% | +15,000+1.3% | Added |
| Geode Capital Management, LLC | 1,666,791 | $9.75M | 0.00% | −56,297−3.3% | Reduced |
| Vanguard Group Inc | 1,766,547 | $10.3M | 0.00% | −144,278−7.6% | Reduced |
| State Street Corp | 1,842,214 | $10.8M | 0.00% | +60,715+3.4% | Added |
| Deep Track Capital, LP | 2,500,000 | $14.6M | 0.47% | −316,594−11.2% | Reduced |
| Marshall Wace, LLP | 2,593,157 | $15.2M | 0.02% | +91,766+3.7% | Added |
| Octagon Capital Advisors LP | 3,018,000 | $17.7M | 3.84% | 00.0% | Unchanged |
| Driehaus Capital Management LLC | 3,351,405 | $19.6M | 0.19% | −24,802−0.7% | Reduced |
| Blackstone Group Inc. | 3,587,479 | $21.0M | 0.09% | 00.0% | Unchanged |
| Commodore Capital LP | 4,525,000 | $26.5M | 1.95% | +216,575+5.0% | Added |
| BlackRock, Inc. | 5,715,713 | $33.4M | 0.00% | −354,340−5.8% | Reduced |
| Tri Locum Partners LP | 0 | $0 | 0.00% | −820,793−100.0% | Sold out |
| Millennium Management LLC | 0 | $0 | 0.00% | −185,721−100.0% | Sold out |
| Allostery Investments LP | 0 | $0 | 0.00% | −130,000−100.0% | Sold out |
| BIT Capital GmbH | 0 | $0 | 0.00% | −63,405−100.0% | Sold out |
| ADAR1 Capital Management, LLC | 0 | $0 | 0.00% | −25,000−100.0% | Sold out |
| Two Sigma Advisers, LP | 0 | $0 | 0.00% | −24,650−100.0% | Sold out |
| SG Americas Securities, LLC | 0 | $0 | 0.00% | −24,406−100.0% | Sold out |
| Corton Capital Inc. | 0 | $0 | 0.00% | −14,416−100.0% | Sold out |
| Foundations Investment Advisors, LLC | 0 | $0 | 0.00% | −13,100−100.0% | Sold out |