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Amylyx Pharmaceuticals, Inc.

AMLX
Exchange
Nasdaq
Industry
Pharmaceutical Preparations
SEC CIK
0001658551

In the last 90 days, Amylyx Pharmaceuticals, Inc. insiders filed 0 open-market purchases and 6 sales; 206 institutions reported holding it in 13F filings for Q2 2026, worth $2.07B in total; no superinvestor holds it.

13F holders, Q3 2026

Institutional positions in Amylyx Pharmaceuticals, Inc. as of Sep 30, 2026. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works

Q3 2026 data is still coming in (13F filing deadline: Nov 16, 2026), so these numbers are incomplete.

Institutional holders
2
0 vs. Q2 2026
Shares held
1.07K
−66 (−5.8%) vs. Q2 2026
Total value
$31.3K
+$10.8K (+52.7%) vs. Q2 2026
New holders
0
0 more added
Sold out
0
1 more reduced

204 institutions that held it in Q2 2026 haven't filed for Q3 2026 yet. Not filing isn't selling, so they aren't counted as sold out or in the changes above.

Compare with Q2 2026: new holders, sold out and not filed yet

Holders and value by quarter

Institutions reporting AMLX on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.

Institutional holders
Q1 2021: 0 institutionsQ2 2021: 0 institutionsQ3 2021: 0 institutionsQ4 2021: 0 institutionsQ1 2022: 72 institutionsQ2 2022: 78 institutionsQ3 2022: 95 institutionsQ4 2022: 133 institutionsQ1 2023: 147 institutionsQ2 2023: 154 institutionsQ3 2023: 170 institutionsQ4 2023: 178 institutionsQ1 2024: 143 institutionsQ2 2024: 119 institutionsQ3 2024: 110 institutionsQ4 2024: 122 institutionsQ1 2025: 136 institutionsQ2 2025: 131 institutionsQ3 2025: 169 institutionsQ4 2025: 180 institutionsQ1 2026: 171 institutionsQ2 2026: 206 institutions
Value held
Q1 2021: $0Q2 2021: $0Q3 2021: $0Q4 2021: $0Q1 2022: $299.9MQ2 2022: $512.9MQ3 2022: $1.05BQ4 2022: $1.79BQ1 2023: $1.51BQ2 2023: $1.18BQ3 2023: $1.08BQ4 2023: $887.4MQ1 2024: $141.5MQ2 2024: $82.9MQ3 2024: $140.8MQ4 2024: $188.3MQ1 2025: $261.6MQ2 2025: $523.6MQ3 2025: $1.49BQ4 2025: $1.36BQ1 2026: $1.59BQ2 2026: $2.07B
Institutions holding AMLX and their total value by quarter
QuarterHoldersValue
Q2 2026206$2.07B
Q1 2026171$1.59B
Q4 2025180$1.36B
Q3 2025169$1.49B
Q2 2025131$523.6M
Q1 2025136$261.6M
Q4 2024122$188.3M
Q3 2024110$140.8M
Q2 2024119$82.9M
Q1 2024143$141.5M
Q4 2023178$887.4M
Q3 2023170$1.08B
Q2 2023154$1.18B
Q1 2023147$1.51B
Q4 2022133$1.79B
Q3 202295$1.05B
Q2 202278$512.9M
Q1 202272$299.9M
Q4 20210$0
Q3 20210$0
Q2 20210$0
Q1 20210$0

Institutions, Q3 2026

Shares, value and share of portfolio for each institution holding Amylyx Pharmaceuticals, Inc.; share changes are against Q2 2026.

Institutions holding AMLX in Q3 2026
InstitutionSharesValue% of portfolioChange in sharesAction
Eastern Bank721$21.0K0.00%00.0%Unchanged
Massmutual Trust Co FSB354$10.3K0.00%−66−15.7%Reduced
FMR LLC––––Not filed
BlackRock, Inc.––––Not filed
Perceptive Advisors LLC––––Not filed
TCG Crossover Management, LLC––––Not filed
Commodore Capital LP––––Not filed
Jupiter Topco LLC––––Not filed
Saturn V Capital Management LLC––––Not filed
Vanguard Capital Management LLC––––Not filed
Morgan Stanley––––Not filed
Driehaus Capital Management LLC––––Not filed
First Light Asset Management, LLC––––Not filed
Franklin Resources Inc––––Not filed
Goldman Sachs Group Inc––––Not filed
State Street Corp––––Not filed
Geode Capital Management, LLC––––Not filed
JPMorgan Chase & Co––––Not filed
Adage Capital Partners GP, L.L.C.––––Not filed
Siren, L.L.C.––––Not filed
Eventide Asset Management, LLC––––Not filed
683 Capital Management, LLC––––Not filed
Vanguard Portfolio Management LLC––––Not filed
Alyeska Investment Group, L.P.––––Not filed
Almitas Capital LLC––––Not filed
Dimensional Fund Advisors LP––––Not filed
Jones Hill Capital LP––––Not filed
Woodline Partners LP––––Not filed
Northern Trust Corp––––Not filed
Bank of America Corp––––Not filed
Boxer Capital Management, LLC––––Not filed
Standard Life Aberdeen plc––––Not filed
Charles Schwab Investment Management Inc––––Not filed
Connor, Clark & Lunn Investment Management Ltd.––––Not filed
Great Point Partners LLC––––Not filed
Balyasny Asset Management LLC––––Not filed
Qube Research & Technologies Ltd––––Not filed
Vanguard Fiduciary Trust Co––––Not filed
Two Sigma Investments, LP––––Not filed
Deutsche Bank AG––––Not filed
Rock Springs Capital Management LP––––Not filed
ADAR1 Capital Management, LLC––––Not filed
Nantahala Capital Management, LLC––––Not filed
Federated Hermes, Inc.––––Not filed
Nearwater Capital Markets, Ltd––––Not filed
Parkman Healthcare Partners LLC––––Not filed
HighVista Strategies LLC––––Not filed
StemPoint Capital LP––––Not filed
Logos Global Management LP––––Not filed
Trexquant Investment LP––––Not filed
Nuveen, LLC––––Not filed
Ensign Peak Advisors, Inc––––Not filed
iA Global Asset Management Inc.––––Not filed
Jane Street Group, LLC––––Not filed
Polygon Management Ltd.––––Not filed
Jupiter Asset Management Ltd––––Not filed
Bank of New York Mellon Corp––––Not filed
UBS Group AG––––Not filed
First Trust Advisors LP––––Not filed
SummitTX Capital, L.P.––––Not filed
Wellington Management Group LLP––––Not filed
Cormorant Asset Management, LP––––Not filed
Aldebaran Capital, LLC––––Not filed
Walleye Capital LLC––––Not filed
OrbiMed Advisors LLC––––Not filed
Citadel Advisors LLC––––Not filed
D. E. Shaw & Co., Inc.––––Not filed
UBS Asset Management Americas Inc––––Not filed
Acuta Capital Partners, LLC––––Not filed
Norges Bank––––Not filed
Falcon Edge Capital, LP––––Not filed
Price T Rowe Associates Inc––––Not filed
Swiss National Bank––––Not filed
PFM Health Sciences, LP––––Not filed
Invesco Ltd.––––Not filed
Wells Fargo & Company––––Not filed
Ameriprise Financial Inc––––Not filed
Lighthouse Investment Partners, LLC––––Not filed
Ikarian Capital, LLC––––Not filed
Rhumbline Advisers––––Not filed
Alps Advisors Inc––––Not filed
Elmind Capital, LP––––Not filed
Campbell & CO Investment Adviser LLC––––Not filed
Affinity Asset Advisors, LLC––––Not filed
Russell Investments Group, Ltd.––––Not filed
Quantinno Capital Management LP––––Not filed
Alliancebernstein L.P.––––Not filed
California State Teachers Retirement System––––Not filed
1492 Capital Management LLC––––Not filed
Citigroup Inc––––Not filed
Schonfeld Strategic Advisors LLC––––Not filed
State of Wisconsin Investment Board––––Not filed
CI Private Wealth, LLC––––Not filed
Moody Aldrich Partners LLC––––Not filed
Vanguard Asset Management, Ltd––––Not filed
Legal & General Group Plc––––Not filed
Barclays PLC––––Not filed
MetLife Investment Management––––Not filed
SG Americas Securities, LLC––––Not filed
Hudson Bay Capital Management LP––––Not filed